Biallelic loss of BCMA as a resistance mechanism to CAR T cell therapy in a patient with multiple myeloma von Samur, Mehmet Kemal, Fulciniti, Mariateresa, Aktas Samur, Anil, Bazarbachi, Abdul Hamid, Tai, Yu-Tzu, Prabhala, Rao, Alonso, Alejandro, Sperling, Adam S., Campbell, Timothy, Petrocca, Fabio, Hege, Kristen, Kaiser, Shari, Loiseau, Hervé Avet, Anderson, Kenneth C., Munshi, Nikhil C.

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A First-in-Human Study of Novel Cereblon Modulator Avadomide (CC-122) in Advanced Malignancies von Rasco, Drew W, Papadopoulos, Kyriakos P, Pourdehnad, Michael, Gandhi, Anita K, Hagner, Patrick R, Li, Yan, Wei, Xin, Chopra, Rajesh, Hege, Kristen, DiMartino, Jorge, Shih, Kent

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Safety, tumor trafficking and immunogenicity of chimeric antigen receptor (CAR)-T cells specific for TAG-72 in colorectal cancer von Hege, Kristen M, Bergsland, Emily K, Fisher, George A, Nemunaitis, John J, Warren, Robert S, McArthur, James G, Lin, Andy A, Schlom, Jeffrey, June, Carl H, Sherwin, Stephen A

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Context matters in CAR T cell tonic signaling von Hege, Kristen

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CAR Talk: How Cancer-Specific CAR T Cells Can Instruct How to Build CAR T Cells to Cure HIV von Kim, Gloria B, Hege, Kristen, Riley, James L

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Allogeneic Granulocyte Macrophage Colony-Stimulating Factor–Secreting Tumor Immunotherapy Alone or in Sequence with Cyclophosphamide for Metastatic Pancreatic Cancer: A Pilot Study... von LAHERU, Dan, LUTZ, Eric, HEGE, Kristen, JAFFEE, Elizabeth, BURKE, James, BIEDRZYCKI, Barbara, SOLT, Sara, ONNERS, Beth, TARTAKOVSKY, Irena, NEMUNAITIS, John, LE, Dung, SUGAR, Elizabeth

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A phase 2 study of an oral mTORC1/mTORC2 kinase inhibitor (CC-223) for non-pancreatic neuroendocrine tumors with or without carcinoid symptoms von Wolin, Edward, Mita, Alain, Mahipal, Amit, Meyer, Tim, Bendell, Johanna, Nemunaitis, John, Munster, Pam N, Paz-Ares, Luis, Filvaroff, Ellen H, Li, Shaoyi, Hege, Kristen, de Haan, Hans, Mita, Monica

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Dual TORK/DNA-PK inhibition blocks critical signaling pathways in chronic lymphocytic leukemia von Thijssen, Rachel, ter Burg, Johanna, Garrick, Brett, van Bochove, Gregor G.W., Brown, Jennifer R., Fernandes, Stacey M., Rodríguez, María Solé, Michot, Jean-Marie, Hallek, Michael, Eichhorst, Barbara, Reinhardt, Hans Christian, Bendell, Johanna, Derks, Ingrid A.M., van Kampen, Roel J.W., Hege, Kristen, Kersten, Marie José, Trowe, Torsten, Filvaroff, Ellen H., Eldering, Eric, Kater, Arnon P.

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First-In-Human Phase I Study Of A Dual mTOR Kinase And DNA-PK Inhibitor (CC-115) In Advanced Malignancy von Munster, Pamela, Mita, Monica, Mahipal, Amit, Nemunaitis, John, Massard, Christophe, Mikkelsen, Tom, Cruz, Cristina, Paz-Ares, Luis, Hidalgo, Manuel, Rathkopf, Dana, Blumenschein, Jr, George, Smith, David C, Eichhorst, Barbara, Cloughesy, Tim, Filvaroff, Ellen H, Li, Shaoyi, Raymon, Heather, de Haan, Hans, Hege, Kristen, Bendell, Johanna C

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The trials and tribulations of CAR-T cell development for cancer and AIDS von Hege, Kristen

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Granulocyte Macrophage Colony-Stimulating Factor–Secreting Allogeneic Cellular Immunotherapy for Hormone-Refractory Prostate Cancer von SMALL, Eric J, SACKS, Natalie, NGUYEN, Minh, HEGE, Kristen, SIMONS, Jonathan W, NEMUNAITIS, John, URBA, Walter J, DULA, Eugene, CENTENO, Arthur S, NELSON, William G, ANDO, Dale, HOWARD, Catherine, BORELLINI, Flavia

