Oral administration of the pimelic diphenylamide HDAC inhibitor HDACi 4b is unsuitable for chronic inhibition of HDAC activity in the CNS in vivo von Beconi, Maria, Aziz, Omar, Matthews, Kim, Moumné, Lara, O'Connell, Catherine, Yates, Dawn, Clifton, Steven, Pett, Hannah, Vann, Julie, Crowley, Lynsey, Haughan, Alan F, Smith, Donna L, Woodman, Ben, Bates, Gillian P, Brookfield, Fred, Bürli, Roland W, McAllister, George, Dominguez, Celia, Munoz-Sanjuan, Ignacio, Beaumont, Vahri

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Identification of a Potent, Selective, and Brain-Penetrant Rho Kinase Inhibitor and its Activity in a Mouse Model of Huntington’s Disease von Ladduwahetty, Tammy, Lee, Matthew R., Maillard, Michel C., Cachope, Roger, Todd, Daniel, Barnes, Michael, Beaumont, Vahri, Chauhan, Alka, Gallati, Caroline, Haughan, Alan F., Kempf, Georg, Luckhurst, Christopher A., Matthews, Kim, McAllister, George, Mitchell, Philip, Patel, Hiral, Rose, Mark, Saville-Stones, Elizabeth, Steinbacher, Stefan, Stott, Andrew J., Thatcher, Emma, Tierney, Jason, Urbonas, Liudvikas, Munoz-Sanjuan, Ignacio, Dominguez, Celia

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Design, Synthesis, and Biological Evaluation of Potent and Selective Class IIa Histone Deacetylase (HDAC) Inhibitors as a Potential Therapy for Huntington’s Disease von Bürli, Roland W, Luckhurst, Christopher A, Aziz, Omar, Matthews, Kim L, Yates, Dawn, Lyons, Kathy. A, Beconi, Maria, McAllister, George, Breccia, Perla, Stott, Andrew J, Penrose, Stephen D, Wall, Michael, Lamers, Marieke, Leonard, Philip, Müller, Ilka, Richardson, Christine M, Jarvis, Rebecca, Stones, Liz, Hughes, Samantha, Wishart, Grant, Haughan, Alan F, O’Connell, Catherine, Mead, Tania, McNeil, Hannah, Vann, Julie, Mangette, John, Maillard, Michel, Beaumont, Vahri, Munoz-Sanjuan, Ignacio, Dominguez, Celia

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Identification and Optimization of RNA-Splicing Modulators as Huntingtin Protein-Lowering Agents for the Treatment of Huntington’s Disease von Liu, Longbin, Malagu, Karine, Haughan, Alan F., Khetarpal, Vinod, Stott, Andrew J., Esmieu, William, Vater, Huw D., Webster, Stephen J., Van de Poël, Amanda J., Clissold, Cole, Cosgrove, Brett, Sutton, Benjamin, Spencer, Jonathan A., Breccia, Perla, Gancia, Emanuela, Bonomo, Silvia, Ladduwahetty, Tammy, Lazari, Ovadia, Patel, Hiral, Atton, Helen C., Clifton, Steve, Mota, Daniel M., Magnani, Dario, O’Neill, Amy, Stebbeds, Marta, Macabuag, Natsuko, Todd, Daniel, Herva, Maria E., Mitchell, Philip, Visser, Mijke, Compte Sancerni, Sara, Grand Moursel, Laure, da Silva, Marta, Kritikou, Eva, Heikkinen, Taneli T., Bolkvadze, Tamuna, Fodale, Valentina, Spadafora, Debora, Daldin, Manuel, Bresciani, Alberto, Mangette, John E., Doherty, Elizabeth M., Lee, Matthew R., Herbst, Todd, Monteagudo, Edith, Macdonald, Douglas, Plotnikov, Nikolay V., Chambers, Mark, McAllister, George, Muňoz-Sanjuan, Ignacio, Dominguez, Celia

