Molecular obesity, potency and other addictions in drug discovery von Hann, Michael M.

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Prediction of intracellular exposure bridges the gap between target- and cell-based drug discovery von Mateus, André, Gordon, Laurie J., Wayne, Gareth J., Almqvist, Helena, Axelsson, Hanna, Seashore-Ludlow, Brinton, Treyer, Andrea, Matsson, Pär, Lundbäck, Thomas, West, Andy, Hann, Michael M., Artursson, Per

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Type IIA topoisomerase inhibition by a new class of antibacterial agents von Giordano, Ilaria, Spitzfaden, Claus E, Jones, Emma, Theobald, Andrew J, Gorrec, Fabrice, Jones, Jo, Hann, Michael M, May, Earl W, Saunders, Martin R, Fosberry, Andrew, Chan, Pan F, Eggleston, Drake S, Hibbs, Martin, Brown, Kristin Koretke, Lewis, Ceri J, Bax, Benjamin D, Singh, Onkar, Pearson, Neil D, Wohlkonig, Alexandre, Hennessy, Alan, Gentry, Daniel R, Huang, Jianzhong, Shen, Carol, Gwynn, Michael N, Shillings, Anthony

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Lessons in Transcellular Membrane Transport Re-Learned von Hann, Michael M.

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Reactive fragments targeting carboxylate residues employing direct to biology, high-throughput chemistry von Thomas, Ross P, Grant, Emma K, Dickinson, Eleanor R, Zappacosta, Francesca, Edwards, Lee J, Hann, Michael M, House, David, Tomkinson, Nicholas C. O, Bush, Jacob T

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Crystal structure and ligandability of the 14-3-3/pyrin interface von Lau, Roxanne, Hann, Michael M., Ottmann, Christian

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Finding the sweet spot: the role of nature and nurture in medicinal chemistry von Hann, Michael M., Keserü, György M.

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The PROTACtable genome von Schneider, Melanie, Radoux, Chris J., Hercules, Andrew, Ochoa, David, Dunham, Ian, Zalmas, Lykourgos-Panagiotis, Hessler, Gerhard, Ruf, Sven, Shanmugasundaram, Veerabahu, Hann, Michael M., Thomas, Pam J., Queisser, Markus A., Benowitz, Andrew B., Brown, Kris, Leach, Andrew R.

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Unlocking the secrets of the gatekeeper: Methods for stabilizing and crystallizing GPCRs von Bertheleme, Nicolas, Chae, Pil Seok, Singh, Shweta, Mossakowska, Danuta, Hann, Michael M., Smith, Kathrine J., Hubbard, Julia A., Dowell, Simon J., Byrne, Bernadette

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Molecular complexity and fragment-based drug discovery: ten years on von Leach, Andrew R, Hann, Michael M

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Design Principles for Fragment Libraries: Maximizing the Value of Learnings from Pharma Fragment-Based Drug Discovery (FBDD) Programs for Use in Academia von Keserű, György M, Erlanson, Daniel A, Ferenczy, György G, Hann, Michael M, Murray, Christopher W, Pickett, Stephen D

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Molecular Complexity and Its Impact on the Probability of Finding Leads for Drug Discovery von Hann, Michael M, Leach, Andrew R, Harper, Gavin

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Structural basis of DNA gyrase inhibition by antibacterial QPT-1, anticancer drug etoposide and moxifloxacin von Chan, Pan F., Srikannathasan, Velupillai, Huang, Jianzhong, Cui, Haifeng, Fosberry, Andrew P., Gu, Minghua, Hann, Michael M., Hibbs, Martin, Homes, Paul, Ingraham, Karen, Pizzollo, Jason, Shen, Carol, Shillings, Anthony J., Spitzfaden, Claus E., Tanner, Robert, Theobald, Andrew J., Stavenger, Robert A., Bax, Benjamin D., Gwynn, Michael N.

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A direct-to-biology high-throughput chemistry approach to reactive fragment screening von Thomas, Ross P, Heap, Rachel E, Zappacosta, Francesca, Grant, Emma K, Pogány, Peter, Besley, Stephen, Fallon, David J, Hann, Michael M, House, David, Tomkinson, Nicholas C. O, Bush, Jacob T

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A Photoaffinity‐Based Fragment‐Screening Platform for Efficient Identification of Protein Ligands von Grant, Emma K., Fallon, David J., Hann, Michael M., Fantom, Ken G. M., Quinn, Chad, Zappacosta, Francesca, Annan, Roland S., Chung, Chun‐wa, Bamborough, Paul, Dixon, David P., Stacey, Peter, House, David, Patel, Vipulkumar K., Tomkinson, Nicholas C. O., Bush, Jacob T.

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Intracellular drug concentration and disposition – The missing link? von Hann, Michael M., Simpson, Graham L.

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Approaches to target tractability assessment - a practical perspective von Brown, Kristin K, Hann, Michael M, Lakdawala, Ami S, Santos, Rita, Thomas, Pamela J, Todd, Kieran

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Direct Measurement of Intracellular Compound Concentration by RapidFire Mass Spectrometry Offers Insights into Cell Permeability von Gordon, Laurie J., Allen, Morven, Artursson, Per, Hann, Michael M., Leavens, Bill J., Mateus, André, Readshaw, Simon, Valko, Klara, Wayne, Gareth J., West, Andy

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Fragment screening: an introduction von Leach, Andrew R, Hann, Michael M, Burrows, Jeremy N, Griffen, Ed J

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What is the future for fragment-based drug discovery? von Keser, György M, Hann, Michael M

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