Structural basis of HLX10 PD-1 receptor recognition, a promising anti-PD-1 antibody clinical candidate for cancer immunotherapy von Issafras, Hassan, Fan, Shilong, Tseng, Chi-Ling, Cheng, Yunchih, Lin, Peihua, Xiao, Lisa, Huang, Yun-Ju, Tu, Chih-Hsiang, Hsiao, Ya-Chin, Li, Min, Chen, Yen-Hsiao, Ho, Chien-Hsin, Li, Ou, Wang, Yanling, Chen, Sandra, Ji, Zhenyu, Zhang, Eric, Mao, Yi-Ting, Liu, Eugene, Yang, Shumin, Jiang, Weidong

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Constitutive Agonist-independent CCR5 Oligomerization and Antibody-mediated Clustering Occurring at Physiological Levels of Receptors von Issafras, Hassan, Angers, Stéphane, Bulenger, Sébastien, Blanpain, Cédric, Parmentier, Marc, Labbé-Jullié, Catherine, Bouvier, Michel, Marullo, Stefano

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XOMA 052, a potent, high-affinity monoclonal antibody for the treatment of IL-1β-mediated diseases von Owyang, Alexander M., Issafras, Hassan, Corbin, John, Ahluwalia, Kiran, Larsen, Paul, Pongo, Elizabeth, Handa, Masahisa, Horwitz, Arnold H., Roell, Marina K., Haak-Frendscho, Mary, Masat, Linda

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Application of an In Vivo Hepatic Triacylglycerol Production Method in the Setting of a High-Fat Diet in Mice von Ono-Moore, Kikumi D, Ferguson, Matthew, Blackburn, Michael L, Issafras, Hassan, Adams, Sean H

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Multiple active states and oligomerization of CCR5 revealed by functional properties of monoclonal antibodies von Blanpain, Cédric, Vanderwinden, Jean-Marie, Cihak, Josef, Wittamer, Valérie, Le Poul, Emmanuel, Issafras, Hassan, Stangassinger, Manfred, Vassart, Gilbert, Marullo, Stefano, Schlndorff, Detlef, Parmentier, Marc, Mack, Matthias

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Abstract 2786: A FcgR IIB tumor enriching anti-CD137 novel antibody to avoid liver Immuno-toxicity von Xue, Jie, Chang, Jen-Kuan, Dong, Chen, Mao, Yi-Ting, Raghavendra, Pallavi, Li, Ou, Issafras, Hassan, Xu, Wenfeng, Jiang, Weidong

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Monoclonal antibodies targeting IL-1 beta reduce biomarkers of atherosclerosis in vitro and inhibit atherosclerotic plaque formation in Apolipoprotein E-deficient mice von Bhaskar, Vinay, Yin, Johnny, Mirza, Amer M, Phan, Dan, Vanegas, Sandra, Issafras, Hassan, Michelson, Kristen, Hunter, John J, Kantak, Seema S

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Abstract 2451: A novel single domain antibody targeting TIGIT for cancer use in combination therapies von Hua, Botong, Yang, Ming, Xue, Jie, Dong, Chen, Mao, Yi-Ting, Li, Ou, Cheung, Eric, Issafras, Hassan, Xu, Wenfeng, Jiang, Weidong

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Detailed mechanistic analysis of gevokizumab, an allosteric anti-IL-1β antibody with differential receptor-modulating properties von Issafras, Hassan, Corbin, John A, Goldfine, Ira D, Roell, Marina K

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Enhancement of antibody fragment secretion into the Escherichia coli periplasm by co-expression with the peptidyl prolyl isomerase, FkpA, in the cytoplasm von Levy, Raphael, Ahluwalia, Kiran, Bohmann, David J., Giang, Hoa M., Schwimmer, Lauren J., Issafras, Hassan, Reddy, Nithin B., Chan, Chung, Horwitz, Arnold H., Takeuchi, Toshihiko

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Characterization of murine CEACAM1 in vivo reveals low expression on CD8 + T cells and no tumor growth modulating activity by anti-CEACAM1 mAb CC1 von McLeod, Robbie L, Angagaw, Minilik H, Baral, Toya Nath, Liu, Liming, Moniz, Raymond Joseph, Laskey, Jason, Hsieh, SuChun, Lee, Mike, Han, Jin-Hwan, Issafras, Hassan, Javaid, Sarah, Loboda, Andrey, Sadekova, Svetlana, O'Connor, Joann A, Tse, Archie, Punnonen, Juha

