Monomeric Targeted Protein Degraders von Hanan, Emily J, Liang, Jun, Wang, Xiaojing, Blake, Robert A, Blaquiere, Nicole, Staben, Steven T

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Structure of the essential inner membrane lipopolysaccharide–PbgA complex von Clairfeuille, Thomas, Buchholz, Kerry R., Li, Qingling, Verschueren, Erik, Liu, Peter, Sangaraju, Dewakar, Park, Summer, Noland, Cameron L., Storek, Kelly M., Nickerson, Nicholas N., Martin, Lynn, Dela Vega, Trisha, Miu, Anh, Reeder, Janina, Ruiz-Gonzalez, Maria, Swem, Danielle, Han, Guanghui, DePonte, Daniel P., Hunter, Mark S., Gati, Cornelius, Shahidi-Latham, Sheerin, Xu, Min, Skelton, Nicholas, Sellers, Benjamin D., Skippington, Elizabeth, Sandoval, Wendy, Hanan, Emily J., Payandeh, Jian, Rutherford, Steven T.

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Discovery of GDC-0077 (Inavolisib), a Highly Selective Inhibitor and Degrader of Mutant PI3Kα von Hanan, Emily J., Braun, Marie-Gabrielle, Heald, Robert A., MacLeod, Calum, Chan, Connie, Clausen, Saundra, Edgar, Kyle A., Eigenbrot, Charles, Elliott, Richard, Endres, Nicholas, Friedman, Lori S., Gogol, Emily, Gu, Xiao-Hui, Thibodeau, Rebecca Hong, Jackson, Philip S., Kiefer, James R., Knight, Jamie D., Nannini, Michelle, Narukulla, Raman, Pace, Amanda, Pang, Jodie, Purkey, Hans E., Salphati, Laurent, Sampath, Deepak, Schmidt, Stephen, Sideris, Steve, Song, Kyung, Sujatha-Bhaskar, Swathi, Ultsch, Mark, Wallweber, Heidi, Xin, Jianfeng, Yeap, SiewKuen, Young, Amy, Zhong, Yu, Staben, Steven T.

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RTK-Dependent Inducible Degradation of Mutant PI3Kα Drives GDC-0077 (Inavolisib) Efficacy von Song, Kyung W, Edgar, Kyle A, Hanan, Emily J, Hafner, Marc, Oeh, Jason, Merchant, Mark, Sampath, Deepak, Nannini, Michelle A, Hong, Rebecca, Phu, Lilian, Forrest, William F, Stawiski, Eric, Schmidt, Stephen, Endres, Nicholas, Guan, Jane, Wallin, Jeffrey J, Cheong, Jonathan, Plise, Emile G, Lewis Phillips, Gail D, Salphati, Laurent, Heffron, Timothy P, Olivero, Alan G, Malek, Shiva, Staben, Steven T, Kirkpatrick, Donald S, Dey, Anwesha, Friedman, Lori S

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Discovery of Potent and Selective Pyrazolopyrimidine Janus Kinase 2 Inhibitors von Hanan, Emily J, van Abbema, Anne, Barrett, Kathy, Blair, Wade S, Blaney, Jeff, Chang, Christine, Eigenbrot, Charles, Flynn, Sean, Gibbons, Paul, Hurley, Christopher A, Kenny, Jane R, Kulagowski, Janusz, Lee, Leslie, Magnuson, Steven R, Morris, Claire, Murray, Jeremy, Pastor, Richard M, Rawson, Tom, Siu, Michael, Ultsch, Mark, Zhou, Aihe, Sampath, Deepak, Lyssikatos, Joseph P

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Unstable Mechanisms of Resistance to Inhibitors of Escherichia coli Lipoprotein Signal Peptidase von Pantua, Homer, Skippington, Elizabeth, Braun, Marie-Gabrielle, Noland, Cameron L., Diao, Jingyu, Peng, Yutian, Gloor, Susan L., Yan, Donghong, Kang, Jing, Katakam, Anand Kumar, Reeder, Janina, Castanedo, Georgette M., Garland, Keira, Komuves, Laszlo, Sagolla, Meredith, Austin, Cary D., Murray, Jeremy, Xu, Yiming, Modrusan, Zora, Xu, Min, Hanan, Emily J., Kapadia, Sharookh B.

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Noncovalent Mutant Selective Epidermal Growth Factor Receptor Inhibitors: A Lead Optimization Case Study von Heald, Robert, Bowman, Krista K, Bryan, Marian C, Burdick, Daniel, Chan, Bryan, Chan, Emily, Chen, Yuan, Clausen, Saundra, Dominguez-Fernandez, Belen, Eigenbrot, Charles, Elliott, Richard, Hanan, Emily J, Jackson, Philip, Knight, Jamie, La, Hank, Lainchbury, Michael, Malek, Shiva, Mann, Sam, Merchant, Mark, Mortara, Kyle, Purkey, Hans, Schaefer, Gabriele, Schmidt, Stephen, Seward, Eileen, Sideris, Steve, Shao, Lily, Wang, Shumei, Yeap, Kuen, Yen, Ivana, Yu, Christine, Heffron, Timothy P

