Lung-selective mRNA delivery of synthetic lipid nanoparticles for the treatment of pulmonary lymphangioleiomyomatosis von Qiu, Min, Tang, Yan, Chen, Jinjin, Muriph, Rachel, Ye, Zhongfeng, Huang, Changfeng, Evans, Jason, Henske, Elizabeth P, Xu, Qiaobing

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Unjamming and cell shape in the asthmatic airway epithelium von Park, Jin-Ah, Kim, Jae Hun, Bi, Dapeng, Mitchel, Jennifer A., Qazvini, Nader Taheri, Tantisira, Kelan, Park, Chan Young, McGill, Maureen, Kim, Sae-Hoon, Gweon, Bomi, Notbohm, Jacob, Steward Jr, Robert, Burger, Stephanie, Randell, Scott H., Kho, Alvin T., Tambe, Dhananjay T., Hardin, Corey, Shore, Stephanie A., Israel, Elliot, Weitz, David A., Tschumperlin, Daniel J., Henske, Elizabeth P., Weiss, Scott T., Manning, M. Lisa, Butler, James P., Drazen, Jeffrey M., Fredberg, Jeffrey J.

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Midkine expression by stem-like tumor cells drives persistence to mTOR inhibition and an immune-suppressive microenvironment von Tang, Yan, Kwiatkowski, David J., Henske, Elizabeth P.

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Renal disease in tuberous sclerosis complex: pathogenesis and therapy von Lam, Hilaire C., Siroky, Brian J., Henske, Elizabeth P.

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The mTORC1 Pathway Stimulates Glutamine Metabolism and Cell Proliferation by Repressing SIRT4 von Csibi, Alfred, Fendt, Sarah-Maria, Li, Chenggang, Poulogiannis, George, Choo, Andrew Y., Chapski, Douglas J., Jeong, Seung Min, Dempsey, Jamie M., Parkhitko, Andrey, Morrison, Tasha, Henske, Elizabeth P., Haigis, Marcia C., Cantley, Lewis C., Stephanopoulos, Gregory, Yu, Jane, Blenis, John

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mTORC1 upregulates B7-H3/CD276 to inhibit antitumor T cells and drive tumor immune evasion von Liu, Heng-Jia, Du, Heng, Khabibullin, Damir, Zarei, Mahsa, Wei, Kevin, Freeman, Gordon J., Kwiatkowski, David J., Henske, Elizabeth P.

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TSC2 regulates lysosome biogenesis via a non-canonical RAGC and TFEB-dependent mechanism von Alesi, Nicola, Akl, Elie W., Khabibullin, Damir, Liu, Heng-Jia, Nidhiry, Anna S., Garner, Emma R., Filippakis, Harilaos, Lam, Hilaire C., Shi, Wei, Viswanathan, Srinivas R., Morroni, Manrico, Ferguson, Shawn M., Henske, Elizabeth P.

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Regulation of YAP by mTOR and autophagy reveals a therapeutic target of tuberous sclerosis complex von Liang, Ning, Zhang, Chi, Dill, Patricia, Panasyuk, Ganna, Pion, Delphine, Koka, Vonda, Gallazzini, Morgan, Olson, Eric N, Lam, Hilaire, Henske, Elizabeth P, Dong, Zheng, Apte, Udayan, Pallet, Nicolas, Johnson, Randy L, Terzi, Fabiola, Kwiatkowski, David J, Scoazec, Jean-Yves, Martignoni, Guido, Pende, Mario

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Bi-steric mTORC1 inhibitors induce apoptotic cell death in tumor models with hyperactivated mTORC1 von Du, Heng, Yang, Yu Chi, Liu, Heng-Jia, Yuan, Min, Asara, John M, Wong, Kwok-Kin, Henske, Elizabeth P, Singh, Mallika, Kwiatkowski, David J

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Loss of FLCN inhibits canonical WNT signaling via TFE3 von Kennedy, John C, Khabibullin, Damir, Hougard, Thomas, Nijmeh, Julie, Shi, Wei, Henske, Elizabeth P

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Impairment of gamma-glutamyl transferase 1 activity in the metabolic pathogenesis of chromophobe renal cell carcinoma von Priolo, Carmen, Khabibullin, Damir, Reznik, Ed, Filippakis, Harilaos, Ogórek, Barbara, Kavanagh, Taylor R., Nijmeh, Julie, Herbert, Zachary T., Asara, John M., Kwiatkowski, David J., Wu, Chin-Lee, Henske, Elizabeth P.

