Co-inhibition of CD73 and A2AR Adenosine Signaling Improves Anti-tumor Immune Responses von Young, Arabella, Ngiow, Shin Foong, Barkauskas, Deborah S., Sult, Erin, Hay, Carl, Blake, Stephen J., Huang, Qihui, Liu, Jing, Takeda, Kazuyoshi, Teng, Michele W.L., Sachsenmeier, Kris, Smyth, Mark J.

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Targeting CD73 in the tumor microenvironment with MEDI9447 von Hay, Carl M., Sult, Erin, Huang, Qihui, Mulgrew, Kathy, Fuhrmann, Stacy R., McGlinchey, Kelly A., Hammond, Scott A., Rothstein, Raymond, Rios-Doria, Jonathan, Poon, Edmund, Holoweckyj, Nick, Durham, Nicholas M., Leow, Ching Ching, Diedrich, Gundo, Damschroder, Melissa, Herbst, Ronald, Hollingsworth, Robert E., Sachsenmeier, Kris F.

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Conversion of ATP to adenosine by CD39 and CD73 in multiple myeloma can be successfully targeted together with adenosine receptor A2A blockade von Yang, Rui, Elsaadi, Samah, Misund, Kristine, Abdollahi, Pegah, Vandsemb, Esten Nymoen, Moen, Siv Helen, Kusnierczyk, Anna, Slupphaug, Geir, Standal, Therese, Waage, Anders, Slørdahl, Tobias S, Rø, Torstein Baade, Rustad, Even, Sundan, Anders, Hay, Carl, Cooper, Zachary, Schuller, Alwin G, Woessner, Richard, Borodovsky, Alexandra, Menu, Eline, Børset, Magne, Sponaas, Anne Marit

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Combining phenotypic and proteomic approaches to identify membrane targets in a 'triple negative' breast cancer cell type von Rust, Steven, Guillard, Sandrine, Sachsenmeier, Kris, Hay, Carl, Davidson, Max, Karlsson, Anders, Karlsson, Roger, Brand, Erin, Lowne, David, Elvin, John, Flynn, Matt, Kurosawa, Gene, Hollingsworth, Robert, Jermutus, Lutz, Minter, Ralph

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Selective activation of anti-CD73 mechanisms in control of primary tumors and metastases von Vijayan, Dipti, Barkauskas, Deborah S., Stannard, Kimberley, Sult, Erin, Buonpane, Rebecca, Takeda, Kazuyoshi, Teng, Michele W. L., Sachsenmeier, Kris, Hay, Carl, Smyth, Mark J.

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Dopaminergic Neurons Protected from Degeneration by GDNF Gene Therapy von Choi-Lundberg, Derek L., Lin, Qing, Chang, Yung-Nien, Chiang, Yawen L., Hay, Carl M., Mohajeri, Hasan, Davidson, Beverly L., Bohn, Martha C.

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A novel tumor-specific replication-restricted adenoviral vector for gene therapy of hepatocellular carcinoma von HALLENBECK, P. L, CHANG, Y.-N, HAY, C, GOLIGHTLY, D, STEWART, D, LIN, J, PHIPPS, S, CHIANG, Y. L

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Complete genome sequence analysis of Seneca Valley virus-001, a novel oncolytic picornavirus von Hales, Laura M, Knowles, Nick J, Reddy, P. Seshidar, Xu, Ling, Hay, Carl, Hallenbeck, Paul L

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Development of a Trispecific Antibody Designed to Simultaneously and Efficiently Target Three Different Antigens on Tumor Cells von Dimasi, Nazzareno, Fleming, Ryan, Hay, Carl, Woods, Rob, Xu, Linda, Wu, Herren, Gao, Changshou

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Abstract LB-117: Role of ectoenzymes CD39 and CD73 in the immune response to multiple myeloma von Yang, Rui, Elsaadi, Samah, Misund, Kristine, Slupphaug, Geir, Menu, Eline, Hay, Carl, Cooper, Zac, Vanderkerken, Karin, Børset, Magne, Sponaas, Anne Marit

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Identification of anti-tumour biologics using primary tumour models, 3-D phenotypic screening and image-based multi-parametric profiling von Sandercock, Alan M, Rust, Steven, Guillard, Sandrine, Sachsenmeier, Kris F, Holoweckyj, Nick, Hay, Carl, Flynn, Matt, Huang, Qihui, Yan, Kuan, Herpers, Bram, Price, Leo S, Soden, Jo, Freeth, Jim, Jermutus, Lutz, Hollingsworth, Robert, Minter, Ralph

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Seneca Valley Virus, a Systemically Deliverable Oncolytic Picornavirus, and the Treatment of Neuroendocrine Cancers von Reddy, P. Seshidhar, Burroughs, Kevin D., Hales, Laura M., Ganesh, Shanthi, Jones, Brian H., Idamakanti, Neeraja, Hay, Carl, Li, Shawn S., Skele, Kristine L., Vasko, Ann-Jeanette, Yang, Jingping, Watkins, D. Neil, Rudin, Charles M., Hallenbeck, Paul L.

