Hepatoprotective effects of the dual peroxisome proliferator‐activated receptor alpha/delta agonist, GFT505, in rodent models of nonalcoholic fatty liver disease/nonalcoholic steat... von Staels, Bart, Rubenstrunk, Anne, Noel, Benoit, Rigou, Géraldine, Delataille, Philippe, Millatt, Lesley J., Baron, Morgane, Lucas, Anthony, Tailleux, Anne, Hum, Dean W., Ratziu, Vlad, Cariou, Bertrand, Hanf, Rémy

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Dual Peroxisome Proliferator-Activated Receptor α/δ Agonist GFT505 Improves Hepatic and Peripheral Insulin Sensitivity in Abdominally Obese Subjects von CARIOU, Bertrand, HANF, Rémy, LAMBERT-PORCHERON, Stéphanie, ZAÏR, Yassine, SAUVINET, Valérie, NOËL, Benoit, FLET, Laurent, VIDAL, Hubert, STAELS, Bart, LAVILLE, Martine

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Safety issues and prospects for future generations of PPAR modulators von Rubenstrunk, Anne, Hanf, Rémy, Hum, Dean W., Fruchart, Jean-Charles, Staels, Bart

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A blood-based biomarker panel (NIS4) for non-invasive diagnosis of non-alcoholic steatohepatitis and liver fibrosis: a prospective derivation and global validation study von Harrison, Stephen A, Ratziu, Vlad, Boursier, Jérôme, Francque, Sven, Bedossa, Pierre, Majd, Zouher, Cordonnier, Geneviève, Sudrik, Fouad Ben, Darteil, Raphael, Liebe, Roman, Magnanensi, Jérémy, Hajji, Yacine, Brozek, John, Roudot, Alice, Staels, Bart, Hum, Dean W, Megnien, Sophie Jeannin, Hosmane, Suneil, Dam, Noémie, Chaumat, Pierre, Hanf, Rémy, Anstee, Quentin M, Sanyal, Arun J

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Bile acids associate with glucose metabolism, but do not predict conversion from impaired fasting glucose to diabetes von Chávez-Talavera, Oscar, Wargny, Matthieu, Pichelin, Matthieu, Descat, Amandine, Vallez, Emmanuelle, Kouach, Mostafa, Bigot-Corbel, Edith, Joliveau, Marielle, Goossens, Jean-François, Le May, Cédric, Hadjadj, Samy, Hanf, Rémy, Tailleux, Anne, Staels, Bart, Cariou, Bertrand

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Mo1591 ASSESSMENT OF THE DRUG-DRUG INTERACTION POTENTIAL OF ELAFIBRANOR WITH INDOMETHACIN IN HEALTHY ADULT MALE PARTICIPANTS: AN OPEN-LABEL PHASE I TRIAL von Pedret-Dunn, Anna, Mazain, Sarah, Allan, Richard, Gattolliat, Olivier, Hanf, Rémy

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Mo1585 ASSESSMENT OF THE DRUG-DRUG INTERACTION POTENTIAL OF ELAFIBRANOR WITH WARFARIN IN HEALTHY ADULT MALE PARTICIPANTS: AN OPEN-LABEL PHASE I TRIAL von Pedret-Dunn, Anna, Mazain, Sarah, Allan, Richard, Gattolliat, Olivier, Hanf, Rémy