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Discovery of a class of highly potent Janus Kinase 1/2 (JAK1/2) inhibitors demonstrating effective cell-based blockade of IL-13 signaling von Zak, Mark, Hanan, Emily J., Lupardus, Patrick, Brown, David G., Robinson, Colin, Siu, Michael, Lyssikatos, Joseph P., Romero, F. Anthony, Zhao, Guiling, Kellar, Terry, Mendonca, Rohan, Ray, Nicholas C., Goodacre, Simon C., Crackett, Peter H., McLean, Neville, Hurley, Christopher A., Yuen, Po-wai, Cheng, Yun-Xing, Liu, Xiongcai, Liimatta, Marya, Kohli, Pawan Bir, Nonomiya, Jim, Salmon, Gary, Buckley, Gerry, Lloyd, Julia, Gibbons, Paul, Ghilardi, Nico, Kenny, Jane R., Johnson, Adam

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Optimization of globomycin analogs as novel gram-negative antibiotics von Garland, Keira, Pantua, Homer, Braun, Marie-Gabrielle, Burdick, Daniel J., Castanedo, Georgette M., Chen, Yi-Chen, Cheng, Yun-Xing, Cheong, Jonathan, Daniels, Blake, Deshmukh, Gauri, Fu, Yuhong, Gibbons, Paul, Gloor, Susan L., Hua, Rongbao, Labadie, Sharada, Liu, Xiongcai, Pastor, Richard, Stivala, Craig, Xu, Min, Xu, Yiming, Zheng, Hao, Kapadia, Sharookh B., Hanan, Emily J.

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Discovery of potent dihydro-oxazinoquinolinone inhibitors of GuaB for the treatment of tuberculosis von Zhou, Yuebiao, Aliagas, Ignacio, Wang, Shumei, Li, Chun Sing, Liu, Zhiguo, Bowman, Christine M., Burdick, Daniel J., Clark, Kevin R., Dening, Tahnee J., Flygare, John, Ganti, Anjani, Girgis, Hany S., Hanan, Emily J., Harris, Seth F., Hu, Chloe, Kapadia, Sharookh B., Koehler, Michael F.T., Lai, Tommy, Liang, Jun, Liu, Xingrong, Ma, Fang, Mao, Jialin, Nicolai, Jeremy, Sims, Jessica, Unhayaker, Savita, Wai, John, Wang, Xiaojing, Wu, Ping, Xu, Yiming, Yen, Chun-Wan, Zhang, Renwei, Elfert, Torben F., Tan, Man-Wah, Kofoed, Eric M., Crawford, Terry D.

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4-Aminoindazolyl-dihydrofuro[3,4-d]pyrimidines as non-covalent inhibitors of mutant epidermal growth factor receptor tyrosine kinase von Hanan, Emily J., Baumgardner, Matt, Bryan, Marian C., Chen, Yuan, Eigenbrot, Charles, Fan, Peter, Gu, Xiao-Hui, La, Hank, Malek, Shiva, Purkey, Hans E., Schaefer, Gabriele, Schmidt, Stephen, Sideris, Steve, Yen, Ivana, Yu, Christine, Heffron, Timothy P.

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Discovery of Selective and Noncovalent Diaminopyrimidine-Based Inhibitors of Epidermal Growth Factor Receptor Containing the T790M Resistance Mutation von Hanan, Emily J, Eigenbrot, Charles, Bryan, Marian C, Burdick, Daniel J, Chan, Bryan K, Chen, Yuan, Dotson, Jennafer, Heald, Robert A, Jackson, Philip S, La, Hank, Lainchbury, Michael D, Malek, Shiva, Purkey, Hans E, Schaefer, Gabriele, Schmidt, Stephen, Seward, Eileen M, Sideris, Steve, Tam, Christine, Wang, Shumei, Yeap, Siew Kuen, Yen, Ivana, Yin, Jianping, Yu, Christine, Zilberleyb, Inna, Heffron, Timothy P

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Lipid Tales: Optimizing Arylomycin Membrane Anchors von Koehler, Michael F T, Chen, Yi-Chen, Chen, Yongsheng, Chen, Yuan, Crawford, James J, Durk, Matthew R, Garland, Keira, Hanan, Emily J, Higuchi, Robert I, Hu, Huiyong, Ly, Cuong Q, Paraselli, Prasuna G, Roberts, Tucker C, Schwarz, Jacob B, Smith, Peter A, Yu, Zhiyong, Heise, Christopher E

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Discovery of a Noncovalent, Mutant-Selective Epidermal Growth Factor Receptor Inhibitor von Chan, Bryan K, Hanan, Emily J, Bowman, Krista K, Bryan, Marian C, Burdick, Daniel, Chan, Emily, Chen, Yuan, Clausen, Saundra, Dela Vega, Trisha, Dotson, Jennafer, Eigenbrot, Charles, Elliott, Richard L, Heald, Robert A, Jackson, Philip S, Knight, Jamie D, La, Hank, Lainchbury, Michael D, Malek, Shiva, Purkey, Hans E, Schaefer, Gabriele, Schmidt, Stephen, Seward, Eileen M, Sideris, Steve, Shao, Lily, Wang, Shumei, Yeap, Siew Kuen, Yen, Ivana, Yu, Christine, Heffron, Timothy P

