On-microscope staging of live cells reveals changes in the dynamics of transcriptional bursting during differentiation von Jeziorska, D. M., Tunnacliffe, E. A. J., Brown, J. M., Ayyub, H., Sloane-Stanley, J., Sharpe, J. A., Lagerholm, B. C., Babbs, C., Smith, A. J. H., Buckle, V. J., Higgs, D. R.

Volltext

Alpha Thalassaemias von Higgs, D. R, Weatherall, D. J

Volltext

Variable cells with identical genetic codes von Babbs, C., Higgs, D.R.

Volltext

Mutations in ATRX , encoding a SWI/SNF-like protein, cause diverse changes in the pattern of DNA methylation von Higgs, Douglas R, Gibbons, Richard J, McDowell, Tarra L, Raman, Sundhya, O'Rourke, Delia M, Garrick, David, Ayyub, Helena

Volltext

Single-tube multiplex-PCR screen for common deletional determinants of α-thalassemia von CHONG, S. S, BOEHM, C. D, HIGGS, D. R, CUTTING, G. R

Volltext

Localization of a Putative Transcriptional Regulator (ATRX) at Pericentromeric Heterochromatin and the Short Arms of Acrocentric Chromosomes von McDowell, T. L., Gibbons, R. J., Sutherland, H., O'Rourke, D. M., Bickmore, W. A., Pombo, A., Turley, H., Gatter, K., Picketts, D. J., Buckle, V. J., Chapman, L., Rhodes, D., Higgs, D. R.

Volltext

Homozygous mutations in a predicted endonuclease are a novel cause of congenital dyserythropoietic anemia type I von Babbs, C., Roberts, N. A., Sanchez-Pulido, L., McGowan, S. J., Ahmed, M. R., Brown, J. M., Sabry, M. A., Bentley, D. R., McVean, G. A., Donnelly, P., Gileadi, O., Ponting, C. P., Higgs, D. R., Buckle, V. J.

Volltext

The Pattern of Replication at a Human Telomeric Region (16p13.3): Its Relationship to Chromosome Structure and Gene Expression von Smith, Zoe E., Higgs, Douglas R.

Volltext

Understanding α-Globin Gene Regulation: Aiming to Improve the Management of Thalassemia von HIGGS, D.R., GARRICK, D., ANGUITA, E., DE GOBBI, M., HUGHES, J., MUERS, M., VERNIMMEN, D., LOWER, K., LAW, M., ARGENTARO, A., DEVILLE, M. A., GIBBONS, R.

Volltext

ATRX Encodes a Novel Member of the SNF2 Family of Proteins: Mutations Point to a Common Mechanism Underlying the ATR-X Syndrome von Picketts, David J., Higgs, Douglas R., Bachoo, Satvinder, Blake, Derek J., Quarrell, Oliver W. J., Gibbons, Richard J.

Volltext

A Review of the Molecular Genetics of the Human α-Globin Gene Cluster von Higgs, D.R., Vickers, M.A., Wilkie, A.O.M., Pretorius, I.M., Jarman, A.P., Weatherall, D.J.

Volltext

Healing of broken human chromosomes by the addition of telomeric repeats von FLINT, J, CRADDOCK, C. F, VILLEGAS, A, BENTLEY, D. P, WILLIAMS, H. J, GALANELLO, R, CAO, A, WOOD, W. G, AYYUB, H, HIGGS, D. R

Volltext

Sequence Comparison of Human and Yeast Telomeres Identifies Structurally Distinct Subtelomeric Domains von Flint, J., Bates, G. P., Clark, K., Dorman, A., Willingham, D., Roe, B. A., Micklem, G., Higgs, D. R., Louis, E. J.

Volltext

The relationship between chromosome structure and function at a human telomeric region von Flint, Jonathan, Thomas, Karen, Micklem, Gos, Raynham, Helen, Clark, Kevin, Doggett, Norman A, Andrew, Andrew, Higgs, Douglas R

Volltext

A major positive regulatory region located far upstream of the human α-globin gene locus von HIGGS, D. R, WOOD, W. G, JARMAN, A. P, SHARPE, J, LIDA, J, PRETORIUS, I.-M, AYYUB, H

Volltext

Recombination at the human α-globin gene cluster: Sequence features and topological constraints von Nicholls, R.D., Fischel-Ghodsian, N., Higgs, D.R.

Volltext

A nonsense mutation of the ATRX gene causing mild mental retardation and epilepsy von Guerrini, Renzo, Shanahan, Jennifer L., Carrozzo, Romeo, Bonanni, Paolo, Higgs, Douglas R., Gibbons, Richard J.

Volltext

Cis-acting sequences regulating expression of the human α-globin cluster lie within constitutively open chromatin von Vyas, P., Vickers, M.A., Simmons, D.L., Ayyub, H., Craddock, C.F., Higgs, D.R.

Volltext

Phenotype/genotype relationships in sickle cell disease: a pilot twin study von WEATHERALL, M. W., HIGGS, D. R., WEISS, H., WEATHERALL, D. J., SERJEANT, G. R.

Volltext

A highly polymorphic DNA marker linked to adult polycystic kidney disease on chromosome 16 von Reeders, S. T, Breuning, M. H, Davies, K. E, Nicholls, R. D, Jarman, A. P, Higgs, D. R, Pearson, P. L, Weatherall, D. J

Volltext