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Homo- and Hetero-oligomerization of β-Arrestins in Living Cells von Storez, Hélène, Scott, Mark G.H., Issafras, Hassan, Burtey, Anne, Benmerah, Alexandre, Muntaner, Olivier, Piolot, Tristan, Tramier, Marc, Coppey-Moisan, Maité, Bouvier, Michel, Labbé-Jullié, Catherine, Marullo, Stefano

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Selective Allosteric Antibodies to the Insulin Receptor for the Treatment of Hyperglycemic and Hypoglycemic Disorders von Issafras, Hassan, Bedinger, Daniel H., Corbin, John A., Goldfine, Ira D., Bhaskar, Vinay, White, Mark L., Rubin, Paul, Scannon, Patrick J.

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Kinetic Approach to Pathway Attenuation Using XOMA 052, a Regulatory Therapeutic Antibody That Modulates Interleukin-1β Activity von Roell, Marina K., Issafras, Hassan, Bauer, Robert J., Michelson, Kristen S., Mendoza, Nerissa, Vanegas, Sandra I., Gross, Lisa M., Larsen, Paul D., Bedinger, Daniel H., Bohmann, David J., Nonet, Genevieve H., Liu, Naichi, Lee, Steve R., Handa, Masahisa, Kantak, Seema S., Horwitz, Arnold H., Hunter, John J., Owyang, Alexander M., Mirza, Amer M., Corbin, John A., White, Mark L.

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Structural basis of HLX10 PD-1 receptor recognition, a promising anti-PD-1 antibody clinical candidate for cancer immunotherapy von Hassan Issafras, Shilong Fan, Chi-Ling Tseng, Yunchih Cheng, Peihua Lin, Lisa Xiao, Yun-Ju Huang, Chih-Hsiang Tu, Ya-Chin Hsiao, Min Li, Yen-Hsiao Chen, Chien-Hsin Ho, Ou Li, Yanling Wang, Sandra Chen, Zhenyu Ji, Eric Zhang, Yi-Ting Mao, Eugene Liu, Shumin Yang, Weidong Jiang

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Inhibition of insulin receptor function by a human, allosteric monoclonal antibody: A potential new approach for the treatment of hyperinsulinemic hypoglycemia von Corbin, John A, Bhaskar, Vinay, Goldfine, Ira D, Issafras, Hassan, Bedinger, Daniel H, Lau, Angela, Michelson, Kristen, Gross, Lisa M, Maddux, Betty A, Kuan, Hua F, Tran, Catarina, Lao, Llewelyn, Handa, Masahisa, Watson, Susan R, Narasimha, Ajay J, Zhu, Shirley, Levy, Raphael, Webster, Lynn, Wijesuriya, Sujeewa D, Liu, Naichi, Wu, Xiaorong, Chemla-Vogel, David, Lee, Steve R, Wong, Steve, Wilcock, Diane, Rubin, Paul, White, Mark L

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Kinetic Approach to Pathway Attenuation Using XOMA 052, a Regulatory Therapeutic Antibody That Modulates Interleukin-1b Activity von Roell, Marina K, Issafras, Hassan, Bauer, Robert J, Michelson, Kristen S, Mendoza, Nerissa, Vanegas, Sandra I, Gross, Lisa M, Larsen, Paul D, Bedinger, Daniel H, Bohmann, David J, Nonet, Genevieve H, Liu, Naichi, Lee, Steve R, Handa, Masahisa, Kantak, Seema S, Horwitz, Arnold H, Hunter, John J, Owyang, Alexander M, Mirza, Amer M, Corbin, John A, White, Mark L

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MODIFIED ANTIBODIES, ANTIBODY FRAGMENTS THEREOF, AND ANTIBODY-DRUG CONJUGATES von GAO, Changshou, YANG, Xiao, ISSAFRAS, Hassan, ZHANG, Xiao, ZHU, Chenchen, GAO, Cuihua

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ANTI-PDL1 ANTIBODIES AND METHODS OF USE von XUE, Jie, LIN, Pei-Hua, ISSAFRAS, Hassan, JIANG, Wei-Dong, XU, Wenfeng

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ANTI-PDL1 ANTIBODIES AND METHODS OF USE von XUE, Jie, LIN, Pei-Hua, ISSAFRAS, Hassan, JIANG, Wei-Dong, XU, Wenfeng

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