Roflumilast, a phosphodiesterase 4 inhibitor, alleviates bleomycin‐induced lung injury von Cortijo, J, Iranzo, A, Milara, X, Mata, M, Cerdá‐Nicolás, M, Ruiz‐Saurí, A, Tenor, H, Hatzelmann, A, Morcillo, EJ

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Roflumilast inhibits leukocyte‐endothelial cell interactions, expression of adhesion molecules and microvascular permeability von Sanz, M‐J, Cortijo, J, Taha, M A, Cerdá‐Nicolás, M, Schatton, E, Burgbacher, B, Klar, J, Tenor, H, Schudt, C, Issekutz, A C, Hatzelmann, A, Morcillo, E J

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PDE isoenzymes as targets for anti-asthma drugs von Schudt, C, Tenor, H, Hatzelmann, A

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The New Phosphodiesterase 4 Inhibitor Roflumilast Is Efficacious in Exercise-Induced Asthma and Leads to Suppression of LPS-Stimulated TNF-α Ex Vivo von Timmer, Wolfgang, Leclerc, Violette, Birraux, Guillaume, Neuhauser, Markus, Hatzelmann, Armin, Bethke, Thomas, Wurst, Wilhelm

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A phosphodiesterase 4 inhibitor, roflumilast N-oxide, inhibits human lung fibroblast functions in vitro von Sabatini, F, Petecchia, L, Boero, S, Silvestri, M, Klar, J, Tenor, H, Beume, R, Hatzelmann, A, Rossi, G.A

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The preclinical pharmacology of roflumilast – A selective, oral phosphodiesterase 4 inhibitor in development for chronic obstructive pulmonary disease von Hatzelmann, Armin, Morcillo, Esteban J, Lungarella, Giuseppe, Adnot, Serge, Sanjar, Shahin, Beume, Rolf, Schudt, Christian, Tenor, Hermann

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Novel Selective PDE4 Inhibitors. 1. Synthesis, Structure−Activity Relationships, and Molecular Modeling of 4-(3,4-Dimethoxyphenyl)-2H-phthalazin-1-ones and Analogues von Van der Mey, Margaretha, Hatzelmann, Armin, Van der Laan, Ivonne J, Sterk, Geert J, Thibaut, Ulrich, Timmerman, Hendrik

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Effects of theophylline and rolipram on leukotriene C4 (LTC4) synthesis and chemotaxis of human eosinophils from normal and atopic subjects von Tenor, Hermann, Hatzelmann, Armin, Church, Martin K., Schudt, Christian, Shute, Janis K.

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Novel Selective PDE4 Inhibitors. 2. Synthesis and Structure−Activity Relationships of 4-Aryl-Substituted cis-Tetra- and cis-Hexahydrophthalazinones von Van der Mey, Margaretha, Hatzelmann, Armin, Van Klink, Gerard P. M, Van der Laan, Ivonne J, Sterk, Geert J, Thibaut, Ulrich, Ulrich, Wolf R, Timmerman, Hendrik

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Potent Inhibition of Ca2+ Release-activated Ca2+ Channels and T-lymphocyte Activation by the Pyrazole Derivative BTP2 von Zitt, Christof, Strauss, Bettina, Schwarz, Eva C., Spaeth, Nicola, Rast, Georg, Hatzelmann, Armin, Hoth, Markus

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Novel Selective PDE4 Inhibitors. 3. In Vivo Antiinflammatory Activity of a New Series of N-Substituted cis-Tetra- and cis-Hexahydrophthalazinones von Van der Mey, Margaretha, Boss, Hildegard, Hatzelmann, Armin, Van der Laan, Ivonne J, Sterk, Geert J, Timmerman, Hendrik

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Therapeutic Potential of Selective PDE Inhibitors in Asthma von Schudt, C., Gantner, F., Tenors, H., Hatzelmann, A.

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Cyclic nucleotide phosphodiesterases from purified human CD4+ and CD8+ T lymphocytes von TENOR, H., STANICIU, L., SCHUDT, C., HATZELMANN, A., WENDEL, A., DJUKANOVIC, R., CHURCH, M. K., SHUTE, J. K.

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Tumor necrosis factor-α–dependent expression of phosphodiesterase 2: role in endothelial hyperpermeability von Seybold, Joachim, Thomas, Dirk, Witzenrath, Martin, Boral, Şengül, Hocke, Andreas C., Bürger, Alexander, Hatzelmann, Armin, Tenor, Hermann, Schudt, Christian, Krüll, Matthias, Schütte, Hartwig, Hippenstiel, Stefan, Suttorp, Norbert

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Cyclic nucleotide phosphodiesterase isoenzyme activities in human alveolar macrophages von TENOR, H., HATZELMANN, A., KUPFERSCHMIDT, R., STANCIU, L., DJUKANOVIC, R., SCHUDT, C., WENDEL, A., CHURCH, M. K., SHUTE, J. K.

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The effect of Sildenafil on human platelet secretory function is controlled by a complex interplay between phosphodiesterases 2, 3 and 5 von Dunkern, Torsten R., Hatzelmann, Armin

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Celecoxib dilates guinea-pig coronaries and rat aortic rings and amplifies NO/cGMP signaling by PDE5 inhibition von Klein, Thomas, Eltze, Manfrid, Grebe, Thomas, Hatzelmann, Armin, Kömhoff, Martin

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Mode of action of the new selective leukotriene synthesis inhibitor BAY X 1005 {( R)-2-[4-(quinolin-2-yl-methoxy)phenyl]-2-cyclopentyl acetic acid} and structurally related compoun... von Hatzelmann, A., Fruchtmann, R., Mohrs, K.H., Raddatz, S., Müller-Peddinghaus, R.

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Effects of the soluble guanylyl cyclase activator, YC‐1, on vascular tone, cyclic GMP levels and phosphodiesterase activity von Galle, Jan, Zabel, Ulrike, Hübner, Ulrich, Hatzelmann, Armin, Wagner, Birgit, Wanner, Christoph, Schmidt, Harald H H W

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Influence of selective phosphodiesterase inhibitors on human neutrophil functions and levels of cAMP and Cai von SCHUDT, C, WINDER, S, FORDERKUNZ, S, HATZELMANN, A, ULLRICH, V

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