Discovery and structural characterization of peficitinib (ASP015K) as a novel and potent JAK inhibitor von Hamaguchi, Hisao, Amano, Yasushi, Moritomo, Ayako, Shirakami, Shohei, Nakajima, Yutaka, Nakai, Kazuo, Nomura, Naoko, Ito, Misato, Higashi, Yasuyuki, Inoue, Takayuki

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A novel JAK inhibitor, peficitinib, demonstrates potent efficacy in a rat adjuvant-induced arthritis model von Ito, Misato, Yamazaki, Shunji, Yamagami, Kaoru, Kuno, Masako, Morita, Yoshiaki, Okuma, Kenji, Nakamura, Koji, Chida, Noboru, Inami, Masamichi, Inoue, Takayuki, Shirakami, Shohei, Higashi, Yasuyuki

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Role of JAK-STAT signaling in the pathogenic behavior of fibroblast-like synoviocytes in rheumatoid arthritis: Effect of the novel JAK inhibitor peficitinib von Emori, Takashi, Kasahara, Michiko, Sugahara, Shingo, Hashimoto, Motomu, Ito, Hiromu, Narumiya, Shuh, Higashi, Yasuyuki, Fujii, Yasutomo

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Investigation of pulmonary inflammatory responses following intratracheal instillation of and inhalation exposure to polypropylene microplastics von Tomonaga, Taisuke, Higashi, Hidenori, Izumi, Hiroto, Nishida, Chinatsu, Kawai, Naoki, Sato, Kazuma, Morimoto, Toshiki, Higashi, Yasuyuki, Yatera, Kazuhiro, Morimoto, Yasuo

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Pulmonary disorder induced by cross‐linked polyacrylic acid von Higashi, Yasuyuki, Morimoto, Yasuo, Nishida, Chinatsu, Tomonaga, Taisuke, Izumi, Hiroto, Wang, Ke‐Yong, Higashi, Hidenori, Ono, Ryohei, Sumiya, Kazuki, Sakurai, Kazuo, Yamasaki, Kei, Yatera, Kazuhiro

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Crosslinked Structure of Polyacrylic Acid Affects Pulmonary Fibrogenicity in Rats von Tomonaga, Taisuke, Nishida, Chinatsu, Izumi, Hiroto, Kawai, Naoki, Wang, Ke-Yong, Higashi, Hidenori, Takeshita, Jun-Ichi, Ono, Ryohei, Sumiya, Kazuki, Fujii, Shota, Hata, Yuki, Sakurai, Kazuo, Morimoto, Toshiki, Higashi, Yasuyuki, Yamasaki, Kei, Yatera, Kazuhiro, Morimoto, Yasuo

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Effect of Different Molecular Weights of Polyacrylic Acid on Rat Lung Following Intratracheal Instillation von Nishida, Chinatsu, Izumi, Hiroto, Tomonaga, Taisuke, Wang, Ke-Yong, Higashi, Hidenori, Takeshita, Jun-Ichi, Ono, Ryohei, Sumiya, Kazuki, Fujii, Shota, Hata, Yuki, Sakurai, Kazuo, Higashi, Yasuyuki, Yamasaki, Kei, Yatera, Kazuhiro, Morimoto, Yasuo

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The Effects of Endoplasmic Reticulum Stress via Intratracheal Instillation of Water-Soluble Acrylic Acid Polymer on the Lungs of Rats von Morimoto, Toshiki, Izumi, Hiroto, Tomonaga, Taisuke, Nishida, Chinatsu, Kawai, Naoki, Higashi, Yasuyuki, Wang, Ke-Yong, Ono, Ryohei, Sumiya, Kazuki, Sakurai, Kazuo, Moriyama, Akihiro, Takeshita, Jun-Ichi, Yamasaki, Kei, Yatera, Kazuhiro, Morimoto, Yasuo

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Synthesis and Evaluation of 1H-Pyrrolo[2,3-b]pyridine Derivatives as Novel Immunomodulators Targeting Janus Kinase 3 von Nakajima, Yutaka, Tojo, Takashi, Morita, Masataka, Hatanaka, Keiko, Shirakami, Shohei, Tanaka, Akira, Sasaki, Hiroshi, Nakai, Kazuo, Mukoyoshi, Koichiro, Hamaguchi, Hisao, Takahashi, Fumie, Moritomo, Ayako, Higashi, Yasuyuki, Inoue, Takayuki

