Histone methylation status of H3K4me3 and H3K9me3 under methionine restriction is unstable in methionine-addicted cancer cells, but stable in normal cells von Yamamoto, Jun, Han, Qinghong, Inubushi, Sachiko, Sugisawa, Norihiko, Hamada, Kazuyuki, Nishino, Hiroto, Miyake, Kentaro, Kumamoto, Takafumi, Matsuyama, Ryusei, Bouvet, Michael, Endo, Itaru, Hoffman, Robert M.

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Gas-filled Cavities in the Liver von Hamada, Kazuyuki, Sasaki, Yasutsuna

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Emerging Immune-Monitoring System for Immune Checkpoint Inhibitors von Hamada, Kazuyuki, Tsunoda, Takuya, Yoshimura, Kiyoshi

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A high number of PD-L1+ CD14+ monocytes in peripheral blood is correlated with shorter survival in patients receiving immune checkpoint inhibitors von Ando, Kiyohiro, Hamada, Kazuyuki, Shida, Midori, Ohkuma, Ryotaro, Kubota, Yutaro, Horiike, Atsushi, Matsui, Hiroto, Ishiguro, Tomoyuki, Hirasawa, Yuya, Ariizumi, Hirotsugu, Watanabe, Makoto, Onoue, Rie, Tsurutani, Junji, Yoshimura, Kiyoshi, Tsunoda, Takuya, Kobayashi, Shinichi, Wada, Satoshi

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Lack of correlation between the costs of anticancer drugs and clinical benefits in Japan von Satoh, Etsuko, Sasaki, Yasutsuna, Ohkuma, Ryotaro, Takahashi, Takehiro, Kubota, Yutaro, Ishida, Hiroo, Hamada, Kazuyuki, Kiuchi, Yuji, Tsunoda, Takuya

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Reversion of methionine addiction of osteosarcoma cells to methionine independence results in loss of malignancy, modulation of the epithelial-mesenchymal phenotype and alteration... von Aoki, Yusuke, Han, Qinghong, Tome, Yasunori, Yamamoto, Jun, Kubota, Yutaro, Masaki, Noriyuki, Obara, Koya, Hamada, Kazuyuki, Wang, Justin D., Inubushi, Sachiko, Bouvet, Michael, Clarke, Steven G., Nishida, Kotaro, Hoffman, Robert M.

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Turicibacter and Acidaminococcus predict immune-related adverse events and efficacy of immune checkpoint inhibitor von Hamada, Kazuyuki, Isobe, Junya, Hattori, Kouya, Hosonuma, Masahiro, Baba, Yuta, Murayama, Masakazu, Narikawa, Yoichiro, Toyoda, Hitoshi, Funayama, Eiji, Tajima, Kohei, Shida, Midori, Hirasawa, Yuya, Tsurui, Toshiaki, Ariizumi, Hirotsugu, Ishiguro, Tomoyuki, Suzuki, Risako, Ohkuma, Ryotaro, Kubota, Yutaro, Sambe, Takehiko, Tsuji, Mayumi, Wada, Satoshi, Kiuchi, Yuji, Kobayashi, Shinichi, Kuramasu, Atsuo, Horiike, Atsushi, Kim, Yun-Gi, Tsunoda, Takuya, Yoshimura, Kiyoshi

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Isobutyric acid enhances the anti-tumour effect of anti-PD-1 antibody von Murayama, Masakazu, Hosonuma, Masahiro, Kuramasu, Atsuo, Kobayashi, Sei, Sasaki, Akiko, Baba, Yuta, Narikawa, Yoichiro, Toyoda, Hitoshi, Isobe, Junya, Funayama, Eiji, Tajima, Kohei, Sasaki, Aya, Maruyama, Yuki, Yamazaki, Yoshitaka, Shida, Midori, Hamada, Kazuyuki, Hirasawa, Yuya, Tsurui, Toshiaki, Ariizumi, Hirotsugu, Ishiguro, Tomoyuki, Suzuki, Risako, Ohkuma, Ryotaro, Kubota, Yutaro, Horiike, Atsushi, Sambe, Takehiko, Tsuji, Mayumi, Wada, Satoshi, Kobayashi, Shinichi, Shimane, Toshikazu, Tsunoda, Takuya, Kobayashi, Hitome, Kiuchi, Yuji, Yoshimura, Kiyoshi

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Obesity Strongly Promotes Growth of Mouse MC38 Colon Cancer in an Orthotopic-syngeneic C57BL/6 Mouse Model von HAMADA, KAZUYUKI, KUBOTA, YUTARO, AOKI, YUSUKE, SUGISAWA, NORIHIKO, YAMAMOTO, JUN, TASHIRO, YOSHIHIKO, BOUVET, MICHAEL, TSUNODA, TAKUYA, HOFFMAN, ROBERT M.

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A case report on severe nivolumab-induced adverse events similar to primary sclerosing cholangitis refractory to immunosuppressive therapy von Hirasawa, Yuya, Yoshimura, Kiyoshi, Matsui, Hiroto, Kubota, Yutaro, Ishida, Hiroo, Arai, Jun, Sakaki, Masashi, Oguro, Nao, Shida, Midori, Taniguchi, Makoto, Hamada, Kazuyuki, Ariizumi, Hirotsugu, Ishiguro, Tomoyuki, Ohkuma, Ryotaro, Sambe, Takehiko, Horiike, Atsushi, Imamura, Chiyo K., Shiozawa, Eisuke, Wada, Satoshi, Tsurutani, Junji, Iwamoto, Sanju, Uchida, Naoki, Kiuchi, Yuji, Tate, Genshu, Kobayashi, Shinichi, Tsunoda, Takuya

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Linkage of methionine addiction, histone lysine hypermethylation, and malignancy von Yamamoto, Jun, Inubushi, Sachiko, Han, Qinghong, Tashiro, Yoshihiko, Sugisawa, Norihiko, Hamada, Kazuyuki, Aoki, Yusuke, Miyake, Kentaro, Matsuyama, Ryusei, Bouvet, Michael, Clarke, Steven G., Endo, Itaru, Hoffman, Robert M.

