BMS-936564/MDX-1338: A Fully Human Anti-CXCR4 Antibody Induces Apoptosis In Vitro and Shows Antitumor Activity In Vivo in Hematologic Malignancies von KUHNE, Michelle R, MULVEY, Tanya, COHEN, Lewis J, KORMAN, Alan J, CARDARELLI, Pina M, BELANGER, Blake, CHEN, Sharline, PAN, Chin, COLIN CHONG, FEI CAO, NIEKRO, Wafa, KEMPE, Tom, HENNING, Karla A

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The anti-SLAMF7 antibody elotuzumab mediates NK cell activation through both CD16-dependent and -independent mechanisms von Pazina, Tatiana, James, Ashley M., MacFarlane, Alexander W., Bezman, Natalie A., Henning, Karla A., Bee, Christine, Graziano, Robert F., Robbins, Michael D., Cohen, Adam D., Campbell, Kerry S.

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Anti-CTLA-4 antibodies of IgG2a isotype enhance antitumor activity through reduction of intratumoral regulatory T cells von Selby, Mark J, Engelhardt, John J, Quigley, Michael, Henning, Karla A, Chen, Timothy, Srinivasan, Mohan, Korman, Alan J

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Immune-stimulating antibody conjugates elicit robust myeloid activation and durable antitumor immunity von Ackerman, Shelley E., Pearson, Cecelia I., Gregorio, Joshua D., Gonzalez, Joseph C., Kenkel, Justin A., Hartmann, Felix J., Luo, Angela, Ho, Po Y., LeBlanc, Heidi, Blum, Lisa K., Kimmey, Samuel C., Luo, Andrew, Nguyen, Murray L., Paik, Jason C., Sheu, Lauren Y., Ackerman, Benjamin, Lee, Arthur, Li, Hai, Melrose, Jennifer, Laura, Richard P., Ramani, Vishnu C., Henning, Karla A., Jackson, David Y., Safina, Brian S., Yonehiro, Grant, Devens, Bruce H., Carmi, Yaron, Chapin, Steven J., Bendall, Sean C., Kowanetz, Marcin, Dornan, David, Engleman, Edgar G., Alonso, Michael N.

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Human Artificial Chromosomes Generated by Modification of a Yeast Artificial Chromosome Containing Both Human Alpha Satellite and Single-Copy DNA Sequences von Henning, Karla A., Novotny, Elizabeth A., Compton, Sheila T., Guan, Xin-Yuan, Liu, Pu P., Ashlock, Melissa A.

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821 The combination of a trastuzumab ISAC and pertuzumab augments anti-tumor efficacy in multiple HER2+ tumor models relative to trastuzumab plus pertuzumab von Pearson, Cecelia I, Luo, Andrew, Henning, Karla A, Lucas, Anthony, Omstead, David, McEachin, Katelynn A, Ponath, Paul D, Chapin, Steven J, Ackerman, Shelley E, Perez, Edith A, Kim, Han K, Alonso, Michael N

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1147-D Preclinical characterization of a novel claudin 18.2 targeting-ISAC with robust potency and acceptable safety profile von Kim, Han K, Monnier, Justin, Fu, Chi-Ling, Zhou, Matthew, Melrose, Jennifer E, Dao, Hung, Ponath, Paul D, McEachin, Katelynn A, Omstead, David T, Kreder, Cindy, Chun, Stefan, Lee, Ying Yueh, Grgich, Rachel, Lin, Tracey J, Walker, Joshua A, Henning, Karla A, Kudirka, Romas, Ackerman, Shelley E, Carrera, Diane, Chapin, Steven J, Mallet, William, Jackson, Dowdy, Gao, Changshou, Alonso, Michael N

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Humanizing the Yeast Telomerase Template von Henning, Karla A., Moskowitz, Naomi, Ashlock, Melissa A., Liu, Pu P.

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UV-Induced Ubiquitination of RNA Polymerase II: A Novel Modification Deficient in Cockayne Syndrome Cells von Bregman, David B., Halaban, Ruth, Van Gool, Alain J., Henning, Karla A., Friedberg, Errol C., Warren, Stephen L.

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Enhanced protein production by engineered zinc finger proteins von Reik, Andreas, Zhou, Yuanyue, Collingwood, Trevor N., Warfe, Lyndon, Bartsevich, Victor, Kong, Yanhong, Henning, Karla A., Fallentine, Barrett K., Zhang, Lei, Zhong, Xiaohong, Jouvenot, Yann, Jamieson, Andrew C., Rebar, Edward J., Case, Casey C., Korman, Alan, Li, Xiao-Yong, Black, Amelia, King, David J., Gregory, Philip D.

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Abstract 2883: Dectin-2 agonist antibodies reprogram tumor-associated macrophages to drive anti-tumor immunity von Kenkel, Justin A., Ho, Po Y., Henning, Karla A., Kreder, Cindy L., Nolin, Jess L., Kongara, Sameera, Chapin, Steven J., Husain, Amreen, Kowanetz, Marcin, Engleman, Edgar G., Alonso, Michael N., Dornan, David, Ackerman, Shelley E.