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GM-CSF Gene-Modifed Cancer Cell Immunotherapies: Of Mice and Men von Hege, Kristen M., Jooss, Karin, Pardoll, Drew

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Phase I/II Trial of an Allogeneic Cellular Immunotherapy in Hormone-Naïve Prostate Cancer von SIMONS, Jonathan W, CARDUCCI, Michael A, MULLIGAN, Richard, NELSON, William G, MIKHAK, Bahar, LIM, Michael, BIEDRZYCKI, Barbara, BORELLINI, Flavia, CLIFT, Shirley M, HEGE, Kristen M, ANDO, Dale G, PIANTADOSI, Steven

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Characterizing the exposure–response relationship of idecabtagene vicleucel in patients with relapsed/refractory multiple myeloma von Connarn, Jamie N., Witjes, Han, van Zutphen‐van Geffen, Marielle, Greef, Rik, Campbell, Timothy B., Hege, Kristen, Zhou, Simon, Lamba, Manisha

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Granulocyte-macrophage colony-stimulating factor (GM-CSF)–secreting cellular immunotherapy in combination with autologous stem cell transplantation (ASCT) as postremission therapy... von Borrello, Ivan M., Levitsky, Hyam I., Stock, Wendy, Sher, Dorie, Qin, Lu, DeAngelo, Daniel J., Alyea, Edwin P., Stone, Richard M., Damon, Lloyd E., Linker, Charles A., Maslyar, Daniel J., Hege, Kristen M.

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Indirect treatment comparison of idecabtagene vicleucel versus conventional care in triple-class exposed multiple myeloma von Shah, Nina, Mojebi, Ali, Ayers, Dieter, Cope, Shannon, Dhanasiri, Sujith, Davies, Faith E, Hari, Parameswaran, Patel, Payal, Hege, Kristen, Dhanda, Devender

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K562/GM-CSF Immunotherapy Reduces Tumor Burden in Chronic Myeloid Leukemia Patients with Residual Disease on Imatinib Mesylate von Smith, B Douglas, Kasamon, Yvette L, Kowalski, Jeanne, Gocke, Christopher, Murphy, Kathleen, Miller, Carole B, Garrett-Mayer, Elizabeth, Tsai, Hua-Ling, Qin, Lu, Chia, Christina, Biedrzycki, Barbara, Harding, Thomas C, Tu, Guang Haun, Jones, Richard, Hege, Kristen, Levitsky, Hyam I

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The mTOR Kinase Inhibitors, CC214-1 and CC214-2, Preferentially Block the Growth of EGFRvIII-Activated Glioblastomas von GINI, Beatrice, ZANCA, Ciro, SHAOJUN ZHU, TANAKA, Kazuhiro, BABIC, Ivan, AKHAVAN, David, LIN, Kelly, ASSUNCAO, Alvaro, YUCHAO GU, BONETTI, Bruno, MORTENSEN, Deborah S, SHUICHAN XU, DELIANG GUO, RAYMON, Heather K, CAVENEE, Webster K, FURNARI, Frank B, JAMES, C. David, KROEMER, Guido, HEATH, James R, HEGE, Kristen, CHOPRA, Rajesh, CLOUGHESY, Timothy F, MISCHEL, Paul S, MATSUTANI, Tomoo, MASUI, Kenta, IKEGAMI, Shiro, HUIJUN YANG, NATHANSON, David, VILLA, Genaro R, SHACKELFORD, David

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S193: BMS‐986393 (CC‐95266), A G PROTEIN–COUPLED RECEPTOR CLASS C GROUP 5 MEMBER D (GPRC5D)–TARGETED CAR T‐CELL THERAPY FOR RELAPSED/REFRACTORY MULTIPLE MYELOMA (RRMM): RESULTS FRO... von Bal, Susan, Berdeja, Jesus, Htut, Myo, Kocoglu, Mehmet, Gregory, Tara, Anderson, Larry D., Rossi, Adriana, Egan, Daniel, Costa, Luciano, Kelly, Lisa, Ziyad, Safiyyah, Hu, Hongxiang, Chen, Yanping, Kaeding, Allison J., Burgess, Michael, Hege, Kristen, Nadeem, Omar

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A Phase II Randomized Study of HIV-Specific T-Cell Gene Therapy in Subjects with Undetectable Plasma Viremia on Combination Antiretroviral Therapy von Deeks, Steven G., Wagner, Bridget, Anton, Peter A., Mitsuyasu, Ronald T., Scadden, David T., Huang, Christine, Macken, Catherine, Richman, Douglas D., Christopherson, Cindy, June, Carl H., Lazar, Richard, Broad, David F., Jalali, Sayeh, Hege, Kristen M.

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