1,4-Disubstituted imidazoles are potential antibacterial agents functioning as inhibitors of enoyl acyl carrier protein reductase (FabI) von Heerding, Dirk A, Chan, George, DeWolf, Walter E, Fosberry, Andrew P, Janson, Cheryl A, Jaworski, Deborah D, McManus, Edward, Miller, William H, Moore, Terrance D, Payne, David J, Qiu, Xiayang, Rittenhouse, Stephen F, Slater-Radosti, Courtney, Smith, Ward, Takata, Dennis T, Vaidya, Kalindi S, Yuan, Catherine C.K, Huffman, William F

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Novel peptidomimetic hematoregulatory compounds von HEERDING, D. A, ABRUZZESE, M, TAKATA, J. S, BHATNAGAR, P. K, ALBERTS, D, BURGESS, J, CALLAHAN, J. F, HUFFMAN, W. F, KING, A. G, LOCASTRO, S, DEMARSH, P, PELUS, L. M

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Long-Range Inhibitor-Induced Conformational Regulation of Human IRE1 Endoribonuclease Activity von Concha, N. O., Smallwood, A., Bonnette, W., Totoritis, R., Zhang, G., Federowicz, K., Yang, J., Qi, H., Chen, S., Campobasso, N., Choudhry, A. E., Shuster, L. E., Evans, K. A., Ralph, J., Sweitzer, S., Heerding, D. A., Buser, C. A., Su, D. -S., DeYoung, M. P.

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Discovery of a Novel and Potent Class of FabI-Directed Antibacterial Agents von PAYNE, David J, MILLER, William H, HEERDING, Dirk A, JANSON, Cheryl A, JAWORSKI, Deborah D, KELLER, Paul M, MANLEY, Peter J, MOORE, Terrance D, NEWLANDER, Kenneth A, PEARSON, Stewart, POLIZZI, Brian J, XIAYANG QIU, BERRY, Valerie, RITTENHOUSE, Stephen F, SLATER-RADOSTI, Courtney, SALYERS, Kevin L, SEEFELD, Mark A, SMYTH, Martin G, TAKATA, Dennis T, UZINSKAS, Irene N, VAIDYA, Kalindi, WALLIS, Nicola G, WINRAM, Scott B, BROSKY, John, YUAN, Catherine C. K, HUFFMAN, William F, BURGESS, Walter J, CHEN, Emile, DEWOLF, Walter E, FOSBERRY, Andrew P, GREENWOOD, Rebecca, HEAD, Martha S

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Simple method for controlling stereoselection in Mannich cyclization reactions of aldehydes von Heerding, Dirk A, Hong, Chang Y, Kado, Noriyuki, Look, Gary C, Overman, Larry E

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Discovery of Aminopyridine-Based Inhibitors of Bacterial Enoyl-ACP Reductase (FabI) von Miller, William H, Seefeld, Mark A, Newlander, Kenneth A, Uzinskas, Irene N, Burgess, Walter J, Heerding, Dirk A, Yuan, Catherine C. K, Head, Martha S, Payne, David J, Rittenhouse, Stephen F, Moore, Terrance D, Pearson, Stewart C, Berry, Valerie, DeWolf, Walter E, Keller, Paul M, Polizzi, Brian J, Qiu, Xiayang, Janson, Cheryl A, Huffman, William F

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New benzimidazoles as thrombopoietin receptor agonists von Safonov, Igor G., Heerding, Dirk A., Keenan, Richard M., Price, Alan T., Erickson-Miller, Connie L., Hopson, Christopher B., Levin, Jenna L., Lord, Kenneth A., Tapley, Peter M.

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New benzylidenethiazolidinediones as antibacterial agents von HEERDING, Dirk A, CHRISTMANN, Lisa T, CLARK, Tammy J, HOLMES, David J, RITTENHOUSE, Stephen F, TAKATA, Dennis T, VENSLAVSKY, Joseph W

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Discovery of Orally Active Nonpeptide Vitronectin Receptor Antagonists Based on a 2-Benzazepine Gly-Asp Mimetic von Miller, William H, Alberts, Doreen P, Bhatnagar, Pradip K, Bondinell, William E, Callahan, James F, Calvo, Raul R, Cousins, Russell D, Erhard, Karl F, Heerding, Dirk A, Keenan, Richard M, Kwon, Chet, Manley, Peter J, Newlander, Kenneth A, Ross, Stephen T, Samanen, James M, Uzinskas, Irene N, Venslavsky, Joseph W, Yuan, Catherine C.-K, Haltiwanger, R. Curtis, Gowen, Maxine, Hwang, Shing-Mei, James, Ian E, Lark, Michael W, Rieman, David J, Stroup, George B, Azzarano, Leonard M, Salyers, Kevin L, Smith, Brian R, Ward, Keith W, Johanson, Kyung O, Huffman, William F

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Combinatorial chemistry. Use of an intramolecular ruthenium catalyzed olefin/alkyne metathesis reaction in tandem with a Diels-Alder cycloaddition reaction to construct functionali... von Heerding, Dirk A., Takata, Dennis T., Kwon, Chet, Huffman, William F., Samanen, James

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Phenylbutyrates as potent, orally bioavailable vitronectin receptor (integrin αvβ3) antagonists von Miller, William H, Manley, Peter J, Cousins, Russell D, Erhard, Karl F, Heerding, Dirk A, Kwon, Chet, Ross, Stephen T, Samanen, James M, Takata, Dennis T, Uzinskas, Irene N, Yuan, Catherine C.K, Haltiwanger, R.Curtis, Gress, Catherine J, Lark, Michael W, Hwang, Shing-Mei, James, Ian E, Rieman, David J, Willette, Robert N, Yue, Tian-Li, Azzarano, Leonard M, Salyers, Kevin L, Smith, Brian R, Ward, Keith W, Johanson, Kyung O, Huffman, William F

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Synthesis of substituted tetrahydropyridines by cyclizations of silicon-containing iminium ions von Daub, G.William, Heerding, Dirt A., Overman, Larry E.