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Discovery of a potent and selective Aurora kinase inhibitor von Oslob, Johan D., Romanowski, Michael J., Allen, Darin A., Baskaran, Subramanian, Bui, Minna, Elling, Robert A., Flanagan, William M., Fung, Amy D., Hanan, Emily J., Harris, Shannon, Heumann, Stacey A., Hoch, Ute, Jacobs, Jeffrey W., Lam, Joni, Lawrence, Chris E., McDowell, Robert S., Nannini, Michelle A., Shen, Wang, Silverman, Jeffrey A., Sopko, Michelle M., Tangonan, Bradley T., Teague, Juli, Yoburn, Josh C., Yu, Chul H., Zhong, Min, Zimmerman, Kristin M., O’Brien, Tom, Lew, Willard

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Discovery and Optimization of C-2 Methyl Imidazopyrrolopyridines as Potent and Orally Bioavailable JAK1 Inhibitors with Selectivity over JAK2 von Zak, Mark, Mendonca, Rohan, Balazs, Mercedesz, Barrett, Kathy, Bergeron, Philippe, Blair, Wade S, Chang, Christine, Deshmukh, Gauri, DeVoss, Jason, Dragovich, Peter S, Eigenbrot, Charles, Ghilardi, Nico, Gibbons, Paul, Gradl, Stefan, Hamman, Chris, Hanan, Emily J, Harstad, Eric, Hewitt, Peter R, Hurley, Christopher A, Jin, Tian, Johnson, Adam, Johnson, Tony, Kenny, Jane R, Koehler, Michael F. T, Bir Kohli, Pawan, Kulagowski, Janusz J, Labadie, Sharada, Liao, Jiangpeng, Liimatta, Marya, Lin, Zhonghua, Lupardus, Patrick J, Maxey, Robert J, Murray, Jeremy M, Pulk, Rebecca, Rodriguez, Madeleine, Savage, Scott, Shia, Steven, Steffek, Micah, Ubhayakar, Savita, Ultsch, Mark, van Abbema, Anne, Ward, Stuart I, Xiao, Ling, Xiao, Yisong

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Pyridones as Highly Selective, Noncovalent Inhibitors of T790M Double Mutants of EGFR von Bryan, Marian C, Burdick, Daniel J, Chan, Bryan K, Chen, Yuan, Clausen, Saundra, Dotson, Jennafer, Eigenbrot, Charles, Elliott, Richard, Hanan, Emily J, Heald, Robert, Jackson, Philip, La, Hank, Lainchbury, Michael, Malek, Shiva, Mann, Sam E, Purkey, Hans E, Schaefer, Gabriele, Schmidt, Stephen, Seward, Eileen, Sideris, Steve, Wang, Shumei, Yen, Ivana, Yu, Christine, Heffron, Timothy P

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Discovery and Development of Potent LFA-1/ICAM-1 Antagonist SAR 1118 as an Ophthalmic Solution for Treating Dry Eye von Zhong, Min, Gadek, Thomas R, Bui, Minna, Shen, Wang, Burnier, John, Barr, Kenneth J, Hanan, Emily J, Oslob, Johan D, Yu, Chul H, Zhu, Jiang, Arkin, Michelle R, Evanchik, Marc J, Flanagan, W. Mike, Hoch, Ute, Hyde, Jennifer, Prabhu, Saileta, Silverman, Jeffrey A, Wright, Jasmin

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Preclinical development of the PI3K Alpha selective and PIK3CA Mutant selective inhibitor GDC-0077 and prediction of its human pharmacokinetics von Pang, Jodie, Baumgardner, Matthew, Braun, Marie-Gabrielle, Cheong, Jonathan, Edgar, Kyle, Friedman, Lori, Hanan, Emily, Jaochico, Allan, Ma, Shuguang, Plise, Emile, Schmidt, Stephen, Liu, Ning, Song, Kyung, Staben, Steve, Salphati, Laurent

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Correction to Noncovalent Mutant Selective Epidermal Growth Factor Receptor Inhibitors: A Lead Optimization Case Study von Heald, Robert, Bowman, Krista K, Bryan, Marian C, Burdick, Daniel, Chan, Bryan, Chan, Emily, Chen, Yuan, Clausen, Saundra, Dominguez-Fernandez, Belen, Eigenbrot, Charles, Elliott, Richard, Hanan, Emily J, Jackson, Philip, Knight, Jamie, La, Hank, Lainchbury, Michael, Malek, Shiva, Mann, Sam, Merchant, Mark, Mortara, Kyle, Purkey, Hans, Schaefer, Gabriele, Schmidt, Stephen, Seward, Eileen, Sideris, Steve, Shao, Lily, Wang, Shumei, Yeap, Kuen, Yen, Ivana, Yu, Christine, Heffron, Timothy P

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