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Evaluation of 5‑(Trifluoromethyl)-1,2,4-oxadiazole-Based Class IIa HDAC Inhibitors for Huntington’s Disease von Stott, Andrew J, Maillard, Michel C, Beaumont, Vahri, Allcock, David, Aziz, Omar, Borchers, Alexander H, Blackaby, Wesley, Breccia, Perla, Creighton-Gutteridge, Gillian, Haughan, Alan F, Jarvis, Rebecca E, Luckhurst, Christopher A, Matthews, Kim L, McAllister, George, Pollack, Scott, Saville-Stones, Elizabeth, Van de Poël, Amanda J, Vater, Huw D, Vann, Julie, Williams, Rachel, Yates, Dawn, Muñoz-Sanjuán, Ignacio, Dominguez, Celia

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Development and characterization of a CNS-penetrant benzhydryl hydroxamic acid class IIa histone deacetylase inhibitor von Luckhurst, Christopher A., Aziz, Omar, Beaumont, Vahri, Bürli, Roland W., Breccia, Perla, Maillard, Michel C., Haughan, Alan F., Lamers, Marieke, Leonard, Phil, Matthews, Kim L., Raphy, Gilles, Stott, Andrew J., Munoz-Sanjuan, Ignacio, Thomas, Beth, Wall, Michael, Wishart, Grant, Yates, Dawn, Dominguez, Celia

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Inter- and Intramolecular Annulation Strategies to a Cyclopentanone Building Block Containing an All-Carbon Quaternary Stereogenic Center von Penrose, Stephen D, Stott, Andrew J, Breccia, Perla, Haughan, Alan F, Bürli, Roland W, Jarvis, Rebecca E, Dominguez, Celia

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Synthesis and SAR of aminopyrimidines as novel c-Jun N-terminal kinase (JNK) inhibitors von Alam, Mahbub, Beevers, Rebekah E., Ceska, Tom, Davenport, Richard J., Dickson, Karen M., Fortunato, Mara, Gowers, Lewis, Haughan, Alan F., James, Lynwen A., Jones, Mark W., Kinsella, Natasha, Lowe, Christopher, Meissner, Johannes W.G., Nicolas, Anne-Lise, Perry, Benjamin G., Phillips, David J., Pitt, William R., Platt, Adam, Ratcliffe, Andrew J., Sharpe, Andrew, Tait, Laura J.

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Quinazolinethiones and quinazolinediones, novel inhibitors of inosine monophosphate dehydrogenase: synthesis and initial structure–activity relationships von Buckley, George M., Davies, Natasha, Dyke, Hazel J., Gilbert, Philip J., Hannah, Duncan R., Haughan, Alan F., Hunt, Caroline A., Pitt, William R., Profit, Rachael H., Ray, Nicholas C., Richard, Marianna D., Sharpe, Andrew, Taylor, Alicia J., Whitworth, Justine M., Williams, Sophie C.

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Novel 7-methoxy-6-oxazol-5-yl-2,3-dihydro-1H-quinazolin-4-ones as IMPDH inhibitors von BIRCH, Helen L, BUCKLEY, George M, PITT, William R, RATCLIFFE, Andrew J, RAY, Nicholas C, RICHARD, Marianna D, SHARPE, Andrew, TAYLOR, Alicia J, WHITWORTH, Justine M, WILLIAMS, Sophie C, DAVIES, Natasha, DYKE, Hazel J, FROST, Elizabeth J, GILBERT, Philip J, HANNAH, Duncan R, HAUGHAN, Alan F, MADIGAN, Michael J, MORGAN, Trevor

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Novel indole inhibitors of IMPDH from fragments: Synthesis and initial structure–activity relationships von Beevers, Rebekah E., Buckley, George M., Davies, Natasha, Fraser, Joanne L., Galvin, Francis C., Hannah, Duncan R., Haughan, Alan F., Jenkins, Kerry, Mack, Stephen R., Pitt, William R., Ratcliffe, Andrew J., Richard, Marianna D., Sabin, Verity, Sharpe, Andrew, Williams, Sophie C.

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Low molecular weight indole fragments as IMPDH inhibitors von Beevers, Rebekah E., Buckley, George M., Davies, Natasha, Fraser, Joanne L., Galvin, Francis C., Hannah, Duncan R., Haughan, Alan F., Jenkins, Kerry, Mack, Stephen R., Pitt, William R., Ratcliffe, Andrew J., Richard, Marianna D., Sabin, Verity, Sharpe, Andrew, Williams, Sophie C.

