Hsp90, an unlikely ally in the war on cancer von Barrott, Jared J., Haystead, Timothy A. J.

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Fasnall, a Selective FASN Inhibitor, Shows Potent Anti-tumor Activity in the MMTV-Neu Model of HER2+ Breast Cancer von Alwarawrah, Yazan, Hughes, Philip, Loiselle, David, Carlson, David A., Darr, David B., Jordan, Jamie L., Xiong, Jessie, Hunter, Lucas M., Dubois, Laura G., Thompson, J. Will, Kulkarni, Manjusha M., Ratcliff, Annette N., Kwiek, Jesse J., Haystead, Timothy A.J.

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Pharmacological inhibition of TAK1, with the selective inhibitor takinib, alleviates clinical manifestation of arthritis in CIA mice von Scarneo, Scott A, Eibschutz, Liesl S, Bendele, Phillip J, Yang, Kelly W, Totzke, Juliane, Hughes, Philip, Fox, David A, Haystead, Timothy A J

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Death‐associated protein kinase 3 regulates the myogenic reactivity of cerebral arteries von Turner, Sara R., Al‐Ghabkari, Abdulhameed, Carlson, David A., Chappellaz, Mona, Sutherland, Cindy, Haystead, Timothy A. J., Cole, William C., MacDonald, Justin A.

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Molecular Biologist's Guide to Proteomics von GRAVES, Paul R, HAYSTEAD, Timothy A. J

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An inducible heat shock protein 70 small molecule inhibitor demonstrates anti-dengue virus activity, validating Hsp70 as a host antiviral target von Howe, Matthew K, Speer, Brittany L, Hughes, Philip F, Loiselle, David R, Vasudevan, Subhash, Haystead, Timothy A J

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Takinib, a Selective TAK1 Inhibitor, Broadens the Therapeutic Efficacy of TNF-α Inhibition for Cancer and Autoimmune Disease von Totzke, Juliane, Gurbani, Deepak, Raphemot, Rene, Hughes, Philip F., Bodoor, Khaldon, Carlson, David A., Loiselle, David R., Bera, Asim K., Eibschutz, Liesl S., Perkins, Marisha M., Eubanks, Amber L., Campbell, Phillip L., Fox, David A., Westover, Kenneth D., Haystead, Timothy A.J., Derbyshire, Emily R.

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Expression of membrane Hsp90 is a molecular signature of T cell activation von Scarneo, Scott A., Smith, Aaron P., Favret, Jacob, O’Connell, Robert, Pickeral, Joy, Yang, Kelly W., Ferrari, Guido, Loiselle, David R., Hughes, Philip F., Kulkarni, Manjusha M., Gargesha, Madhusudhana, Scott, Bryan, Roy, Debashish, Haynes, Barton F., Kwiek, Jesse J., Haystead, Timothy A. J.

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TAK1: a potent tumour necrosis factor inhibitor for the treatment of inflammatory diseases von Totzke, Juliane, Scarneo, Scott A., Yang, Kelly W., Haystead, Timothy A. J.

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A bioorthogonal chemical reporter for fatty acid synthase–dependent protein acylation von Karthigeyan, Krithika P., Zhang, Lizhi, Loiselle, David R., Haystead, Timothy A.J., Bhat, Menakshi, Yount, Jacob S., Kwiek, Jesse J.

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A Small Molecule Pyrazolo[3,4-d]Pyrimidinone Inhibitor of Zipper-Interacting Protein Kinase Suppresses Calcium Sensitization of Vascular Smooth Muscle von MacDonald, Justin A., Sutherland, Cindy, Carlson, David A., Bhaidani, Sabreena, Al-Ghabkari, Abdulhameed, Swärd, Karl, Haystead, Timothy A.J., Walsh, Michael P.

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A Fluorescent Hsp90 Probe Demonstrates the Unique Association between Extracellular Hsp90 and Malignancy in Vivo von Crowe, Lauren B, Hughes, Philip F, Alcorta, David A, Osada, Takuya, Smith, Aaron P, Totzke, Juliane, Loiselle, David R, Lutz, Isaac D, Gargesha, Madhusudhana, Roy, Debasish, Roques, Jose, Darr, David, Lyerly, H. Kim, Spector, Neil L, Haystead, Timothy A.J

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A highly selective inhibitor of interleukin-1 receptor–associated kinases 1/4 (IRAK-1/4) delineates the distinct signaling roles of IRAK-1/4 and the TAK1 kinase von Scarneo, Scott A., Hughes, Philip F., Yang, Kelly W., Carlson, David A., Gurbani, Deepak, Westover, Kenneth D., Haystead, Timothy A.J.

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Genetic and pharmacological validation of TAK1 inhibition in macrophages as a therapeutic strategy to effectively inhibit TNF secretion von Scarneo, Scott A., Mansourati, Antoine, Eibschutz, Liesl S., Totzke, Juliane, Roques, Jose R., Loiselle, David, Carlson, David, Hughes, Philip, Haystead, Timothy A. J.

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Selective targeting of Plasmodium falciparum Hsp90 disrupts the 26S proteasome von Mansfield, Christopher R., Quan, Baiyi, Chirgwin, Michael E., Eduful, Benjamin, Hughes, Philip F., Neveu, Gaëlle, Sylvester, Kayla, Ryan, Daniel H., Kafsack, Björn F.C., Haystead, Timothy A.J., Leahy, James W., Fitzgerald, Michael C., Derbyshire, Emily R.

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Near-simultaneous intravital microscopy of glucose uptake and mitochondrial membrane potential, key endpoints that reflect major metabolic axes in cancer von Zhu, Caigang, Martinez, Amy F., Martin, Hannah L., Li, Martin, Crouch, Brian T., Carlson, David A., Haystead, Timothy A. J., Ramanujam, Nimmi

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Methods to validate Hsp90 inhibitor specificity, to identify off-target effects, and to rethink approaches for further clinical development von Neckers, Len, Blagg, Brian, Haystead, Timothy, Trepel, Jane B., Whitesell, Luke, Picard, Didier

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Targeting Borrelia burgdorferi HtpG with a berserker molecule, a strategy for anti-microbial development von Carlson, Dave L., Kowalewski, Mark, Bodoor, Khaldon, Lietzan, Adam D., Hughes, Philip F., Gooden, David, Loiselle, David R., Alcorta, David, Dingman, Zoey, Mueller, Elizabeth A., Irnov, Irnov, Modla, Shannon, Chaya, Tim, Caplan, Jeffrey, Embers, Monica, Miller, Jennifer C., Jacobs-Wagner, Christine, Redinbo, Matthew R., Spector, Neil, Haystead, Timothy A.J.

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The RNA-binding protein Fus directs translation of localized mRNAs in APC-RNP granules von Yasuda, Kyota, Zhang, Huaye, Loiselle, David, Haystead, Timothy, Macara, Ian G, Mili, Stavroula

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Angiotensin II Type 1A Receptors in Vascular Smooth Muscle Cells Do Not Influence Aortic Remodeling in Hypertension von Sparks, Matthew A, Parsons, Kelly K, Stegbauer, Johannes, Gurley, Susan B, Vivekanandan-Giri, Anuradha, Fortner, Christopher N, Snouwaert, Jay, Raasch, Eric W, Griffiths, Robert C, Haystead, Timothy A.J, Le, Thu H, Pennathur, Subramaniam, Koller, Beverly, Coffman, Thomas M

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