The Crystal Structure of Dipeptidyl Peptidase IV (CD26) Reveals Its Functional Regulation and Enzymatic Mechanism von Engel, Michael, Hoffmann, Torsten, Wagner, Leona, Wermann, Michael, Heiser, Ulrich, Kiefersauer, Reiner, Huber, Robert, Bode, Wolfram, Demuth, Hans-Ulrich, Brandstetter, Hans

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Inhibitors for Human Glutaminyl Cyclase by Structure Based Design and Bioisosteric Replacement von Buchholz, Mirko, Hamann, Antje, Aust, Susanne, Brandt, Wolfgang, Böhme, Livia, Hoffmann, Torsten, Schilling, Stephan, Demuth, Hans-Ulrich, Heiser, Ulrich

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The First Potent Inhibitors for Human Glutaminyl Cyclase:  Synthesis and Structure−Activity Relationship von Buchholz, Mirko, Heiser, Ulrich, Schilling, Stephan, Niestroj, André J, Zunkel, Katrin, Demuth, Hans-Ulrich

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Temperature-Dependent Behavior of a Symmetric Long-Chain Bolaamphiphile with Phosphocholine Headgroups in Water:  From Hydrogel to Nanoparticles von Köhler, Karen, Förster, Günter, Hauser, Anton, Dobner, Bodo, Heiser, Ulrich F, Ziethe, Friederike, Richter, Walter, Steiniger, Frank, Drechsler, Markus, Stettin, Heiko, Blume, Alfred

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Inhibition of glutaminyl cyclase alters pyroglutamate formation in mammalian cells von Cynis, Holger, Schilling, Stephan, Bodnár, Mandy, Hoffmann, Torsten, Heiser, Ulrich, Saido, Takaomi C., Demuth, Hans-Ulrich

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Self-Assembly in a Bipolar Phosphocholine-Water System: The Formation of Nanofibers and Hydrogels von Köhler, Karen, Förster, Günter, Hauser, Anton, Dobner, Bodo, Heiser, Ulrich F., Ziethe, Friederike, Richter, Walter, Steiniger, Frank, Drechsler, Markus, Stettin, Heiko, Blume, Alfred

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Glutaminyl Cyclase Inhibitor PQ912 Improves Cognition in Mouse Models of Alzheimer’s Disease—Studies on Relation to Effective Target Occupancy von Hoffmann, Torsten, Meyer, Antje, Heiser, Ulrich, Kurat, Stephan, Böhme, Livia, Kleinschmidt, Martin, Bühring, Karl-Ulrich, Hutter-Paier, Birgit, Farcher, Martina, Demuth, Hans-Ulrich, Lues, Inge, Schilling, Stephan

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Structure–Activity Relationships of Benzimidazole-Based Glutaminyl Cyclase Inhibitors Featuring a Heteroaryl Scaffold von Ramsbeck, Daniel, Buchholz, Mirko, Koch, Birgit, Böhme, Livia, Hoffmann, Torsten, Demuth, Hans-Ulrich, Heiser, Ulrich

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Glutaminyl cyclase inhibition attenuates pyroglutamate Aβ and Alzheimer's disease–like pathology von Schilling, Stephan, Zeitschel, Ulrike, Hoffmann, Torsten, Heiser, Ulrich, Francke, Mike, Kehlen, Astrid, Holzer, Max, Hutter-Paier, Birgit, Prokesch, Manuela, Windisch, Manfred, Jagla, Wolfgang, Schlenzig, Dagmar, Lindner, Christiane, Rudolph, Thomas, Reuter, Gunter, Cynis, Holger, Montag, Dirk, Demuth, Hans-Ulrich, Rossner, Steffen

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Semi-empirical derived descriptors for the modelling of properties of N-containing heterocycles von Entzian, Alexander, Bögel, Horst, Buchholz, Mirko, Heiser, Ulrich

