The Biology of Cancer: Metabolic Reprogramming Fuels Cell Growth and Proliferation von DeBerardinis, Ralph J., Lum, Julian J., Hatzivassiliou, Georgia, Thompson, Craig B.

Volltext

ATP-Citrate Lyase Links Cellular Metabolism to Histone Acetylation von Wellen, Kathryn E, Hatzivassiliou, Georgia, Sachdeva, Uma M, Bui, Thi V, Cross, Justin R, Thompson, Craig B

Volltext

ATP citrate lyase is an important component of cell growth and transformation von Bauer, Daniel E, Hatzivassiliou, Georgia, Zhao, Fangping, Andreadis, Charalambos, Thompson, Craig B

Volltext

Metabolite profiling stratifies pancreatic ductal adenocarcinomas into subtypes with distinct sensitivities to metabolic inhibitors von Daemen, Anneleen, Peterson, David, Sahu, Nisebita, McCord, Ron, Du, Xiangnan, Liu, Bonnie, Kowanetz, Katarzyna, Hong, Rebecca, Moffat, John, Gao, Min, Boudreau, Aaron, Mroue, Rana, Corson, Laura, O’Brien, Thomas, Qing, Jing, Sampath, Deepak, Merchant, Mark, Yauch, Robert, Manning, Gerard, Settleman, Jeffrey, Hatzivassiliou, Georgia, Evangelista, Marie

Volltext

NRF2 activates growth factor genes and downstream AKT signaling to induce mouse and human hepatomegaly von He, Feng, Antonucci, Laura, Yamachika, Shinichiro, Zhang, Zechuan, Taniguchi, Koji, Umemura, Atsushi, Hatzivassiliou, Georgia, Roose-Girma, Merone, Reina-Campos, Miguel, Duran, Angeles, Diaz-Meco, Maria T., Moscat, Jorge, Sun, Beicheng, Karin, Michael

Volltext

The Hippo pathway effector TAZ induces TEAD-dependent liver inflammation and tumors von Hagenbeek, Thijs J, Webster, Joshua D, Kljavin, Noelyn M, Chang, Matthew T, Pham, Trang, Lee, Ho-June, Klijn, Christiaan, Cai, Allen G, Totpal, Klara, Ravishankar, Buvana, Yang, Naiying, Lee, Da-Hye, Walsh, Kevin B, Hatzivassiliou, Georgia, de la Cruz, Cecile C, Gould, Stephen E, Wu, Xiumin, Lee, Wyne P, Yang, Shuqun, Zhang, Zhixiang, Gu, Qingyang, Ji, Qunsheng, Jackson, Erica L, Lim, Dae-Sik, Dey, Anwesha

Volltext

Metabolic plasticity underpins innate and acquired resistance to LDHA inhibition von Boudreau, Aaron, Purkey, Hans E, Hitz, Anna, Robarge, Kirk, Peterson, David, Labadie, Sharada, Kwong, Mandy, Hong, Rebecca, Gao, Min, Del Nagro, Christopher, Pusapati, Raju, Ma, Shuguang, Salphati, Laurent, Pang, Jodie, Zhou, Aihe, Lai, Tommy, Li, Yingjie, Chen, Zhongguo, Wei, Binqing, Yen, Ivana, Sideris, Steve, McCleland, Mark, Firestein, Ron, Corson, Laura, Vanderbilt, Alex, Williams, Simon, Daemen, Anneleen, Belvin, Marcia, Eigenbrot, Charles, Jackson, Peter K, Malek, Shiva, Hatzivassiliou, Georgia, Sampath, Deepak, Evangelista, Marie, O'Brien, Thomas

Volltext

RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth von Hatzivassiliou, Georgia, Song, Kyung, Yen, Ivana, Brandhuber, Barbara J., Anderson, Daniel J., Alvarado, Ryan, Ludlam, Mary J. C., Stokoe, David, Gloor, Susan L., Vigers, Guy, Morales, Tony, Aliagas, Ignacio, Liu, Bonnie, Sideris, Steve, Hoeflich, Klaus P., Jaiswal, Bijay S., Seshagiri, Somasekar, Koeppen, Hartmut, Belvin, Marcia, Friedman, Lori S., Malek, Shiva

Volltext

Activation Mechanism of Oncogenic Deletion Mutations in BRAF, EGFR, and HER2 von Foster, Scott A., Whalen, Daniel M., Özen, Ayşegül, Wongchenko, Matthew J., Yin, JianPing, Yen, Ivana, Schaefer, Gabriele, Mayfield, John D., Chmielecki, Juliann, Stephens, Philip J., Albacker, Lee A., Yan, Yibing, Song, Kyung, Hatzivassiliou, Georgia, Eigenbrot, Charles, Yu, Christine, Shaw, Andrey S., Manning, Gerard, Skelton, Nicholas J., Hymowitz, Sarah G., Malek, Shiva