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Diagnostic accuracy of non-invasive tests for advanced fibrosis in patients with NAFLD: an individual patient data meta-analysis von Lee, Jenny A, Selvaraj, Emmanuel Anandraj, Staufer, Katharina, Younes, Ramy, Okanoue, Takeshi, Mahadeva, Sanjiv, Chan, Wah-Kheong, Eddowes, Peter J, Hirschfield, Gideon M, Newsome, Philip Noel, Wong, Vincent Wai-Sun, Fan, Jiangao, Cobbold, Jeremy F, Labenz, Christian, Lee, Myoung Seok, Wiegand, Johannes, Karlas, Thomas, Yılmaz, Yusuf, Aggarwal, Sandeep, Nakajima, Atsushi, Yoneda, Masato, Barget, Nathalie, Brosnan, M. Julia, Anstee, Quentin Mark, Neubauer, Stefan, Pavlides, Michael, Anstee, Quentin, Daly, Ann, Johnson, Katherine, Cockell, Simon, Bedossa, Pierre, Cordell, Heather, Day, Chris, Wonders, Kristy, Bossuyt, Patrick, Zafarmand, Hadi, Vali, Yasaman, Lee, Jenny, Clement, Karine, Schattenberg, Jörn, Vidal-Puig, Toni, Rodrigues-Cuenca, Sergio, Allison, Mike, Kamzolas, Ioannis, Petsalaki, Evangelia, Oresic, Matej, Mato, Jose M, Millet, Oscar, Berzigotti, Annalisa, Harrison, Stephen, Neubauer, Stefan, Cobbold, Jeremy, Mozes, Ferenc, Shumbayawonda, Elizabeth, Erpicum, Charlotte, Graham, Micheala, Romero-Gómez, Manuel, Gallego-Durán, Rocío, Fernández, Isabel, Montero-Vallejo, Rocío, Karsdal, Morten, Erhardtsen, Elisabeth, Rasmussen, Daniel, Leeming, Diana Julie, Fisker, Mette Juul, Tonini, Manuela, Bugianesi, Elisabetta, Rosso, Chiara, Armandi, Angelo, Marra, Fabio, Svegliati, Gianluca, Francque, Sven, Yki-Jarvinen, Hannele, Porthan, Kimmo, Mil, Saskia van, Valenti, Luca, Aithal, Guru, Newsome, Philip, Wenn, David, Rodrigues, Cecília Maria, Chaumat, Pierre, Hanf, Rémy, Duffin, Kevin, Tuthill, Theresa, McLeod, Euan, Ertle, Judith, Ostroff, Rachel, Alexander, Leigh, Kjær, Mette Skalshøi, Mikkelsen, Lars Friis, Brass, Clifford, Martic, Miljen, Loeffler, Juergen, Hanauer, Guido, Fournier, Céline, Pepin, Kay, Ehman, Richard, Myers, Joel, Myers, Rob, Doward, Lynda

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Diagnostic accuracy of elastography and magnetic resonance imaging in patients with NAFLD: A systematic review and meta-analysis von Selvaraj, Emmanuel Anandraj, Jayaswal, Arjun Narayan Ajmer, Zafarmand, Mohammad Hadi, Vali, Yasaman, Lee, Jenny A., Levick, Christina Kim, Young, Liam Arnold Joseph, Palaniyappan, Naaventhan, Liu, Chang-Hai, Aithal, Guruprasad Padur, Romero-Gómez, Manuel, Tuthill, Theresa A., Anstee, Quentin M., Neubauer, Stefan, Harrison, Stephen A., Bossuyt, Patrick M., Pavlides, Michael, Anstee, Quentin, Daly, Ann, Johnson, Katherine, Cockell, Simon, Bedossa, Pierre, Oakley, Fiona, Cordell, Heather, Day, Chris, Wonders, Kristy, Zafarmand, Hadi, Vali, Yasaman, Lee, Jenny, Ratziu, Vlad, Pais, Raluca, Schattenberg, Jörn, Vidal-Puig, Toni, Vacca, Michele, Rodrigues-Cuenca, Sergio, Allison, Mike, Kamzolas, Ioannis, Hyötyläinen, Tuulia, McGlinchey, Aiden, Mato, Jose M., Millet, Oscar, Dufour, Jean-François, Berzigotti, Annalisa, Pavlides, Michael, Harrison, Stephen, Neubauer, Stefan, Cobbold, Jeremy, Mozes, Ferenc, Akhtar, Salma, Banerjee, Rajarshi, Kelly, Matt, Erpicum, Charlotte, Romero-Gómez, Manuel, Gómez-González, Emilio, Ampuero, Javier, Gallego-Durán, Rocío, Fernández, Isabel, Montero-Vallejo, Rocío, Fisker, Mette Juul, Sinisi, Antonia, Musa, Kishwar, Sandt, Estelle, Tonini, Manuela, Rosso, Chiara, Armandi, Angelo, Marra, Fabio, Gastaldelli, Amalia, Svegliati, Gianluca, Francque, Sven, Vonghia, Luisa, Luukkonen, Panu, van Mil, Saskia, Papatheodoridis, George, Cortez-Pinto, Helena, Petta, Salvatore, Miele, Luca, Geier, Andreas, Aithal, Guru, Wenn, David, Pereira Rodrigues, Cecília Maria, Chaumat, Pierre, Ortiz, Pablo, Duffin, Kevin, Brosnan, Julia, Tuthill, Theresa, Ertle, Judith, Younes, Ramy, Ostroff, Rachel, Alexander, Leigh, Mikkelsen, Lars Friis, Balp, Maria-Magdalena, Jennings, Lori, Loeffler, Juergen, Hanauer, Guido, Fournier, Céline, Pepin, Kay, Ehman, Richard, Myers, Joel, Torstenson, Richard, Doward, Lynda