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Renal Cell Carcinoma in Tuberous Sclerosis Complex von Henske, Elizabeth P., Cornejo, Kristine M., Wu, Chin-Lee

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Whole Exome Sequencing Identifies TSC1/TSC2 Biallelic Loss as the Primary and Sufficient Driver Event for Renal Angiomyolipoma Development von Giannikou, Krinio, Malinowska, Izabela A, Pugh, Trevor J, Yan, Rachel, Tseng, Yuen-Yi, Oh, Coyin, Kim, Jaegil, Tyburczy, Magdalena E, Chekaluk, Yvonne, Liu, Yang, Alesi, Nicola, Finlay, Geraldine A, Wu, Chin-Lee, Signoretti, Sabina, Meyerson, Matthew, Getz, Gad, Boehm, Jesse S, Henske, Elizabeth P, Kwiatkowski, David J

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Kidney intercalated cells and the transcription factor FOXi1 drive cystogenesis in tuberous sclerosis complex von Barone, Sharon, Zahedi, Kamyar, Brooks, Marybeth, Henske, Elizabeth P., Yang, Yirong, Zhang, Erik, Bissler, John J., Yu, Jane J., Soleimani, Manoocher

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Mechanisms of pulmonary cyst pathogenesis in Birt–Hogg–Dube syndrome: The stretch hypothesis von Kennedy, John C., Khabibullin, Damir, Henske, Elizabeth P.

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A Comparison of Clinical and Radiological Presentations of Sporadic and Tuberous Sclerosis Complex-Associated Lymphangioleiomyomatosis von Savage, Taylor E, Geenen, Kennedy R, Price, Melissa C, El-Chemaly, Souheil Y, Henske, Elizabeth P, Sharma, Amita, Thiele, Elizabeth A

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TFEB drives mTORC1 hyperactivation and kidney disease in Tuberous Sclerosis Complex von Alesi, Nicola, Khabibullin, Damir, Rosenthal, Dean M., Akl, Elie W., Cory, Pieter M., Alchoueiry, Michel, Salem, Samer, Daou, Melissa, Gibbons, William F., Chen, Jennifer A., Zhang, Long, Filippakis, Harilaos, Graciotti, Laura, Miceli, Caterina, Monfregola, Jlenia, Vilardo, Claudia, Morroni, Manrico, Di Malta, Chiara, Napolitano, Gennaro, Ballabio, Andrea, Henske, Elizabeth P.

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MITF is a driver oncogene and potential therapeutic target in kidney angiomyolipoma tumors through transcriptional regulation of CYR61 von Zarei, Mahsa, Giannikou, Krinio, Du, Heng, Liu, Heng-Jia, Duarte, Melissa, Johnson, Sneha, Nassar, Amin H., Widlund, Hans R., Henske, Elizabeth P., Long, Henry W., Kwiatkowski, David J.

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The mTORC1 pathway stimulates glutamine metabolism and cell proliferation by repressing SIRT4 von Csibi, Alfred, Fendt, Sarah-Maria, Li, Chenggang, Poulogiannis, George, Choo, Andrew Y., Chapski, Douglas J., Jeong, Seung Min, Dempsey, Jamie M., Parkhitko, Andrey, Morrison, Tasha, Henske, Elizabeth P., Haigis, Marcia C., Cantley, Lewis C., Stephanopoulos, Gregory, Yu, Jane, Blenis, John

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Mesenchymal folliculin is required for alveolar development: implications for cystic lung disease in Birt-Hogg-Dubé syndrome von Chu, Ling, Luo, Yongfeng, Chen, Hui, Miao, Qing, Wang, Larry, Moats, Rex, Wang, Tiansheng, Kennedy, John C, Henske, Elizabeth P, Shi, Wei

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