Triple Angiokinase Inhibitor Nintedanib Directly Inhibits Tumor Cell Growth and Induces Tumor Shrinkage via Blocking Oncogenic Receptor Tyrosine Kinases von Hilberg, Frank, Tontsch-Grunt, Ulrike, Baum, Anke, Le, Anh T, Doebele, Robert C, Lieb, Simone, Gianni, Davide, Voss, Tilman, Garin-Chesa, Pilar, Haslinger, Christian, Kraut, Norbert

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Design, Synthesis, and Evaluation of Indolinones as Triple Angiokinase Inhibitors and the Discovery of a Highly Specific 6-Methoxycarbonyl-Substituted Indolinone (BIBF 1120) von Roth, Gerald J, Heckel, Armin, Colbatzky, Florian, Handschuh, Sandra, Kley, Jörg, Lehmann-Lintz, Thorsten, Lotz, Ralf, Tontsch-Grunt, Ulrike, Walter, Rainer, Hilberg, Frank

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Epigenetic SMAD3 Repression in Tumor-Associated Fibroblasts Impairs Fibrosis and Response to the Antifibrotic Drug Nintedanib in Lung Squamous Cell Carcinoma von Ikemori, Rafael, Gabasa, Marta, Duch, Paula, Vizoso, Miguel, Bragado, Paloma, Arshakyan, Marselina, Luis, Iuliana-Cristiana, Marin, Albert, Moran, Sebastian, Castro, Manuel, Fuster, Gemma, Gea-Sorli, Sabrina, Jauset, Toni, Soucek, Laura, Montuenga, Luis M., Esteller, Manel, Mons, Eduard, Peinado, Victor Ivo, Gascon, Pere, Fillat, Cristina, Hilberg, Frank, Reguart, Noemi, Alcaraz, Jordi

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Therapeutic impact of Nintedanib with paclitaxel and/or a PD-L1 antibody in preclinical models of orthotopic primary or metastatic triple negative breast cancer von Reguera-Nuñez, Elaine, Xu, Ping, Chow, Annabelle, Man, Shan, Hilberg, Frank, Kerbel, Robert S

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Nintedanib and a bi-specific anti-VEGF/Ang2 nanobody selectively prevent brain metastases of lung adenocarcinoma cells von Kovalchuk, Bogdana, Berghoff, Anna S., Karreman, Matthia A., Frey, Katharina, Piechutta, Manuel, Fischer, Manuel, Grosch, Julia, Heiland, Sabine, Breckwoldt, Michael O., Hilberg, Frank, Wick, Wolfgang, Winkler, Frank

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Nintedanib Is Active in Malignant Pleural Mesothelioma Cell Models and Inhibits Angiogenesis and Tumor Growth In Vivo von Laszlo, Viktoria, Valko, Zsuzsanna, Kovacs, Ildiko, Ozsvar, Judit, Hoda, Mir Alireza, Klikovits, Thomas, Lakatos, Dora, Czirok, Andras, Garay, Tamas, Stiglbauer, Alexander, Helbich, Thomas H, Gröger, Marion, Tovari, Jozsef, Klepetko, Walter, Pirker, Christine, Grusch, Michael, Berger, Walter, Hilberg, Frank, Hegedus, Balazs, Dome, Balazs

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Enhancing gastric cancer conventional chemotherapy effects by triple angiokinase inhibitor nintedanib in preclinical models von Awasthi, Niranjan, Schwarz, Margaret A, Kaurich, Quinn, Zhang, Changhua, Hilberg, Frank, Schwarz, Roderich E

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CD44 Suppresses TLR-Mediated Inflammation von Kawana, Hidetada, Karaki, Hirokazu, Higashi, Morihiro, Miyazaki, Masaru, Hilberg, Frank, Kitagawa, Motoo, Harigaya, Kenichi

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Functions of c-Jun in Liver and Heart Development von Eferl, Robert, Sibilia, Maria, Hilberg, Frank, Fuchsbichler, Andrea, Kufferath, Iris, Guertl, Barbara, Zenz, Rainer, Wagner, Erwin F., Zatloukal, Kurt

