Large-scale prediction and testing of drug activity on side-effect targets von Lounkine, Eugen, Keiser, Michael J., Whitebread, Steven, Mikhailov, Dmitri, Hamon, Jacques, Jenkins, Jeremy L., Lavan, Paul, Weber, Eckhard, Doak, Allison K., Côté, Serge, Shoichet, Brian K., Urban, Laszlo

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Discovery of NVP-BYL719 a potent and selective phosphatidylinositol-3 kinase alpha inhibitor selected for clinical evaluation von Furet, Pascal, Guagnano, Vito, Fairhurst, Robin A., Imbach-Weese, Patricia, Bruce, Ian, Knapp, Mark, Fritsch, Christine, Blasco, Francesca, Blanz, Joachim, Aichholz, Reiner, Hamon, Jacques, Fabbro, Doriano, Caravatti, Giorgio

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Keynote review: In vitro safety pharmacology profiling: an essential tool for successful drug development von Whitebread, Steven, Hamon, Jacques, Bojanic, Dejan, Urban, Laszlo

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Identification of the C3a Receptor (C3AR1) as the Target of the VGF-derived Peptide TLQP-21 in Rodent Cells von Hannedouche, Sebastien, Beck, Valerie, Leighton-Davies, Juliet, Beibel, Martin, Roma, Guglielmo, Oakeley, Edward J., Lannoy, Vincent, Bernard, Jerome, Hamon, Jacques, Barbieri, Samuel, Preuss, Inga, Lasbennes, Marie-Christine, Sailer, Andreas W., Suply, Thomas, Seuwen, Klaus, Parker, Christian N., Bassilana, Frederic

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Reducing safety-related drug attrition: the use of in vitro pharmacological profiling von Bowes, Joanne, Brown, Andrew J., Hamon, Jacques, Jarolimek, Wolfgang, Sridhar, Arun, Waldron, Gareth, Whitebread, Steven

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Structure-based design and synthesis of novel non-zinc chelating MMP-12 inhibitors von Dublanchet, Anne-Claude, Ducrot, Pierre, Andrianjara, Charles, O’Gara, Margaret, Morales, Renaud, Compère, Delphine, Denis, Alexis, Blais, Stéphane, Cluzeau, Philippe, Courté, Karine, Hamon, Jacques, Moreau, François, Prunet, Marie-Laure, Tertre, Anita

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In vitro safety pharmacology profiling : an essential tool for successful drug development von WHITEBREAD, Steven, HAMON, Jacques, BOJANIC, Dejan, URBAN, Laszlo

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Actual share repurchases, timing and liquidity von Ginglinger, Edith, Hamon, Jacques

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Multidimensional De Novo Design Reveals 5-HT2B Receptor-Selective Ligands von Rodrigues, Tiago, Hauser, Nadine, Reker, Daniel, Reutlinger, Michael, Wunderlin, Tiffany, Hamon, Jacques, Koch, Guido, Schneider, Gisbert

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Discovery of WRN inhibitor HRO761 with synthetic lethality in MSI cancers von Ferretti, Stephane, Hamon, Jacques, de Kanter, Ruben, Scheufler, Clemens, Andraos-Rey, Rita, Barbe, Stephanie, Bechter, Elisabeth, Blank, Jutta, Bordas, Vincent, Dammassa, Ernesta, Decker, Andrea, Di Nanni, Noemi, Dourdoigne, Marion, Gavioli, Elena, Hattenberger, Marc, Heuser, Alisa, Hemmerlin, Christelle, Hinrichs, Jürgen, Kerr, Grainne, Laborde, Laurent, Jaco, Isabel, Núñez, Eloísa Jiménez, Martus, Hans-Joerg, Quadt, Cornelia, Reschke, Markus, Romanet, Vincent, Schaeffer, Fanny, Schoepfer, Joseph, Schrapp, Maxime, Strang, Ross, Voshol, Hans, Wartmann, Markus, Welly, Sarah, Zécri, Frédéric, Hofmann, Francesco, Möbitz, Henrik, Cortés-Cros, Marta

