Why do SGLT2 inhibitors reduce heart failure hospitalization? A differential volume regulation hypothesis von Hallow, Karen M., Helmlinger, Gabriel, Greasley, Peter J., McMurray, John J. V., Boulton, David W.

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A mechanistic tumor penetration model to guide antibody drug conjugate design von Vasalou, Christina, Helmlinger, Gabriel, Gomes, Bruce

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Primary proximal tubule hyperreabsorption and impaired tubular transport counterregulation determine glomerular hyperfiltration in diabetes: a modeling analysis von Hallow, K Melissa, Gebremichael, Yeshitila, Helmlinger, Gabriel, Vallon, Volker

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An integrative mechanistic model of thymocyte dynamics von Kulesh, Victoria, Peskov, Kirill, Helmlinger, Gabriel, Bocharov, Gennady

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Mathematical modeling of endogenous and exogenously administered T cell recirculation in mouse and its application to pharmacokinetic studies of cell therapies von Nikitich, Antonina, Helmlinger, Gabriel, Peskov, Kirill, Bocharov, Gennady

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Interpretation of metabolic memory phenomenon using a physiological systems model: What drives oxidative stress following glucose normalization? von Voronova, Veronika, Zhudenkov, Kirill, Helmlinger, Gabriel, Peskov, Kirill

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Mathematical modeling in autoimmune diseases: from theory to clinical application von Ugolkov, Yaroslav, Nikitich, Antonina, Leon, Cristina, Helmlinger, Gabriel, Peskov, Kirill, Sokolov, Victor, Volkova, Alina

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Quantitative Mechanistic Modeling in Support of Pharmacological Therapeutics Development in Immuno-Oncology von Peskov, Kirill, Azarov, Ivan, Chu, Lulu, Voronova, Veronika, Kosinsky, Yuri, Helmlinger, Gabriel

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Role of T Cell-To-Dendritic Cell Chemoattraction in T Cell Priming Initiation in the Lymph Node: An Agent-Based Modeling Study von Azarov, Ivan, Peskov, Kirill, Helmlinger, Gabriel, Kosinsky, Yuri

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A Generic Mechanism for Enhanced Cytokine Signaling via Cytokine-Neutralizing Antibodies von Shulgin, Boris, Helmlinger, Gabriel, Kosinsky, Yuri

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Elaborating on anti CTLA-4 mechanisms of action using an agent-based modeling approach von Azarov, Ivan, Helmlinger, Gabriel, Kosinsky, Yuri, Peskov, Kirill

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Assessment of NSCLC disease burden: A survival model-based meta-analysis study von Kudryashova, Nataliya, Shulgin, Boris, Katuninks, Nikolai, Kulesh, Victoria, Helmlinger, Gabriel, Zhudenkov, Kirill, Peskov, Kirill

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Quantification of Scheduling Impact on Safety and Efficacy Outcomes of Brain Metastasis Radio- and Immuno-Therapies: A Systematic Review and Meta-Analysis von Voronova, Veronika, Lebedeva, Svetlana, Sekacheva, Marina, Helmlinger, Gabriel, Peskov, Kirill

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Comparative quantitative systems pharmacology modeling of anti-PCSK9 therapeutic modalities in hypercholesterolemia[S] von Sokolov, Victor, Helmlinger, Gabriel, Nilsson, Catarina, Zhudenkov, Kirill, Skrtic, Stanko, Hamrén, Bengt, Peskov, Kirill, Hurt-Camejo, Eva, Jansson-Löfmark, Rasmus

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Optimization of the MACE endpoint composition to increase power in studies of lipid-lowering therapies-a model-based meta-analysis von Volkova, Alina, Shulgin, Boris, Helmlinger, Gabriel, Peskov, Kirill, Sokolov, Victor

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Radiation and PD-(L)1 treatment combinations: immune response and dose optimization via a predictive systems model von Kosinsky, Yuri, Dovedi, Simon J, Peskov, Kirill, Voronova, Veronika, Chu, Lulu, Tomkinson, Helen, Al-Huniti, Nidal, Stanski, Donald R, Helmlinger, Gabriel

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A workflow for the joint modeling of longitudinal and event data in the development of therapeutics: Tools, statistical methods, and diagnostics von Zhudenkov, Kirill, Gavrilov, Sergey, Sofronova, Alina, Stepanov, Oleg, Kudryashova, Nataliya, Helmlinger, Gabriel, Peskov, Kirill

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Dose dependence of treatment-related adverse events for immune checkpoint inhibitor therapies: a model-based meta-analysis von Shulgin, Boris, Kosinsky, Yuri, Omelchenko, Andrey, Chu, Lulu, Mugundu, Ganesh, Aksenov, Sergey, Pimentel, Rodrigo, DeYulia, Garrett, Kim, Geoffrey, Peskov, Kirill, Helmlinger, Gabriel

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Evaluation of Combination Strategies for the A2AR Inhibitor AZD4635 Across Tumor Microenvironment Conditions via a Systems Pharmacology Model von Voronova, Veronika, Peskov, Kirill, Kosinsky, Yuri, Helmlinger, Gabriel, Chu, Lulu, Borodovsky, Alexandra, Woessner, Richard, Sachsenmeier, Kris, Shao, Wenlin, Kumar, Rakesh, Pouliot, Gayle, Merchant, Melinda, Kimko, Holly, Mugundu, Ganesh

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Interstitial pH and pO2 gradients in solid tumors in vivo: High-resolution measurements reveal a lack of correlation von Helmlinger, Gabriel, Yuan, Fan, Dellian, Marc, Jain, Rakesh K.

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