Discriminating self from non-self in nucleic acid sensing von Schlee, Martin, Hartmann, Gunther

Volltext

Cooperative activation of human TLR9 and consequences for the clinical development of antisense and CpG oligodeoxynucleotides von Hartmann, Gunther

Volltext

RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III-transcribed RNA intermediate von Hornung, Veit, Hartmann, Gunther, Ablasser, Andrea, Bauernfeind, Franz, Latz, Eicke, Fitzgerald, Katherine A

Volltext

Oxidative Damage of DNA Confers Resistance to Cytosolic Nuclease TREX1 Degradation and Potentiates STING-Dependent Immune Sensing von Gehrke, Nadine, Mertens, Christina, Zillinger, Thomas, Wenzel, Jörg, Bald, Tobias, Zahn, Sabine, Tüting, Thomas, Hartmann, Gunther, Barchet, Winfried

Volltext

Infection fatality rate of SARS-CoV2 in a super-spreading event in Germany von Streeck, Hendrik, Schulte, Bianca, Kümmerer, Beate M., Richter, Enrico, Höller, Tobias, Fuhrmann, Christine, Bartok, Eva, Dolscheid-Pommerich, Ramona, Berger, Moritz, Wessendorf, Lukas, Eschbach-Bludau, Monika, Kellings, Angelika, Schwaiger, Astrid, Coenen, Martin, Hoffmann, Per, Stoffel-Wagner, Birgit, Nöthen, Markus M., Eis-Hübinger, Anna M., Exner, Martin, Schmithausen, Ricarda Maria, Schmid, Matthias, Hartmann, Gunther

Volltext

Cyclic [G(2′,5′)pA(3′,5′)p] Is the Metazoan Second Messenger Produced by DNA-Activated Cyclic GMP-AMP Synthase von Gao, Pu, Ascano, Manuel, Wu, Yang, Barchet, Winfried, Gaffney, Barbara L., Zillinger, Thomas, Serganov, Artem A., Liu, Yizhou, Jones, Roger A., Hartmann, Gunther, Tuschl, Thomas, Patel, Dinshaw J.

Volltext

Structure-Function Analysis of STING Activation by c[G(2′,5′)pA(3′,5′)p] and Targeting by Antiviral DMXAA von Gao, Pu, Ascano, Manuel, Zillinger, Thomas, Wang, Weiyi, Dai, Peihong, Serganov, Artem A., Gaffney, Barbara L., Shuman, Stewart, Jones, Roger A., Deng, Liang, Hartmann, Gunther, Barchet, Winfried, Tuschl, Thomas, Patel, Dinshaw J.

Volltext

Memory B cells targeting SARS-CoV-2 spike protein and their dependence on CD4+ T cell help von Pušnik, Jernej, Richter, Enrico, Schulte, Bianca, Dolscheid-Pommerich, Ramona, Bode, Christian, Putensen, Christian, Hartmann, Gunther, Alter, Galit, Streeck, Hendrik

Volltext

Immune Sensing of Synthetic, Bacterial, and Protozoan RNA by Toll-like Receptor 8 Requires Coordinated Processing by RNase T2 and RNase 2 von Ostendorf, Thomas, Zillinger, Thomas, Andryka, Katarzyna, Schlee-Guimaraes, Thais Marina, Schmitz, Saskia, Marx, Samira, Bayrak, Kübra, Linke, Rebecca, Salgert, Sarah, Wegner, Julia, Grasser, Tatjana, Bauersachs, Sonja, Soltesz, Leon, Hübner, Marc P., Nastaly, Maximilian, Coch, Christoph, Kettwig, Matthias, Roehl, Ingo, Henneke, Marco, Hoerauf, Achim, Barchet, Winfried, Gärtner, Jutta, Schlee, Martin, Hartmann, Gunther, Bartok, Eva

Volltext

The Chase for the RIG-I Ligand—Recent Advances von Schlee, Martin, Hartmann, Gunther

