Discovery and Development of Highly Potent and Orally Bioavailable Nonpeptidic αvβ6 Integrin Inhibitors von Procopiou, Panayiotis A., Barrett, John, Crawford, Matthew H. J., Hatley, Richard J. D., Hancock, Ashley P., Pritchard, John M., Rowedder, James E., Copley, Royston C. B., Slack, Robert J., Sollis, Steven L., Thorp, Lee R., Lippa, Rhys A., Macdonald, Simon J. F., Barrett, Tim N.

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Discovery and Development of Highly Potent and Orally Bioavailable Nonpeptidic α v β 6 Integrin Inhibitors von Procopiou, Panayiotis A, Barrett, John, Crawford, Matthew H J, Hatley, Richard J D, Hancock, Ashley P, Pritchard, John M, Rowedder, James E, Copley, Royston C B, Slack, Robert J, Sollis, Steven L, Thorp, Lee R, Lippa, Rhys A, Macdonald, Simon J F, Barrett, Tim N

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A knowledge-based, structural-aided discovery of a novel class of 2-phenylimidazo[1,2-a]pyridine-6-carboxamide H-PGDS inhibitors von Schulte, Christie A., Deaton, David N., Diaz, Elsie, Do, Young, Gampe, Robert T., Guss, Jeffrey H., Hancock, Ashley P., Hobbs, Heather, Hodgson, Simon T., Holt, Jason, Jeune, Michael R., Kahler, Kirsten M., Kramer, H. Fritz, Le, Joelle, Mortenson, Paul N., Musetti, Caterina, Nolte, Robert T., Orband-Miller, Lisa A., Peckham, Gregory E., Petrov, Kim G., Pietrak, Beth L., Poole, Chuck, Price, Daniel J., Saxty, Gordon, Shillings, Anthony, Smalley, Terrence L., Somers, Don O., Stewart, Eugene L., Stuart, J. Darren, Thomson, Stephen A.

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The discovery of quinoline-3-carboxamides as hematopoietic prostaglandin D synthase (H-PGDS) inhibitors von Deaton, David N., Do, Young, Holt, Jason, Jeune, Michael R., Kramer, H. Fritz, Larkin, Andrew L., Orband-Miller, Lisa A., Peckham, Gregory E., Poole, Chuck, Price, Daniel J., Schaller, Lee T., Shen, Ying, Shewchuk, Lisa M., Stewart, Eugene L., Stuart, J. Darren, Thomson, Stephen A., Ward, Paris, Wilson, Joseph W., Xu, Tianshun, Guss, Jeffrey H., Musetti, Caterina, Rendina, Alan R., Affleck, Karen, Anders, David, Hancock, Ashley P., Hobbs, Heather, Hodgson, Simon T., Hutchinson, Jonathan, Leveridge, Melanie V., Nicholls, Harry, Smith, Ian E.D., Somers, Don O., Sneddon, Helen F., Uddin, Sorif, Cleasby, Anne, Mortenson, Paul N., Richardson, Caroline, Saxty, Gordon

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Discovery of (S)‑3-(3-(3,5-Dimethyl‑1H‑pyrazol-1-yl)phenyl)-4-((R)‑3-(2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl)pyrrolidin-1-yl)butanoic Acid, a Nonpeptidic αvβ6 Integrin I... von Procopiou, Panayiotis A, Anderson, Niall A, Barrett, John, Barrett, Tim N, Crawford, Matthew H. J, Fallon, Brendan J, Hancock, Ashley P, Le, Joelle, Lemma, Seble, Marshall, Richard P, Morrell, Josie, Pritchard, John M, Rowedder, James E, Saklatvala, Paula, Slack, Robert J, Sollis, Steven L, Suckling, Colin J, Thorp, Lee R, Vitulli, Giovanni, Macdonald, Simon J. F

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Discovery of ( S)-3-(3-(3,5-Dimethyl-1 H-pyrazol-1-yl)phenyl)-4-(( R)-3-(2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl)pyrrolidin-1-yl)butanoic Acid, a Nonpeptidic α v β 6 Inte... von Procopiou, Panayiotis A, Anderson, Niall A, Barrett, John, Barrett, Tim N, Crawford, Matthew H J, Fallon, Brendan J, Hancock, Ashley P, Le, Joelle, Lemma, Seble, Marshall, Richard P, Morrell, Josie, Pritchard, John M, Rowedder, James E, Saklatvala, Paula, Slack, Robert J, Sollis, Steven L, Suckling, Colin J, Thorp, Lee R, Vitulli, Giovanni, Macdonald, Simon J F

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The discovery of quinoline based single-ligand human H 1 and H 3 receptor antagonists von Procopiou, Panayiotis A, Ancliff, Rachael A, Gore, Paul M, Hancock, Ashley P, Hodgson, Simon T, Holmes, Duncan S, Keeling, Steven P, Looker, Brian E, Parr, Nigel A, Rowedder, James E, Slack, Robert J

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Synthesis and Structure–Activity Relationships of Indazole Arylsulfonamides as Allosteric CC-Chemokine Receptor 4 (CCR4) Antagonists von Procopiou, Panayiotis A, Barrett, John W, Barton, Nicholas P, Begg, Malcolm, Clapham, David, Copley, Royston C. B, Ford, Alison J, Graves, Rebecca H, Hall, David A, Hancock, Ashley P, Hill, Alan P, Hobbs, Heather, Hodgson, Simon T, Jumeaux, Coline, Lacroix, Yannick M. L, Miah, Afjal H, Morriss, Karen M. L, Needham, Deborah, Sheriff, Emma B, Slack, Robert J, Smith, Claire E, Sollis, Steven L, Staton, Hugo

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Identification of selective 8-(piperidin-4-yloxy)quinoline sulfone and sulfonamide histamine H1 receptor antagonists for use in allergic rhinitis von Procopiou, Panayiotis A., Ford, Alison J., Gore, Paul M., Hancock, Ashley P., Hodgson, Simon T., Holmes, Duncan S., Looker, Brian E., Vile, Sadie, Clark, Kenneth L., Saunders, Ken A., Slack, Robert J., Watts, Clarissa J.

