Structural basis for GPR40 allosteric agonism and incretin stimulation von Ho, Joseph D., Chau, Betty, Rodgers, Logan, Lu, Frances, Wilbur, Kelly L., Otto, Keith A., Chen, Yanyun, Song, Min, Riley, Jonathan P., Yang, Hsiu-Chiung, Reynolds, Nichole A., Kahl, Steven D., Lewis, Anjana Patel, Groshong, Christopher, Madsen, Russell E., Conners, Kris, Lineswala, Jayana P., Gheyi, Tarun, Saflor, Melbert-Brian Decipulo, Lee, Matthew R., Benach, Jordi, Baker, Kenton A., Montrose-Rafizadeh, Chahrzad, Genin, Michael J., Miller, Anne R., Hamdouchi, Chafiq

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New Ref-1/APE1 targeted inhibitors demonstrating improved potency for clinical applications in multiple cancer types von Gampala, Silpa, Moon, Hye-ran, Wireman, Randall, Peil, Jacqueline, Kiran, Sonia, Mitchell, Dana K., Brewster, Kylee, Mang, Henry, Masters, Andi, Bach, Christine, Smith-Kinnamen, Whitney, Doud, Emma H., Rai, Ratan, Mosley, Amber L., Quinney, Sara K., Clapp, D. Wade, Hamdouchi, Chafiq, Wikel, James, Zhang, Chi, Han, Bumsoo, Georgiadis, Millie M., Kelley, Mark R., Fishel, Melissa L.

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Delayed Functional Expression of Neuronal Chemokine Receptors Following Focal Nerve Demyelination in the Rat: A Mechanism for the Development of Chronic Sensitization of Peripheral... von Bhangoo, Sonia, Ren, Dongjun, Miller, Richard J, Henry, Kenneth J, Lineswala, Jayana, Hamdouchi, Chafiq, Li, Baolin, Monahan, Patrick E, Chan, David M, Ripsch, Matthew S, White, Fletcher A

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2-Amino-3-substituted-6-[(E)-1-phenyl-2-(N-methylcarbamoyl)vinyl]imidazo[1,2-a]pyridines as a Novel Class of Inhibitors of Human Rhinovirus:  Stereospecific Synthesis and Antiviral... von Hamdouchi, Chafiq, de Blas, Jesús, del Prado, Mirian, Gruber, Joseph, Heinz, Beverly A, Vance, Lori

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Novel route to the synthesis of 4-quinolyl isothiocyanates von Zhong, Boyu, Al-Awar, Rima S., Shih, Chuan, Grimes, John H., Vieth, Michal, Hamdouchi, Chafiq

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The Role of GPR40 (FFAR1) in Pharmacological vs Physiological Control of Incretin Secretion von Chen, Yanyun, Song, Min, Riley, Jonathan, Reynolds, Nichole, Hamdouchi, Chafiq, Miller, Anne

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The Discovery, Preclinical, and Early Clinical Development of Potent and Selective GPR40 Agonists for the Treatment of Type 2 Diabetes Mellitus (LY2881835, LY2922083, and LY2922470... von Hamdouchi, Chafiq, Kahl, Steven D, Patel Lewis, Anjana, Cardona, Guemalli R, Zink, Richard W, Chen, Keyue, Eessalu, Thomas E, Ficorilli, James V, Marcelo, Marialuisa C, Otto, Keith A, Wilbur, Kelly L, Lineswala, Jayana P, Piper, Jared L, Coffey, D. Scott, Sweetana, Stephanie A, Haas, Joseph V, Brooks, Dawn A, Pratt, Edward J, Belin, Ruth M, Deeg, Mark A, Ma, Xiaosu, Cannady, Ellen A, Johnson, Jason T, Yumibe, Nathan P, Chen, Qi, Maiti, Pranab, Montrose-Rafizadeh, Chahrzad, Chen, Yanyun, Reifel Miller, Anne

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The discovery of a new structural class of cyclin-dependent kinase inhibitors, aminoimidazo[1,2-a]pyridines von Hamdouchi, Chafiq, Keyser, Heather, Collins, Elizabeth, Jaramillo, Carlos, De Diego, Jose Eugenio, Spencer, Charles D, Dempsey, Jack Alan, Anderson, Bryan D, Leggett, Tillie, Stamm, Nancy B, Schultz, Richard M, Watkins, Scott A, Cocke, Kim, Lemke, Stephanie, Burke, Teresa F, Beckmann, Richard P, Dixon, Jeffrey T, Gurganus, Thomas M, Rankl, Nancy B, Houck, Keith A, Zhang, Faming, Vieth, Michal, Espinosa, Juan, Timm, David E, Campbell, Robert M, Patel, Bharvin K R, Brooks, Harold B

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3-(4-Chloro-2-Morpholin-4-yl-Thiazol-5-yl)-8-(1-Ethylpropyl)-2,6-Dimethyl-Imidazo[1,2-b]Pyridazine: A Novel Brain-Penetrant, Orally Available Corticotropin-Releasing Factor Recepto... von Gehlert, Donald R, Cippitelli, Andrea, Thorsell, Annika, Le, Anh Dzung, Hipskind, Philip A, Hamdouchi, Chafiq, Lu, Jianliang, Hembre, Erik J, Cramer, Jeffrey, Song, Min, McKinzie, David, Morin, Michelle, Ciccocioppo, Roberto, Heilig, Markus