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Nintedanib: From Discovery to the Clinic von Roth, Gerald J, Binder, Rudolf, Colbatzky, Florian, Dallinger, Claudia, Schlenker-Herceg, Rozsa, Hilberg, Frank, Wollin, Stefan-Lutz, Kaiser, Rolf

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Abstract 1043: Enhancing cytotoxic chemotherapy effects by nintedanib in gastric cancer preclinical models von Awasthi, Niranjan, Schwarz, Margaret A., Hilberg, Frank, Schwarz, Roderich E.

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Drug resistance profiles of mutations in the RET kinase domain von Liu, Xuan, Shen, Tao, Mooers, Blaine H M, Hilberg, Frank, Wu, Jie

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Bortezomib, Dexamethasone, and Fibroblast Growth Factor Receptor 3–Specific Tyrosine Kinase Inhibitor in t(4;14) Myeloma von BISPING, Guido, WENNING, Doris, VOLPERT, Sarah, MESTERS, Rolf M, BERDEL, Wolfgang E, KIENAST, Joachim, KROPFF, Martin, GUSTAVUS, Dirk, MÜLLER-TIDOW, Carsten, STELLJES, Matthias, MUNZERT, Gerd, HILBERG, Frank, ROTH, Gerald J, STEFANIC, Martin

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CD44 is a determinant of inflammatory bone loss von Hayer, Silvia, Steiner, Günter, Görtz, Birgit, Reiter, Erika, Tohidast-Akrad, Makiyeh, Amling, Michael, Hoffmann, Oskar, Redlich, Kurt, Zwerina, Jochen, Skriner, Karl, Hilberg, Frank, Wagner, Erwin F, Smolen, Josef S, Schett, Georg

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BIBF 1120: triple angiokinase inhibitor with sustained receptor blockade and good antitumor efficacy von Hilberg, Frank, Roth, Gerald J, Krssak, Martin, Kautschitsch, Susanna, Sommergruber, Wolfgang, Tontsch-Grunt, Ulrike, Garin-Chesa, Pilar, Bader, Gerd, Zoephel, Andreas, Quant, Jens, Heckel, Armin, Rettig, Wolfgang J

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Abstract 2869: Nintedanib abrogates the activation and tumor-promoting effects of fibroblasts from lung adenocarcinoma patients von Alcaraz, Jordi, Gabasa, Marta, Ikemori, Rafael, Hilberg, Frank, Reguart, Noemí

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Structural basis of resistance of mutant RET protein-tyrosine kinase to its inhibitors nintedanib and vandetanib von Terzyan, Simon S., Shen, Tao, Liu, Xuan, Huang, Qingling, Teng, Peng, Zhou, Mi, Hilberg, Frank, Cai, Jianfeng, Mooers, Blaine H.M., Wu, Jie

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Abstract 2982: Unraveling the antifibrotic mode of action of nintedanib against the TGF-β pathway in tumor-associated fibroblasts in non-small cell lung cancer von Ikemori, Rafael, Gabasa, Marta, Duch, Paula, Hilberg, Frank, Reguart, Noemí, Alcaraz, Jordi

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Tumour-infiltrating neutrophils counteract anti-VEGF therapy in metastatic colorectal cancer von Schiffmann, Lars Mortimer, Fritsch, Melanie, Gebauer, Florian, Günther, Saskia Diana, Stair, Neil Richard, Seeger, Jens Michael, Thangarajah, Fabinshy, Dieplinger, Georg, Bludau, Marc, Alakus, Hakan, Göbel, Heike, Quaas, Alexander, Zander, Thomas, Hilberg, Frank, Bruns, Christiane Josephine, Kashkar, Hamid, Coutelle, Oliver

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Abstract B09: Nintedanib inhibits tumor and vessel growth and leads to vascular normalization in A549-NSCLC-xenografts von Ackermann, Maximilian, Hilberg, Frank, Konerding, Moritz Anton

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