Efficacy and Safety of Dabrafenib in Pediatric Patients with BRAF V600 Mutation-Positive Relapsed or Refractory Low-Grade Glioma: Results from a Phase I/IIa Study von Hargrave, Darren R, Bouffet, Eric, Tabori, Uri, Broniscer, Alberto, Cohen, Kenneth J, Hansford, Jordan R, Geoerger, Birgit, Hingorani, Pooja, Dunkel, Ira J, Russo, Mark W, Tseng, Lillian, Dasgupta, Kohinoor, Gasal, Eduard, Whitlock, James A, Kieran, Mark W

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Phase II Trial of Dabrafenib Plus Trametinib in Relapsed/Refractory BRAF V600-Mutant Pediatric High-Grade Glioma von Hargrave, Darren R, Terashima, Keita, Hara, Junichi, Kordes, Uwe R, Upadhyaya, Santhosh A, Sahm, Felix, Bouffet, Eric, Packer, Roger J, Witt, Olaf, Sandalic, Larissa, Kieloch, Agnieszka, Russo, Mark, Cohen, Kenneth J

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Dabrafenib plus Trametinib in Pediatric Glioma with BRAF V600 Mutations von Bouffet, Eric, Hansford, Jordan R., Garrè, Maria Luisa, Hara, Junichi, Plant-Fox, Ashley, Aerts, Isabelle, Locatelli, Franco, van der Lugt, Jasper, Papusha, Ludmila, Sahm, Felix, Tabori, Uri, Cohen, Kenneth J., Packer, Roger J., Witt, Olaf, Sandalic, Larissa, Bento Pereira da Silva, Ana, Russo, Mark, Hargrave, Darren R.

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Diffuse brainstem glioma in children: critical review of clinical trials von Hargrave, Darren, Bartels, Ute, Bouffet, Eric

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Recurrent activating ACVR1 mutations in diffuse intrinsic pontine glioma von Taylor, Kathryn R, Mackay, Alan, Truffaux, Nathalène, Butterfield, Yaron S, Morozova, Olena, Philippe, Cathy, Castel, David, Grasso, Catherine S, Vinci, Maria, Carvalho, Diana, Carcaboso, Angel M, de Torres, Carmen, Cruz, Ofelia, Mora, Jaume, Entz-Werle, Natacha, Ingram, Wendy J, Monje, Michelle, Hargrave, Darren, Bullock, Alex N, Puget, Stéphanie, Yip, Stephen, Jones, Chris, Grill, Jacques

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Pediatric pan-central nervous system tumor analysis of immune-cell infiltration identifies correlates of antitumor immunity von Grabovska, Yura, Mackay, Alan, O’Hare, Patricia, Crosier, Stephen, Finetti, Martina, Schwalbe, Edward C., Pickles, Jessica C., Fairchild, Amy R., Avery, Aimee, Cockle, Julia, Hill, Rebecca, Lindsey, Janet, Hicks, Debbie, Kristiansen, Mark, Chalker, Jane, Anderson, John, Hargrave, Darren, Jacques, Thomas S., Straathof, Karin, Bailey, Simon, Jones, Chris, Clifford, Steven C., Williamson, Daniel

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Pediatric high-grade glioma: biologically and clinically in need of new thinking von Jones, Chris, Karajannis, Matthias A, Jones, David T W, Kieran, Mark W, Monje, Michelle, Baker, Suzanne J, Becher, Oren J, Cho, Yoon-Jae, Gupta, Nalin, Hawkins, Cynthia, Hargrave, Darren, Haas-Kogan, Daphne A, Jabado, Nada, Li, Xiao-Nan, Mueller, Sabine, Nicolaides, Theo, Packer, Roger J, Persson, Anders I, Phillips, Joanna J, Simonds, Erin F, Stafford, James M, Tang, Yujie, Pfister, Stefan M, Weiss, William A

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Integrated Molecular Genetic Profiling of Pediatric High-Grade Gliomas Reveals Key Differences With the Adult Disease von Paugh, Barbara S, Qu, Chunxu, Jones, Chris, Liu, Zhaoli, Adamowicz-Brice, Martyna, Zhang, Junyuan, Bax, Dorine A, Coyle, Beth, Barrow, Jennifer, Hargrave, Darren, Lowe, James, Gajjar, Amar, Zhao, Wei, Broniscer, Alberto, Ellison, David W, Grundy, Richard G, Baker, Suzanne J

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Radiological Evaluation of Newly Diagnosed Non-Brainstem Pediatric High-Grade Glioma in the HERBY Phase II Trial von Gutierrez, Daniel Rodriguez, Jones, Chris, Varlet, Pascale, Mackay, Alan, Warren, Daniel, Warmuth-Metz, Monika, Aliaga, Esther Sanchez, Calmon, Raphael, Hargrave, Darren R., Canete, Adela, Massimino, Maura, Azizi, Amedeo A., Le Deley, Marie-Cecile, Saran, Frank, Rousseau, Raphael F., Zahlmann, Gudrun, Garcia, Josep, Vassal, Gilles, Grill, Jacques, Morgan, Paul S., Jaspan, Tim

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Histone H3.3. mutations drive pediatric glioblastoma through upregulation of MYCN von Bjerke, Lynn, Mackay, Alan, Nandhabalan, Meera, Burford, Anna, Jury, Alexa, Popov, Sergey, Bax, Dorine A, Carvalho, Diana, Taylor, Kathryn R, Vinci, Maria, Bajrami, Ilirjana, McGonnell, Imelda M, Lord, Christopher J, Reis, Rui M, Hargrave, Darren, Ashworth, Alan, Workman, Paul, Jones, Chris

