APVO210: A Bispecific Anti-CD86-IL-10 Fusion Protein (ADAPTIR™) to Induce Antigen-Specific T Regulatory Type 1 Cells von Pellerin, Laurence, Chen, Ping, Gregori, Silvia, Hernandez-Hoyos, Gabriela, Bacchetta, Rosa, Roncarolo, Maria Grazia

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The Ras/MAPK cascade and the control of positive selection von Alberola-Ila, José, Hernández-Hoyos, Gabriela

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Regulation of GATA-3 expression during CD4 lineage differentiation von Gimferrer, Idoia, Hu, Taishan, Simmons, Amie, Wang, Chi, Souabni, Abdallah, Busslinger, Meinrad, Bender, Timothy P, Hernandez-Hoyos, Gabriela, Alberola-Ila, José

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851 Potent tumor-directed T cell activation and in vivo tumor inhibition induced by a 4–1BB x 5T4 ADAPTIR™ bispecific antibody von Nelson, Michelle, Miller, Robert, Nilsson, Anneli, Ljung, Lill, Chunyk, Allison, McMahan, Catherine, Bienvenue, David, Askmyr, Maria, Hernandez-Hoyos, Gabriela, Fritzell, Sara

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633 Dual-targeting of 4–1BB and OX40 with an ADAPTIR™ bispecific antibody enhances anti-tumor responses to solid tumor von Nelson, Michelle, Miller, Robert, Blahnik-Fagan, Gabriele, Loh, Lauren, Citters, Danielle Van, Misher, Lynda, Sprague, Megan, Dasovich, Maria, Barber, Irene, Maggiora, Kathy, Gruswitz, Franz, Woodruff, Brian, Huntington, Kelsey, Guinn, Aelish, Aguilar, Megan, Daugherty, Mollie, Haglin, Elizabeth, Gross, Jane, Pavlik, Peter, McMahan, Catherine, Bienvenue, David, Hernandez-Hoyos, Gabriela

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A developmental transition in definitive erythropoiesis: erythropoietin expression is sequentially regulated by retinoic acid receptors and HNF4 von Makita, T, Hernandez-Hoyos, G, Chen, T H, Wu, H, Rothenberg, E V, Sucov, H M

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GATA-3 Expression Is Controlled by TCR Signals and Regulates CD4/CD8 Differentiation von Hernández-Hoyos, Gabriela, Anderson, Michele K., Wang, Chi, Rothenberg, Ellen V., Alberola-Ila, Jose

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Duration of the initial TCR stimulus controls the magnitude but not functionality of the CD8+ T cell response von Prlic, Martin, Hernandez-Hoyos, Gabriela, Bevan, Michael J

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Abstract LB173: APVO603: A dual 4-1BB and OX40 bispecific approach utilizing ADAPTIRTMtechnology designed to deliver a conditional T cell/NK response against solid tumors von Nelson, Michelle H., Miller, Robert E., Franke-Welch, Secil, Chenault, Ruth, Fang, Hang, Chunyk, Allison, Hernandez-Hoyos, Gabriela, Ramos, Hilario J., Bienvenue, David, McMahan, Catherine

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Abstract LB172: APVO442: A bispecific T cell-engaging candidate utilizing the ADAPTIR-FLEXTMplatform technology with unique properties designed for optimal tumor distribution and c... von Gottschalk, Rebecca, Miller, Robert E., Misher, Lynda, Nelson, Michelle H., Chunyk, Allison, Woodruff, Brian, Haglin, Elizabeth, Hernandez-Hoyos, Gabriela, Pavlik, Peter, McMahan, Catherine, Ramos, Hilario J., Bienvenue, David

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MOR209/ES414, a Novel Bispecific Antibody Targeting PSMA for the Treatment of Metastatic Castration-Resistant Prostate Cancer von Hernandez-Hoyos, Gabriela, Sewell, Toddy, Bader, Robert, Bannink, Jeannette, Chenault, Ruth A, Daugherty, Mollie, Dasovich, Maria, Fang, Hang, Gottschalk, Rebecca, Kumer, John, Miller, Robert E, Ravikumar, Padma, Wiens, Jennifer, Algate, Paul A, Bienvenue, David, McMahan, Catherine J, Natarajan, Sateesh K, Gross, Jane A, Blankenship, John W

