Canonical DNA Repair Pathways Influence R-Loop-Driven Genome Instability von Stirling, Peter C., Hieter, Philip

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International Cooperation to Enable the Diagnosis of All Rare Genetic Diseases von Boycott, Kym M., Rath, Ana, Chong, Jessica X., Hartley, Taila, Alkuraya, Fowzan S., Baynam, Gareth, Brookes, Anthony J., Brudno, Michael, Carracedo, Angel, den Dunnen, Johan T., Dyke, Stephanie O.M., Estivill, Xavier, Goldblatt, Jack, Gonthier, Catherine, Groft, Stephen C., Gut, Ivo, Hamosh, Ada, Hieter, Philip, Höhn, Sophie, Hurles, Matthew E., Kaufmann, Petra, Knoppers, Bartha M., Krischer, Jeffrey P., Macek, Milan, Matthijs, Gert, Olry, Annie, Parker, Samantha, Paschall, Justin, Philippakis, Anthony A., Rehm, Heidi L., Robinson, Peter N., Sham, Pak-Chung, Stefanov, Rumen, Taruscio, Domenica, Unni, Divya, Vanstone, Megan R., Zhang, Feng, Brunner, Han, Bamshad, Michael J., Lochmüller, Hanns

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MinION-based long-read sequencing and assembly extends the Caenorhabditis elegans reference genome von Tyson, John R, O'Neil, Nigel J, Jain, Miten, Olsen, Hugh E, Hieter, Philip, Snutch, Terrance P

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Mechanisms of genome instability induced by RNA-processing defects von Chan, Yujia A, Hieter, Philip, Stirling, Peter C

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Genome-wide profiling of yeast DNA:RNA hybrid prone sites with DRIP-chip von Chan, Yujia A, Aristizabal, Maria J, Lu, Phoebe Y T, Luo, Zongli, Hamza, Akil, Kobor, Michael S, Stirling, Peter C, Hieter, Philip

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Model Organisms Facilitate Rare Disease Diagnosis and Therapeutic Research von Wangler, Michael F, Yamamoto, Shinya, Chao, Hsiao-Tuan, Posey, Jennifer E, Westerfield, Monte, Postlethwait, John, Hieter, Philip, Boycott, Kym M, Campeau, Philippe M, Bellen, Hugo J

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R-loop-mediated genome instability in mRNA cleavage and polyadenylation mutants von Stirling, Peter C, Chan, Yujia A, Minaker, Sean W, Aristizabal, Maria J, Barrett, Irene, Sipahimalani, Payal, Kobor, Michael S, Hieter, Philip

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MRE11-RAD50-NBS1 promotes Fanconi Anemia R-loop suppression at transcription–replication conflicts von Chang, Emily Yun-Chia, Tsai, Shuhe, Aristizabal, Maria J., Wells, James P., Coulombe, Yan, Busatto, Franciele F., Chan, Yujia A., Kumar, Arun, Dan Zhu, Yi, Wang, Alan Ying-Hsu, Fournier, Louis-Alexandre, Hieter, Philip, Kobor, Michael S., Masson, Jean-Yves, Stirling, Peter C.

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Overexpression screens identify conserved dosage chromosome instability genes in yeast and human cancer von Duffy, Supipi, Fam, Hok Khim, Wang, Yi Kan, Styles, Erin B., Kim, Jung-Hyun, Ang, J. Sidney, Singh, Tejomayee, Larionov, Vladimir, Shah, Sohrab P., Andrews, Brenda, Boerkoel, Cornelius F., Hieter, Philip

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An E4 Ligase Facilitates Polyubiquitination of Plant Immune Receptor Resistance Proteins in Arabidopsis von Huang, Yan, Minaker, Sean, Roth, Charlotte, Huang, Shuai, Hieter, Philip, Lipka, Volker, Wiermer, Marcel, Li, Xin

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Toward a Comprehensive Temperature-Sensitive Mutant Repository of the Essential Genes of Saccharomyces cerevisiae von Ben-Aroya, Shay, Coombes, Candice, Kwok, Teresa, O'Donnell, Kathryn A., Boeke, Jef D., Hieter, Philip

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Chromatid cohesion defects may underlie chromosome instability in human colorectal cancers von Barber, Thomas D, McManus, Kirk, Yuen, Karen W.Y, Reis, Marcelo, Parmigiani, Giovanni, Shen, Dong, Barrett, Irene, Nouhi, Yasaman, Spencer, Forrest, Markowitz, Sanford, Velculescu, Victor E, Kinzler, Kenneth W, Vogelstein, Bert, Lengauer, Christoph, Hieter, Philip

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The complete spectrum of yeast chromosome instability genes identifies candidate CIN cancer genes and functional roles for ASTRA complex components von Stirling, Peter C, Bloom, Michelle S, Solanki-Patil, Tejomayee, Smith, Stephanie, Sipahimalani, Payal, Li, Zhijian, Kofoed, Megan, Ben-Aroya, Shay, Myung, Kyungjae, Hieter, Philip

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Glioblastoma cells containing mutations in the cohesin component STAG2 are sensitive to PARP inhibition von Bailey, Melanie L, O'Neil, Nigel J, van Pel, Derek M, Solomon, David A, Waldman, Todd, Hieter, Philip

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Specific synthetic lethal killing of RAD54B-deficient human colorectal cancer cells by FEN1 silencing von McManus, Kirk J, Barrett, Irene J, Nouhi, Yasaman, Hieter, Philip

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An evolutionarily conserved synthetic lethal interaction network identifies FEN1 as a broad-spectrum target for anticancer therapeutic development von van Pel, Derek M, Barrett, Irene J, Shimizu, Yoko, Sajesh, Babu V, Guppy, Brent J, Pfeifer, Tom, McManus, Kirk J, Hieter, Philip

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A Robust Toolkit for Functional Profiling of the Yeast Genome von Pan, Xuewen, Yuan, Daniel S., Xiang, Dong, Wang, Xiaoling, Sookhai-Mahadeo, Sharon, Bader, Joel S., Hieter, Philip, Spencer, Forrest, Boeke, Jef D.

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Synthetic lethality and cancer: cohesin and PARP at the replication fork von O’Neil, Nigel J, van Pel, Derek M, Hieter, Philip

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Synthetic lethality of cohesins with PARPs and replication fork mediators von McLellan, Jessica L, O'Neil, Nigel J, Barrett, Irene, Ferree, Elizabeth, van Pel, Derek M, Ushey, Kevin, Sipahimalani, Payal, Bryan, Jennifer, Rose, Ann M, Hieter, Philip

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Identification of protein complexes required for efficient sister chromatid cohesion von Mayer, Melanie L, Pot, Isabelle, Chang, Michael, Xu, Hong, Aneliunas, Victoria, Kwok, Teresa, Newitt, Rick, Aebersold, Ruedi, Boone, Charles, Brown, Grant W, Hieter, Philip

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