Characterisation of lung macrophage subpopulations in COPD patients and controls von Dewhurst, Jennifer A., Lea, Simon, Hardaker, Elizabeth, Dungwa, Josiah V., Ravi, Arjun K., Singh, Dave

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Longitudinal immune characterization of syngeneic tumor models to enable model selection for immune oncology drug discovery von Taylor, Molly A., Hughes, Adina M., Walton, Josephine, Coenen-Stass, Anna M. L., Magiera, Lukasz, Mooney, Lorraine, Bell, Sigourney, Staniszewska, Anna D., Sandin, Linda C., Barry, Simon T., Watkins, Amanda, Carnevalli, Larissa S., Hardaker, Elizabeth L.

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Functional significance of co-occurring mutations in PIK3CA and MAP3K1 in breast cancer von Avivar-Valderas, Alvaro, McEwen, Robert, Taheri-Ghahfarokhi, Amir, Carnevalli, Larissa S, Hardaker, Elizabeth L, Maresca, Marcello, Hudson, Kevin, Harrington, Elizabeth A, Cruzalegui, Francisco

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Development of an ObLiGaRe Doxycycline Inducible Cas9 system for pre-clinical cancer drug discovery von Lundin, Anders, Porritt, Michelle J., Jaiswal, Himjyot, Seeliger, Frank, Johansson, Camilla, Bidar, Abdel Wahad, Badertscher, Lukas, Wimberger, Sandra, Davies, Emma J., Hardaker, Elizabeth, Martins, Carla P., James, Emily, Admyre, Therese, Taheri-Ghahfarokhi, Amir, Bradley, Jenna, Schantz, Anna, Alaeimahabadi, Babak, Clausen, Maryam, Xu, Xiufeng, Mayr, Lorenz M., Nitsch, Roberto, Bohlooly-Y, Mohammad, Barry, Simon T., Maresca, Marcello

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Tafenoquine versus Primaquine to Prevent Relapse of Plasmodium vivax Malaria von Llanos-Cuentas, Alejandro, Lacerda, Marcus V.G., Hien, Tran T., Vélez, Iván D., Namaik-larp, Chayadol, Chu, Cindy S., Villegas, Maria F., Val, Fernando, Monteiro, Wuelton M., Brito, Marcelo A.M., Costa, Mônica R.F., Chuquiyauri, Raul, Casapía, Martín, Nguyen, Chau H., Aruachan, Sandra, Papwijitsil, Ratchadaporn, Nosten, François H., Bancone, Germana, Angus, Brian, Duparc, Stephan, Craig, Graham, Rousell, Victoria M., Jones, Siôn W., Hardaker, Elizabeth, Clover, Donna D., Kendall, Lindsay, Mohamed, Khadeeja, Koh, Gavin C.K.W., Wilches, Viviana M., Breton, John J., Green, Justin A.

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PI3Kα/δ inhibition promotes anti-tumor immunity through direct enhancement of effector CD8 + T-cell activity von Carnevalli, Larissa S, Sinclair, Charles, Taylor, Molly A, Gutierrez, Pablo Morentin, Langdon, Sophie, Coenen-Stass, Anna M L, Mooney, Lorraine, Hughes, Adina, Jarvis, Laura, Staniszewska, Anna, Crafter, Claire, Sidders, Ben, Hardaker, Elizabeth, Hudson, Kevin, Barry, Simon T

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The ATR inhibitor ceralasertib potentiates cancer checkpoint immunotherapy by regulating the tumor microenvironment von Hardaker, Elizabeth L., Sanseviero, Emilio, Karmokar, Ankur, Taylor, Devon, Milo, Marta, Michaloglou, Chrysis, Hughes, Adina, Mai, Mimi, King, Matthew, Solanki, Anisha, Magiera, Lukasz, Miragaia, Ricardo, Kar, Gozde, Standifer, Nathan, Surace, Michael, Gill, Shaan, Peter, Alison, Talbot, Sara, Tohumeken, Sehmus, Fryer, Henderson, Mostafa, Ali, Mulgrew, Kathy, Lam, Carolyn, Hoffmann, Scott, Sutton, Daniel, Carnevalli, Larissa, Calero-Nieto, Fernando J., Jones, Gemma N., Pierce, Andrew J., Wilson, Zena, Campbell, David, Nyoni, Lynet, Martins, Carla P., Baker, Tamara, Serrano de Almeida, Gilberto, Ramlaoui, Zainab, Bidar, Abdel, Phillips, Benjamin, Boland, Joseph, Iyer, Sonia, Barrett, J. Carl, Loembé, Arsene-Bienvenu, Fuchs, Serge Y., Duvvuri, Umamaheswar, Lou, Pei-Jen, Nance, Melonie A., Gomez Roca, Carlos Alberto, Cadogan, Elaine, Critichlow, Susan E., Fawell, Steven, Cobbold, Mark, Dean, Emma, Valge-Archer, Viia, Lau, Alan, Gabrilovich, Dmitry I., Barry, Simon T.