Volltext

Sequence-specific activation of the DNA sensor cGAS by Y-form DNA structures as found in primary HIV-1 cDNA von Herzner, Anna-Maria, Hagmann, Cristina Amparo, Goldeck, Marion, Wolter, Steven, Kübler, Kirsten, Wittmann, Sabine, Gramberg, Thomas, Andreeva, Liudmila, Hopfner, Karl-Peter, Mertens, Christina, Zillinger, Thomas, Jin, Tengchuan, Xiao, Tsan Sam, Bartok, Eva, Coch, Christoph, Ackermann, Damian, Hornung, Veit, Ludwig, Janos, Barchet, Winfried, Hartmann, Gunther, Schlee, Martin

Volltext

ATG16L1 orchestrates interleukin-22 signaling in the intestinal epithelium via cGAS-STING von Aden, Konrad, Tran, Florian, Ito, Go, Sheibani-Tezerji, Raheleh, Lipinski, Simone, Kuiper, Jan W, Tschurtschenthaler, Markus, Saveljeva, Svetlana, Bhattacharyya, Joya, Häsler, Robert, Bartsch, Kareen, Luzius, Anne, Jentzsch, Marlene, Falk-Paulsen, Maren, Stengel, Stephanie T, Welz, Lina, Schwarzer, Robin, Rabe, Björn, Barchet, Winfried, Krautwald, Stefan, Hartmann, Gunther, Pasparakis, Manolis, Blumberg, Richard S, Schreiber, Stefan, Kaser, Arthur, Rosenstiel, Philip

Volltext

Immune Sensing Mechanisms that Discriminate Self from Altered Self and Foreign Nucleic Acids von Bartok, Eva, Hartmann, Gunther

Volltext

An NLRP3-specific inflammasome inhibitor attenuates crystal-induced kidney fibrosis in mice von Ludwig-Portugall, Isis, Bartok, Eva, Dhana, Ermanila, Evers, Beatrix D.G., Primiano, Michael J., Hall, J. Perry, Franklin, Bernardo S., Knolle, Percy A., Hornung, Veit, Hartmann, Gunther, Boor, Peter, Latz, Eicke, Kurts, Christian

Volltext

5'-Triphosphate RNA Is the Ligand for RIG-I von Hornung, Veit, Ellegast, Jana, Kim, Sarah, Brzózka, Krzysztof, Jung, Andreas, Kato, Hiroki, Poeck, Hendrik, Akira, Shizuo, Conzelmann, Karl-Klaus, Schlee, Martin, Endres, Stefan, Hartmann, Gunther

Volltext

Increased IKKϵ protein stability ensures efficient type I interferon responses in conditions of TBK1 deficiency von Wegner, Julia, Hunkler, Charlotte, Ciupka, Katrin, Hartmann, Gunther, Schlee, Martin

Volltext

Listeria monocytogenes is sensed by the NLRP3 and AIM2 inflammasome von Kim, Sarah, Bauernfeind, Franz, Ablasser, Andrea, Hartmann, Gunther, Fitzgerald, Katherine A., Latz, Eicke, Hornung, Veit

Volltext

Quantitative protein biomarker panels: a path to improved clinical practice through proteomics von Hartl, Johannes, Kurth, Florian, Kappert, Kai, Horst, David, Mülleder, Michael, Hartmann, Gunther, Ralser, Markus

Volltext

Deficiency in coatomer complex I causes aberrant activation of STING signalling von Steiner, Annemarie, Hrovat-Schaale, Katja, Prigione, Ignazia, Yu, Chien-Hsiung, Laohamonthonkul, Pawat, Harapas, Cassandra R., Low, Ronnie Ren Jie, De Nardo, Dominic, Dagley, Laura F., Mlodzianoski, Michael J., Rogers, Kelly L., Zillinger, Thomas, Hartmann, Gunther, Gantier, Michael P., Gattorno, Marco, Geyer, Matthias, Volpi, Stefano, Davidson, Sophia, Masters, Seth L.

Volltext

Proapoptotic signaling induced by RIG-I and MDA-5 results in type I interferon-independent apoptosis in human melanoma cells von Besch, Robert, Poeck, Hendrik, Hohenauer, Tobias, Senft, Daniela, Häcker, Georg, Berking, Carola, Hornung, Veit, Endres, Stefan, Ruzicka, Thomas, Rothenfusser, Simon, Hartmann, Gunther

Volltext