Preclinical profile of a dopamine D1 potentiator suggests therapeutic utility in neurological and psychiatric disorders von Bruns, Robert F., Mitchell, Stephen N., Wafford, Keith A., Harper, Alex J., Shanks, Elaine A., Carter, Guy, O'Neill, Michael J., Murray, Tracey K., Eastwood, Brian J., Schaus, John M., Beck, James P., Hao, Junliang, Witkin, Jeffrey M., Li, Xia, Chernet, Eyassu, Katner, Jason S., Wang, Hong, Ryder, John W., Masquelin, Meghane E., Thompson, Linda K., Love, Patrick L., Maren, Deanna L., Falcone, Julie F., Menezes, Michelle M., Zhang, Linli, Yang, Charles R., Svensson, Kjell A.

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Synthesis and Pharmacological Characterization of C4-Disubstituted Analogs of 1S,2S,5R,6S‑2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylate: Identification of a Potent, Selective Metab... von Monn, James A, Prieto, Lourdes, Taboada, Lorena, Pedregal, Concepcion, Hao, Junliang, Reinhard, Matt R, Henry, Steven S, Goldsmith, Paul J, Beadle, Christopher D, Walton, Lesley, Man, Teresa, Rudyk, Helene, Clark, Barry, Tupper, David, Baker, S. Richard, Lamas, Carlos, Montero, Carlos, Marcos, Alicia, Blanco, Jaime, Bures, Mark, Clawson, David K, Atwell, Shane, Lu, Frances, Wang, Jing, Russell, Marijane, Heinz, Beverly A, Wang, Xushan, Carter, Joan H, Xiang, Chuanxi, Catlow, John T, Swanson, Steven, Sanger, Helen, Broad, Lisa M, Johnson, Michael P, Knopp, Kelly L, Simmons, Rosa M. A, Johnson, Bryan G, Shaw, David B, McKinzie, David L

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Synthesis and Pharmacological Characterization of C4‑(Thiotriazolyl)-substituted-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylates. Identification of (1R,2S,4R,5R,6R)‑2-Amino-4-(1H‑1,... von Monn, James A, Prieto, Lourdes, Taboada, Lorena, Hao, Junliang, Reinhard, Matthew R, Henry, Steven S, Beadle, Christopher D, Walton, Lesley, Man, Teresa, Rudyk, Helene, Clark, Barry, Tupper, David, Baker, S. Richard, Lamas, Carlos, Montero, Carlos, Marcos, Alicia, Blanco, Jaime, Bures, Mark, Clawson, David K, Atwell, Shane, Lu, Frances, Wang, Jing, Russell, Marijane, Heinz, Beverly A, Wang, Xushan, Carter, Joan H, Getman, Brian G, Catlow, John T, Swanson, Steven, Johnson, Bryan G, Shaw, David B, McKinzie, David L

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Unified Total Synthesis of Pteriatoxins and Their Diastereomers von Matsuura, Fumiyoshi, Peters, René, Anada, Masahiro, Harried, Scott S, Hao, Junliang, Kishi, Yoshito

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On the origin of the 2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylate scaffold’s unique group II selectivity for the mGlu receptors von Hao, Junliang, Chen, Qi

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Chemistry and Biology of Diazonamide A:  Second Total Synthesis and Biological Investigations von Nicolaou, K. C, Hao, Junliang, Reddy, Mali V, Rao, Paraselli Bheema, Rassias, Gerasimos, Snyder, Scott A, Huang, Xianhai, Chen, David Y.-K, Brenzovich, William E, Giuseppone, Nicolas, Giannakakou, Paraskevi, O'Brate, Aurora

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The Second Total Synthesis of Diazonamide A von Nicolaou, K. C., Bheema Rao, Paraselli, Hao, Junliang, Reddy, Mali Venkat, Rassias, Gerasimos, Huang, Xianhai, Chen, David Y.-K., Snyder, Scott A.

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Total Synthesis and Stereochemistry of Pinnatoxins B and C von Matsuura, Fumiyoshi, Hao, Junliang, Reents, Reinhard, Kishi, Yoshito

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Stereochemistry of Pteriatoxins A, B, and C von Hao, Junliang, Matsuura, Fumiyoshi, Kishi, Yoshito, Kita, Masaki, Uemura, Daisuke, Asai, Naoki, Iwashita, Takashi

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A concise review on hPXR ligand-recognizing residues and structure-based strategies to alleviate hPXR transactivation risk von Liu, Tao, Beck, James P, Hao, Junliang

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The allosteric dopamine D1 receptor potentiator, DETQ, ameliorates subchronic phencyclidine-induced object recognition memory deficits and enhances cortical acetylcholine efflux in... von Meltzer, Herbert Y., Rajagopal, Lakshmi, Matrisciano, Francesco, Hao, Junliang, Svensson, Kjell A., Huang, Mei

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Ensemble Docking Approach to Mitigate Pregnane X Receptor-Mediated CYP3A4 Induction Risk von Chen, Qi, Zhou, Xin, Rehmel, Jessica, Steele, James P., Svensson, Kjell A., Beck, James P., Hembre, Erik J., Hao, Junliang

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Effects of DPTQ, a novel positive allosteric modulator of the dopamine D1 receptor, on spontaneous eye blink rate and spatial working memory in the nonhuman primate von Castner, Stacy A., Zhang, Linli, Yang, Charles R., Hao, Junliang, Cramer, Jeffrey W., Wang, Xushan, Bruns, Robert F., Marston, Hugh, Svensson, Kjell A., Williams, Graham V.