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Release mechanisms of tacrolimus-loaded PLGA and PLA microspheres and immunosuppressive effects of the microspheres in a rat heart transplantation model von Kojima, Ryo, Yoshida, Takatsune, Tasaki, Hiroaki, Umejima, Hiroyuki, Maeda, Masashi, Higashi, Yasuyuki, Watanabe, Shunsuke, Oku, Naoto

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Waterproof spray‐induced lung injury while using a heater von Higashi, Yasuyuki, Yamasaki, Kei, Orihashi, Takeshi, Yatera, Kazuhiro

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A rare case of double primary lung adenocarcinomas with uncommon complex EGFR G719X and S768I mutations and pleomorphic carcinoma von Morimoto, Toshiki, Yamasaki, Kei, Shingu, Tatsuya, Higashi, Yasuyuki, Maeda, Yukinori, Uryu, Takumu, Kubo, Naoto, Kawaguchi, Takako, Nishida, Chinatsu, Yatera, Kazuhiro

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Difficulty differentiating primary mediastinal classical Hodgkin lymphoma from inflammatory myofibroblastic tumor: A case report von Akata, Kentaro, Yamasaki, Kei, Chiba, Yosuke, Kawaguchi, Takako, Dosaka, Hiroki, Morimoto, Toshiki, Higashi, Yasuyuki, Nishida, Chinatsu, Shimajiri, Shohei, Yatera, Kazuhiro

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Inhibition of c-Rel DNA binding is critical for the anti-inflammatory effects of novel PIKfyve inhibitor von Terajima, Masaomi, Kaneko-Kobayashi, Yoko, Nakamura, Naoto, Yuri, Masatoshi, Hiramoto, Masashi, Naitou, Masanori, Hattori, Kazuyuki, Yokota, Hiroyuki, Mizuhara, Hidekazu, Higashi, Yasuyuki

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Efficacy of Oral Treatment With Tacrolimus in the Renal Transplant Model in Cynomolgus Monkeys von Kinugasa, Fumitaka, Nagatomi, Itsuo, Ishikawa, Hirofumi, Nakanishi, Tomonori, Maeda, Masashi, Hirose, Jun, Fukahori, Hidehiko, Ooshima, Shinsuke, Noto, Takahisa, Higashi, Yasuyuki, Seki, Nobuo, Mutoh, Seitaro

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P-487 INVESTIGATION OF LUNG DISORDER BY MICROPLASTIC; SHORT-TERM INHALATION EXPOSURE OF POLYPROPYLENE IN RATS von Tomonaga, Taisuke, Izumi, Hiroto, Kawai, Naoki, Sato, Kazuma, Nishida, Chinatsu, Higashi, Yasuyuki, Morimoto, Toshiki, Higashi, Hidenori, Yatera, Kazuhiro, Morimoto, Yasuo

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Tacrolimus suppressed the production of cytokines involved in atopic dermatitis by direct stimulation of human PBMC system. (Comparison with steroids) von Sakuma, Shozo, Higashi, Yasuyuki, Sato, Natuki, Sasakawa, Tatsuya, Sengoku, Takanori, Ohkubo, Yoshitaka, Amaya, Tadahiro, Goto, Toshio

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Inhalation exposure to cross-linked polyacrylic acid induces pulmonary disorders von Higashi, Yasuyuki, Nishida, Chinatsu, Izumi, Hiroto, Sato, Kazuma, Kawai, Naoki, Tomonaga, Taisuke, Morimoto, Toshiki, Yamasaki, Kei, Wang, Ke-Yong, Higashi, Hidenori, Moriyama, Akihiro, Takeshita, Jun-Ichi, Kojima, Takuma, Sakurai, Kazuo, Yatera, Kazuhiro, Morimoto, Yasuo

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Intratracheal instillation of polyacrylic acid induced pulmonary fibrosis with elevated transforming growth factor-β1 and connective tissue growth factor von Higashi, Yasuyuki, Nishida, Chinatsu, Tomonaga, Taisuke, Izumi, Hiroto, Kawai, Naoki, Morimoto, Toshiki, Hara, Kanako, Yamasaki, Kei, Moriyama, Akihiro, Takeshita, Jun-ichi, Wang, Ke-Yong, Higashi, Hidenori, Ono, Ryohei, Sumiya, Kazuki, Sakurai, Kazuo, Yatera, Kazuhiro, Morimoto, Yasuo

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JAK inhibitors as a new generation of small-molecule immunosuppressants von Higashi, Yasuyuki

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