Online control of cell culture redox potential prevents antibody interchain disulfide bond reduction von Handlogten, Michael W., Wang, Jihong, Ahuja, Sanjeev

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Glutathione and thioredoxin systems contribute to recombinant monoclonal antibody interchain disulfide bond reduction during bioprocessing von Handlogten, Michael W., Zhu, Min, Ahuja, Sanjeev

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Intracellular response of CHO cells to oxidative stress and its influence on metabolism and antibody production von Handlogten, Michael W., Zhu, Min, Ahuja, Sanjeev

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Elevated endoplasmic reticulum pH is associated with high growth and bisAb aggregation in CHO cells von McFarland, Kevin S., Hegadorn, Kaitlin, Betenbaugh, Michael J., Handlogten, Michael W.

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Intracellular response to process optimization and impact on productivity and product aggregates for a high‐titer CHO cell process von Handlogten, Michael W., Lee‐O'Brien, Allison, Roy, Gargi, Levitskaya, Sophia V., Venkat, Raghavan, Singh, Shailendra, Ahuja, Sanjeev

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Perfusion reduces bispecific antibody aggregation via mitigating mitochondrial dysfunction-induced glutathione oxidation and ER stress in CHO cells von Sinharoy, Pritam, Aziz, Aaron H., Majewska, Natalia I., Ahuja, Sanjeev, Handlogten, Michael W.

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Engineering redox sensors into CHO cells enables near‐real‐time quantification of intracellular redox in bioprocesses von McFarland, Kevin S., Zhu, Jie, Sinharoy, Pritam, Betenbaugh, Michael J., Handlogten, Michael W.

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Redox as a bioprocess parameter: analytical redox quantification in biological therapeutic production von Sinharoy, Pritam, McFarland, Kevin S, Majewska, Natalia I, Betenbaugh, Michael J, Handlogten, Michael W

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Accelerated cell culture process development and characterization for cilgavimab/tixagevimab (AZD7442) for the prevention and treatment of COVID-19 von Handlogten, Michael W, Bosley, Stefanie, Dunn, Sarah, Zhu, Jie, Lee-O'Brien, Allison, Li, Lina, Therres, Jamy, Chakrabarti, Lina, Khanal, Bijay, Mowery, Rachel, Arumugam, Subhashini, Klover, Judith, Taleb, Mohammed, Reier, Jason, Hatton, Diane, Schmelzer, Albert

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Design of a heterotetravalent synthetic allergen that reflects epitope heterogeneity and IgE antibody variability to study mast cell degranulation von Handlogten, Michael W, Kiziltepe, Tanyel, Bilgicer, Basar

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Harnessing structure-activity relationship to engineer a cisplatin nanoparticle for enhanced antitumor efficacy von Paraskar, Abhimanyu S., Soni, Shivani, Chin, Kenneth T., Chaudhuri, Padmaparna, Muto, Katherine W., Berkowitz, Julia, Handlogten, Michael W., Alves, Nathan J., Bilgicer, Basar, Dinulescu, Daniela M., Mashelkar, Raghunath A., Sengupta, Shiladitya

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Prevention of Fab-arm exchange and antibody reduction via stabilization of the IgG4 hinge region von Handlogten, Michael W, Peng, Li, Christian, Elizabeth A, Xu, Weichen, Lin, Shihua, Venkat, Raghavan, Dall'Acqua, William, Ahuja, Sanjeev

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Inhibition of weak-affinity epitope-IgE interactions prevents mast cell degranulation von Handlogten, Michael W, Kiziltepe, Tanyel, Serezani, Ana P, Kaplan, Mark H, Bilgicer, Basar

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Small-Molecule-Based Affinity Chromatography Method for Antibody Purification via Nucleotide Binding Site Targeting von Alves, Nathan J, Stimple, Samuel D, Handlogten, Michael W, Ashley, Jonathan D, Kiziltepe, Tanyel, Bilgicer, Basar

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Selective photocrosslinking of functional ligands to antibodies via the conserved nucleotide binding site von Alves, Nathan J, Champion, Matthew M, Stefanick, Jared F, Handlogten, Michael W, Moustakas, Demetri T, Shi, Yunhua, Shaw, Bryan F, Navari, Rudolph M, Kiziltepe, Tanyel, Bilgicer, Basar

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Functionalized liposome purification via Liposome Extruder Purification (LEP) von Alves, Nathan J, Cusick, William, Stefanick, Jared F, Ashley, Jonathan D, Handlogten, Michael W, Bilgicer, Basar

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Nonchromatographic Affinity Precipitation Method for the Purification of Bivalently Active Pharmaceutical Antibodies from Biological Fluids von Handlogten, Michael W, Stefanick, Jared F, Alves, Nathan J, Bilgicer, Basar

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Affinity-based precipitation via a bivalent peptidic hapten for the purification of monoclonal antibodies von Handlogten, Michael W, Stefanick, Jared F, Deak, Peter E, Bilgicer, Basar

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Synthetic Allergen Design Reveals the Significance of Moderate Affinity Epitopes in Mast Cell Degranulation von Handlogten, Michael W, Kiziltepe, Tanyel, Alves, Nathan J, Bilgicer, Basar

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A heterobivalent ligand inhibits mast cell degranulation via selective inhibition of allergen-IgE interactions in vivo von Handlogten, Michael W, Serezani, Ana P, Sinn, Anthony L, Pollok, Karen E, Kaplan, Mark H, Bilgicer, Basar

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