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Abstract 2964: Targeting tumor-associated macrophages to enhance anti-tumor immunity with the Dectin-2 agonistic antibody BDC-3042 von Kenkel, Justin A., Xiao, Fang, Ho, Po Y., Nolin, Jess L., Gadkari, Rishali K., Torrez, Laughing Bear, Omstead, David T., McEachin, Katelynn A., Ptacek, Jason, Grgich, Rachel, Pearson, Cecelia I., Chun, Stefan, Kreder, Cindy L., Henning, Karla A., Kim, Han K., Xu, Lu, Chapin, Steven J., Alonso, Michael N., Ackerman, Shelley E.

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Abstract 4252: PD-L1-targeted ISAC combines myeloid cell activation, immune-checkpoint inhibition and ADCP to improve anti-tumor efficacy over anti-PD-L1 antibodies in preclinical... von Kenkel, Justin A., Gadkari, Rishali, Ho, Po Y., Blum, Lisa K., Kudirka, Romas, Henning, Karla A., Mallet, William G., Melrose, Jennifer E., Sarma, Ganapathy, Chapin, Steven J., Zhou, Matthew, Deol, Suprit, Kreder, Cindy, Shen, Yuyi, Hug, Bruce, Anand, Puneet, Lee, Arthur, Li, Hai, Ackerman, Shelley E., Safina, Brian S., Dornan, David, Alonso, Michael N., Kowanetz, Marcin

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Abstract 2911: The CEA-targeted ISAC, BDC-2034, shows preclinical efficacy associated with innate immune activation, phagocytosis, and myeloid reprogramming von Blum, Lisa K., Pearson, Cecelia I., Dulgeroff, Laughing Bear Torrez, Gadkari, Rishali, Luo, Angela, Luo, Andrew, Melrose, Jennifer E., Nolin, Jess L., Li, Hai, Lee, Arthur, Zhou, Matthew N., Anand, Puneet, Sarma, Ganapathy, Henning, Karla A., Chapin, Steven J., Ackerman, Shelley E., Kudirka, Romas, Shen, Yuyi, Hug, Bruce, Perez, Edith A., Kowanetz, Marcin, Alonso, Michael N., Safina, Brian S., Dornan, David, Mallet, William G.

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An improved method for routine preparation of intact artificial chromosome DNA (340–1000 kb) for transfection into human cells von Compton, Sheila T., Henning, Karla A., Chen, Min, Mansoura, Monique K., Ashlock, Melissa A.

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BMS-936564/MDX-1338: A Fully Human Anti-CXCR4 Antibody Induces Apoptosis In Vitro and Shows Anti Tumor Activity In Vivo von Kuhne, Michelle R., Mulvey, Tanya, Chen, Sharline, Pan, Chin, Chong, Colin, Niekro, Wafa, Kempe, Tom, Henning, Karla A., Cohen, Lewis, Korman, Alan, Cardarelli, Pina M

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Immune-stimulating antibody conjugates elicit robust myeloid activation and durable anti-tumor immunity von Ackerman, Shelley E., Gonzalez, Joseph C., Pearson, Cecelia I., Gregorio, Joshua D., Hartmann, Felix J., Kenkel, Justin A., Luo, Angela, Ho, Po Y., LeBlanc, Heidi, Kimmey, Samuel C., Nguyen, Murray L., Paik, Jason C., Blum, Lisa K., Sheu, Lauren Y., Ackerman, Benjamin, Lee, Arthur, Li, Hai, Melrose, Jennifer, Dulgeroff, Laughing Bear Torrez, Laura, Richard P., Ramani, Vishnu C., Henning, Karla A., Chapin, Steven J., Jackson, David Y., Safina, Brian S., Yonehiro, Grant, Devens, Bruce H., Carmi, Yaron, Kowanetz, Marcin, Bendall, Sean C., Dornan, David, Engleman, Edgar G., Alonso, Michael N.

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The Cockayne syndrome group A gene encodes a WD repeat protein that interacts with CSB protein and a subunit of RNA polymerase II TFIIH von Henning, Karla A., Li, Lei, Iyer, Narayan, McDaniel, Lisa D., Reagan, Michael S., Legerski, Randy, Schultz, Roger A., Stefanini, Miria, Lehmann, Alan R., Mayne, Lynne V., Friedberg, Errol C.

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항-DECTIN-2 항체 von KENKEL JUSTIN A, HENNING KARLA A, ACKERMAN SHELLEY ERIN, DORNAN DAVID

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ANTIBODIES COMPRISING MODIFIED HEAVY CONSTANT REGIONS von SELBY MARK J, RAJPAL ARVIND, BARNHART BRYAN C, LONBERG NILS, YAMNIUK AARON P, HAN MICHELLE MINHUA, SCHWEIZER LIANG, LEI MING, HENNING KARLA A, KORMAN ALAN J, HATCHER SANDRA V, SRINIVASAN MOHAN

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