Therapeutic Implications for the Induced Levels of Chk1 in Myc-Expressing Cancer Cells von HÖGLUND, Andreas, NILSSON, Lisa M, VEPPIL MURALIDHARAN, Somsundar, HASVOLD, Lisa A, MERTA, Philip, RUDELIUS, Martina, NIKOLOVA, Viktoriya, KELLER, Ulrich, NILSSON, Jonas A

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Discovery of N‑Ethyl-4-[2-(4-fluoro-2,6-dimethyl-phenoxy)-5-(1-hydroxy-1-methyl-ethyl)phenyl]-6-methyl-7-oxo‑1H‑pyrrolo[2,3‑c]pyridine-2-carboxamide (ABBV-744), a BET Bromodomain I... von Sheppard, George S, Wang, Le, Fidanze, Steven D, Hasvold, Lisa A, Liu, Dachun, Pratt, John K, Park, Chang H, Longenecker, Kenton, Qiu, Wei, Torrent, Maricel, Kovar, Peter J, Bui, Mai, Faivre, Emily, Huang, Xiaoli, Lin, Xiaoyu, Wilcox, Denise, Zhang, Lu, Shen, Yu, Albert, Daniel H, Magoc, Terrance J, Rajaraman, Ganesh, Kati, Warren M, McDaniel, Keith F

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Discovery of N -Ethyl-4-[2-(4-fluoro-2,6-dimethyl-phenoxy)-5-(1-hydroxy-1-methyl-ethyl)phenyl]-6-methyl-7-oxo-1 H -pyrrolo[2,3- c ]pyridine-2-carboxamide (ABBV-744), a BET Bromodom... von Sheppard, George S, Wang, Le, Fidanze, Steven D, Hasvold, Lisa A, Liu, Dachun, Pratt, John K, Park, Chang H, Longenecker, Kenton, Qiu, Wei, Torrent, Maricel, Kovar, Peter J, Bui, Mai, Faivre, Emily, Huang, Xiaoli, Lin, Xiaoyu, Wilcox, Denise, Zhang, Lu, Shen, Yu, Albert, Daniel H, Magoc, Terrance J, Rajaraman, Ganesh, Kati, Warren M, McDaniel, Keith F

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Discovery of N‑(4-(2,4-Difluorophenoxy)-3-(6-methyl-7-oxo-6,7-dihydro‑1H‑pyrrolo[2,3‑c]pyridin-4-yl)phenyl)ethanesulfonamide (ABBV-075/Mivebresib), a Potent and Orally Available Br... von McDaniel, Keith F, Wang, Le, Soltwedel, Todd, Fidanze, Steven D, Hasvold, Lisa A, Liu, Dachun, Mantei, Robert A, Pratt, John K, Sheppard, George S, Bui, Mai H, Faivre, Emily J, Huang, Xiaoli, Li, Leiming, Lin, Xiaoyu, Wang, Rongqi, Warder, Scott E, Wilcox, Denise, Albert, Daniel H, Magoc, Terrance J, Rajaraman, Ganesh, Park, Chang H, Hutchins, Charles W, Shen, Jianwei J, Edalji, Rohinton P, Sun, Chaohong C, Martin, Ruth, Gao, Wenqing, Wong, Shekman, Fang, Guowei, Elmore, Steven W, Shen, Yu, Kati, Warren M

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Design, Synthesis, and Biological Activity of 5,10-Dihydro-dibenzo[b,e][1,4]diazepin-11-one-Based Potent and Selective Chk-1 Inhibitors von Wang, Le, Sullivan, Gerard M, Hexamer, Laura A, Hasvold, Lisa A, Thalji, Reema, Przytulinska, Magdalena, Tao, Zhi-Fu, Li, Gaoquan, Chen, Zehan, Xiao, Zhan, Gu, Wen-Zhen, Xue, John, Bui, Mai-Ha, Merta, Philip, Kovar, Peter, Bouska, Jennifer J, Zhang, Haiying, Park, Chang, Stewart, Kent D, Sham, Hing L, Sowin, Thomas J, Rosenberg, Saul H, Lin, Nan-Horng

