Pleckstrin homology domains bind to phosphatidylinositol-4,5-bisphosphate von Harlan, John E, Hajduk, Philip J, Yoon, Ho Sup, Fesik, Stephen W

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Novel method to specifically determine the structures of non-N297 glycans in IgGs von Bhide, Gaurang P, Bohrer, Natalie E, Song, Danying, Cabel, Jeanne, Lake, Marc R, Harlan, John E, Miesbauer, Laura J

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Structural Characterization of a Soluble Amyloid β-Peptide Oligomer von Yu, Liping, Edalji, Rohinton, Harlan, John E, Holzman, Thomas F, Lopez, Ana Pereda, Labkovsky, Boris, Hillen, Heinz, Barghorn, Stefan, Ebert, Ulrich, Richardson, Paul L, Miesbauer, Laura, Solomon, Larry, Bartley, Diane, Walter, Karl, Johnson, Robert W, Hajduk, Philip J, Olejniczak, Edward T

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Ligand association rates to the inner-variable-domain of a dual-variable-domain immunoglobulin are significantly impacted by linker design von DiGiammarino, Enrico L., Harlan, John E., Walter, Karl A., Ladror, Uri S., Edalji, Rohinton P., Hutchins, Charles W., Lake, Marc R., Greischar, Amy J., Liu, Junjian, Ghayur, Tariq, Jakob, Clarissa G.

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Azaindole-Based Inhibitors of Cdc7 Kinase: Impact of the Pre-DFG Residue, Val 195 von Tong, Yunsong, Stewart, Kent D, Florjancic, Alan S, Harlan, John E, Merta, Philip J, Przytulinska, Magdalena, Soni, Nirupama, Swinger, Kerren K, Zhu, Haizhong, Johnson, Eric F, Shoemaker, Alexander R, Penning, Thomas D

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Iniparib Nonselectively Modifies Cysteine-Containing Proteins in Tumor Cells and Is Not a Bona Fide PARP Inhibitor von XUESONG LIU, YAN SHI, XU, Allison J, LAYER, Ramesh, HARLAN, John E, SOLOMON, Larry R, DONAWHO, Cherrie K, PENNING, Thomas D, JOHNSON, Eric F, SHOEMAKER, Alexander R, MAAG, David X, PALMA, Joann P, PATTERSON, Melanie J, ELLIS, Paul A, SURBER, Bruce W, READY, Damien B, SONI, Niru B, LADROR, Uri S

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A potent erythropoietin-mimicking human antibody interacts through a novel binding site von Liu, Zhihong, Stoll, Vincent S., DeVries, Peter J., Jakob, Clarissa G., Xie, Nancy, Simmer, Robert L., Lacy, Susan E., Egan, David A., Harlan, John E., Lesniewski, Richard R., Reilly, Edward B.

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Structure and ligand recognition of the phosphotyrosine binding domain of Shc von Zhou, Ming-Ming, Ravichandran, Kodimangalam S, Olejniczak, Edward T, Petros, Andrew M, Meadows, Robert P, Sattler, Michael, Harlan, John E, Wade, Warren S, Burakoff, Steven J, Fesik, Stephen W

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NMR Structure and Mutagenesis of the N-Terminal Dbl Homology Domain of the Nucleotide Exchange Factor Trio von Liu, Xiaohong, Wang, Hong, Eberstadt, Matthias, Schnuchel, Arndt, Olejniczak, Edward T, Meadows, Robert P, Schkeryantz, Jeff M, Janowick, David A, Harlan, John E, Harris, Edith A.S, Staunton, Donald E, Fesik, Stephen W

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Structure of Bcl-x-Bak peptide complex: recognition between regulators of apoptosis von Sattler, Michael, Nettesheim, David, Meadows, Robert P, Harlan, John E, Eberstadt, Matthias, Yoon, Ho Sup, Shuker, Suzanne B, Chang, Brian S, Minn, Andy J, Thompson, Craig B, Fesik, Stephen W

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Structural Characterization of the Interaction between a Pleckstrin Homology Domain and Phosphatidylinositol 4,5-Bisphosphate von Harlan, John E, Yoon, Ho Sup, Hajduk, Philip J, Fesik, Stephen W

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X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death von Muchmore, Steven W., Sattler, Michael, Liang, Heng, Meadows, Robert P., Harlan, John E., Yoon, Ho Sup, Nettesheim, David, Chang, Brian S., Thompson, Craig B., Wong, Sui-Lam, Ng, Shi-Chung, Fesik, Stephen W.

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Structure of MurF from Streptococcus pneumoniae co‐crystallized with a small molecule inhibitor exhibits interdomain closure von Longenecker, Kenton L., Stamper, Geoffrey F., Hajduk, Philip J., Fry, Elizabeth H., Jakob, Clarissa G., Harlan, John E., Edalji, Rohinton, Bartley, Diane M., Walter, Karl A., Solomon, Larry R., Holzman, Thomas F., Gu, Yu Gui, Lerner, Claude G., Beutel, Bruce A., Stoll, Vincent S.

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Recombinant kringle 5 from plasminogen antagonises hepatocyte growth factor-mediated signalling von Ansell, Peter J, Zhang, Haiying, Davidson, Don J, Harlan, John E, Xue, John, Brodjian, Sevan, Lesniewski, Rick, McKeegan, Evelyn

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Discovery of Potent Inhibitors of Dihydroneopterin Aldolase Using CrystaLEAD High-Throughput X-ray Crystallographic Screening and Structure-Directed Lead Optimization von Sanders, William J, Nienaber, Vicki L, Lerner, Claude G, McCall, J. Owen, Merrick, Sean M, Swanson, Susan J, Harlan, John E, Stoll, Vincent S, Stamper, Geoffrey F, Betz, Stephen F, Condroski, Kevin R, Meadows, Robert P, Severin, Jean M, Walter, Karl A, Magdalinos, Peter, Jakob, Clarissa G, Wagner, Rolf, Beutel, Bruce A

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Synthesis and evaluation of inhibitors of cytochrome P450 3A (CYP3A) for pharmacokinetic enhancement of drugs von Flentge, Charles A., Randolph, John T., Huang, Peggy P., Klein, Larry L., Marsh, Kennan C., Harlan, John E., Kempf, Dale J.

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On-column ligand exchange for structure-based drug design: a case study with human 11[beta]-hydroxysteroid dehydrogenase type 1 von Qin, Wenying, Judge, Russell A, Longenecker, Kenton L, Solomon, Larry R, Harlan, John E

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Evidence for a requirement for both phospholipid and phosphotyrosine binding via the Shc phosphotyrosine-binding domain in vivo von Ravichandran, Kodimangalam S., Zhou, Ming-Ming, Pratt, Joanne C., Harlan, John E., Walk, Scott F., Fesik, Stephen W., Burakoff, Steven J.

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On-column ligand exchange for structure-based drug design: a case study with human 11β-hydroxysteroid dehydrogenase type 1 von Qin, Wenying, Judge, Russell A., Longenecker, Kenton L., Solomon, Larry R., Harlan, John E.

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P2-483: Biophysical characterization of soluble amyloid-β peptide oligomers von Olejniczak, Edward T, Yu, Liping, Edalji, Rohinton, Harlan, John E, Holzman, Thomas F, Lopez, Ana Perada, Labkovsky, Boris, Hillen, Heinz, Barghorn, Stefan, Ebert, Ulrich, Richardson, Paul L, Miesbauer, Laura, Solomon, Larry, Bartley, Diane, Walter, Karl, Johnson, Robert, Hajduk, Philip

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