Dysregulation of the mevalonate pathway promotes transformation von Clendening, James W., Pandyra, Aleks, Boutros, Paul C., Ghamrasni, Samah El, Khosravi, Fereshteh, Trentin, Grace A., Martirosyan, Anna, Hakem, Anne, Hakem, Razqallah, Jurisica, Igor, Penn, Linda Z., Mak, Tak Wah

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RNF168 ubiquitylates 53BP1 and controls its response to DNA double-strand breaks von Bohgaki, Miyuki, Bohgaki, Toshiyuki, El Ghamrasni, Samah, Srikumar, Tharan, Maire, Georges, Panier, Stephanie, Fradet-Turcotte, Amélie, Stewart, Grant S., Raught, Brian, Hakem, Anne, Hakem, Razqallah

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RNF168 and USP10 regulate topoisomerase IIα function via opposing effects on its ubiquitylation von Guturi, Kiran Kumar Naidu, Bohgaki, Miyuki, Bohgaki, Toshiyuki, Srikumar, Tharan, Ng, Deborah, Kumareswaran, Ramya, El Ghamrasni, Samah, Jeon, Justin, Patel, Parasvi, Eldin, Mohamed Saad, Bristow, Rob, Cheung, Peter, Stewart, Grant S., Raught, Brian, Hakem, Anne, Hakem, Razqallah

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Rnf8 deficiency impairs class switch recombination, spermatogenesis, and genomic integrity and predisposes for cancer von Li, Li, Halaby, Marie-Jo, Hakem, Anne, Cardoso, Renato, El Ghamrasni, Samah, Harding, Shane, Chan, Norman, Bristow, Robert, Sanchez, Otto, Durocher, Daniel, Hakem, Razqallah

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Pirh2 E3 Ubiquitin Ligase Monoubiquitinates DNA Polymerase Eta To Suppress Translesion DNA Synthesis von Jung, Yong-Sam, Hakem, Anne, Hakem, Razqallah, Chen, Xinbin

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RhoC is dispensable for embryogenesis and tumor initiation but essential for metastasis von Hakem, Anne, Sanchez-Sweatman, Otto, You-Ten, Annick, Duncan, Gordon, Wakeham, Andrew, Khokha, Rama, Mak, Tak W

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Genomic instability, defective spermatogenesis, immunodeficiency, and cancer in a mouse model of the RIDDLE syndrome von Bohgaki, Toshiyuki, Bohgaki, Miyuki, Cardoso, Renato, Panier, Stephanie, Zeegers, Dimphy, Li, Li, Stewart, Grant S, Sanchez, Otto, Hande, M Prakash, Durocher, Daniel, Hakem, Anne, Hakem, Razqallah

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A high-throughput approach to identify BRCA1-downregulating compounds to enhance PARP inhibitor sensitivity von Sellars, Erin, Savguira, Margarita, Wu, Jie, Cancelliere, Sabrina, Jen, Mark, Krishnan, Rehna, Hakem, Anne, Barsyte-Lovejoy, Dalia, Hakem, Razqallah, Narod, Steven A., Kotsopoulos, Joanne, Salmena, Leonardo

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Lats2/Kpm is required for embryonic development, proliferation control and genomic integrity von McPherson, John Peter, Tamblyn, Laura, Elia, Andrew, Migon, Eva, Shehabeldin, Amro, Matysiak-Zablocki, Elzbieta, Lemmers, Bénédicte, Salmena, Leonardo, Hakem, Anne, Fish, Jason, Kassam, Farah, Squire, Jeremy, Bruneau, Benoit G, Hande, M Prakash, Hakem, Razqallah

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Role of Pirh2 in mediating the regulation of p53 and c-Myc von Hakem, Anne, Bohgaki, Miyuki, Lemmers, Bénédicte, Tai, Elisabeth, Salmena, Leonardo, Matysiak-Zablocki, Elzbieta, Jung, Yong-Sam, Karaskova, Jana, Kaustov, Lilia, Duan, Shili, Madore, Jason, Boutros, Paul, Sheng, Yi, Chesi, Marta, Bergsagel, P Leif, Perez-Ordonez, Bayardo, Mes-Masson, Anne-Marie, Penn, Linda, Squire, Jeremy, Chen, Xinbin, Jurisica, Igor, Arrowsmith, Cheryl, Sanchez, Otto, Benchimol, Samuel, Hakem, Razqallah