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Discovery of LY3104607: A Potent and Selective G Protein-Coupled Receptor 40 (GPR40) Agonist with Optimized Pharmacokinetic Properties to Support Once Daily Oral Treatment in Patie... von Hamdouchi, Chafiq, Maiti, Pranab, Warshawsky, Alan M, DeBaillie, Amy C, Otto, Keith A, Wilbur, Kelly L, Kahl, Steven D, Patel Lewis, Anjana, Cardona, Guemalli R, Zink, Richard W, Chen, Keyue, CR, Siddaramaiah, Lineswala, Jayana P, Neathery, Grace L, Bouaichi, Cecilia, Diseroad, Benjamin A, Campbell, Alison N, Sweetana, Stephanie A, Adams, Lisa A, Cabrera, Over, Ma, Xiaosu, Yumibe, Nathan P, Montrose-Rafizadeh, Chahrzad, Chen, Yanyun, Miller, Anne Reifel

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A novel application of the Ullmann coupling reaction for the alkylsulfenylation of 2-amino-imidazo[1,2- a]pyridine von Hamdouchi, Chafiq, de Blas, Jesús, Ezquerra, Jesús

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Regioselective synthesis of 3,6-disubstituted-2-aminoimidazo[1,2- a]pyridines von Jaramillo, Carlos, Carretero, Juan Carlos, de Diego, J.Eugenio, del Prado, Miriam, Hamdouchi, Chafiq, Roldán, José Luis, Sánchez-Martı́nez, Concha

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Abstract C129: Development of new increased potency Ref-1/APE1 targeted inhibitors that show promise for clinical applications against solid tumors von Gampala, Silpa, Moon, Hye-Ran, Wireman, Randall, Peil, Jacqueline, Kiran, Sonia, Masters, Andi, Bach, Christine, Smith-Kinnamen, Whitney, Doud, Emma, Rai, Ratan, Mosley, Amber L, Georgiadis, Millie M, Han, Bumsoo, Zhang, Chi, Hamdouchi, Chafiq, Wikel, James, Kelley, Mark R, Fishel, Melissa L

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A new approach to the asymmetric cyclopropanation via a chiral sulfinyl group von Hamdouchi, Chafiq

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Cloning and functional characterization of the rabbit C-C chemokine receptor 2 von Lu, Deshun, Yuan, Xiu-juan, Evans, Jr, Robert J, Pappas, Amy T, Wang, He, Su, Eric W, Hamdouchi, Chafiq, Venkataraman, Chandrasekar

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Structure-based design of a new class of highly selective aminoimidazo[1,2- a]pyridine-based inhibitors of cyclin dependent kinases von Hamdouchi, Chafiq, Zhong, Boyu, Mendoza, Jose, Collins, Elizabeth, Jaramillo, Carlos, De Diego, Jose Eugenio, Robertson, Daniel, Spencer, Charles D., Anderson, Bryan D., Watkins, Scott A., Zhang, Faming, Brooks, Harold B.

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Stress-related neuropeptides and alcoholism: CRH, NPY, and beyond von Ciccocioppo, Roberto, Gehlert, Donald R, Ryabinin, Andrey, Kaur, Simranjit, Cippitelli, Andrea, Thorsell, Annika, Lê, Anh D, Hipskind, Philip A, Hamdouchi, Chafiq, Lu, Jianliang, Hembre, Erik J, Cramer, Jeffrey, Song, Min, McKinzie, David, Morin, Michelle, Economidou, Daina, Stopponi, Serena, Cannella, Nazzareno, Braconi, Simone, Kallupi, Marsida, de Guglielmo, Giordano, Massi, Maurizio, George, David T, Gilman, Jody, Hersh, Jacqueline, Tauscher, Johannes T, Hunt, Stephen P, Hommer, Daniel, Heilig, Markus

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A selective GPR40 (FFAR1) agonist LY2881835 provides immediate and durable glucose control in rodent models of type 2 diabetes von Chen, Yanyun, Song, Min, Riley, Jonathan P., Hu, Charlie C., Peng, Xianbu, Scheuner, Donalyn, Bokvist, Krister, Maiti, Pranab, Kahl, Steven D., Montrose‐Rafizadeh, Chahrzad, Hamdouchi, Chafiq, Miller, Anne Reifel

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Inhibition of inflammatory gene expression in adipose tissue and development of glucose intolerance in DIO mice by a chemokine receptor 2/5 dual antagonist von Yu, Xiaohong, Wang, Guoming, Hamdouchi, Chafiq, Kowala, Mark, Zimmerman, Karen, Singh, Jaipal

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Application of the low-valent titanium reductive elimination of 1,6-dibenzoate-2,4-dienes to the total synthesis of 6(E)-5(S)-12(R)-leukotriene B4 von SOLLADIE, G, STONE, G. B, CHAFIQ HAMDOUCHI

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