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Fragment-Based, Structure-Enabled Discovery of Novel Pyridones and Pyridone Macrocycles as Potent Bromodomain and Extra-Terminal Domain (BET) Family Bromodomain Inhibitors von Wang, Le, Pratt, John K, Soltwedel, Todd, Sheppard, George S, Fidanze, Steven D, Liu, Dachun, Hasvold, Lisa A, Mantei, Robert A, Holms, James H, McClellan, William J, Wendt, Michael D, Wada, Carol, Frey, Robin, Hansen, T. Matthew, Hubbard, Robert, Park, Chang H, Li, Leiming, Magoc, Terrance J, Albert, Daniel H, Lin, Xiaoyu, Warder, Scott E, Kovar, Peter, Huang, Xiaoli, Wilcox, Denise, Wang, Rongqi, Rajaraman, Ganesh, Petros, Andrew M, Hutchins, Charles W, Panchal, Sanjay C, Sun, Chaohong, Elmore, Steven W, Shen, Yu, Kati, Warren M, McDaniel, Keith F

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Synthesis and biological evaluation of 1-(2,4,5-trisubstituted phenyl)-3-(5-cyanopyrazin-2-yl)ureas as potent Chk1 kinase inhibitors von Li, Gaoquan, Hasvold, Lisa A., Tao, Zhi-Fu, Wang, Gary T., Gwaltney, Stephen L., Patel, Jyoti, Kovar, Peter, Credo, Robert B., Chen, Zehan, Zhang, Haiying, Park, Chang, Sham, Hing L., Sowin, Thomas, Rosenberg, Saul H., Lin, Nan-Horng

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Discovery and optimization of novel constrained pyrrolopyridone BET family inhibitors von Fidanze, Steven D., Liu, Dachun, Mantei, Robert A., Hasvold, Lisa A., Pratt, John K., Sheppard, George S., Wang, Le, Holms, James H., Dai, Yujia, Aguirre, Ana, Bogdan, Andrew, Dietrich, Justin D., Marjanovic, Jasmina, Park, Chang H., Hutchins, Charles W., Lin, Xiaoyu, Bui, Mai H., Huang, Xiaoli, Wilcox, Denise, Li, Leiming, Wang, Rongqi, Kovar, Peter, Magoc, Terrance J., Rajaraman, Ganesh, Albert, Daniel H., Shen, Yu, Kati, Warren M., McDaniel, Keith F.

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Methylpyrrole inhibitors of BET bromodomains von Hasvold, Lisa A., Sheppard, George S., Wang, Le, Fidanze, Steven D., Liu, Dachun, Pratt, John K., Mantei, Robert A., Wada, Carol K., Hubbard, Robbert, Shen, Yu, Lin, Xiaoyu, Huang, Xiaoli, Warder, Scott E., Wilcox, Denise, Li, Leiming, Buchanan, F. Greg, Smithee, Lauren, Albert, Daniel H., Magoc, Terrance J., Park, Chang H., Petros, Andrew M., Panchal, Sanjay C., Sun, Chaohong, Kovar, Peter, Soni, Nirupama B., Elmore, Steven W., Kati, Warren M., McDaniel, Keith F.

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Discovery of 3H-Benzo[4,5]thieno[3,2-d]pyrimidin-4-ones as Potent, Highly Selective, and Orally Bioavailable Inhibitors of the Human Protooncogene Proviral Insertion Site in Molone... von Tao, Zhi-Fu, Hasvold, Lisa A, Leverson, Joel D, Han, Edward K, Guan, Ran, Johnson, Eric F, Stoll, Vincent S, Stewart, Kent D, Stamper, Geoff, Soni, Nirupama, Bouska, Jennifer J, Luo, Yan, Sowin, Thomas J, Lin, Nan-Horng, Giranda, Vincent S, Rosenberg, Saul H, Penning, Thomas D

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Palladium(II)-Catalyzed Cyclization of Olefinic Tosylamides von Larock, Richard C, Hightower, Timothy R, Hasvold, Lisa A, Peterson, Karl P

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Selective inhibition of the BD2 bromodomain of BET proteins in prostate cancer von Faivre, Emily J., McDaniel, Keith F., Albert, Daniel H., Mantena, Srinivasa R., Plotnik, Joshua P., Wilcox, Denise, Zhang, Lu, Bui, Mai H., Sheppard, George S., Wang, Le, Sehgal, Vasudha, Lin, Xiaoyu, Huang, Xiaoli, Lu, Xin, Uziel, Tamar, Hessler, Paul, Lam, Lloyd T., Bellin, Richard J., Mehta, Gaurav, Fidanze, Steve, Pratt, John K., Liu, Dachun, Hasvold, Lisa A., Sun, Chaohong, Panchal, Sanjay C., Nicolette, John J., Fossey, Stacey L., Park, Chang H., Longenecker, Kenton, Bigelow, Lance, Torrent, Maricel, Rosenberg, Saul H., Kati, Warren M., Shen, Yu