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877 Intermittent dosing of the ataxia telangiectasia and Rad3-related (ATR) inhibitor ceralasertib promotes antitumor immunity by remodelling the tumor immune microenvironment in p... von Hardaker, Elizabeth, Karmokar, Ankur, Milo, Marta, Michaloglou, Chrysiis, Hughes, Adina, King, Matthew, Solanki, Anisha, Magiera, Lukasz, Miragaia, Ricardo, Kar, Gozde, Peter, Alison, Talbot, Sara, Lam, Carolyn, Sutton, Daniel, Hoffmann, Scott, Carnevalli, Larissa, Wilson, Zena, Fawell, Stephen, Cobbold, Mark, Valge-Archer, Viia, Gabrilovich, Dmitry, Lau, Alan, Barry, Simon

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Regulation of TNF‐α and IFN‐γ induced CXCL10 expression: participation of the airway smooth muscle in the pulmonary inflammatory response in chronic obstructive pulmonary disease... von Hardaker, Elizabeth L., Bacon, Alicia M., Carlson, Karey, Roshak, Amy K., Foley, James J., Schmidt, Dulcie B., Buckley, Peter T., Comegys, Meghan, Panettieri, Reynold A., Sarau, Henry M., Belmonte, Kristen E.

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Novel Role for the Liver X Nuclear Receptor in the Suppression of Lung Inflammatory Responses von Birrell, Mark A., Catley, Matthew C., Hardaker, Elizabeth, Wong, Sissie, Willson, Timothy M., McCluskie, Kerryn, Leonard, Thomas, Farrow, Stuart N., Collins, Jon L., Haj-Yahia, Saleem, Belvisi, Maria G.

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Tafenoquine versus Primaquine to Prevent Relapse of Plasmodium vivax Malaria von Llanos-Cuentas, Alejandro, Lacerda, Marcus V.G, Hien, Tran T, Vélez, Iván D, Namaik-larp, Chayadol, Chu, Cindy S, Villegas, Maria F, Val, Fernando, Monteiro, Wuelton M, Brito, Marcelo A.M, Costa, Mônica R.F, Chuquiyauri, Raul, Casapía, Martín, Nguyen, Chau H, Aruachan, Sandra, Papwijitsil, Ratchadaporn, Nosten, François H, Bancone, Germana, Angus, Brian, Duparc, Stephan, Craig, Graham, Rousell, Victoria M, Jones, Siôn W, Hardaker, Elizabeth, Clover, Donna D, Kendall, Lindsay, Mohamed, Khadeeja, Koh, Gavin C.K.W, Wilches, Viviana M, Breton, John J, Green, Justin A

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Single-Dose Tafenoquine to Prevent Relapse of Plasmodium vivax Malaria von Lacerda, Marcus V.G, Llanos-Cuentas, Alejandro, Krudsood, Srivicha, Lon, Chanthap, Saunders, David L, Mohammed, Rezika, Yilma, Daniel, Batista Pereira, Dhelio, Espino, Fe E.J, Mia, Reginaldo Z, Chuquiyauri, Raul, Val, Fernando, Casapía, Martín, Monteiro, Wuelton M, Brito, Marcelo A.M, Costa, Mônica R.F, Buathong, Nillawan, Noedl, Harald, Diro, Ermias, Getie, Sisay, Wubie, Kalehiwot M, Abdissa, Alemseged, Zeynudin, Ahmed, Abebe, Cherinet, Tada, Mauro S, Brand, Françoise, Beck, Hans-Peter, Angus, Brian, Duparc, Stephan, Kleim, Jörg-Peter, Kellam, Lynda M, Rousell, Victoria M, Jones, Siôn W, Hardaker, Elizabeth, Mohamed, Khadeeja, Clover, Donna D, Fletcher, Kim, Breton, John J, Ugwuegbulam, Cletus O, Green, Justin A, Koh, Gavin C.K.W

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Prostanoid receptor expression by human airway smooth muscle cells and regulation of the secretion of granulocyte colony-stimulating factor von Clarke, Deborah L, Belvisi, Maria G, Smith, Susan J, Hardaker, Elizabeth, Yacoub, Magdi H, Meja, Koremu K, Newton, Robert, Slater, Donna M, Giembycz, Mark A