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Phase II Study of Weekly Vinblastine in Recurrent or Refractory Pediatric Low-Grade Glioma von BOUFFET, Eric, JAKACKI, Regina, HILDEN, Joanne, ETZL, Michael, WILSON, Beverly, STEPHENS, Derek, TABORI, Uri, BARUCHEL, Sylvain, GOLDMAN, Stewart, HARGRAVE, Darren, HAWKINS, Cynthia, SHROFF, Manohar, HUKIN, Juliette, BARTELS, Ute, FOREMAN, Nicholas, KELLIE, Stewart

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Visual outcomes in children with neurofibromatosis type 1-associated optic pathway glioma following chemotherapy: a multicenter retrospective analysis von Fisher, Michael J, Loguidice, Michael, Gutmann, David H, Listernick, Robert, Ferner, Rosalie E, Ullrich, Nicole J, Packer, Roger J, Tabori, Uri, Hoffman, Robert O, Ardern-Holmes, Simone L, Hummel, Trent R, Hargrave, Darren R, Bouffet, Eric, Charrow, Joel, Bilaniuk, Larissa T, Balcer, Laura J, Liu, Grant T

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Biological medicines for diffuse intrinsic pontine glioma (DIPG) eradication (BIOMEDE): Final results of an international randomized phase II platform trial comparing 3 targeted th... von Grill, Jacques, Le Teuff, Gwenael, Varlet, Pascale, Hargrave, Darren R., Nysom, Karsten, Blomgrenn, Klas, McCowage, Geoffrey Brian, Bautista, Francisco, Van Vuurden, Dannis, Debily, Marie-Anne, Kergrohen, Thomas, Puget, Stephanie, Bolle, Stephanie, Abbou, Samuel, Leblond, Pierre, Boddaert, Nathalie, Vassal, Gilles, Le Deley, Marie-Cecile

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Classification of paediatric brain tumours by diffusion weighted imaging and machine learning von Novak, Jan, Zarinabad, Niloufar, Rose, Heather, Arvanitis, Theodoros, MacPherson, Lesley, Pinkey, Benjamin, Oates, Adam, Hales, Patrick, Grundy, Richard, Auer, Dorothee, Gutierrez, Daniel Rodriguez, Jaspan, Tim, Avula, Shivaram, Abernethy, Laurence, Kaur, Ramneek, Hargrave, Darren, Mitra, Dipayan, Bailey, Simon, Davies, Nigel, Clark, Christopher, Peet, Andrew

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Quality of health information on the Internet in pediatric neuro-oncology von Hargrave, Darren R, Hargrave, Ursula A, Bouffet, Eric

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A five-gene hedgehog signature developed as a patient preselection tool for hedgehog inhibitor therapy in medulloblastoma von Shou, Yaping, Robinson, Douglas M, Amakye, Dereck D, Rose, Kristine L, Cho, Yoon-Jae, Ligon, Keith L, Sharp, Thad, Haider, Asifa S, Bandaru, Raj, Ando, Yuichi, Geoerger, Birgit, Doz, François, Ashley, David M, Hargrave, Darren R, Casanova, Michela, Tawbi, Hussein A, Rodon, Jordi, Thomas, Anne L, Mita, Alain C, MacDonald, Tobey J, Kieran, Mark W

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Resistance, rebound, and recurrence regrowth patterns in pediatric low-grade glioma treated by MAPK inhibition: A modified Delphi approach to build international consensus-based de... von O’Hare, Patricia, Cooney, Tabitha, de Blank, Peter, Gutmann, David H, Kieran, Mark, Milde, Till, Fangusaro, Jason, Fisher, Michael, Avula, Shivaram, Packer, Roger, Fukuoka, Kohei, Mankad, Kshitij, Mueller, Sabine, Waanders, Angela J, Opocher, Enrico, Bouffet, Eric, Raabe, Eric, Werle, Natacha Entz, Azizi, Amedeo A, Robison, Nathan J, Hernáiz Driever, Pablo, Russo, Mark, Schouten, Netteke, van Tilburg, Cornelis M, Sehested, Astrid, Grill, Jacques, Bandopadhayay, Pratiti, Kilday, John-Paul, Witt, Olaf, Ashley, David M, Ertl-Wagner, Birgit Betina, Tabori, Uri, Hargrave, Darren R

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Characterisation of paediatric brain tumours by their MRS metabolite profiles von Gill, Simrandip K, Rose, Heather E L, Wilson, Martin, Rodriguez Gutierrez, Daniel, Worthington, Lara, Davies, Nigel P, MacPherson, Lesley, Hargrave, Darren R, Saunders, Dawn E, Clark, Christopher A, Payne, Geoffrey S, Leach, Martin O, Howe, Franklyn A, Auer, Dorothee P, Jaspan, Tim, Morgan, Paul S, Grundy, Richard G, Avula, Shivaram, Pizer, Barry, Arvanitis, Theodoros N, Peet, Andrew C

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New drugs for children and adolescents with cancer: the need for novel development pathways von Vassal, Gilles, Prof, Zwaan, C Michel, MD PhD, Ashley, David, Prof, Le Deley, Marie Cecile, MD PhD, Hargrave, Darren, MD PhD, Blanc, Patricia, MIM, Adamson, Peter C, MD

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Alcohol-abuse drug disulfiram targets pediatric glioma via MLL degradation von Meier, Stefanie, Cantilena, Sandra, Niklison Chirou, Maria Victoria, Anderson, John, Hargrave, Darren, Salomoni, Paolo, de Boer, Jasper, Michod, David

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