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Investigation of novel 7,8-disubstituted-5,10-dihydro-dibenzo[ b, e][1,4]diazepin-11-ones as potent Chk1 inhibitors von Hasvold, Lisa A., Wang, Le, Przytulinska, Magdalena, Xiao, Zhan, Chen, Zehan, Gu, Wen-Zhen, Merta, Philip J., Xue, John, Kovar, Peter, Zhang, Haiying, Park, Chang, Sowin, Thomas J., Rosenberg, Saul H., Lin, Nan-Horng

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Design and synthesis of o-trifluoromethylbiphenyl substituted 2-amino-nicotinonitriles as inhibitors of farnesyltransferase von Wang, Gary T., Wang, Xilu, Wang, Weibo, Hasvold, Lisa A., Sullivan, Gerry, Hutchins, Charles W., O’Conner, Steve, Gentiles, Robert, Sowin, Thomas, Cohen, Jerry, Gu, Wen-Zhen, Zhang, Haiying, Rosenberg, Saul H., Sham, Hing L.

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Abstract 931: Discovery of ABBV-744, a first-in-class highly BDII-selective BET bromodomain inhibitor von Sheppard, George S., Wang, Le, Fidanze, Steven D., Hasvold, Lisa A., Liu, Dachun, Pratt, John K., Park, Chang H., Bui, Mai-Ha, Faivre, Emily J., Huang, Xiaoli, Lin, Xiaoyu, Wilcox, Denise M., Shen, Yu, Albert, Daniel H., Magoc, Terrance J., Rajaraman, Ganesh, Kati, Warren M., McDaniel, Keith F.

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Methylpyrrole inhibitors of BET bromodomains von Hasvold, Lisa A., Sheppard, George S., Wang, Le, Fidanze, Steven D., Liu, Dachun, Pratt, John K., Mantei, Robert A., Wada, Carol K., Hubbard, Robbert, Shen, Yu, Lin, Xiaoyu, Huang, Xiaoli, Warder, Scott E., Wilcox, Denise, Li, Leiming, Buchanan, F. Greg, Smithee, Lauren, Albert, Daniel H., Magoc, Terrance J., Park, Chang H., Petros, Andrew M., Panchal, Sanjay C., Sun, Chaohong, Kovar, Peter, Soni, Nirupama B., Elmore, Steven W., Kati, Warren M., McDaniel, Keith F.

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Discovery of 3 H -Benzo[4,5]thieno[3,2- d ]pyrimidin-4-ones as Potent, Highly Selective, and Orally Bioavailable Inhibitors of the Human Protooncogene Proviral Insertion Site in Mo... von Tao, Zhi-Fu, Hasvold, Lisa A., Leverson, Joel D., Han, Edward K., Guan, Ran, Johnson, Eric F., Stoll, Vincent S., Stewart, Kent D., Stamper, Geoff, Soni, Nirupama, Bouska, Jennifer J., Luo, Yan, Sowin, Thomas J., Lin, Nan-Horng, Giranda, Vincent S., Rosenberg, Saul H., Penning, Thomas D.

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Investigation of novel 7,8-disubstituted-5,10-dihydro-dibenzo-[b,e][1,4]diazepin-11-ones as potent Chkl inhibitors von HASVOLD, Lisa A, LE WANG, PARK, Chang, SOWIN, Thomas J, ROSENBERG, Saul H, LIN, Nan-Horng, PRZYTULINSKA, Magdalena, ZHAN XIAO, ZEHAN CHEN, GU, Wen-Zhen, MERTA, Philip J, XUE, John, KOVAR, Peter, HAIYING ZHANG

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Bromodomain Inhibitors von Fidanze, Steven D, Wang, Le, Pratt, John, Sheppard, George, McDaniel, Keith F, Liu, Dachun, Schrimpf, Michael, Hasvold, Lisa A, Li, Bing

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Pyridone-Containing farnesyltransferase inhibitors: synthesis and biological evaluation von Hasvold, Lisa A., Wang, Weibo, Gwaltney, Stephen L., Rockway, Todd W., Nelson, Lissa T.J., Mantei, Robert A., Fakhoury, Stephen A., Sullivan, Gerard M., Li, Qun, Lin, Nan-Horng, Wang, Le, Zhang, Haiying, Cohen, Jerome, Gu, Wen-Zhen, Marsh, Kennan, Bauch, Joy, Rosenberg, Saul, Sham, Hing L.

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