Volltext

Mechanism of MEK inhibition determines efficacy in mutant KRAS- versus BRAF-driven cancers von Hatzivassiliou, Georgia, Haling, Jacob R., Chen, Huifen, Song, Kyung, Price, Steve, Heald, Robert, Hewitt, Joanne F. M., Zak, Mark, Peck, Ariana, Orr, Christine, Merchant, Mark, Hoeflich, Klaus P., Chan, Jocelyn, Luoh, Shiuh-Ming, Anderson, Daniel J., Ludlam, Mary J. C., Wiesmann, Christian, Ultsch, Mark, Friedman, Lori S., Malek, Shiva, Belvin, Marcia

Volltext

Pan-Cancer Metabolic Signature Predicts Co-Dependency on Glutaminase and De Novo Glutathione Synthesis Linked to a High-Mesenchymal Cell State von Daemen, Anneleen, Liu, Bonnie, Song, Kyung, Kwong, Mandy, Gao, Min, Hong, Rebecca, Nannini, Michelle, Peterson, David, Liederer, Bianca M., de la Cruz, Cecile, Sangaraju, Dewakar, Jaochico, Allan, Zhao, Xiaofeng, Sandoval, Wendy, Hunsaker, Thomas, Firestein, Ron, Latham, Sheerin, Sampath, Deepak, Evangelista, Marie, Hatzivassiliou, Georgia

Volltext

ATP citrate lyase inhibition can suppress tumor cell growth von Hatzivassiliou, Georgia, Zhao, Fangping, Bauer, Daniel E., Andreadis, Charalambos, Shaw, Anthony N., Dhanak, Dashyant, Hingorani, Sunil R., Tuveson, David A., Thompson, Craig B.

Volltext

An Integrated Genomic Screen Identifies LDHB as an Essential Gene for Triple-Negative Breast Cancer von MCCLELAND, Mark L, ADLER, Adam S, BELVIN, Marcia, HATZIVASSILIOU, Georgia, BLACKWOOD, Elizabeth M, CORSON, Laura, EVANGELISTA, Marie, JIPING ZHA, FIRESTEIN, Ron, YONGLEI SHANG, HUNSAKER, Thomas, TRUONG, Tom, PETERSON, David, TORRES, Eric, LI LI, HALEY, Benjamin, STEPHAN, Jean-Philippe

Volltext

PERK-dependent regulation of lipogenesis during mouse mammary gland development and adipocyte differentiation von Bobrovnikova-Marjon, Ekaterina, Hatzivassiliou, Georgia, Grigoriadou, Christina, Romero, Margarita, Cavener, Douglas R, Thompson, Craig B, Diehl, J. Alan

Volltext

ERK inhibition overcomes acquired resistance to MEK inhibitors von Hatzivassiliou, Georgia, Liu, Bonnie, O'Brien, Carol, Spoerke, Jill M, Hoeflich, Klaus P, Haverty, Peter M, Soriano, Robert, Forrest, William F, Heldens, Sherry, Chen, Huifen, Toy, Karen, Ha, Connie, Zhou, Wei, Song, Kyung, Friedman, Lori S, Amler, Lukas C, Hampton, Garret M, Moffat, John, Belvin, Marcia, Lackner, Mark R

Volltext

The glucose dependence of Akt-transformed cells can be reversed by pharmacologic activation of fatty acid β-oxidation von Buzzai, Monica, Bauer, Daniel E, Jones, Russell G, DeBerardinis, Ralph J, Hatzivassiliou, Georgia, Elstrom, Rebecca L, Thompson, Craig B

Volltext

Bax and Bak Can Localize to the Endoplasmic Reticulum to Initiate Apoptosis von Zong, Wei-Xing, Li, Chi, Hatzivassiliou, Georgia, Lindsten, Tullia, Yu, Qian-Chun, Yuan, Junying, Thompson, Craig B.

Volltext

Metabolic Response to NAD Depletion across Cell Lines Is Highly Variable von Xiao, Yang, Kwong, Mandy, Daemen, Anneleen, Belvin, Marcia, Liang, Xiaorong, Hatzivassiliou, Georgia, O'Brien, Thomas

Volltext

Metabolic and transcriptional profiling reveals pyruvate dehydrogenase kinase 4 as a mediator of epithelial-mesenchymal transition and drug resistance in tumor cells von Sun, Yuting, Daemen, Anneleen, Hatzivassiliou, Georgia, Arnott, David, Wilson, Catherine, Zhuang, Guanglei, Gao, Min, Liu, Peter, Boudreau, Aaron, Johnson, Leisa, Settleman, Jeff

Volltext

Preparation and evaluation of L- and D-5-[18 F]fluorotryptophan as PET imaging probes for indoleamine and tryptophan 2,3-dioxygenases von Tang, Tang, Gill, Herman S, Ogasawara, Annie, Tinianow, Jeff N, Vanderbilt, Alexander N, Williams, Simon-Peter, Hatzivassiliou, Georgia, White, Sharla, Sandoval, Wendy, DeMent, Kevin, Wong, Mengling, Marik, Jan

Volltext