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Identification of selective 8-(piperidin-4-yloxy)quinoline sulfone and sulfonamide histamine H 1 receptor antagonists for use in allergic rhinitis von Procopiou, Panayiotis A, Ford, Alison J, Gore, Paul M, Hancock, Ashley P, Hodgson, Simon T, Holmes, Duncan S, Looker, Brian E, Vile, Sadie, Clark, Kenneth L, Saunders, Ken A, Slack, Robert J, Watts, Clarissa J

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The discovery of quinoline based single-ligand human H1 and H3 receptor antagonists von Procopiou, Panayiotis A., Ancliff, Rachael A., Gore, Paul M., Hancock, Ashley P., Hodgson, Simon T., Holmes, Duncan S., Keeling, Steven P., Looker, Brian E., Parr, Nigel A., Rowedder, James E., Slack, Robert J.

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The Discovery of Phthalazinone-Based Human H1 and H3 Single-Ligand Antagonists Suitable for Intranasal Administration for the Treatment of Allergic Rhinitis von Procopiou, Panayiotis A, Browning, Christopher, Buckley, Jennifer M, Clark, Kenneth L, Fechner, Lise, Gore, Paul M, Hancock, Ashley P, Hodgson, Simon T, Holmes, Duncan S, Kranz, Michael, Looker, Brian E, Morriss, Karen M. L, Parton, Daniel L, Russell, Linda J, Slack, Robert J, Sollis, Steven L, Vile, Sadie, Watts, Clarissa J

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Selective Plasma Hydrolysis of Glucocorticoid γ-Lactones and Cyclic Carbonates by the Enzyme Paraoxonase: An Ideal Plasma Inactivation Mechanism von Biggadike, Keith, Angell, Richard M, Burgess, Colin M, Farrell, Rosanne M, Hancock, Ashley P, Harker, Andy J, Irving, Wendy R, Ioannou, Chris, Procopiou, Panayiotis A, Shaw, Rupert E, Solanke, Yemisi E, Singh, Onkar M. P, Snowden, Michael A, Stubbs, Rob J, Walton, Sarah, Weston, Helen E

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Oxazolidinones as novel human CCR8 antagonists von Jin, Jian, Wang, Yonghui, Wang, Feng, Kerns, Jeffery K., Vinader, Victoria M., Hancock, Ashley P., Lindon, Matthew J., Stevenson, Graeme I., Morrow, Dwight M., Rao, Parvathi, Nguyen, Cuc, Barrett, Victoria J., Browning, Chris, Hartmann, Guido, Andrew, David P., Sarau, Henry M., Foley, James J., Jurewicz, Anthony J., Fornwald, James A., Harker, Andy J., Moore, Michael L., Rivero, Ralph A., Belmonte, Kristen E., Connor, Helen E.

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Novel Glucocorticoid Antedrugs Possessing a 17β-(γ-Lactone) Ring von Procopiou, Panayiotis A, Biggadike, Keith, English, Alan F, Farrell, Rosanne M, Hagger, Graham N, Hancock, Ashley P, Haase, Michael V, Irving, Wendy R, Sareen, Meenu, Snowden, Michael A, Solanke, Yemisi E, Tralau-Stewart, Cathy J, Walton, Sarah E, Wood, Jenny A

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Novel glucocorticoid antedrugs possessing a 21-(γ-lactone) ring von Angell, Richard M., Biggadike, Keith, Farrell, Rosanne M., Flack, Stephen S., Hancock, Ashley P., Irving, Wendy R., Lynn, Sean M., Procopiou, Panayiotis A.

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Synthesis and anti-HIV-1 activity of a series of imidazo[1,5-b]pyridazines von Livermore, David G. H, Bethell, Richard C, Cammack, Nicholas, Hancock, Ashley P, Hann, Michael M, Green, Darren V. S, Lamont, R. Brian, Noble, Stewart A, Orr, David C

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The Discovery of Phthalazinone-Based Human H 1 and H 3 Single-Ligand Antagonists Suitable for Intranasal Administration for the Treatment of Allergic Rhinitis von Procopiou, Panayiotis A., Browning, Christopher, Buckley, Jennifer M., Clark, Kenneth L., Fechner, Lise, Gore, Paul M., Hancock, Ashley P., Hodgson, Simon T., Holmes, Duncan S., Kranz, Michael, Looker, Brian E., Morriss, Karen M. L., Parton, Daniel L., Russell, Linda J., Slack, Robert J., Sollis, Steven L., Vile, Sadie, Watts, Clarissa J.

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6,6′-Bis(2-hydroxyphenyl)-2,2′-bipyridine manganese(III) complexes: A novel series of superoxide dismutase and catalase mimetics von Giblin, Gerard M.P, Box, Philip C, Campbell, Ian B, Hancock, Ashley P, Roomans, Susan, Mills, Gary I, Molloy, Christopher, Tranter, George E, Walker, Ann L, Doctrow, Susan R, Huffman, Karl, Malfroy, Bernard

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Semi-synthetic qualestatins: Squalene synthase inhibition and antifungal activity. The SAR of C6 and C7 modifications von Giblin, Gerard M.P., Bell, Richard, Hancock, Ashley P, Hartley, C David, Inglis, Graham G.A., Payne, Jeremy J, Procopiou, Panayiotis A, Shingler, Anthony H, Smith, Colin, Spooner, Stephen J

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