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Apaf1 Is Required for Mitochondrial Pathways of Apoptosis and Brain Development von Yoshida, Hiroki, Kong, Young-Yun, Yoshida, Ritsuko, Elia, Andrew J, Hakem, Anne, Hakem, Razqallah, Penninger, Josef M, Mak, Tak W

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Synergistic interaction of Rnf8 and p53 in the protection against genomic instability and tumorigenesis von Halaby, Marie-Jo, Hakem, Anne, Li, Li, El Ghamrasni, Samah, Venkatesan, Shriram, Hande, Prakash M, Sanchez, Otto, Hakem, Razqallah

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Inactivation of chk2 and mus81 leads to impaired lymphocytes development, reduced genomic instability, and suppression of cancer von El Ghamrasni, Samah, Pamidi, Ashwin, Halaby, Marie Jo, Bohgaki, Miyuki, Cardoso, Renato, Li, Li, Venkatesan, Shriram, Sethu, Swaminathan, Hirao, Atsushi, Mak, Tak W, Hande, Manoor Prakash, Hakem, Anne, Hakem, Razqallah

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Functional interplay of p53 and Mus81 in DNA damage responses and cancer von PAMIDI, Ashwin, CARDOSO, Renato, HAKEM, Anne, MATYSIAK-ZABLOCKI, Elzbieta, POONEPALLI, Anuradha, TAMBLYN, Laura, PEREZ-ORDONEZ, Bayardo, PRAKASH HANDE, M, SANCHEZ, Otto, HAKEM, Razqallah

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Collaboration of Brca1 and Chk2 in tumorigenesis von McPherson, John Peter, Lemmers, Bénédicte, Hirao, Atsushi, Hakem, Anne, Abraham, Jacinth, Migon, Eva, Matysiak-Zablocki, Elzbieta, Tamblyn, Laura, Sanchez-Sweatman, Otto, Khokha, Rama, Squire, Jeremy, Hande, M Prakash, Mak, Tak W, Hakem, Razqallah

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Pirh2: An E3 ligase with central roles in the regulation of cell cycle, DNA damage response, and differentiation von Halaby, Marie-jo, Hakem, Razqallah, Hakem, Anne

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DNA double-strand break–capturing nuclear envelope tubules drive DNA repair von Shokrollahi, Mitra, Stanic, Mia, Hundal, Anisha, Chan, Janet N. Y., Urman, Defne, Jordan, Chris A., Hakem, Anne, Espin, Roderic, Hao, Jun, Krishnan, Rehna, Maass, Philipp G., Dickson, Brendan C., Hande, Manoor P., Pujana, Miquel A., Hakem, Razqallah, Mekhail, Karim

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RNF168 regulates R-loop resolution and genomic stability in BRCA1/2-deficient tumors von Patel, Parasvi S, Abraham, Karan Joshua, Guturi, Kiran Kumar Naidu, Halaby, Marie-Jo, Khan, Zahra, Palomero, Luis, Ho, Brandon, Duan, Shili, St-Germain, Jonathan, Algouneh, Arash, Mateo, Francesca, El Ghamrasni, Samah, Barbour, Haithem, Barnes, Daniel R, Beesley, Jonathan, Sanchez, Otto, Berman, Hal K, Brown, Grant W, Affar, El Bachir, Chenevix-Trench, Georgia, Antoniou, Antonis C, Arrowsmith, Cheryl H, Raught, Brian, Pujana, Miquel Angel, Mekhail, Karim, Hakem, Anne, Hakem, Razqallah

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The cyclin-dependent kinase Cdk2 regulates thymocyte apoptosis von Hakem, A, Sasaki, T, Kozieradzki, I, Penninger, J M

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Dual Role of Caspase 8 in Adipocyte Apoptosis and Metabolic Inflammation von Luk, Cynthia T., Chan, Carmen K., Chiu, Felix, Shi, Sally Yu, Misra, Paraish S., Li, Yu Zhe, Pollock-Tahiri, Evan, Schroer, Stephanie A., Desai, Harsh R., Sivasubramaniyam, Tharini, Cai, Erica P., Krishnamurthy, Mansa, Han, Daniel J., Chowdhury, Apu, Aslam, Rukhsana, Yuen, Darren A., Hakem, Anne, Hakem, Razqallah, Woo, Minna

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