Recommendations for application of the functional evidence PS3/BS3 criterion using the ACMG/AMP sequence variant interpretation framework von Brnich, Sarah E, Abou Tayoun, Ahmad N, Couch, Fergus J, Cutting, Garry R, Greenblatt, Marc S, Heinen, Christopher D, Kanavy, Dona M, Luo, Xi, McNulty, Shannon M, Starita, Lea M, Tavtigian, Sean V, Wright, Matt W, Harrison, Steven M, Biesecker, Leslie G, Berg, Jonathan S

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ATR-Chk1 activation mitigates replication stress caused by mismatch repair-dependent processing of DNA damage von Gupta, Dipika, Lin, Bo, Cowan, Ann, Heinen, Christopher D.

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Enhanced CRISPR-based DNA demethylation by Casilio-ME-mediated RNA-guided coupling of methylcytosine oxidation and DNA repair pathways von Taghbalout, Aziz, Du, Menghan, Jillette, Nathaniel, Rosikiewicz, Wojciech, Rath, Abhijit, Heinen, Christopher D., Li, Sheng, Cheng, Albert W.

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The mismatch repair-dependent DNA damage response: Mechanisms and implications von Gupta, Dipika, Heinen, Christopher D.

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Enhanced gene targeting to evaluate Lynch syndrome alterations von Fishel, Richard, Heinen, Christopher D.

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Mismatch repair defects and Lynch syndrome: The role of the basic scientist in the battle against cancer von Heinen, Christopher D.

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Milestones of Lynch syndrome: 1895–2015 von Lynch, Henry T., Snyder, Carrie L., Shaw, Trudy G., Heinen, Christopher D., Hitchins, Megan P.

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Mutations in BRAF and KRAS differentially distinguish serrated versus non-serrated hyperplastic aberrant crypt foci in humans von ROSENBERG, Daniel W, SHI YANG, PLEAU, Devon C, GREENSPAN, Emily J, STEVENS, Richard G, RAJAN, Thiruchandurai V, HEINEN, Christopher D, LEVINE, Joel, YIJIAN ZHOU, O'BRIEN, Michael J

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DNA Mismatch Repair Proteins Are Required for Efficient Herpes Simplex Virus 1 Replication von MOHNI, Kareem N, MASTROCOLA, Adam S, PING BAI, WELLER, Sandra K, HEINEN, Christopher D

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Lynch syndrome-associated mutations in MSH2 alter DNA repair and checkpoint response functions in vivo von Mastrocola, Adam S, Heinen, Christopher D

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Human Pluripotent Stem Cells Have a Novel Mismatch Repair-dependent Damage Response von Lin, Bo, Gupta, Dipika, Heinen, Christopher D.

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Hereditary Cancer-associated Missense Mutations in hMSH6 Uncouple ATP Hydrolysis from DNA Mismatch Binding von Cyr, Jennifer L., Heinen, Christopher D.

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Aberrant crypt foci as predictors of colorectal neoplasia on repeat colonoscopy von Anderson, Joseph C., Swede, Helen, Rustagi, Tarun, Protiva, Petr, Pleau, Devon, Brenner, Bruce M., Rajan, Thiruchandurai V., Heinen, Christopher D., Levine, Joel B., Rosenberg, Daniel W.

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Determining the functional significance of mismatch repair gene missense variants using biochemical and cellular assays von Heinen, Christopher D, Juel Rasmussen, Lene

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Loss of DNA mismatch repair imparts a selective advantage in planarian adult stem cells von Hollenbach, Jessica P, Resch, Alissa M, Palakodeti, Dasaradhi, Graveley, Brenton R, Heinen, Christopher D

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Functional interrogation of Lynch syndrome‐associated MSH2 missense variants via CRISPR‐Cas9 gene editing in human embryonic stem cells von Rath, Abhijit, Mishra, Akriti, Ferreira, Victoria Duque, Hu, Chaoran, Omerza, Gregory, Kelly, Kevin, Hesse, Andrew, Reddi, Honey V., Grady, James P., Heinen, Christopher D.

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Functional and phenotypic consequences of an unusual inversion in MSH2 von Pelletier, Dylan, Rath, Abhijit, Sabbaghian, Nelly, Pelmus, Manuela, Hudon, Catherine, Jacob, Karine, Witowski, Leora, Saskin, Avi, Heinen, Christopher D., Foulkes, William D.

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DNA Repair and Tumorigenesis: Lessons from Hereditary Cancer Syndromes von Heinen, Christopher D., Schmutte, Christoph, Fishel, Richard

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A calibrated cell‐based functional assay to aid classification of MLH1 DNA mismatch repair gene variants von Rath, Abhijit, Radecki, Alexander A., Rahman, Kaussar, Gilmore, Rachel B., Hudson, Jonathan R., Cenci, Matthew, Tavtigian, Sean V., Grady, James P., Heinen, Christopher D.

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Loss of mismatch repair promotes a direct selective advantage in human stem cells von Madden-Hennessey, Kirby, Gupta, Dipika, Radecki, Alexander A., Guild, Caroline, Rath, Abhijit, Heinen, Christopher D.

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