A phase1 study of stereotactic gene delivery of AAV2-NGF for Alzheimer's disease von Rafii, Michael S, Baumann, Tiffany L, Bakay, Roy A.E, Ostrove, Jeffrey M, Siffert, Joao, Fleisher, Adam S, Herzog, Christopher D, Barba, David, Pay, Mary, Salmon, David P, Chu, Yaping, Kordower, Jeffrey H, Bishop, Kathie, Keator, David, Potkin, Steven, Bartus, Raymond T

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Bioactivity of AAV2-neurturin gene therapy (CERE-120): Differences between Parkinson's disease and nonhuman primate brains von Bartus, Raymond T., Herzog, Christopher D., Chu, Yaping, Wilson, Alistair, Brown, Lamar, Siffert, Joao, Johnson Jr, Eugene M., Olanow, C. Warren, Mufson, Elliott J., Kordower, Jeffrey H.

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Delivery of neurturin by AAV2 (CERE-120)-mediated gene transfer provides structural and functional neuroprotection and neurorestoration in MPTP-treated monkeys von Kordower, Jeffrey H., Herzog, Christopher D., Dass, Biplob, Bakay, Roy A. E., Stansell III, James, Gasmi, Mehdi, Bartus, Raymond T.

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Advancing neurotrophic factors as treatments for age-related neurodegenerative diseases: developing and demonstrating “clinical proof-of-concept” for AAV-neurturin (CERE-120) in Pa... von Bartus, Raymond T, Baumann, Tiffany L, Brown, Lamar, Kruegel, Brian R, Ostrove, Jeffrey M, Herzog, Christopher D

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Striatal delivery of CERE-120, an AAV2 vector encoding human neurturin, enhances activity of the dopaminergic nigrostriatal system in aged monkeys von Herzog, Christopher D., Dass, Biplob, Holden, James E., Stansell III, James, Gasmi, Mehdi, Tuszynski, Mark H., Bartus, Raymond T., Kordower, Jeffrey H.

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Enhanced neurotrophic distribution, cell signaling and neuroprotection following substantia nigral versus striatal delivery of AAV2-NRTN (CERE-120) von Herzog, Christopher D, Brown, Lamar, Kruegel, Brian R, Wilson, Alistair, Tansey, Malú G, Gage, Fred H, Johnson, Eugene M, Bartus, Raymond T

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Gene therapy for infantile malignant osteopetrosis: review of pre-clinical research and proof-of-concept for phenotypic reversal von Moscatelli, Ilana, Almarza, Elena, Schambach, Axel, Ricks, David, Schulz, Ansgar, Herzog, Christopher D., Henriksen, Kim, Askmyr, Maria, Schwartz, Jonathan D., Richter, Johan

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AAV2-mediated delivery of human neurturin to the rat nigrostriatal system: Long-term efficacy and tolerability of CERE-120 for Parkinson’s disease von Gasmi, Mehdi, Brandon, Eugene P, Herzog, Christopher D, Wilson, Alistair, Bishop, Kathie M, Hofer, Eva K, Cunningham, Justine J, Printz, Marie A, Kordower, Jeffrey H, Bartus, Raymond T

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Properly scaled and targeted AAV2-NRTN (neurturin) to the substantia nigra is safe, effective and causes no weight loss: Support for nigral targeting in Parkinson's disease von Bartus, Raymond T, Brown, Lamar, Wilson, Alistair, Kruegel, Brian, Siffert, Joao, Johnson, Eugene M, Kordower, Jeffrey H, Herzog, Christopher D

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Transgene Expression, Bioactivity, and Safety of CERE-120 (AAV2-Neurturin) Following Delivery to the Monkey Striatum von Herzog, Christopher D, Dass, Biplob, Gasmi, Mehdi, Bakay, Roy, Stansell, James E, Tuszynski, Mark, Bankiewicz, Krystof, Chen, Er-Yun, Chu, Yaping, Bishop, Kathie, Kordower, Jeffrey H, Bartus, Raymond T

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Viral Delivery of Glial Cell Line-Derived Neurotrophic Factor Improves Behavior and Protects Striatal Neurons in a Mouse Model of Huntington's Disease von McBride, Jodi L., Ramaswamy, Shilpa, Gasmi, Mehdi, Bartus, Raymond T., Herzog, Christopher D., Brandon, Eugene P., Zhou, Lili, Pitzer, Mark R., Berry-Kravis, Elizabeth M., Kordower, Jeffrey H.

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Intrastriatal CERE-120 (AAV-Neurturin) protects striatal and cortical neurons and delays motor deficits in a transgenic mouse model of Huntington's disease von Ramaswamy, Shilpa, McBride, Jodi L, Han, Ina, Berry-Kravis, Elizabeth M, Zhou, Lili, Herzog, Christopher D, Gasmi, Mehdi, Bartus, Raymond T, Kordower, Jeffrey H

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Safety/feasibility of targeting the substantia nigra with AAV2-neurturin in Parkinson patients von Bartus, Raymond T, Baumann, Tiffany L, Siffert, Joao, Herzog, Christopher D, Alterman, Ron, Boulis, Nicholas, Turner, Dennis A, Stacy, Mark, Lang, Anthony E, Lozano, Andres M, Olanow, C Warren

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Neurturin gene therapy improves motor function and prevents death of striatal neurons in a 3-nitropropionic acid rat model of Huntington's disease von Ramaswamy, Shilpa, McBride, Jodi L, Herzog, Christopher D, Brandon, Eugene, Gasmi, Mehdi, Bartus, Raymond T, Kordower, Jeffrey H

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Gene transfer provides a practical means for safe, long-term, targeted delivery of biologically active neurotrophic factor proteins for neurodegenerative diseases von Herzog, Christopher D., Bishop, Kathie M., Brown, Lamar, Wilson, Alistair, Kordower, Jeffrey H., Bartus, Raymond T.

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Striatal Delivery of Neurturin by CERE-120, an AAV2 Vector for the Treatment of Dopaminergic Neuron Degeneration in Parkinson's Disease von Gasmi, Mehdi, Herzog, Christopher D, Brandon, Eugene P, Cunningham, Justine J, Ramirez, G Anthony, Ketchum, Elias T, Bartus, Raymond T

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Expression, bioactivity, and safety 1 year after adeno-associated viral vector type 2-mediated delivery of neurturin to the monkey nigrostriatal system support cere-120 for Parkins... von Herzog, Christopher D, Brown, Lamar, Gammon, Dawn, Kruegel, Brian, Lin, Richard, Wilson, Alistair, Bolton, Ariadne, Printz, Marie, Gasmi, Mehdi, Bishop, Kathie M, Kordower, Jeffrey H, Bartus, Raymond T

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Issues regarding gene therapy products for Parkinson's disease: The development of CERE-120 (AAV-NTN) as one reference point von Bartus, Raymond T, Herzog, Christopher D, Bishop, Kathie, Ostrove, Jeffrey M, Tuszynski, Mark, Kordower, Jeffrey H, Gasmi, Mehdi

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Microdialysis without acetylcholinesterase inhibition reveals an age-related attenuation in stimulated cortical acetylcholine release von Herzog, Christopher D., Nowak, Kelly A., Sarter, Martin, Bruno, John P.

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Interactions between aging and cortical cholinergic deafferentation on attention von Burk, Joshua A, Herzog, Christopher D, Porter, M.Christine, Sarter, Martin

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