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High expression of olfactomedin-4 is correlated with chemoresistance and poor prognosis in pancreatic cancer von Ohkuma, Ryotaro, Yada, Erica, Ishikawa, Shumpei, Komura, Daisuke, Ishizaki, Hidenobu, Tamada, Koji, Kubota, Yutaro, Hamada, Kazuyuki, Ishida, Hiroo, Hirasawa, Yuya, Ariizumi, Hirotsugu, Satoh, Etsuko, Shida, Midori, Watanabe, Makoto, Onoue, Rie, Ando, Kiyohiro, Tsurutani, Junji, Yoshimura, Kiyoshi, Yokobori, Takehiko, Sasada, Tetsuro, Aoki, Takeshi, Murakami, Masahiko, Norose, Tomoko, Ohike, Nobuyuki, Takimoto, Masafumi, Izumizaki, Masahiko, Kobayashi, Shinichi, Tsunoda, Takuya, Wada, Satoshi

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Over-methylation of Histone H3 Lysines Is a Common Molecular Change Among the Three Major Types of Soft-tissue Sarcoma in Patient-derived Xenograft (PDX) Mouse Models von AOKI, YUSUKE, YAMAMOTO, JUN, TOME, YASUNORI, HAMADA, KAZUYUKI, MASAKI, NORIYUKI, INUBUSHI, SACHIKO, TASHIRO, YOSHIHIKO, BOUVET, MICHAEL, ENDO, ITARU, NISHIDA, KOTARO, HOFFMAN, ROBERT M.

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Histone H3 lysine-trimethylation markers are decreased by recombinant methioninase and increased by methotrexate at concentrations which inhibit methionine-addicted osteosarcoma ce... von Aoki, Yusuke, Tome, Yasunori, Han, Qinghong, Yamamoto, Jun, Hamada, Kazuyuki, Masaki, Noriyuki, Bouvet, Michael, Nishida, Kotaro, Hoffman, Robert M.

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Case Report: Combined pembrolizumab, 5-fluorouracil, and cisplatin therapy were remarkably effective in p16-positive squamous cell carcinoma of unknown primary von Suzuki, Risako, Hamada, Kazuyuki, Ohkuma, Ryotaro, Homma, Mayumi, Tsurui, Toshiaki, Iriguchi, Nana, Ishiguro, Tomoyuki, Hirasawa, Yuya, Ariizumi, Hirotsugu, Kubota, Yutaro, Horiike, Atsushi, Yoshimura, Kiyoshi, Wada, Satoshi, Yamochi, Toshiko, Tsunoda, Takuya

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Good response to tolvaptan shortens hospitalization in patients with congestive heart failure von Kogure, Tomohito, Jujo, Kentaro, Hamada, Kazuyuki, Saito, Katsumi, Hagiwara, Nobuhisa

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Increased Plasma Soluble PD-1 Concentration Correlates with Disease Progression in Patients with Cancer Treated with Anti-PD-1 Antibodies von Ohkuma, Ryotaro, Ieguchi, Katsuaki, Watanabe, Makoto, Takayanagi, Daisuke, Goshima, Tsubasa, Onoue, Rie, Hamada, Kazuyuki, Kubota, Yutaro, Horiike, Atsushi, Ishiguro, Tomoyuki, Hirasawa, Yuya, Ariizumi, Hirotsugu, Tsurutani, Junji, Yoshimura, Kiyoshi, Tsuji, Mayumi, Kiuchi, Yuji, Kobayashi, Shinichi, Tsunoda, Takuya, Wada, Satoshi

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Wnt/β-Catenin Signaling and Resistance to Immune Checkpoint Inhibitors: From Non-Small-Cell Lung Cancer to Other Cancers von Muto, Satoshi, Enta, Akio, Maruya, Yoshiyuki, Inomata, Sho, Yamaguchi, Hikaru, Mine, Hayato, Takagi, Hironori, Ozaki, Yuki, Watanabe, Masayuki, Inoue, Takuya, Yamaura, Takumi, Fukuhara, Mitsuro, Okabe, Naoyuki, Matsumura, Yuki, Hasegawa, Takeo, Osugi, Jun, Hoshino, Mika, Higuchi, Mitsunori, Shio, Yutaka, Hamada, Kazuyuki, Suzuki, Hiroyuki

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Sutureless Surgical Orthotopic Implantation Technique of Primary and Metastatic Cancer in the Liver of Mouse Models von Nishino, Hiroto, Hollandsworth, Hannah M, Sugisawa, Norihiko, Yamamoto, Jun, Tashiro, Yoshihiko, Inubushi, Sachiko, Hamada, Kazuyuki, Sun, Y U, Lim, Hyein, Amirfakhri, Siamak, Filemoni, Filemoni, Hoffman, Robert M, Bouvet, Michael

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Is repeating FOLFIRINOX in the original dosage and treatment schedule tolerable in Japanese patients with pancreatic cancer? von Sasaki, Yasutsuna, Hamada, Kazuyuki, Kaneta, Toshikado, Takahashi, Takehiro, Kubota, Yutaro, Ishida, Hiroo, Ichikawa, Wataru

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