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Abstract 272: Checkpoint inhibitor combinations in a human mixed leukocyte reaction von Sult, Erin, Hay, Carl, Huang, Qihui, Fuhrmann, Stacy, Hollingsworth, Robert, Sachsenmeier, Kris F.

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Abstract 3751: Inhibition of A2AR by AZD4635 induces anti-tumor immunity alone and in combination with anti-PD-L1 in preclinical models von Borodovsky, Alexandra, Wang, Yanjun, Ye, Minwei, Shaw, Joseph C., Sachsenmeier, Kris, Deng, Nanhua, Goodwin, Kelly, Clarke, James D., Goodwin, Richard, Strittmatter, Nicole, Hay, Carl, Sah, Vasu, Deborah, Lawson, Reimer, Corinne, Congreve, Miles, Mason, Jonathan, Marshall, Fiona, Lyne, Paul, Woessner, Richard

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Preclinical Analyses Support Clinical Investigation of Combined PD-L1 Blockade and Anti-CD19 CAR T Cell Therapy for the Treatment of NHL von Larson, Ryan P, Ports, Michael, Jessup, Heidi, Manriquez, Guadalupe, Hay, Carl, Stewart, Ross, Rebelatto, Marlon, Hollingsworth, Robert, Odegard, Valerie

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Abstract 285: MEDI9447: enhancing anti-tumor immunity by targeting CD73 In the tumor microenvironment von Hay, Carl, Sult, Erin, Huang, Qihui, Hammond, Scott, Mulgrew, Kathy, McGlinchey, Kelly, Fuhrmann, Stacy, Rothstein, Raymond, Poon, Edmund, Stewart, Ross, Hollingsworth, Robert, Sachsenmeier, Kris

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Abstract 5580: Preclinical pharmacodynamics and antitumor activity of AZD4635, a novel adenosine 2A receptor inhibitor that reverses adenosine mediated T cell suppression von Borodovsky, Alexandra, Wang, Yanjun, Ye, Minwei, Shaw, Joseph C., Sachsenmeier, Kris F., Deng, Nanhua, DelSignore, Kelly J., Fretland, Adrian J., Clarke, James D., Goodwin, Richard J., Strittmatter, Nicole, Hay, Carl, Sah, Vasu R., Lawson, Deborah, Reimer, Corinne, Congreve, Miles, Mason, Jonathan S., Marshall, Fiona H., Lyne, Paul, Woessner, Richard

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Guiding bispecific monovalent antibody formation through proteolysis of IgG1 single-chain von Dimasi, Nazzareno, Fleming, Ryan, Sachsenmeier, Kris F, Bezabeh, Binyam, Hay, Carl, Wu, Jincheng, Sult, Erin, Rajan, Saravanan, Zhuang, Li, Cariuk, Peter, Buchanan, Andrew, Bowen, Michael A, Wu, Herren, Gao, Changshou

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Immunosuppressive adenosine - a novel treatment target for multiple myeloma von Yang, Rui, Elsaadi, Samah, Misund, Kristine, Abdollahi, Pegah, Vandsemb, Esten, Moen, Siv H., geir Slupphaug, Standal, Therese, Waage, Anders, Slørdahl, Tobias S., Rø, Torstein Baade, Rustad, Even Holth, Sundan, Anders, Hay, Carl, Cooper, Zachary A., Woessner, Richard, Borodovsky, Alexandra, Menu, Eline, Børset, Magne, Sponaas, Anne

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Enhanced Gene Transfer to Rabbit Jugular Veins by an Adenovirus Containing a Cyclic RGD Motif in the HI Loop of the Fiber Knob von Hay, Carl M., de Leon, Hector, Jafari, Jonathon D., Jakubczak, John L., Mech, Christine A., Hallenbeck, Paul L., Powell, Sharon K., Liau, Gene, Stevenson, Susan C.

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