Evaluation of farnesyl:Protein transferase and geranylgeranyl:Protein transferase inhibitor combinations in preclinical models von LOBELL, Robert B, OMER, Charles A, KRAL, Astrid M, DONGMING LIU, LUMMA, William C, MACHOTKA, Samuel V, RANDS, Elaine, WILLIAMS, Theresa M, GRAHAM, Samuel L, HARTMAN, George D, OLIFF, Allen I, HEIMBROOK, David C, ABRAMS, Marc T, KOHL, Nancy E, BHIMNATHWALA, Hema G, BRUCKER, Mary Jo, BUSER, Carolyn A, DAVIDE, Joseph P, DESOLMS, S. Jane, DINSMORE, Christopher J, ELLIS-HUTCHINGS, Michelle S

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Comparison of closed chamber and open chamber evaporimetry von Cohen, J. C., Hartman, D. G., Garofalo, M. J., Basehoar, A., Raynor, B., Ashbrenner, E., Akin, F. J.

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Imidazole-containing diarylether and diarylsulfone inhibitors of farnesyl-protein transferase von Dinsmore, Christopher J., Williams, Theresa M., O'Neill, Timothy J., Liu, Dongming, Rands, Elaine, Culberson, J.Christopher, Lobell, Robert B., Koblan, Kenneth S., Kohl, Nancy E., Gibbs, Jackson B., Oliff, Allen I., Graham, Samuel L., Hartman, George D.

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Non-Peptide GPIIb/IIIa Inhibitors. 20. Centrally Constrained Thienothiophene α-Sulfonamides Are Potent, Long Acting in Vivo Inhibitors of Platelet Aggregation von Egbertson, Melissa S, Cook, Jacquelynn J, Bednar, Bohumil, Prugh, John D, Bednar, Rodney A, Gaul, Stanley L, Gould, Robert J, Hartman, George D, Homnick, Carl F, Holahan, Marie A, Libby, Laura A, Lynch, Joseph J, Lynch, Robert J, Sitko, Gary R, Stranieri, Maria T, Vassallo, Laura M

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Design and in Vivo Analysis of Potent Non-Thiol Inhibitors of Farnesyl Protein Transferase von Anthony, Neville J, Gomez, Robert P, Schaber, Micheal D, Mosser, Scott D, Hamilton, Kelly A, O'Neil, Timothy J, Koblan, Kenneth S, Graham, Samuel L, Hartman, George D, Shah, Daksha, Rands, Elaine, Kohl, Nancy E, Gibbs, Jackson B, Oliff, Allen I

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Conformational Restriction of Flexible Ligands Guided by the Transferred NOE Experiment:  Potent Macrocyclic Inhibitors of Farnesyltransferase von Dinsmore, Christopher J, Bogusky, Michael J, Culberson, J. Christopher, Bergman, Jeffrey M, Homnick, Carl F, Zartman, C. Blair, Mosser, Scott D, Schaber, Michael D, Robinson, Ronald G, Koblan, Kenneth S, Huber, Hans E, Graham, Samuel L, Hartman, George D, Huff, Joel R, Williams, Theresa M

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2-Substituted Piperazines as Constrained Amino Acids. Application to the Synthesis of Potent, Non Carboxylic Acid Inhibitors of Farnesyltransferase von Williams, Theresa M, Ciccarone, Terrence M, MacTough, Suzanne C, Bock, Rhonda L, Conner, Michael W, Davide, Joseph P, Hamilton, Kelly, Koblan, Kenneth S, Kohl, Nancy E, Kral, Astrid M, Mosser, Scott D, Omer, Charles A, Pompliano, David L, Rands, Elaine, Schaber, Michael D, Shah, Daksha, Wilson, Francine R, Gibbs, Jackson B, Graham, Samuel L, Hartman, George D, Oliff, Allen I, Smith, Robert L

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Non-thiol 3-aminomethylbenzamide inhibitors of farnesyl-protein transferase von Ciccarone, Terrence M., MacTough, Suzanne C., Williams, Theresa M., Dinsmore, Christopher J., O'Neill, Timothy J., Shah, Daksha, Culberson, J.Christopher, Koblan, Kenneth S., Kohl, Nancy E., Gibbs, Jackson B., Oliff, Allen I., Graham, Samuel L., Hartman, George D.

