Dithiol Proteins as Guardians of the Intracellular Redox Milieu in Parasites: Old and New Drug Targets in Trypanosomes and Malaria-Causing Plasmodia von Krauth-Siegel, R. Luise, Bauer, Holger, Schirmer, R. Heiner

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Subcellular localization of adenylate kinases in Plasmodium falciparum von Ma, Jipeng, Rahlfs, Stefan, Jortzik, Esther, Heiner Schirmer, R., Przyborski, Jude M., Becker, Katja

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Glutathione Reductase-Catalyzed Cascade of Redox Reactions To Bioactivate Potent Antimalarial 1,4-Naphthoquinones – A New Strategy to Combat Malarial Parasites von Müller, Tobias, Johann, Laure, Jannack, Beate, Brückner, Margit, Lanfranchi, Don Antoine, Bauer, Holger, Sanchez, Cecilia, Yardley, Vanessa, Deregnaucourt, Christiane, Schrével, Joseph, Lanzer, Michael, Schirmer, R. Heiner, Davioud-Charvet, Elisabeth

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Strong gametocytocidal effect of methylene blue-based combination therapy against falciparum malaria: a randomised controlled trial von Coulibaly, Boubacar, Zoungrana, Augustin, Mockenhaupt, Frank P, Schirmer, R Heiner, Klose, Christina, Mansmann, Ulrich, Meissner, Peter E, Müller, Olaf

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Interactions of Methylene Blue with Human Disulfide Reductases and Their Orthologues from Plasmodium falciparum von BUCHHOLZ, Kathrin, SCHIRMER, R. Heiner, EUBEL, Jana K, AKOACHERE, Monique B, DANDEKAR, Thomas, BECKER, Katja, GROMER, Stephan

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5-Substituted Tetrazoles as Bioisosteres of Carboxylic Acids. Bioisosterism and Mechanistic Studies on Glutathione Reductase Inhibitors as Antimalarials von Biot, Christophe, Bauer, Holger, Schirmer, R. Heiner, Davioud-Charvet, Elisabeth

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Safety and efficacy of methylene blue combined with artesunate or amodiaquine for uncomplicated falciparum malaria: a randomized controlled trial from Burkina Faso von Zoungrana, Augustin, Coulibaly, Boubacar, Sié, Ali, Walter-Sack, Ingeborg, Mockenhaupt, Frank P, Kouyaté, Bocar, Schirmer, R Heiner, Klose, Christina, Mansmann, Ulrich, Meissner, Peter, Müller, Olaf

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Efficacy of methylene blue monotherapy in semi-immune adults with uncomplicated falciparum malaria: a controlled trial in Burkina Faso von Bountogo, Mamadou, Zoungrana, Augustin, Coulibaly, Boubacar, Klose, Christina, Mansmann, Ulrich, Mockenhaupt, Frank P, Burhenne, Jürgen, Mikus, Gerd, Walter-Sack, Ingeborg, Heiner Schirmer, R, Sié, Ali, Meissner, Peter, Müller, Olaf

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In Vitro Assessment of Methylene Blue on Chloroquine-Sensitive and -Resistant Plasmodium falciparum Strains Reveals Synergistic Action with Artemisinins von AKOACHERE, Monique, BUCHHOLZ, Kathrin, FISCHER, Elisabeth, BURHENNE, Jürgen, HAEFELI, Walter E, SCHIRMER, R. Heiner, BECKER, Katja

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Haemolysis risk in methylene blue treatment of G6PD-sufficient and G6PD-deficient West-African children with uncomplicated falciparum malaria: a synopsis of four RCTs von Müller, Olaf, Mockenhaupt, Frank P., Marks, Bernd, Meissner, Peter, Coulibaly, Boubacar, Kuhnert, Ronny, Buchner, Hannes, Schirmer, R. Heiner, Walter-Sack, Ingeborg, Sié, Ali, Mansmann, Ulrich

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Active Sites of Thioredoxin Reductases: Why Selenoproteins? von Gromer, Stephan, Johansson, Linda, Bauer, Holger, Arscott, L. David, Rauch, Susanne, Ballou, David P., Williams, Charles H., Schirmer, R. Heiner, Elias S. J. Arnér

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Inherited glutathione reductase deficiency and Plasmodium falciparum malaria--a case study von Gallo, Valentina, Schwarzer, Evelin, Rahlfs, Stefan, Schirmer, R Heiner, van Zwieten, Rob, Roos, Dirk, Arese, Paolo, Becker, Katja

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Molecular basis of glutathione reductase deficiency in human blood cells von Kamerbeek, Nanne M., van Zwieten, Rob, de Boer, Martin, Morren, Gert, Vuil, Herma, Bannink, Natalja, Lincke, Carsten, Dolman, Koert M., Becker, Katja, Heiner Schirmer, R., Gromer, Stephan, Roos, Dirk

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Crystal Structure of the Antioxidant Enzyme Glutathione Reductase Inactivated by Peroxynitrite von Savvides, Savvas N., Scheiwein, Michael, Böhme, Catharina C., Arteel, Gavin E., Karplus, P. Andrew, Becker, Katja, Schirmer, R. Heiner

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Lest we forget you — methylene blue von Schirmer, R. Heiner, Adler, Heike, Pickhardt, Marcus, Mandelkow, Eckhard

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Human Thioredoxin Reductase Is Efficiently Inhibited by (2,2‘:6‘,2‘ ‘-Terpyridine)platinum(II) Complexes. Possible Implications for a Novel Antitumor Strategy von Becker, Katja, Herold-Mende, Christel, Park, Jenny J, Lowe, Gordon, Schirmer, R. Heiner

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Methylene blue for malaria in Africa: results from a dose-finding study in combination with chloroquine von Meissner, Peter E, Mandi, Germain, Coulibaly, Boubacar, Witte, Steffen, Tapsoba, Théophile, Mansmann, Ulrich, Rengelshausen, Jens, Schiek, Wolfgang, Jahn, Albrecht, Walter-Sack, Ingeborg, Mikus, Gerd, Burhenne, Jürgen, Riedel, Klaus-Dieter, Schirmer, R Heiner, Kouyaté, Bocar, Müller, Olaf

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Depletion of Plasmodium berghei plasmoredoxin reveals a non-essential role for life cycle progression of the malaria parasite von Buchholz, Kathrin, Rahlfs, Stefan, Schirmer, R Heiner, Becker, Katja, Matuschewski, Kai

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X-Ray Structure of Glutathione S-Transferase from the Malarial Parasite Plasmodium falciparum von Fritz-Wolf, Karin, Becker, Andreas, Rahlfs, Stefan, Harwaldt, Petra, Schirmer, R. Heiner, Kabsch, Wolfgang, Becker, Katja

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Human placenta thioredoxin reductase: Preparation and inhibitor studies von Gromer, Stephan, Merkle, Heiko, Heiner Schirmer, R., Becker, Katja

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