Acetyl-CoA carboxylase inhibition by ND-630 reduces hepatic steatosis, improves insulin sensitivity, and modulates dyslipidemia in rats von Harriman, Geraldine, Greenwood, Jeremy, Bhat, Sathesh, Huang, Xinyi, Wang, Ruiying, Paul, Debamita, Tong, Liang, Saha, Asish K., Westlin, William F., Kapeller, Rosana, Harwood, H. James

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Inhibition of acetyl-CoA carboxylase suppresses fatty acid synthesis and tumor growth of non-small-cell lung cancer in preclinical models von Svensson, Robert U, Parker, Seth J, Eichner, Lillian J, Kolar, Matthew J, Wallace, Martina, Brun, Sonja N, Lombardo, Portia S, Van Nostrand, Jeanine L, Hutchins, Amanda, Vera, Lilliana, Gerken, Laurie, Greenwood, Jeremy, Bhat, Sathesh, Harriman, Geraldine, Westlin, William F, Harwood, H James, Saghatelian, Alan, Kapeller, Rosana, Metallo, Christian M, Shaw, Reuben J

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An allosteric mechanism for potent inhibition of human ATP-citrate lyase von Wei, Jia, Leit, Silvana, Kuai, Jun, Therrien, Eric, Rafi, Salma, Harwood, H. James, DeLaBarre, Byron, Tong, Liang

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Acetyl‐coenzyme A carboxylase inhibition reduces de novo lipogenesis in overweight male subjects: A randomized, double‐blind, crossover study von Stiede, Kathryn, Miao, Wenyan, Blanchette, Heather S., Beysen, Carine, Harriman, Geraldine, Harwood, H. James, Kelley, Heather, Kapeller, Rosana, Schmalbach, Tess, Westlin, William F.

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The adipocyte as an endocrine organ in the regulation of metabolic homeostasis von Harwood, H. James

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Acetyl-coenzyme A carboxylases: Versatile targets for drug discovery von Tong, Liang, Harwood Jr, H. James

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Nonhuman primates and other animal models in diabetes research von Harwood, Jr, H James, Listrani, Paul, Wagner, Janice D

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Treating the metabolic syndrome: acetyl-CoA carboxylase inhibition von Harwood Jr, H James

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CP-346086: an MTP inhibitor that lowers plasma cholesterol and triglycerides in experimental animals and in humans von Chandler, Charles E, Wilder, Donald E, Pettini, Judith L, Savoy, Yvette E, Petras, Stephen F, Chang, George, Vincent, John, Harwood, Jr, H James

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class of selective antibacterials derived from a protein kinase inhibitor pharmacophore von Miller, J. Richard, Dunham, Steve, Mochalkin, Igor, Banotai, Craig, Bowman, Matthew, Buist, Susan, Dunkle, Bill, Hanna, Debra, Harwood, H. James, Huband, Michael D, Karnovsky, Alla, Kuhn, Michael, Limberakis, Chris, Liu, Jia Y, Mehrens, Shawn, Mueller, W. Thomas, Narasimhan, Lakshmi, Ogden, Adam, Ohren, Jeff, Prasad, J.V.N. Vara, Shelly, John A, Skerlos, Laura, Sulavik, Mark, Thomas, V. Hayden, VanderRoest, Steve, Wang, LiAnn, Wang, Zhigang, Whitton, Amy, Zhu, Tong, Stover, C. Kendall

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Isozyme-nonselective N-Substituted Bipiperidylcarboxamide Acetyl-CoA Carboxylase Inhibitors Reduce Tissue Malonyl-CoA Concentrations, Inhibit Fatty Acid Synthesis, and Increase Fat... von Harwood, H.James, Petras, Stephen F., Shelly, Lorraine D., Zaccaro, Lawrence M., Perry, David A., Makowski, Michael R., Hargrove, Diane M., Martin, Kelly A., Tracey, W.Ross, Chapman, Justin G., Magee, William P., Dalvie, Deepak K., Soliman, Victor F., Martin, William H., Mularski, Christian J., Eisenbeis, Shane A.

