Transmission of SARS-CoV-2 in Domestic Cats von Halfmann, Peter J, Hatta, Masato, Chiba, Shiho, Maemura, Tadashi, Fan, Shufang, Takeda, Makoto, Kinoshita, Noriko, Hattori, Shin-ichiro, Sakai-Tagawa, Yuko, Iwatsuki-Horimoto, Kiyoko, Imai, Masaki, Kawaoka, Yoshihiro

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A small molecule compound with an indole moiety inhibits the main protease of SARS-CoV-2 and blocks virus replication von Hattori, Shin-ichiro, Higashi-Kuwata, Nobuyo, Hayashi, Hironori, Allu, Srinivasa Rao, Raghavaiah, Jakka, Bulut, Haydar, Das, Debananda, Anson, Brandon J., Lendy, Emma K., Takamatsu, Yuki, Takamune, Nobutoki, Kishimoto, Naoki, Murayama, Kazutaka, Hasegawa, Kazuya, Li, Mi, Davis, David A., Kodama, Eiichi N., Yarchoan, Robert, Wlodawer, Alexander, Misumi, Shogo, Mesecar, Andrew D., Ghosh, Arun K., Mitsuya, Hiroaki

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Syrian hamsters as a small animal model for SARS-CoV-2 infection and countermeasure development von Imai, Masaki, Iwatsuki-Horimoto, Kiyoko, Hatta, Masato, Loeber, Samantha, Halfmann, Peter J., Nakajima, Noriko, Watanabe, Tokiko, Ujie, Michiko, Takahashi, Kenta, Ito, Mutsumi, Yamada, Shinya, Fan, Shufang, Chiba, Shiho, Kuroda, Makoto, Guan, Lizheng, Takada, Kosuke, Armbrust, Tammy, Balogh, Aaron, Furusawa, Yuri, Okuda, Moe, Ueki, Hiroshi, Yasuhara, Atsuhiro, Sakai-Tagawa, Yuko, Lopes, Tiago J. S., Kiso, Maki, Yamayoshi, Seiya, Kinoshita, Noriko, Ohmagari, Norio, Hattori, Shin-ichiro, Takeda, Makoto, Mitsuya, Hiroaki, Krammer, Florian, Suzuki, Tadaki, Kawaoka, Yoshihiro

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Comparison of Rapid Antigen Tests for COVID-19 von Yamayoshi, Seiya, Sakai-Tagawa, Yuko, Koga, Michiko, Akasaka, Osamu, Nakachi, Ichiro, Koh, Hidefumi, Maeda, Kenji, Adachi, Eisuke, Saito, Makoto, Nagai, Hiroyuki, Ikeuchi, Kazuhiko, Ogura, Takayuki, Baba, Rie, Fujita, Kensuke, Fukui, Takahiro, Ito, Fumimaro, Hattori, Shin-Ichiro, Yamamoto, Kei, Nakamoto, Takato, Furusawa, Yuri, Yasuhara, Atsuhiro, Ujie, Michiko, Yamada, Shinya, Ito, Mutsumi, Mitsuya, Hiroaki, Omagari, Norio, Yotsuyanagi, Hiroshi, Iwatsuki-Horimoto, Kiyoko, Imai, Masaki, Kawaoka, Yoshihiro

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Neutralization of SARS-CoV-2 with IgG from COVID-19-convalescent plasma von Maeda, Kenji, Higashi-Kuwata, Nobuyo, Kinoshita, Noriko, Kutsuna, Satoshi, Tsuchiya, Kiyoto, Hattori, Shin-ichiro, Matsuda, Kouki, Takamatsu, Yuki, Gatanaga, Hiroyuki, Oka, Shinichi, Sugiyama, Haruhito, Ohmagari, Norio, Mitsuya, Hiroaki

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Structure–Activity Relationship Studies of SARS-CoV‑2 Main Protease Inhibitors Containing 4‑Fluorobenzothiazole-2-carbonyl Moieties von Tsuji, Kohei, Ishii, Takahiro, Kobayakawa, Takuya, Higashi-Kuwata, Nobuyo, Shinohara, Kouki, Azuma, Chika, Miura, Yutaro, Nakano, Hiroki, Wada, Naoya, Hattori, Shin-ichiro, Bulut, Haydar, Mitsuya, Hiroaki, Tamamura, Hirokazu