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The Bispecific Tumor Antigen-Conditional 4-1BB x 5T4 Agonist, ALG.APV-527, Mediates Strong T-Cell Activation and Potent Antitumor Activity in Preclinical Studies von Nelson, Michelle H, Fritzell, Sara, Miller, Robert, Werchau, Doreen, Van Citters, Danielle, Nilsson, Anneli, Misher, Lynda, Ljung, Lill, Bader, Robert, Deronic, Adnan, Chunyk, Allison G, Schultz, Lena, Varas, Laura A, Rose, Nadia, Håkansson, Maria, Gross, Jane, Furebring, Christina, Pavlik, Peter, Sundstedt, Anette, Veitonmäki, Niina, Ramos, Hilario J, Säll, Anna, Dahlman, Anna, Bienvenue, David, von Schantz, Laura, McMahan, Catherine J, Askmyr, Maria, Hernandez-Hoyos, Gabriela, Ellmark, Peter

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Abstract 2380: Preclinical safety and efficacy of a tumor-directed T cell activating 4-1BB x 5T4 ADAPTIR™ bispecific antibody von Dahlman, Anna, Nelson, Michelle, Bannink, Jeannette, Johnson, Starrla, Werchau, Doreen, Nilsson, Anneli, Ljung, Lill, Blahnik-Fagan, Gabriele, Bader, Robert, Deronic, Adnan, Ellmark, Peter, Askmyr, Maria, Hernandez-Hoyos, Gabriela, McMahan, Cathy, Fritzell, Sara

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Activation of the CD137 Pathway in T cells by a CD137 × 5T4 bispecific ADAPTIR Molecule Requires Co-engagement of CD137 and 5T4 von Blahnik-Fagan, Gabriele R., Bader, Robert, Bannink, Jeannette, Mitchell, Danielle, Misher, Lynda, McMahan, Cathy, Bienvenue, David, Fritzell, Sara, Säll, Anna, von Schantz, Laura, Ellmark, Peter, Nelson, Michelle, Hernandez-Hoyos, Gabriela

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A New Regulatory Region of the IL-2 Locus That Confers Position-Independent Transgene Expression von Yui, Mary A, Hernandez-Hoyos, Gabriela, Rothenberg, Ellen V

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Precise developmental regulation of Ets family transcription factors during specification and commitment to the T cell lineage von Anderson, M K, Hernandez-Hoyos, G, Diamond, R A, Rothenberg, E V

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Abstract B249: Prolonged cytotoxic activity induced by anti-PSMA x anti-CD3 ADAPTIR™ molecule in the absence of significant cytokine release von Hernandez-Hoyos, Gabriela, Sewell, Toddy, Ravikumar, Padma, Aguilar, Megan, Kumer, John, Bienvenue, David, McMahan, Catherine J., Gross, Jane, Blankenship, John W.

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Constitutive Expression of PU.1 in Fetal Hematopoietic Progenitors Blocks T Cell Development at the Pro-T Cell Stage von Anderson, Michele K, Weiss, Angela H, Hernandez-Hoyos, Gabriela, Dionne, Christopher J, Rothenberg, Ellen V

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Abstract 1236: Pharmacokinetic evaluation and tolerability assessment of anti-PSMA x anti-CD3 SCORPIONTM molecule in humanized mice and non-human primates von McMahan, Catherine J., Hernandez-Hoyos, Gabriela, Bannink, Jeannette, Bader, Robert R., Ravikumar, Padma, Sewell, Toddy, Bannink, Kenneth M., Gottschalk, Rebecca J., Fang, Hang, Johnson, Starrla, Aguilar, Megan, Kumer, John, Algate, Paul A., Bienvenue, David L., Blankenship, John W.

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Bispecific SCORPION™ Molecules Effectively Redirect T-Cell Cytotoxicity Toward CD19-Expressing Tumor Cells von Chenault, Ruth A., Gottschalk, Rebecca, Hernandez-Hoyos, Gabriela, Wiens, Jennifer, Gordon, Brian, Klee, Jennifer, Bienvenue, Jessica, Dasovich, Maria, Kumer, John, Aguilar, Megan, Bannink, Jeannette, McMahan, Catherine J., Natarajan, Sateesh, Algate, Paul A., Blankenship, John W.

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