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The synthesis of a hematoregulatory agent based on HP-5B containing an effective, achiral cystine replacement von LoCastro, Stephen M., Heerding, Dirk A., Bhatnagar, Pradip K., King, Andrew

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Discovery of 7‑Methyl-5-(1-{[3-(trifluoromethyl)phenyl]acetyl}-2,3-dihydro‑1H‑indol-5-yl)‑7H‑pyrrolo[2,3‑d]pyrimidin-4-amine (GSK2606414), a Potent and Selective First-in-Class Inh... von Axten, Jeffrey M, Medina, Jesús R, Feng, Yanhong, Shu, Arthur, Romeril, Stuart P, Grant, Seth W, Li, William Hoi Hong, Heerding, Dirk A, Minthorn, Elisabeth, Mencken, Thomas, Atkins, Charity, Liu, Qi, Rabindran, Sridhar, Kumar, Rakesh, Hong, Xuan, Goetz, Aaron, Stanley, Thomas, Taylor, J. David, Sigethy, Scott D, Tomberlin, Ginger H, Hassell, Annie M, Kahler, Kirsten M, Shewchuk, Lisa M, Gampe, Robert T

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Characterization of an Akt Kinase Inhibitor with Potent Pharmacodynamic and Antitumor Activity von RHODES, Nelson, HEERDING, Dirk A, KAHANA, Jason A, GESKE, Robert S, KIEYMENOVA, Elena V, CHOUDHRY, Anthony E, ZHIHONG LAI, LEBER, Jack D, MINTHORN, Elisabeth A, STRUM, Susan L, WOOD, Edgar R, HUANG, Pearl S, DUCKETT, Derek R, COPELAND, Robert A, KUMAR, Rakesh, EBERWEIN, Derek J, KNICK, Victoria B, LANSING, Timothy J, MCCONNELL, Randy T, GILMER, Tona M, ZHANG, Shu-Yun, ROBELL, Kimberly

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Identification of 4-(2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-{[(3S)-3-piperidinylmethyl]oxy}-1H-imidazo[4,5-c]pyridin-4-yl)-2-methyl-3-butyn-2-ol (GSK690693), a Novel Inhibitor... von Heerding, Dirk A, Rhodes, Nelson, Leber, Jack D, Clark, Tammy J, Keenan, Richard M, Lafrance, Louis V, Li, Mei, Safonov, Igor G, Takata, Dennis T, Venslavsky, Joseph W, Yamashita, Dennis S, Choudhry, Anthony E, Copeland, Robert A, Lai, Zhihong, Schaber, Michael D, Tummino, Peter J, Strum, Susan L, Wood, Edgar R, Duckett, Derek R, Eberwein, Derek, Knick, Victoria B, Lansing, Timothy J, McConnell, Randy T, Zhang, ShuYun, Minthorn, Elisabeth A, Concha, Nestor O, Warren, Gregory L, Kumar, Rakesh

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Discovery of Isoxazole Amides as Potent and Selective SMYD3 Inhibitors von Su, Dai-Shi, Qu, Junya, Schulz, Mark, Blackledge, Chuck W, Yu, Hongyi, Zeng, Jenny, Burgess, Joelle, Reif, Alexander, Stern, Melissa, Nagarajan, Raman, Pappalardi, Melissa Baker, Wong, Kristen, Graves, Alan P, Bonnette, William, Wang, Liping, Elkins, Patricia, Knapp-Reed, Beth, Carson, Jeffrey D, McHugh, Charles, Mohammad, Helai, Kruger, Ryan, Luengo, Juan, Heerding, Dirk A, Creasy, Caretha L

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Aminofurazans as potent inhibitors of AKT kinase von Rouse, Meagan B., Seefeld, Mark A., Leber, Jack D., McNulty, Kenneth C., Sun, Lihui, Miller, William H., Zhang, ShuYun, Minthorn, Elisabeth A., Concha, Nestor O., Choudhry, Anthony E., Schaber, Michael D., Heerding, Dirk A.

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Abstract 2919: Discovery of small-molecule compounds targeting c-MYC using a novel cell-based screen von Mangatt, Biju, Pietra, Anthony D., Waszkiewicz, Anna, Jaworski, Jon-Paul, Ghidelli-Disse, Sonja, Berrodin, Thomas J., Sherk, Christian S., Meinhold, Derrick W., Rutkowska-Klute, Anna, Sundaram, Shanker K., Ganji, Gopinath, Halsey, Wendy S., Livi, George P., Li, William, Mack, James, Romeril, Stuart P., Minthorn, Elisabeth A., Kumar, Rakesh, Drewes, Gerard C., Heerding, Dirk A., Kallal, Lorena A., Buser, Carolyn A., Medina, Jesus R.

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Abstract A044: The discovery of potent KAT6 inhibitors that demonstrate anti-tumor activity in preclinical models of ER+ breast cancer von Palanisamy, Gopinath S., Venkateshappa, Chandregowda, Goyal, Megha, Barratt, Susanna A., Hearn, Brian R., Daginakatte, Girish, B, Aravind A, S, Samiulla D, Bera, Kalisankar, S, Sangeetha, Khare, Leena, Parisian, Alison D., Heerding, Dirk A., Ng, Raymond A., Harmon, Cyrus L., Samajdar, Susanta, Ramachandra, Murali, Myles, David C.

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