shRNA library screening identifies nucleocytoplasmic transport as a mediator of BCR-ABL1 kinase-independent resistance von Khorashad, Jamshid S., Eiring, Anna M., Mason, Clinton C., Gantz, Kevin C., Bowler, Amber D., Redwine, Hannah M., Yu, Fan, Kraft, Ira L., Pomicter, Anthony D., Reynolds, Kimberly R., Iovino, Anthony J., Zabriskie, Matthew S., Heaton, William L., Tantravahi, Srinivas K., Kauffman, Michael, Shacham, Sharon, Chenchik, Alex, Bonneau, Kyle, Ullman, Katharine S., O'Hare, Thomas, Deininger, Michael W.

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Disarming an Electrophilic Warhead: Retaining Potency in Tyrosine Kinase Inhibitor (TKI)-Resistant CML Lines While Circumventing Pharmacokinetic Liabilities von Ali, Ahmed M., Gómez-Biagi, Rodolfo F., Rosa, David A., Lai, Ping-Shan, Heaton, William L., Park, Ji Sung, Eiring, Anna M., Vellore, Nadeem A., de Araujo, Elvin D., Ball, Dan P., Shouksmith, Andrew E., Patel, Ami B., Deininger, Michael W., O'Hare, Thomas, Gunning, Patrick T.

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BCR-ABL1 Compound Mutations Combining Key Kinase Domain Positions Confer Clinical Resistance to Ponatinib in Ph Chromosome-Positive Leukemia von Zabriskie, Matthew S., Eide, Christopher A., Tantravahi, Srinivas K., Vellore, Nadeem A., Estrada, Johanna, Nicolini, Franck E., Khoury, Hanna J., Larson, Richard A., Konopleva, Marina, Cortes, Jorge E., Kantarjian, Hagop, Jabbour, Elias J., Kornblau, Steven M., Lipton, Jeffrey H., Rea, Delphine, Stenke, Leif, Barbany, Gisela, Lange, Thoralf, Hernández-Boluda, Juan-Carlos, Ossenkoppele, Gert J., Press, Richard D., Chuah, Charles, Goldberg, Stuart L., Wetzler, Meir, Mahon, Francois-Xavier, Etienne, Gabriel, Baccarani, Michele, Soverini, Simona, Rosti, Gianantonio, Rousselot, Philippe, Friedman, Ran, Deininger, Marie, Reynolds, Kimberly R., Heaton, William L., Eiring, Anna M., Pomicter, Anthony D., Khorashad, Jamshid S., Kelley, Todd W., Baron, Riccardo, Druker, Brian J., Deininger, Michael W., O’Hare, Thomas

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Autocrine Tnf signaling favors malignant cells in myelofibrosis in a Tnfr2-dependent fashion von Heaton, William L., Senina, Anna V., Pomicter, Anthony D., Salama, Mohamed E., Clair, Phillip M., Yan, Dongqing, Bell, Russell N., Gililland, Jeremy M., Prchal, Josef T., O’Hare, Thomas, Deininger, Michael W.

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SIRT5 IS A DRUGGABLE METABOLIC VULNERABILITY IN ACUTE MYELOID LEUKEMIA von Yan, Dongqing, Franzini, Anca, Pomicter, Anthony D, Halverson, Brayden J, Antelope, Orlando, Mason, Clinton C, Ahmann, Jonathan M, Senina, Anna V, Vellore, Nadeem A, Jones, Courtney L, Zabriskie, Matthew S, Than, Hein, Xiao, Michael J, van Scoyk, Alexandria, Patel, Ami B, Clair, Phillip M, Heaton, William L, Owen, Shawn C, Andersen, Joshua L, Egbert, Christina M, Reisz, Julie A, D'Alessandro, Angelo, Cox, James E, Gantz, Kevin C, Redwine, Hannah M, Iyer, Siddharth M, Khorashad, Jamshid S, Rajabi, Nima, Olsen, Christian A, O'Hare, Thomas, Deininger, Michael W

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Identification and Characterization of AES-135, a Hydroxamic Acid-Based HDAC Inhibitor That Prolongs Survival in an Orthotopic Mouse Model of Pancreatic Cancer von Shouksmith, Andrew E, Shah, Fenil, Grimard, Michelle L, Gawel, Justyna M, Raouf, Yasir S, Geletu, Mulu, Berger-Becvar, Angelika, de Araujo, Elvin D, Luchman, H. Artee, Heaton, William L, Bakhshinyan, David, Adile, Ashley A, Venugopal, Chitra, O’Hare, Thomas, Deininger, Michael W, Singh, Sheila K, Konieczny, Stephen F, Weiss, Samuel, Fishel, Melissa L, Gunning, Patrick T

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Nuclear-Cytoplasmic Transport Is a Therapeutic Target in Myelofibrosis von Yan, Dongqing, Pomicter, Anthony D, Tantravahi, Srinivas, Mason, Clinton C, Senina, Anna V, Ahmann, Jonathan M, Wang, Qiang, Than, Hein, Patel, Ami B, Heaton, William L, Eiring, Anna M, Clair, Phillip M, Gantz, Kevin C, Redwine, Hannah M, Swierczek, Sabina I, Halverson, Brayden J, Baloglu, Erkan, Shacham, Sharon, Khorashad, Jamshid S, Kelley, Todd W, Salama, Mohamed E, Miles, Rodney R, Boucher, Kenneth M, Prchal, Josef T, O'Hare, Thomas, Deininger, Michael W

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Coordinated inhibition of nuclear export and Bcr-Abl1 selectively targets chronic myeloid leukemia stem cells von Than, Hein, Pomicter, Anthony D., Yan, Dongqing, Beaver, Larry P., Eiring, Anna M., Heaton, William L., Senina, Anna, Clair, Phillip M., Shacham, Sharon, Mason, Clinton C., Hare, Thomas O’, Deininger, Michael W.