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A multi-batch design to deliver robust estimates of efficacy and reduce animal use – a syngeneic tumour case study von Karp, Natasha A., Wilson, Zena, Stalker, Eve, Mooney, Lorraine, Lazic, Stanley E., Zhang, Bairu, Hardaker, Elizabeth

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E-Ring 8-Isoprostanes Are Agonists at EP2- and EP4-Prostanoid Receptors on Human Airway Smooth Muscle Cells and Regulate the Release of Colony-Stimulating Factors by Activating cAM... von Clarke, Deborah L, Belvisi, Maria G, Hardaker, Elizabeth, Newton, Robert, Giembycz, Mark A

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Efficacy and pharmacodynamic effect of anti-CD73 and anti-PD-L1 monoclonal antibodies in combination with cytotoxic therapy: observations from mouse tumor models von Kaistha, Brajesh P, Kar, Gozde, Dannhorn, Andreas, Watkins, Amanda, Opoku-Ansah, Grace, Ilieva, Kristina, Mullins, Stefanie, Anderton, Judith, Galvani, Elena, Garcon, Fabien, Lapointe, Jean-Martin, Brown, Lee, Hair, James, Slidel, Tim, Luheshi, Nadia, Ryan, Kelli, Hardaker, Elizabeth, Dovedi, Simon, Kumar, Rakesh, Wilkinson, Robert W, Hammond, Scott A, Eyles, Jim

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Generating Selective Leads for Mer Kinase InhibitorsExample of a Comprehensive Lead-Generation Strategy von Nissink, J. Willem M, Bazzaz, Sana, Blackett, Carolyn, Clark, Matthew A, Collingwood, Olga, Disch, Jeremy S, Gikunju, Diana, Goldberg, Kristin, Guilinger, John P, Hardaker, Elizabeth, Hennessy, Edward J, Jetson, Rachael, Keefe, Anthony D, McCoull, William, McMurray, Lindsay, Olszewski, Allison, Overman, Ross, Pflug, Alexander, Preston, Marian, Rawlins, Philip B, Rivers, Emma, Schimpl, Marianne, Smith, Paul, Truman, Caroline, Underwood, Elizabeth, Warwicker, Juli, Winter-Holt, Jon, Woodcock, Simon, Zhang, Ying

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Optimization of an Imidazo[1,2‑a]pyridine Series to Afford Highly Selective Type I1/2 Dual Mer/Axl Kinase Inhibitors with In Vivo Efficacy von McCoull, William, Boyd, Scott, Brown, Martin R, Coen, Muireann, Collingwood, Olga, Davies, Nichola L, Doherty, Ann, Fairley, Gary, Goldberg, Kristin, Hardaker, Elizabeth, He, Guang, Hennessy, Edward J, Hopcroft, Philip, Hodgson, George, Jackson, Anne, Jiang, Xiefeng, Karmokar, Ankur, Lainé, Anne-Laure, Lindsay, Nicola, Mao, Yumeng, Markandu, Roshini, McMurray, Lindsay, McLean, Neville, Mooney, Lorraine, Musgrove, Helen, Nissink, J. Willem M, Pflug, Alexander, Reddy, Venkatesh Pilla, Rawlins, Philip B, Rivers, Emma, Schimpl, Marianne, Smith, Graham F, Tentarelli, Sharon, Travers, Jon, Troup, Robert I, Walton, Josephine, Wang, Cheng, Wilkinson, Stephen, Williamson, Beth, Winter-Holt, Jon, Yang, Dejian, Zheng, Yuting, Zhu, Qianxiu, Smith, Paul D

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Development of autotaxin inhibitors: A series of tetrazole cinnamides von Thomson, Christopher G., Le Grand, Darren, Dowling, Mark, Beattie, David, Elphick, Lucy, Faller, Michael, Freeman, Mark, Hardaker, Elizabeth, Head, Victoria, Hemmig, Rene, Hill, Johan, Lister, Andrew, Pascoe, David, Rieffel, Sebastien, Shrestha, Binesh, Steward, Oliver, Zink, Florence

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Abstract 1619: Characterising the in vivo response of lung tumors to KrasG12C inhibition von Martins, Carla P., Bidar, Abdel, Karrberg, Lillevi, Porritt, Michelle, Seeliger, Frank, Whiteley, Rebecca, Hanson, Lyndsey, Hallengren, Liselotte, Hardaker, Elizabeth, Barry, Simon, Maresca, Maresca, Bohlooly, Mohammad, Cosulich, Sabina, Ross, Sarah

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