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Inhibition of CDK9 as a therapeutic strategy for inflammatory arthritis von Hellvard, Annelie, Zeitlmann, Lutz, Heiser, Ulrich, Kehlen, Astrid, Niestroj, André, Demuth, Hans-Ulrich, Koziel, Joanna, Delaleu, Nicolas, Jan Potempa, Mydel, Piotr

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Metabolism of glucagon by dipeptidyl peptidase IV (CD26) von Pospisilik, John A, Hinke, Simon A, Pederson, Raymond A, Hoffmann, Torsten, Rosche, Fred, Schlenzig, Dagmar, Glund, Konrad, Heiser, Ulrich, McIntosh, Christopher H.S, Demuth, Hans-Ulrich

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The isoenzyme of glutaminyl cyclase is an important regulator of monocyte infiltration under inflammatory conditions von Cynis, Holger, Hoffmann, Torsten, Friedrich, Daniel, Kehlen, Astrid, Gans, Kathrin, Kleinschmidt, Martin, Rahfeld, Jens‐Ulrich, Wolf, Raik, Wermann, Michael, Stephan, Anett, Haegele, Monique, Sedlmeier, Reinhard, Graubner, Sigrid, Jagla, Wolfgang, Müller, Anke, Eichentopf, Rico, Heiser, Ulrich, Seifert, Franziska, Quax, Paul H. A., de Vries, Margreet R., Hesse, Isabel, Trautwein, Daniela, Wollert, Ulrich, Berg, Sabine, Freyse, Ernst‐Joachim, Schilling, Stephan, Demuth, Hans‐Ulrich

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Inhibition of Glutaminyl Cyclases alleviates CCL2-mediated inflammation of non-alcoholic fatty liver disease in mice von Cynis, Holger, Kehlen, Astrid, Haegele, Monique, Hoffmann, Torsten, Heiser, Ulrich, Fujii, Masato, Shibazaki, Yuichiro, Yoneyama, Hiroyuki, Schilling, Stephan, Demuth, Hans-Ulrich

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Inhibition of glutaminyl cyclase prevents pGlu-Aβ formation after intracortical/hippocampal microinjection in vivo/in situ von Schilling, Stephan, Appl, Thomas, Hoffmann, Torsten, Cynis, Holger, Schulz, Katrin, Jagla, Wolfgang, Friedrich, Daniel, Wermann, Michael, Buchholz, Mirko, Heiser, Ulrich, von Hörsten, Stephan, Demuth, Hans-Ulrich

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CRYSTALLINE PHARMACEUTICALLY ACCEPTABLE SALT AND POLYMORPHIC FORM OF THE GLUTAMINYL CYCLASE INHIBITOR VAROGLUTAMSTAT von HEISER, Ulrich

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Structures of Glycosylated Mammalian Glutaminyl Cyclases Reveal Conformational Variability near the Active Center von Ruiz-Carrillo, David, Koch, Birgit, Parthier, Christoph, Wermann, Michael, Dambe, Tresfore, Buchholz, Mirko, Ludwig, Hans-Henning, Heiser, Ulrich, Rahfeld, Jens-Ulrich, Stubbs, Milton T, Schilling, Stephan, Demuth, Hans-Ulrich

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CRYSTALLINE PHARMACEUTICALLY ACCEPTABLE SALT AND POLYMORPHIC FORM OF THE GLUTAMINYL CYCLASE INHIBITOR VAROGLUTAMSTAT von HEISER, Ulrich

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Glutaminyl Cyclases as Novel Targets for the Treatment of Septic Arthritis von Hellvard, Annelie, Maresz, Katarzyna, Schilling, Stephan, Graubner, Sigrid, Heiser, Ulrich, Jonsson, Roland, Cynis, Holger, Demuth, Hans-Ulrich, Potempa, Jan, Mydel, Piotr

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Inhibition of CDK9 as a therapeutic strategy for inflammatory arthritis von Hellvard, Annelie, Zeitlmann, Lutz, Heiser, Ulrich, Kehlen, Astrid, Niestroj, André, Demuth, Hans-Ulrich, Koziel, Joanna, Delaleu, Nicolas, Potempa, Jan, Mydel, Piotr Mateusz

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