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The dual peroxisome proliferator-activated receptor alpha/delta agonist GFT505 exerts anti-diabetic effects in db/db mice without peroxisome proliferator-activated receptor gamma–a... von Hanf, Rémy, Millatt, Lesley J, Cariou, Bertrand, Noel, Benoit, Rigou, Géraldine, Delataille, Philippe, Daix, Valérie, Hum, Dean W, Staels, Bart

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Activation of intestinal peroxisome proliferator-activated receptor-α increases high-density lipoprotein production von Colin, Sophie, Briand, Olivier, Touche, Véronique, Wouters, Kristiaan, Baron, Morgane, Pattou, François, Hanf, Rémy, Tailleux, Anne, Chinetti, Giulia, Staels, Bart, Lestavel, Sophie

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278-LB: Type 2 Diabetes (T2D) as a Risk Factor for NASH and Significant Liver Fibrosis (F>2) in an International Cohort of 2,363 Patients with Metabolic Steatosis von STAELS, BART, RATZIU, VLAD, SANYAL, ARUN J., FRANCQUE, SVEN, HARRISON, STEPHEN A., ROUDOT, ALICE, BROZEK, JOHN, HAJJI, YACINE, MEGNIEN, SOPHIE, HUM, DEAN W., BIRMAN, PASCAL, HANF, RéMY, CARIOU, BERTRAND

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279-LB: NIS4, a Novel Blood Test, Can Identify "At-Risk" NASH (NAS>4 and Fibrosis>2) in T2D Patients von STAELS, BART, RATZIU, VLAD, FRANCQUE, SVEN, HARRISON, STEPHEN A., BEDOSSA, PIERRE, ROUDOT, ALICE, MAJD, ZOUHER, BROZEK, JOHN, BEN-SUDRIK, FOUAD, BIRMAN, PASCAL, HUM, DEAN W., HOSMANE, SUNEIL, CHAUMAT, PIERRE, HANF, RéMY, CARIOU, BERTRAND, SANYAL, ARUN

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Enhanced liver fibrosis test for the non-invasive diagnosis of fibrosis in patients with NAFLD: A systematic review and meta-analysis von Vali, Yasaman, Lee, Jenny, Boursier, Jérôme, Spijker, René, Löffler, Jürgen, Verheij, Joanne, Brosnan, M. Julia, Böcskei, Zsolt, Anstee, Quentin M., Bossuyt, Patrick M., Zafarmand, Mohammad Hadi, Pavlides, Michael, Levick, Christina, Duffin, Kevin, Hyde, Craig, Bauer, Tim, Bedossa, Pierre, Leeming, Diana, Daly, Ann, Hanf, Remy, Ortiz, Pablo, Oresic, Matej, Schuppan, Detlef, Hanauer, Guido, Chen, Yu, Shumbayawonda, Elizabeth, Bjerring, Peter Nissen, Zwinderman, Koos