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Antibody titers against SARS-CoV-2 decline, but do not disappear for several months von Yamayoshi, Seiya, Yasuhara, Atsuhiro, Ito, Mutsumi, Akasaka, Osamu, Nakamura, Morio, Nakachi, Ichiro, Koga, Michiko, Mitamura, Keiko, Yagi, Kazuma, Maeda, Kenji, Kato, Hideaki, Nojima, Masanori, Pattinson, David, Ogura, Takayuki, Baba, Rie, Fujita, Kensuke, Nagai, Hiroyuki, Yamamoto, Shinya, Saito, Makoto, Adachi, Eisuke, Ochi, Junichi, Hattori, Shin-ichiro, Suzuki, Tetsuya, Miyazato, Yusuke, Chiba, Shiho, Okuda, Moe, Murakami, Jurika, Hamabata, Taiki, Iwatsuki-Horimoto, Kiyoko, Nakajima, Hideaki, Mitsuya, Hiroaki, Omagari, Norio, Sugaya, Norio, Yotsuyanagi, Hiroshi, Kawaoka, Yoshihiro

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GRL-0920, an Indole Chloropyridinyl Ester, Completely Blocks SARS-CoV-2 Infection von Hattori, Shin-Ichiro, Higshi-Kuwata, Nobuyo, Raghavaiah, Jakka, Das, Debananda, Bulut, Haydar, Davis, David A, Takamatsu, Yuki, Matsuda, Kouki, Takamune, Nobutoki, Kishimoto, Naoki, Okamura, Tadashi, Misumi, Shogo, Yarchoan, Robert, Maeda, Kenji, Ghosh, Arun K, Mitsuya, Hiroaki

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Design of Highly Potent, Dual‐Acting and Central‐Nervous‐System‐Penetrating HIV‐1 Protease Inhibitors with Excellent Potency against Multidrug‐Resistant HIV‐1 Variants... von Ghosh, Arun K., Rao, Kalapala Venkateswara, Nyalapatla, Prasanth R., Kovela, Satish, Brindisi, Margherita, Osswald, Heather L., Sekhara Reddy, Bhavanam, Agniswamy, Johnson, Wang, Yuan‐Fang, Aoki, Manabu, Hattori, Shin‐ichiro, Weber, Irene T., Mitsuya, Hiroaki

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Identification of a novel long-acting 4’-modified nucleoside reverse transcriptase inhibitor against HBV von Higashi-Kuwata, Nobuyo, Hayashi, Sanae, Kumamoto, Hiroki, Ogata-Aoki, Hiromi, Das, Debananda, Venzon, David, Hattori, Shin-ichiro, Bulut, Haydar, Hashimoto, Mai, Otagiri, Masaki, Takamune, Nobutoki, Kishimoto, Naoki, Davis, David A., Misumi, Shogo, Kakuni, Masakazu, Tanaka, Yasuhito, Mitsuya, Hiroaki

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Structural features in common of HBV and HIV-1 resistance against chirally-distinct nucleoside analogues entecavir and lamivudine von Yasutake, Yoshiaki, Hattori, Shin-ichiro, Tamura, Noriko, Matsuda, Kouki, Kohgo, Satoru, Maeda, Kenji, Mitsuya, Hiroaki

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Single atom changes in newly synthesized HIV protease inhibitors reveal structural basis for extreme affinity, high genetic barrier, and adaptation to the HIV protease plasticity von Bulut, Haydar, Hattori, Shin-ichiro, Aoki-Ogata, Hiromi, Hayashi, Hironori, Das, Debananda, Aoki, Manabu, Davis, David A., Rao, Kalapala Venkateswara, Nyalapatla, Prasanth R., Ghosh, Arun K., Mitsuya, Hiroaki