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Identification of LY3522348: A Highly Selective and Orally Efficacious Ketohexokinase Inhibitor von Durham, Timothy B., Hao, Junliang, Spinazze, Patrick, Stack, Douglas R., Toth, James L., Massey, Steven, Mbofana, Curren T., Johnston, Richard D., Lineswala, Jayana P., Wrobleski, Aaron, Mínguez, Jose Miguel, Perez, Carlos, Smith, Daryl L., Lamar, Jason, Leon, Rebecca, Corkins, Christopher, Durbin, Jim, Tung, Frances, Guo, Sherry, Linder, Ryan J., Yumibe, Nathan, Wang, Wei, MacKrell, James, Antonellis, Meghan, Mascaro, Bethany

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Intracellular Binding Site for a Positive Allosteric Modulator of the Dopamine D1 Receptor von Wang, Xushan, Heinz, Beverly A., Qian, Yue-Wei, Carter, Joan H., Gadski, Robert A., Beavers, Lisa S., Little, Sheila P., Yang, Charles R., Beck, James P., Hao, Junliang, Schaus, John M., Svensson, Kjell A., Bruns, Robert F.

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Synthesis and Pharmacological Characterization of 2‑(2,6-Dichlorophenyl)-1-((1S,3R)‑5-(3-hydroxy-3-methylbutyl)-3-(hydroxymethyl)-1-methyl-3,4-dihydroisoquinolin-2(1H)‑yl)ethan-1-o... von Hao, Junliang, Beck, James P, Schaus, John M, Krushinski, Joseph H, Chen, Qi, Beadle, Christopher D, Vidal, Paloma, Reinhard, Matthew R, Dressman, Bruce A, Massey, Steven M, Boulet, Serge L, Cohen, Michael P, Watson, Brian M, Tupper, David, Gardinier, Kevin M, Myers, Jason, Johansson, Anette M, Richardson, Jeffery, Richards, Daniel S, Hembre, Erik J, Remick, David M, Coates, David A, Bhardwaj, Rajni M, Diseroad, Benjamin A, Bender, David, Stephenson, Greg, Wolfangel, Craig D, Diaz, Nuria, Getman, Brian G, Wang, Xu-shan, Heinz, Beverly A, Cramer, Jeff W, Zhou, Xin, Maren, Deanna L, Falcone, Julie F, Wright, Rebecca A, Mitchell, Stephen N, Carter, Guy, Yang, Charles R, Bruns, Robert F, Svensson, Kjell A

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Structural Basis for (S)‑3,4-Dicarboxyphenylglycine (DCPG) As a Potent and Subtype Selective Agonist of the mGlu8 Receptor von Chen, Qi, Ho, Joseph D, Ashok, Sheela, Vargas, Michelle C, Wang, Jing, Atwell, Shane, Bures, Mark, Schkeryantz, Jeffery M, Monn, James A, Hao, Junliang

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Synthesis and Pharmacological Characterization of C4-(Thiotriazolyl)-substituted-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylates. Identification of (1R,2S,4R,5R,6R)-2-Amino-4-(1H-1,... von Monn, James A., Prieto, Lourdes, Taboada, Lorena, Hao, Junliang, Reinhard, Matthew R., Henry, Steven S., Beadle, Christopher D., Walton, Lesley, Man, Teresa, Rudyk, Helene, Clark, Barry, Tupper, David, Baker, S. Richard, Lamas, Carlos, Montero, Carlos, Marcos, Alicia, Blanco, Jaime, Bures†, Mark, Clawson, David K., Atwell, Shane, Lu, Frances, Wang, Jing, Russell, Marijane, Heinz, Beverly A., Wang, Xushan, Carter, Joan H., Getman, Brian G., Catlow, John T., Swanson, Steven, Johnson, Bryan G., Shaw, David B., McKinzie, David L.

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Synthesis and Preclinical Characterization of LY3154885, a Human Dopamine D1 Receptor Positive Allosteric Modulator with an Improved Nonclinical Drug–Drug Interaction Risk Profile... von Hao, Junliang, Beck, James, Zhou, Xin, Lackner, Gregory L, Johnston, Richard, Reinhard, Matt, Goldsmith, Paul, Hollinshead, Sean, Dehlinger, Veronique, Filla, Sandra A, Wang, Xu-shan, Richardson, Jeffery, Posada, Maria, Mohutsky, Mike, Schober, Doug, Katner, Jason S, Chen, Qi, Hu, Bingjie, Remick, David M, Coates, David A, Mathes, Brian M, Hawk, Mai K, Svensson, Kjell A, Hembre, Erik

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Development of a Scalable Synthesis of Mevidalen (LY3154207), an Orally Available Positive Allosteric Modulator of the Human Dopamine D1 Receptor von Richardson, Jeffery, Cole, Kevin P, DeBaillie, Amy C, Hao, Junliang, Piper, Jared, Houghton, Peter, Rizzo, John, Jia, Mo, Liu, Peng, Huang, Ping, Kadlecikova, Katarina, Garcia, Conchita F, Richards, Daniel S

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