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PAX8 and MECOM are interaction partners driving ovarian cancer von Bleu, Melusine, Mermet-Meillon, Fanny, Apfel, Verena, Barys, Louise, Holzer, Laura, Bachmann Salvy, Marianne, Lopes, Rui, Amorim Monteiro Barbosa, Inês, Delmas, Cecile, Hinniger, Alexandra, Chau, Suzanne, Kaufmann, Markus, Haenni, Simon, Berneiser, Karolin, Wahle, Maria, Moravec, Ivana, Vissières, Alexandra, Poetsch, Tania, Ahrné, Erik, Carte, Nathalie, Voshol, Johannes, Bechter, Elisabeth, Hamon, Jacques, Meyerhofer, Marco, Erdmann, Dirk, Fischer, Matteo, Stachyra, Therese, Freuler, Felix, Gutmann, Sascha, Fernández, César, Schmelzle, Tobias, Naumann, Ulrike, Roma, Guglielmo, Lawrenson, Kate, Nieto-Oberhuber, Cristina, Cobos-Correa, Amanda, Ferretti, Stephane, Schübeler, Dirk, Galli, Giorgio Giacomo

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Mapping Adverse Drug Reactions in Chemical Space von Scheiber, Josef, Jenkins, Jeremy L, Sukuru, Sai Chetan K, Bender, Andreas, Mikhailov, Dmitri, Milik, Mariusz, Azzaoui, Kamal, Whitebread, Steven, Hamon, Jacques, Urban, Laszlo, Glick, Meir, Davies, John W

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Challenges for the Discovery of Non‐Covalent WRN Helicase Inhibitors von Heuser, Alisa, Abdul Rahman, Wassim, Bechter, Elisabeth, Blank, Jutta, Buhr, Sylvia, Erdmann, Dirk, Fontana, Patrizia, Mermet‐Meillon, Fanny, Meyerhofer, Marco, Strang, Ross, Schrapp, Maxime, Zimmermann, Catherine, Cortes‐Cros, Marta, Möbitz, Henrik, Hamon, Jacques

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Front Cover: Challenges for the Discovery of Non‐Covalent WRN Helicase Inhibitors (ChemMedChem 8/2024) von Heuser, Alisa, Abdul Rahman, Wassim, Bechter, Elisabeth, Blank, Jutta, Buhr, Sylvia, Erdmann, Dirk, Fontana, Patrizia, Mermet‐Meillon, Fanny, Meyerhofer, Marco, Strang, Ross, Schrapp, Maxime, Zimmermann, Catherine, Cortes‐Cros, Marta, Möbitz, Henrik, Hamon, Jacques

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Alkylamides from Echinacea are a new class of cannabinomimetics. Cannabinoid type 2 receptor-dependent and -independent immunomodulatory effects von Raduner, Stefan, Majewska, Adriana, Chen, Jian-Zhong, Xie, Xiang-Qun, Hamon, Jacques, Faller, Bernard, Altmann, Karl-Heinz, Gertsch, Jürg

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Alkylamides from Echinacea Are a New Class of Cannabinomimetics von Raduner, Stefan, Majewska, Adriana, Chen, Jian-Zhong, Xie, Xiang-Qun, Hamon, Jacques, Faller, Bernard, Altmann, Karl-Heinz, Gertsch, Jürg

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Modeling Promiscuity Based on in vitro Safety Pharmacology Profiling Data von Azzaoui, Kamal, Hamon, Jacques, Faller, Bernard, Whitebread, Steven, Jacoby, Edgar, Bender, Andreas, Jenkins, Jeremy L., Urban, Laszlo

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Analysis of Pharmacology Data and the Prediction of Adverse Drug Reactions and Off-Target Effects from Chemical Structure von Bender, Andreas, Scheiber, Josef, Glick, Meir, Davies, John W., Azzaoui, Kamal, Hamon, Jacques, Urban, Laszlo, Whitebread, Steven, Jenkins, Jeremy L.

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Gaining Insight into Off-Target Mediated Effects of Drug Candidates with a Comprehensive Systems Chemical Biology Analysis von Scheiber, Josef, Chen, Bin, Milik, Mariusz, Sukuru, Sai Chetan K, Bender, Andreas, Mikhailov, Dmitri, Whitebread, Steven, Hamon, Jacques, Azzaoui, Kamal, Urban, Laszlo, Glick, Meir, Davies, John W, Jenkins, Jeremy L

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Multidimensional DeNovo Design Reveals 5-HT2B Receptor-Selective Ligands von Rodrigues, Tiago, Hauser, Nadine, Reker, Daniel, Reutlinger, Michael, Wunderlin, Tiffany, Hamon, Jacques, Koch, Guido, Schneider, Gisbert

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