Identification of essential genes in cultured mammalian cells using small interfering RNAs von Harborth, J, Elbashir, S M, Bechert, K, Tuschl, T, Weber, K

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The mitotic-spindle-associated protein astrin is essential for progression through mitosis von Gruber, Jens, Harborth, Jens, Schnabel, Jörg, Weber, Klaus, Hatzfeld, Mechthild

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Essential Roles for Four Cytoplasmic Intermediate Filament Proteins in Caenorhabditis elegans Development von Karabinos, Anton, Schmidt, Henning, Harborth, Jens, Schnabel, Ralf, Weber, Klaus

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Targeting Lysophosphatidic Acid Receptor 1 (LPAR1) with siRNA-Lipid Nanoparticles (siRNA-LNP) Is a Potential Therapeutic Approach for CKD -Associated Kidney Fibrosis: SA-PO443 von Yu, Xing-Xian (Scott), Liu, Yun, Xia, Fengcheng, Quimbo, Alistair Joseph C., Harborth, Jens, Lee, Jingyuan, Clamme, Jean-Pierre

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GAS41, a Highly Conserved Protein in Eukaryotic Nuclei, Binds to NuMA von Harborth, Jens, Weber, Klaus, Osborn, Mary

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Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells von Tuschl, Thomas, Elbashir, Sayda M, Harborth, Jens, Lendeckel, Winfried, Yalcin, Abdullah, Weber, Klaus

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Analysis of gene function in somatic mammalian cells using small interfering RNAs von Elbashir, Sayda M., Harborth, Jens, Weber, Klaus, Tuschl, Thomas

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Evaluation of the safety, tolerability and pharmacokinetics of ALN-RSV01, a novel RNAi antiviral therapeutic directed against respiratory syncytial virus (RSV) von DeVincenzo, John, Cehelsky, Jeffrey E., Alvarez, Rene, Elbashir, Sayda, Harborth, Jens, Toudjarska, Iva, Nechev, Lubomir, Murugaiah, Veeravagu, Vliet, Andre Van, Vaishnaw, Akshay K., Meyers, Rachel

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Abstract 4060: Discovery and preclinical development of KRAS-targeting siRNA therapeutic modality for the treatment of pancreatic cancer von OBrien, Zhihong (Julie), Wang, Li, Cina, Cima, Majeti, Bharat, Chu, James, Wang, Xiaoen, Baclig, Robiel, Lin, James, Ibarra, Jose, Chatterjee, Dhrubamitra, Jin, Jung-Kang, Clamme, Jean-Pierre, Daniels, Jennifer, Wang, Hai, Harborth, Jens, Ying, Wenbin

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Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs von Soutschek, Jürgen, Akinc, Akin, Bramlage, Birgit, Charisse, Klaus, Constien, Rainer, Donoghue, Mary, Elbashir, Sayda, Geick, Anke, Hadwiger, Philipp, Harborth, Jens, John, Matthias, Kesavan, Venkitasamy, Lavine, Gary, Pandey, Rajendra K, Racie, Timothy, Rajeev, Kallanthottathil G, Röhl, Ingo, Toudjarska, Ivanka, Wang, Gang, Wuschko, Silvio, Bumcrot, David, Koteliansky, Victor, Limmer, Stefan, Manoharan, Muthiah, Vornlocher, Hans-Peter

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Abstract 5918: A novel glutathione S-transferase P (GSTP) siRNA (NDT-05-1040) for the treatment of KRAS-driven non-small cell lung cancer von Cina, Cima, Harborth, Jens, O'Brien, Zhihong, Beltran-Raygoza, Nish, Jin, Jung-kang, Xu, Jessica, Lee, Sang Jun, Tsang, Kwok, Yao, Jiping, Adami, Roger, Zabludoff, Sonya, Ying, Wenbin

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Effect of Clathrin Heavy Chain- and α-Adaptin-specific Small Inhibitory RNAs on Endocytic Accessory Proteins and Receptor Trafficking in HeLa Cells von Hinrichsen, Lars, Harborth, Jens, Andrees, Lars, Weber, Klaus, Ungewickell, Ernst J.

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Abstract 5917: A novel lipid nanoparticle (NBF-006) encapsulating glutathione S-transferase P (GSTP) siRNA for the treatment of KRAS-driven non-small cell lung cancer von O'Brien, Zhihong, Wang, Li, Majeti, Bharat, Clamme, Jeanpierre, Baclig, Robiel, Chu, James, Fong, Steven, Harborth, Jens, Ibarra, Jose, Yin, Haiqing, Yu, Jing, Zhang, Clayton, Adami, Roger, Zabludoff, Sonya, Ying, Wenbin

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Nucleoplasmic LAP2α-Lamin A Complexes Are Required to Maintain a Proliferative State in Human Fibroblasts von Pekovic, Vanja, Harborth, Jens, Broers, Jos L. V., Ramaekers, Frans C. S., van Engelen, Baziel, Lammens, Martin, von Zglinicki, Thomas, Foisner, Roland, Hutchison, Chris, Markiewicz, Ewa

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Sequence, chemical, and structural variation of small interfering RNAs and short hairpin RNAs and the effect on mammalian gene silencing von Harborth, Jens, Elbashir, Sayda M, Vandenburgh, Kim, Manninga, Heiko, Scaringe, Stephen A, Weber, Klaus, Tuschl, Thomas

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RNAi-mediated gene silencing in non-human primates von Wheat, Amanda J, Vornlocher, Hans-Peter, Röhl, Ingo, Lam, Kieu, McClintock, Kevin, Koteliansky, Victor, Yaworski, Ed, Jeffs, Lloyd B, MacLachlan, Ian, Soutschek, Jürgen, Toudjarska, Ivanka, Palmer, Lorne R, Heyes, James A, Zedalis, William, Akinc, Akin, Lee, Amy C. H, Bumcrot, David, Manoharan, Muthiah, Judge, Adam D, Racie, Timothy, Shanmugam, Sumi, Sood, Vandana, Seiffert, Stephan, Bramlage, Birgit, Fedoruk, Matthew N, Harborth, Jens, Zimmermann, Tracy S, John, Matthias, Nechev, Lubomir V

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Self assembly of NuMA: multiarm oligomers as structural units of a nuclear lattice von Harborth, Jens, Wang, Jian, Gueth-Hallonet, Catherine, Weber, Klaus, Osborn, Mary

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Abstract 4513: IND-enabling studies for CEQ508 targeting β-catenin of GI polyps: First oral RNAi drug von Bodyak, Natalya, Borrelli, Alex, Fruehauf, Johannes H., Harborth, Jens, Laroux, F. Stephen, Vaze, Moru, Grillot-Courvalin, Catherine, Silva, Alison D.

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565 Ind-Enabling Studies for CEQ508 Targeting β-Catenin of GI Polyps: First Oral RNAI Drug von Bodyak, Natalya, Borrelli, Alex, Fruehauf, Johannes, Harborth, Jens, Vaze, Moreshwar B, Grillot-Courvalin, Catherine, Silva, Alison

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Effects of expressing lamin A mutant protein causing Emery-Dreifuss muscular dystrophy and familial partial lipodystrophy in Hela cells von Bechert, Kim, Lagos-Quintana, Mariana, Harborth, Jens, Weber, Klaus, Osborn, Mary

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