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Exploratory Studies of Effective Inhibitors against the SARS-CoV-2 Main Protease by Halogen Incorporation and Amide Bond Replacement von Tsuji, Kohei, Kobayakawa, Takuya, Ishii, Takahiro, Higashi-Kuwata, Nobuyo, Azuma, Chika, Shinohara, Kouki, Miura, Yutaro, Yamamoto, Kenichi, Nishimura, Soshi, Hattori, Shin-ichiro, Bulut, Haydar, Mitsuya, Hiroaki, Tamamura, Hirokazu

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Design and Synthesis of Potent HIV‑1 Protease Inhibitors Containing Bicyclic Oxazolidinone Scaffold as the P2 Ligands: Structure–Activity Studies and Biological and X‑ray Structura... von Ghosh, Arun K, Williams, Jacqueline N, Ho, Rachel Y, Simpson, Hannah M, Hattori, Shin-ichiro, Hayashi, Hironori, Agniswamy, Johnson, Wang, Yuan-Fang, Weber, Irene T, Mitsuya, Hiroaki

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Regulation of the Dimerization and Activity of SARS-CoV-2 Main Protease through Reversible Glutathionylation of Cysteine 300 von Davis, David A, Bulut, Haydar, Shrestha, Prabha, Yaparla, Amulya, Jaeger, Hannah K, Hattori, Shin-ichiro, Wingfield, Paul T, Mieyal, John J, Mitsuya, Hiroaki, Yarchoan, Robert

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Design, Synthesis and X‐Ray Structural Studies of Potent HIV‐1 Protease Inhibitors Containing C‐4 Substituted Tricyclic Hexahydro‐Furofuran Derivatives as P2 Ligands von Ghosh, Arun K., Kovela, Satish, Sharma, Ashish, Shahabi, Dana, Ghosh, Ajay K., Hopkins, Denver R., Yadav, Monika, Johnson, Megan E., Agniswamy, Johnson, Wang, Yuan‐Fang, Hattori, Shin‐Ichiro, Higashi‐Kuwata, Nobuyo, Aoki, Manabu, Amano, Masayuki, Weber, Irene T., Mitsuya, Hiroaki

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A novel central nervous system-penetrating protease inhibitor overcomes human immunodeficiency virus 1 resistance with unprecedented aM to pM potency von Aoki, Manabu, Hayashi, Hironori, Rao, Kalapala Venkateswara, Das, Debananda, Higashi-Kuwata, Nobuyo, Bulut, Haydar, Aoki-Ogata, Hiromi, Takamatsu, Yuki, Yedidi, Ravikiran S, Davis, David A, Hattori, Shin-Ichiro, Nishida, Noriko, Hasegawa, Kazuya, Takamune, Nobutoki, Nyalapatla, Prasanth R, Osswald, Heather L, Jono, Hirofumi, Saito, Hideyuki, Yarchoan, Robert, Misumi, Shogo, Ghosh, Arun K, Mitsuya, Hiroaki

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Potent HIV-1 protease inhibitors incorporating squaramide-derived P2 ligands: Design, synthesis, and biological evaluation von Ghosh, Arun K., Williams, Jacqueline N., Kovela, Satish, Takayama, Jun, Simpson, Hannah M., Walters, D. Eric, Hattori, Shin-ichiro, Aoki, Manabu, Mitsuya, Hiroaki

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Chloropyridinyl Esters of Nonsteroidal Anti-Inflammatory Agents and Related Derivatives as Potent SARS-CoV-2 3CL Protease Inhibitors von Ghosh, Arun K, Shahabi, Dana, Yadav, Monika, Kovela, Satish, Anson, Brandon J, Lendy, Emma K, Bonham, Connie, Sirohi, Devika, Brito-Sierra, Carlos A, Hattori, Shin-Ichiro, Kuhn, Richard, Mitsuya, Hiroaki, Mesecar, Andrew D

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GRL-079, a Novel HIV-1 Protease Inhibitor, Is Extremely Potent against Multidrug-Resistant HIV-1 Variants and Has a High Genetic Barrier against the Emergence of Resistant Variants von Delino, Nicole S, Aoki, Manabu, Hayashi, Hironori, Hattori, Shin-Ichiro, Chang, Simon B, Takamatsu, Yuki, Martyr, Cuthbert D, Das, Debananda, Ghosh, Arun K, Mitsuya, Hiroaki

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