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Increased serum miR-193a-5p during non-alcoholic fatty liver disease progression: Diagnostic and mechanistic relevance von Johnson, Katherine, Leary, Peter J., Govaere, Olivier, Barter, Matthew J., Cockell, Simon J., Zatorska, Michalina, Bedossa, Pierre, Brosnan, M. Julia, Cobbold, Jeremy F., Ekstedt, Mattias, Aithal, Guruprasad P., Clément, Karine, Schattenberg, Jörn M., Boursier, Jerome, Ratziu, Vlad, Anstee, Quentin M., Daly, Ann K., Clark, James, Cordell, Heather J., Darlay, Rebecca, Day, Christopher P., Hardy, Tim, Liu, Yang-Lin, Oakley, Fiona, Palmer, Jeremy, Queen, Rachel, Bossuyt, Patrick M., Holleboom, Adriaan G., Lee, Jenny, Clement, Karine, Pais, Raluca, Schuppan, Detlef, Allison, Michael, Cuenca, Sergio Rodriguez, Pellegrinelli, Vanessa, Vacca, Michele, McGlinchey, Aidan, Sen, Partho, Mato, Jose, Dufour, Jean-Francois, Neubauer, Stefan, Mozes, Ferenc, Banerjee, Rajarshi, Kelly, Matt, Shumbayawonda, Elizabeth, Dennis, Andrea, Erpicum, Charlotte, Romero-Gomez, Manuel, Gallego-Durán, Rocío, Fernández, Isabel, Karsdal, Morten, Fisker, Mette Juul, Erhardtsen, Elisabeth, Qvist, Per, Tonini, Maria Manuela, Parola, Maurizio, Marra, Fabio, Gastaldelli, Amalia, Francque, Sven, Kechagias, Stergios, Yki-Järvinen, Hannele, Porthan, Kimmo, van Mil, Saskia, Papatheodoridis, George, Cortez-Pinto, Helena, Valenti, Luca, Petta, Salvatore, Geier, Andreas, Trautwein, Christian, Hockings, Paul, Newsome, Phil, Chaumat, Pierre, Rosenquist, Christian, Trylesinski, Aldo, Duffin, Kevin, Yunis, Carla, Miller, Melissa, Tuthill, Theresa, Ertle, Judith, Younes, Ramy, Ostroff, Rachel, Mikkelsen, Lars Friis, Brass, Clifford, Jennings, Lori, Balp, Maria-Magdalena, Martic, Miljen, Hanauer, Guido, Shankar, Sudha, Torstenson, Richard, Fournier, Céline, Ehman, Richard, Kalutkiewicz, Michael, Pepin, Kay, Myers, Joel, Shevell, Diane, Ho, Gideon, Landgren, Henrik, Doward, Lynda, Whalley, Diane, Twiss, James

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METHODS OF TREATMENT OF CHOLESTATIC DISEASES von HANF, Rémy

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THU-174 Assessment of the pharmacokinetic drug-drug interaction potential of elafibranor with atorvastatin in healthy adult male participants: an open-label phase I trial von Pedret-Dunn, Anna, Mazain, Sarah, Allan, Richard, Hanf, Remy, Addy, Carol

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METHODS OF TREATMENT OF CHOLESTATIC DISEASES von HANF, Rémy

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A randomized placebo-controlled trial of elafibranor in patients with primary biliary cholangitis and incomplete response to UDCA von Schattenberg, Jörn M., Pares, Albert, Kowdley, Kris V., Heneghan, Michael A., Caldwell, Stephen, Pratt, Daniel, Bonder, Alan, Hirschfield, Gideon M., Levy, Cynthia, Vierling, John, Jones, David, Tailleux, Anne, Staels, Bart, Megnien, Sophie, Hanf, Remy, Magrez, David, Birman, Pascal, Luketic, Velimir

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Improvement of hepatic and extrahepatic functions and anti-inflammatory effects of nitazoxanide in disease models of LPS-induced systemic inflammation and acute-on-chronic liver fa... von Legry, Vanessa, Delataille, Philippe, Malysiak, Maryse, Daix, Valérie, Debaecker, Simon, Staels, Bart, Hanf, Remy, Hum, Dean

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