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alpha(v)beta(3) Integrin antagonists as inhibitors of bone resorption von Hartman, G D, Duggan, M E

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Nonpeptide alpha(v)beta(3) antagonists. 1. Transformation of a potent, integrin-selective alpha(IIb)beta(3) antagonist into a potent alpha(v)beta(3) antagonist von Duggan, M E, Duong, L T, Fisher, J E, Hamill, T G, Hoffman, W F, Huff, J R, Ihle, N C, Leu, C T, Nagy, R M, Perkins, J J, Rodan, S B, Wesolowski, G, Whitman, D B, Zartman, A E, Rodan, G A, Hartman, G D

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Fibrinogen receptor antagonist-induced thrombocytopenia in chimpanzee and rhesus monkey associated with preexisting drug-dependent antibodies to platelet glycoprotein IIb/IIIa von BEDNAR, B, COOK, J. J, HOLAHAN, M. A, CUNNINGHAM, M. E, JUMES, P. A, BEDNAR, R. A, HARTMAN, G. D, GOULD, R. J

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Farnesyltransferase inhibitors and anti-Ras therapy von GIBBS, J. B, KOHL, N. E, GRAHAM, S. L, HARTMAN, G. D, OLIFF, A, KOBLAN, K. S, OMER, C. A, SEPP-LORENZINO, L, ROSEN, N, ANTHONY, N. J, CONNER, M. W, DESOLMS, S. J, WILLIAMS, T. M

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Non-Peptide Glycoprotein IIb/IIIa Antagonists. 11. Design and in Vivo Evaluation of 3,4-Dihydro-1(1H)-isoquinolinone-Based Antagonists and Ethyl Ester Prodrugs von Hutchinson, John H, Cook, Jacquelynn J, Brashear, Karen M, Breslin, Michael J, Glass, Joan D, Gould, Robert J, Halczenko, Wasyl, Holahan, Marie A, Lynch, Robert J, Sitko, Gary R, Stranieri, Maria T, Hartman, George D

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Nonpeptide GPIIB/IIIA receptor antagonists. Part 21: C-6 flexibility and amide bond orientation are important factors in determining the affinity of compounds for activated or rest... von Egbertson, Melissa S, Bednar, Bohumil, Askew, Ben C, Bednar, Rodney A, Brashear, Karen, Breslin, Michael J, Duggan, Mark E, Fisher, Thorsten E, Halczenko, Wasyl, Hutchinson, John H, Ihle, Nathan, Prugh, John D, Wai, John S, Gould, Robert J, Hartman, George D

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Design and Biological Activity of (S)-4-(5-{[1-(3-Chlorobenzyl)-2- oxopyrrolidin-3-ylamino]methyl}imidazol-1-ylmethyl)benzonitrile, a 3-Aminopyrrolidinone Farnesyltransferase Inhib... von Bell, Ian M, Gallicchio, Steven N, Abrams, Marc, Beshore, Douglas C, Buser, Carolyn A, Culberson, J. Christopher, Davide, Joseph, Ellis-Hutchings, Michelle, Fernandes, Christine, Gibbs, Jackson B, Graham, Samuel L, Hartman, George D, Heimbrook, David C, Homnick, Carl F, Huff, Joel R, Kassahun, Kelem, Koblan, Kenneth S, Kohl, Nancy E, Lobell, Robert B, Lynch, Joseph J, Miller, Patricia A, Omer, Charles A, Rodrigues, A. David, Walsh, Eileen S, Williams, Theresa M

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Nonpeptide glycoprotein IIB/IIIA inhibitors. 19. A new design paradigm employing linearly minimized, centrally constrained, exosite inhibitors von Hartman, George D., Duggan, Mark E., Hoffman, William F., Meissner, Robert J., Perkins, James J., Zartman, Amy E., Naylor-Olsen, Adel M., Cook, Jacquelynn J., Glass, Joan D., Lynch, Robert J., Zhang, Guixiang, Gould, Robert J.

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Non-Peptide Glycoprotein IIb/IIIa Inhibitors. 17. Design and Synthesis of Orally Active, Long-Acting Non-Peptide Fibrinogen Receptor Antagonists von Askew, Benny C, Bednar, Rodney A, Bednar, Bohumil, Claremon, David A, Cook, Jacquelynn J, McIntyre, Charles J, Hunt, Cecila A, Gould, Robert J, Lynch, Robert J, Lynch, Joseph J, Gaul, Stanley L, Stranieri, Maria T, Sitko, Gary R, Holahan, Marie A, Glass, Joan D, Hamill, Terrence, Gorham, Lynn M, Prueksaritanont, Thomayant, Baldwin, John J, Hartman, George D

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Allosteric Akt (PKB) inhibitors: discovery and SAR of isozyme selective inhibitors von Lindsley, Craig W., Zhao, Zhijian, Leister, William H., Robinson, Ronald G., Barnett, Stanley F., Defeo-Jones, Deborah, Jones, Raymond E., Hartman, George D., Huff, Joel R., Huber, Hans E., Duggan, Mark E.

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Seasonal Effects on Sex Ratios in Moles Collected by Trapping von Hartman, Gregory D.

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Farnesyltransferase inhibitors versus Ras inhibitors von Gibbs, Jackson B, Graham, Samuel L, Hartman, George D, Koblan, Kenneth S, Kohl, Nancy E, Omer, Charles A, Oliff, Allen

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