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Discovery of small molecule isozyme non-specific inhibitors of mammalian acetyl-CoA carboxylase 1 and 2 von Corbett, Jeffrey W., Freeman-Cook, Kevin D., Elliott, Richard, Vajdos, Felix, Rajamohan, Francis, Kohls, Darcy, Marr, Eric, Zhang, Hailong, Tong, Liang, Tu, Meihua, Murdande, Sharad, Doran, Shawn D., Houser, Janet A., Song, Wei, Jones, Christopher J., Coffey, Steven B., Buzon, Leanne, Minich, Martha L., Dirico, Kenneth J., Tapley, Susan, Kirk McPherson, R., Sugarman, Eliot, James Harwood, H., Esler, William

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Inhibition of Acetyl-CoA Carboxylase by Phosphorylation or the Inhibitor ND-654 Suppresses Lipogenesis and Hepatocellular Carcinoma von Lally, James S.V., Ghoshal, Sarani, DePeralta, Danielle K., Moaven, Omeed, Wei, Lan, Masia, Ricard, Erstad, Derek J., Fujiwara, Naoto, Leong, Vivian, Houde, Vanessa P., Anagnostopoulos, Alexander E., Wang, Alice, Broadfield, Lindsay A., Ford, Rebecca J., Foster, Robert A., Bates, Jamie, Sun, Hailing, Wang, Ting, Liu, Henry, Ray, Adrian S., Saha, Asish K., Greenwood, Jeremy, Bhat, Sathesh, Harriman, Geraldine, Miao, Wenyan, Rocnik, Jennifer L., Westlin, William F., Muti, Paola, Tsakiridis, Theodoros, Harwood, H. James, Kapeller, Rosana, Hoshida, Yujin, Tanabe, Kenneth K., Steinberg, Gregory R., Fuchs, Bryan C.

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Aminopyrrolidineamide inhibitors of site-1 protease von Hay, Bruce A., Abrams, Barbara, Zumbrunn, Allice Y., Valentine, James J., Warren, Laurie C., Petras, Stephen F., Shelly, Lorraine D., Xia, Angela, Varghese, Alison H., Hawkins, Julie L., Van Camp, Jennifer A., Robbins, Michael D., Landschulz, Katherine, Harwood, H. James

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Old World nonhuman primate models of type 2 diabetes mellitus von Wagner, J.D, Kavanagh, K, Ward, G.M, Auerbach, B.J, Harwood, H.J. Jr, Kaplan, J.R

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A selective peroxisome proliferator-activated receptor alpha agonist, CP-900691, improves plasma lipids, lipoproteins, and glycemic control in diabetic monkeys von Wagner, Janice D, Shadoan, Melanie K, Zhang, Li, Ward, Gina M, Royer, Lori J, Kavanagh, Kylie, Francone, Omar L, Auerbach, Bruce J, Harwood, Jr, H James

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A selective cannabinoid-1 receptor antagonist, PF-95453, reduces body weight and body fat to a greater extent than pair-fed controls in obese monkeys von Wagner, Janice D, Zhang, Li, Kavanagh, Kylie, Ward, Gina M, Chin, Janice E, Hadcock, John R, Auerbach, Bruce J, Harwood, Jr, H James

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Short-term hyperglycemia increases arterial superoxide production and iron dysregulation in atherosclerotic monkeys von Rowe, Patrick A, Kavanagh, Kylie, Zhang, Li, Harwood, H. James, Wagner, Janice D

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Dual-action hypoglycemic and hypocholesterolemic agents that inhibit glycogen phosphorylase and lanosterol demethylase von Harwood, H. James, Petras, Stephen F., Hoover, Dennis J., Mankowski, Dayna C., Soliman, Victor F., Sugarman, Eliot D., Hulin, Bernard, Kwon, Younggil, Gibbs, E. Michael, Mayne, James T., Treadway, Judith L.

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Structure-guided Inhibitor Design for Human Acetyl-coenzyme A Carboxylase by Interspecies Active Site Conversion von Rajamohan, Francis, Marr, Eric, Reyes, Allan R., Landro, James A., Anderson, Marie D., Corbett, Jeffrey W., Dirico, Kenneth J., Harwood, James H., Tu, Meihua, Vajdos, Felix F.

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