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Synthesis and structure–activity relationships of guanine analogues as phosphodiesterase 7 (PDE7) inhibitors von Barnes, Matthew J, Cooper, Nicola, Davenport, Richard J, Dyke, Hazel J, Galleway, Fiona P, Galvin, Frances C.A, Gowers, Lewis, Haughan, Alan F, Lowe, Christopher, Meissner, Johannes W.G, Montana, John G, Morgan, Trevor, Picken, C.Louise, Watson, Robert J

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8-Methoxyquinolines as PDE4 inhibitors von Billah, Motasim, Buckley, George M., Cooper, Nicola, Dyke, Hazel J., Egan, Robert, Ganguly, Ashit, Gowers, Lewis, Haughan, Alan F., Kendall, Hannah J., Lowe, Christopher, Minnicozzi, Michael, Montana, John G., Oxford, Janet, Peake, Joanna C., Picken, C.Louise, Piwinski, John J., Naylor, Robert, Sabin, Verity, Shih, Neng-Yang, Warneck, Julie B.H.

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Synthesis and profile of SCH351591, a novel PDE4 inhibitor von Billah, Motasim, Cooper, Nicola, Cuss, Francis, Davenport, Richard J., Dyke, Hazel J., Egan, Robert, Ganguly, Ashit, Gowers, Lewis, Hannah, Duncan R., Haughan, Alan F., Kendall, Hannah J., Lowe, Christopher, Minnicozzi, Michael, Montana, John G., Naylor, Robert, Oxford, Janet, Peake, Joanna C., Piwinski, John J., Runcie, Karen A., Sabin, Verity, Sharpe, Andrew, Shih, Neng-Yang, Warneck, Julie B.H.

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7-Methoxyfuro[2,3- c]pyridine-4-carboxamides as PDE4 Inhibitors: A Potential Treatment for Asthma von Buckley, George M, Cooper, Nicola, Davenport, Richard J, Dyke, Hazel J, Galleway, Fiona P, Gowers, Lewis, Haughan, Alan F, Kendall, Hannah J, Lowe, Christopher, Montana, John G, Oxford, Janet, Peake, Joanna C, Picken, C.Louise, Richard, Marianna D, Sabin, Verity, Sharpe, Andrew, Warneck, Julie B.H

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8-Methoxyquinoline-5-carboxamides as PDE4 inhibitors: a potential treatment for asthma von Buckley, George M., Cooper, Nicola, Dyke, Hazel J., Galleway, Fiona P., Gowers, Lewis, Haughan, Alan F., Kendall, Hannah J., Lowe, Christopher, Maxey, Robert, Montana, John G., Naylor, Robert, Oxford, Janet, Peake, Joanna C., Picken, C.Louise, Runcie, Karen A., Sabin, Verity, Sharpe, Andrew, Warneck, Julie B.H.

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7-Methoxybenzofuran-4-carboxamides as PDE 4 inhibitors: a potential treatment for asthma von Buckley, George, Cooper, Nicola, Dyke, Hazel J, Galleway, Fiona, Gowers, Lewis, Gregory, Joanna C, Hannah, Duncan R, Haughan, Alan F, Hellewell, Paul G, Kendall, Hannah J, Lowe, Christopher, Maxey, Robert, Montana, John G, Naylor, Robert, Picken, C.Louise, Runcie, Karen A, Sabin, Verity, Tuladhar, Bishwa R, Warneck, Julie B.H

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Synthesis and evaluation of a novel series of phosphodiesterase IV inhibitors. A potential treatment for asthma von Beasley, Steven C., Cooper, Nicola, Gowers, Lewis, Gregory, Joanna P., Haughan, Alan F, Hellewell, Paul G., Macari, David, Miotla, Jadwiga, Montana, John G., Morgan, Trevor, Naylor, Robert, Runcie, Karen A., Tuladhar, Bishwa, Warneck, Julie B.H.

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Hydroxyselanylation of acyloxycyclohex-3-enes von Sweeney, J.B., Haughan, Alan F., Knight, J.R., Thobhani, Smita

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