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Femoral Heads from Total Hip Arthroplasty as a Source of Adult Hematopoietic Cells von Pomicter, Anthony D., Clair, Phillip M., Yan, Dongqing, Heaton, William L., Eiring, Anna M., Anderson, Michael B., Richards, Stephen M., Gililland, Jeremy, O’Hare, Thomas, Deininger, Michael W.

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Discovery and characterization of AZD9272 and AZD6538—Two novel mGluR5 negative allosteric modulators selected for clinical development von Raboisson, Patrick, Breitholtz-Emanuelsson, Anna, Dahllöf, Henrik, Edwards, Louise, Heaton, William L., Isaac, Methvin, Jarvie, Keith, Kers, Annika, Minidis, Alexander B.E., Nordmark, Anna, Sheehan, Susan M., Slassi, Abdelmalik, Ström, Peter, Terelius, Ylva, Wensbo, David, Wilson, Julie M., Xin, Tao, McLeod, Donald A.

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3H-Quinazolin-4-ones as a new calcilytic template for the potential treatment of osteoporosis von SHCHERBAKOVA, Irina, BALANDRIN, Manuel F, FOX, John, GHATAK, Anjan, HEATON, William L, CONKLIN, Rebecca L

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Inside Cover: Disarming an Electrophilic Warhead: Retaining Potency in Tyrosine Kinase Inhibitor (TKI)-Resistant CML Lines While Circumventing Pharmacokinetic Liabilities (ChemMedC... von Ali, Ahmed M., Gómez-Biagi, Rodolfo F., Rosa, David A., Lai, Ping-Shan, Heaton, William L., Park, Ji Sung, Eiring, Anna M., Vellore, Nadeem A., de Araujo, Elvin D., Ball, Dan P., Shouksmith, Andrew E., Patel, Ami B., Deininger, Michael W., O'Hare, Thomas, Gunning, Patrick T.

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Design, new synthesis, and calcilytic activity of substituted 3H-pyrimidin-4-ones von Shcherbakova, Irina, Huang, Guangfei, Geoffroy, Otto J., Nair, Satheesh K., Swierczek, Krzysztof, Balandrin, Manuel F., Fox, John, Heaton, William L., Conklin, Rebecca L.

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Combined STAT3 and BCR-ABL1 inhibition induces synthetic lethality in therapy-resistant chronic myeloid leukemia von Eiring, A M, Page, B D G, Kraft, I L, Mason, C C, Vellore, N A, Resetca, D, Zabriskie, M S, Zhang, T Y, Khorashad, J S, Engar, A J, Reynolds, K R, Anderson, D J, Senina, A, Pomicter, A D, Arpin, C C, Ahmad, S, Heaton, W L, Tantravahi, S K, Todic, A, Colaguori, R, Moriggl, R, Wilson, D J, Baron, R, O'Hare, T, Gunning, P T, Deininger, M W

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Abstract LB109: A critical role for SIRT5 in acute myeloid leukemia metabolism von Yan, Dongqing, Franzini, Anca, Pomicter, Anthony D., Halverson, Brayden J., Antelope, Orlando, Mason, Clinton C., Ahmann, Jonathan M., Senina, Anna V., Jones, Courtney L. L., Zabriskie, Matthew S., Than, Hein, Xiao, Michael J., van Scoyk, Alexandria, Patel, Ami B., Heaton, William L. L., Owen, Shawn C., Andersen, Joshua L., Egbert, Christina M., Reisz, Julie A., D'Alessandro, Angelo, Cox, James E., Gantz, Kevin C., Redwine, Hannah M., Iyer, Siddharth M., Khorashad, Jamshid S., Rajabi, Nima, Olsen, Christian A., O'Hare, Thomas, Deininger, Michael W.

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TNFR2 Signaling Promotes Myeloproliferative Disease Progression: A Role for MAPK8? von Heaton, William L., Senina, Anna, Pomicter, Anthony D., Marvin, James, Prchal, Josef T., O'Hare, Thomas, Deininger, Michael W.

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Stroma-Based Activation of pSTAT3Y705 Confers Resistance to FLT3 Inhibitors in FLT3 ITD-Positive AML von Patel, Ami, Pomicter, Anthony D., Eiring, Anna M., Hein, Than, Heaton, William L., O'Hare, Thomas, Deininger, Michael W.

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SIRT5 As a Therapeutic Target in Acute Myeloid Leukemia von Yan, Dongqing, Pomicter, Anthony D., Heaton, William L., Mason, Clint C., Ahmann, Jonathan, Senina, Anna, Franzini, Anca, Halverson, Brayden, Than, Hein, Clair, Phillip M., Khorashad, Jamshid S, O'Hare, Thomas, Deininger, Michael W.

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Inhibition of Nucleocytoplasmic Export Enhances Selective Elimination of Leukemic Stem Cells in Chronic Myeloid Leukemia von Than, Hein, Pomicter, Anthony D., Mason, Clinton C., Eiring, Anna M., Heaton, William L., Yan, Dongqing, Senina, Anna, Clair, Phillip M., Holyoake, Tessa L., O'Hare, Thomas, Deininger, Michael W.

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Effect of a TNFα Blocker and Peginfa on Polycythemia Vera Clonal Hematopoiesis and Suppressed Normal Dormant Hematopoiesis von Swierczek, Sabina, Kim, Soo Jin, Salama, Mohamed E, Heaton, William L., Deininger, Michael W., Prchal, Josef T.

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