Recent Advances in Selective and Irreversible Covalent Ligand Development and Validation von Zhang, Tinghu, Hatcher, John M., Teng, Mingxing, Gray, Nathanael S., Kostic, Milka

Volltext

Crystal structure of human IRAK1 von Wang, Li, Qiao, Qi, Ferrao, Ryan, Shen, Chen, Hatcher, John M., Buhrlage, Sara J., Gray, Nathanael S., Wu, Hao

Volltext

Passing the Torch von Hatcher, John

Volltext

SRPKIN-1: A Covalent SRPK1/2 Inhibitor that Potently Converts VEGF from Pro-angiogenic to Anti-angiogenic Isoform von Hatcher, John M., Wu, Guowei, Zeng, Chuyue, Zhu, Jie, Meng, Fan, Patel, Sherrina, Wang, Wenqiu, Ficarro, Scott B., Leggett, Alan L., Powell, Chelsea E., Marto, Jarrod A., Zhang, Kang, Ki Ngo, Jacky Chi, Fu, Xiang-Dong, Zhang, Tinghu, Gray, Nathanael S.

Volltext

Specific covalent inhibition of MALT1 paracaspase suppresses B cell lymphoma growth von Fontán, Lorena, Qiao, Qi, Hatcher, John M, Casalena, Gabriella, Us, Ilkay, Teater, Matt, Durant, Matt, Du, Guangyan, Xia, Min, Bilchuk, Natalia, Chennamadhavuni, Spandan, Palladino, Giuseppe, Inghirami, Giorgio, Philippar, Ulrike, Wu, Hao, Scott, David A, Gray, Nathanael S, Melnick, Ari

Volltext

Development of CDK2 and CDK5 Dual Degrader TMX‐2172 von Teng, Mingxing, Jiang, Jie, He, Zhixiang, Kwiatkowski, Nicholas P., Donovan, Katherine A., Mills, Caitlin E., Victor, Chiara, Hatcher, John M., Fischer, Eric S., Sorger, Peter K., Zhang, Tinghu, Gray, Nathanael S.

Volltext

Copper(I)-Catalyzed Addition of Grignard Reagents to in Situ-Derived N-Sulfonyl Azoalkenes: An Umpolung Alkylation Procedure Applicable to the Formation of Up to Three Contiguous Q... von Hatcher, John M, Coltart, Don M

Volltext

Development of Highly Potent and Selective Steroidal Inhibitors and Degraders of CDK8 von Hatcher, John M, Wang, Eric S, Johannessen, Liv, Kwiatkowski, Nicholas, Sim, Taebo, Gray, Nathanael S

Volltext

Development of a highly potent and selective degrader of LRRK2 von Hatcher, John M., Zwirek, Monika, Sarhan, Adil R., Vatsan, Prasanna S., Tonelli, Francesca, Alessi, Dario R., Davies, Paul, Gray, Nathanael S.

Volltext

Louis Gregory von Hatcher, John

Volltext

Helen Elsie Austin von Hatcher, John

Volltext

Catalytic Degraders Effectively Address Kinase Site Mutations in EML4-ALK Oncogenic Fusions von Gao, Yang, Jiang, Baishan, Kim, Hellen, Berberich, Matthew J., Che, Jianwei, Donovan, Katherine A., Hatcher, John M., Huerta, Fidel, Kwiatkowski, Nicholas P., Liu, Yingpeng, Liuni, Peter P., Metivier, Rebecca J., Murali, Vineeth K., Nowak, Radosław P., Zhang, Tinghu, Fischer, Eric S., Gray, Nathanael S., Jones, Lyn H.

Volltext

A kinase-independent role for CDK8 in BCR-ABL1+ leukemia von Menzl, Ingeborg, Zhang, Tinghu, Berger-Becvar, Angelika, Grausenburger, Reinhard, Heller, Gerwin, Prchal-Murphy, Michaela, Edlinger, Leo, Knab, Vanessa M., Uras, Iris Z., Grundschober, Eva, Bauer, Karin, Roth, Mareike, Skucha, Anna, Liu, Yao, Hatcher, John M., Liang, Yanke, Kwiatkowski, Nicholas P., Fux, Daniela, Hoelbl-Kovacic, Andrea, Kubicek, Stefan, Melo, Junia V., Valent, Peter, Weichhart, Thomas, Grebien, Florian, Zuber, Johannes, Gray, Nathanael S., Sexl, Veronika

Volltext

Transcriptional Antagonism by CDK8 Inhibition Improves Therapeutic Efficacy of MEK Inhibitors von Malone, Clare F, Kim, Minjee, Alexe, Gabriela, Engel, Kathleen, Forman, Alexandra B, Robichaud, Amanda, Conway, Amy Saur, Goodale, Amy, Meyer, Ashleigh, Khalid, Delan, Thayakumar, Allen, Hatcher, John M, Gray, Nathanael S, Piccioni, Federica, Stegmaier, Kimberly

Volltext

A Novel HER2-Selective Kinase Inhibitor Is Effective in HER2 Mutant and Amplified Non-Small Cell Lung Cancer von Son, Jieun, Jang, Jaebong, Beyett, Tyler S, Eum, Yoonji, Haikala, Heidi M, Verano, Alyssa, Lin, Mika, Hatcher, John M, Kwiatkowski, Nicholas P, Eser, Pinar Ö, Poitras, Michael J, Wang, Stephen, Xu, Man, Gokhale, Prafulla C, Cameron, Michael D, Eck, Michael J, Gray, Nathanael S, Jänne, Pasi A

Volltext

Characterization of DDR2 Inhibitors for the Treatment of DDR2 Mutated Nonsmall Cell Lung Cancer von Terai, Hideki, Tan, Li, Beauchamp, Ellen M, Hatcher, John M, Liu, Qingsong, Meyerson, Matthew, Gray, Nathanael S, Hammerman, Peter S

Volltext

Conformational flexibility and inhibitor binding to unphosphorylated interleukin-1 receptor–associated kinase 4 (IRAK4) von Wang, Li, Ferrao, Ryan, Li, Qiubai, Hatcher, John M., Choi, Hwan Geun, Buhrlage, Sara J., Gray, Nathanael S., Wu, Hao

Volltext

Discovery of Inhibitors That Overcome the G1202R Anaplastic Lymphoma Kinase Resistance Mutation von Hatcher, John M, Bahcall, Magda, Choi, Hwan Geun, Gao, Yang, Sim, Taebo, George, Rani, Jänne, Pasi A, Gray, Nathanael S

Volltext

Peasant Productivity and Welfare in The Middle Ages and Beyond von Hatcher, John

Volltext

Peptide-based covalent inhibitors of MALT1 paracaspase von Hatcher, John M., Du, Guangyan, Fontán, Lorena, Us, Ilkay, Qiao, Qi, Chennamadhavuni, Spandan, Shao, Jay, Wu, Hao, Melnick, Ari, Gray, Nathanael S., Scott, David A.

Volltext