Analysis of binding site for the novel small‐molecule TLR4 signal transduction inhibitor TAK‐242 and its therapeutic effect on mouse sepsis model von Takashima, K, Matsunaga, N, Yoshimatsu, M, Hazeki, K, Kaisho, T, Uekata, M, Hazeki, O, Akira, S, Iizawa, Y, Ii, M

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Essential role of phosphatidylinositol 3-kinase in insulin-induced glucose transport and antilipolysis in rat adipocytes. Studies with a selective inhibitor wortmannin von Okada, T, Kawano, Y, Sakakibara, T, Hazeki, O, Ui, M

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Blockage of chemotactic peptide-induced stimulation of neutrophils by wortmannin as a result of selective inhibition of phosphatidylinositol 3-kinase von OKADA, T, SAKUMA, L, FUKUI, Y, HAZEKI, O, UI, M

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Role of Phosphoinositide 3-Kinase in Innate Immunity von Hazeki, Kaoru, Nigorikawa, Kiyomi, Hazeki, Osamu

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Involvement of phosphatidylinositol 3-kinase in Fc gamma receptor signaling von Ninomiya, N, Hazeki, K, Fukui, Y, Seya, T, Okada, T, Hazeki, O, Ui, M

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Negative Regulation of Class IA Phosphoinositide 3-kinase by Protein Kinase C  Limits Fc  Receptor-Mediated Phagocytosis in Macrophages von Hazeki, K., Inoue, K., Nigorikawa, K., Hazeki, O.

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A Novel Cyclohexene Derivative, Ethyl (6R)-6-[N-(2-Chloro-4-fluorophenyl)sulfamoyl]cyclohex-1-ene-1-carboxylate (TAK-242), Selectively Inhibits Toll-Like Receptor 4-Mediated Cytoki... von Ii, Masayuki, Matsunaga, Naoko, Hazeki, Kaoru, Nakamura, Kazuyo, Takashima, Katsunori, Seya, Tsukasa, Hazeki, Osamu, Kitazaki, Tomoyuki, Iizawa, Yuji

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Insulin-Stimulated GLUT4 Translocation Is Relevant to the Phosphorylation of IRS-1 and the Activity of PI3 Kinase von Kanai, F., Ito, K., Todaka, M., Hayashi, H., Kamohara, S., Ishii, K., Okada, T., Hazeki, O., Ui, M., Ebina, Y.

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C5a controls TLR-induced IL-10 and IL-12 production independent of phosphoinositide 3-kinase von Okazaki, Natsumi, Hazeki, Kaoru, Izumi, Tatsuhiro, Nigorikawa, Kiyomi, Hazeki, Osamu

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Wortmannin as a unique probe for an intracellular signalling protein, phosphoinositide 3-kinase von Ui, Michio, Okada, Taro, Hazeki, Kaoru, Hazeki, Osamu

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Specific role for p85/p110β in GTP-binding-protein-mediated activation of Akt von Kubo, Hiroshi, Hazeki, Kaoru, Takasuga, Shunsuke, Hazeki, Osamu

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Opposite Effects of Wortmannin and 2-(4-Morpholinyl)-8-phenyl-1(4 H )-benzopyran-4-one Hydrochloride on Toll-Like Receptor-Mediated Nitric Oxide Production: Negative Regulation of... von Hazeki, Kaoru, Kinoshita, Sachiko, Matsumura, Takayo, Nigorikawa, Kiyomi, Kubo, Hiroshi, Hazeki, Osamu

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Modification by islet-activating protein of receptor-mediated regulation of cyclic AMP accumulation in isolated rat heart cells von Hazeki, O, Ui, M

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Activation of PI 3-kinase by G protein βγ subunits von Hazeki, O., Okada, T., Kurosu, H., Takasuga, S., Suzuki, T., Katada, T.

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IRAK-4-dependent Degradation of IRAK-1 is a Negative Feedback Signal for TLR-mediated NF- B Activation von Kubo-Murai, M., Hazeki, K., Nigorikawa, K., Omoto, T., Inoue, N., Hazeki, O.

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Involvement of Phosphoinositide 3-Kinase in Regulation of Adhesive Activity of Highly Metastatic Hepatoma Cells von Saeki, Yoshiko, Seya, Tsukasa, Hazeki, Kaoru, Ui, Michio, Hazeki, Osamu, Akedo, Hitoshi

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Toll‐like receptor‐mediated tyrosine phosphorylation of paxillin via MyD88‐dependent and ‐independent pathways von Hazeki, Kaoru, Masuda, Naoyo, Funami, Kenji, Sukenobu, Naoe, Matsumoto, Misako, Akira, Shizuo, Takeda, Kiyoshi, Seya, Tsukasa, Hazeki, Osamu

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Permissive effect of ceramide on growth factor-induced cell proliferation von Sasaki, T, Hazeki, K, Hazeki, O, Ui, M, Katada, T

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In vivo study of tissue oxygen metabolism using optical and nuclear magnetic resonance spectroscopies von Tamura, M, Hazeki, O, Nioka, S, Chance, B

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Inhibition of lipid A-mediated type I interferon induction by Bactericidal/permeability-increasing protein (BPI) von Azuma, Masahiro, Matsuo, Aya, Fujimoto, Yukari, Fukase, Koichi, Hazeki, Kaoru, Hazeki, Osamu, Matsumoto, Misako, Seya, Tsukasa

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