An Unbiased Oncology Compound Screen to Identify Novel Combination Strategies von O'Neil, Jennifer, Benita, Yair, Feldman, Igor, Chenard, Melissa, Roberts, Brian, Liu, Yaping, Li, Jing, Kral, Astrid, Lejnine, Serguei, Loboda, Andrey, Arthur, William, Cristescu, Razvan, Haines, Brian B, Winter, Christopher, Zhang, Theresa, Bloecher, Andrew, Shumway, Stuart D

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Development of intravenously administered synthetic RNA virus immunotherapy for the treatment of cancer von Kennedy, Edward M., Denslow, Agnieszka, Hewett, Jacqueline, Kong, Lingxin, De Almeida, Ana, Bryant, Jeffrey D., Lee, Jennifer S., Jacques, Judy, Feau, Sonia, Hayes, Melissa, McMichael, Elizabeth L., Wambua, Daniel, Farkaly, Terry, Rahmeh, Amal A, Herschelman, Lauren, Douglas, Danielle, Spinale, Jacob, Adhikari, Sanmit, Deterling, Jessica, Scott, Matt, Haines, Brian B., Finer, Mitchell H., Ashburn, Ted T, Quéva, Christophe, Lerner, Lorena

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Discovery of biomarkers predictive of GSI response in triple-negative breast cancer and adenoid cystic carcinoma von Stoeck, Alexander, Lejnine, Serguei, Truong, Andrew, Pan, Li, Wang, Hongfang, Zang, Chongzhi, Yuan, Jing, Ware, Chris, MacLean, John, Garrett-Engele, Philip W, Kluk, Michael, Laskey, Jason, Haines, Brian B, Moskaluk, Christopher, Zawel, Leigh, Fawell, Stephen, Gilliland, Gary, Zhang, Theresa, Kremer, Brandon E, Knoechel, Birgit, Bernstein, Bradley E, Pear, Warren S, Liu, X Shirley, Aster, Jon C, Sathyanarayanan, Sriram

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Combination of EP4 antagonist MF-766 and anti-PD-1 promotes anti-tumor efficacy by modulating both lymphocytes and myeloid cells von Wang, Yun, Cui, Long, Georgiev, Peter, Singh, Latika, Zheng, Yanyan, Yu, Ying, Grein, Jeff, Zhang, Chunsheng, Muise, Eric S., Sloman, David L., Ferguson, Heidi, Yu, Hongshi, Pierre, Cristina St, Dakle, Pranal J, Pucci, Vincenzo, Baker, James, Loboda, Andrey, Linn, Doug, Brynczka, Christopher, Wilson, Doug, Haines, Brian B, Long, Brian, Wnek, Richard, Sadekova, Svetlana, Rosenzweig, Michael, Haidle, Andrew, Han, Yongxin, Ranganath, Sheila H.

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Combination of the mTOR inhibitor ridaforolimus and the anti-IGF1R monoclonal antibody dalotuzumab: preclinical characterization and phase I clinical trial von Di Cosimo, Serena, Sathyanarayanan, Sriram, Bendell, Johanna C, Cervantes, Andrés, Stein, Mark N, Braña, Irene, Roda, Desamparados, Haines, Brian B, Zhang, Theresa, Winter, Christopher G, Jha, Sharda, Xu, Youyuan, Frazier, Jason, Klinghoffer, Richard A, Leighton-Swayze, Ann, Song, Yang, Ebbinghaus, Scot, Baselga, José

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High Levels of Expression of P-glycoprotein/Multidrug Resistance Protein Result in Resistance to Vintafolide von Guertin, Amy D, O'Neil, Jennifer, Stoeck, Alexander, Reddy, Joseph A, Cristescu, Razvan, Haines, Brian B, Hinton, Marlene C, Dorton, Ryan, Bloomfield, Alicia, Nelson, Melissa, Vetzel, Marilynn, Lejnine, Serguei, Nebozhyn, Michael, Zhang, Theresa, Loboda, Andrey, Picard, Kristen L, Schmidt, Emmett V, Dussault, Isabelle, Leamon, Christopher P

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Design of an Interferon-Resistant Oncolytic HSV-1 Incorporating Redundant Safety Modalities for Improved Tolerability von Kennedy, Edward M., Farkaly, Terry, Grzesik, Peter, Lee, Jennifer, Denslow, Agnieszka, Hewett, Jacqueline, Bryant, Jeffrey, Behara, Prajna, Goshert, Caitlin, Wambua, Daniel, De Almeida, Ana, Jacques, Judith, Deavall, Damian, Rottman, James B., Glorioso, Joseph C., Finer, Mitchell H., Haines, Brian B., Quéva, Christophe, Lerner, Lorena

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A Quantitative Volumetric Micro-Computed Tomography Method to Analyze Lung Tumors in Genetically Engineered Mouse Models von Haines, Brian B., Bettano, Kimberly A., Chenard, Melissa, Sevilla, Raquel S., Ware, Christopher, Angagaw, Minilik H., Winkelmann, Christopher T., Tong, Christopher, Reilly, John F., Sur, Cyrille, Zhang, Weisheng

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ONCR-177, an Oncolytic HSV-1 Designed to Potently Activate Systemic Antitumor Immunity von Haines, Brian B., Denslow, Agnieszka, Grzesik, Peter, Lee, Jennifer S., Farkaly, Terry, Hewett, Jacqueline, Wambua, Daniel, Kong, Lingxin, Behera, Prajna, Jacques, Judith, Goshert, Caitlin, Ball, Michael, Colthart, Allison, Finer, Mitchel H., Hayes, Melissa W., Feau, Sonia, Kennedy, Edward M., Lerner, Lorena, Queva, Christophe

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Identification of the transgenic integration site in 2C T cell receptor transgenic mice von Son, Chae-Yeon, Haines, Brian B., Luch, Andreas, Ryu, Chun Jeih

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Gauging NOTCH1 Activation in Cancer Using Immunohistochemistry von Kluk, Michael J, Ashworth, Todd, Wang, Hongfang, Knoechel, Birgit, Mason, Emily F, Morgan, Elizabeth A, Dorfman, David, Pinkus, Geraldine, Weigert, Oliver, Hornick, Jason L, Chirieac, Lucian R, Hirsch, Michelle, Oh, David J, South, Andrew P, Leigh, Irene M, Pourreyron, Celine, Cassidy, Andrew J, Deangelo, Daniel J, Weinstock, David M, Krop, Ian E, Dillon, Deborah, Brock, Jane E, Lazar, Alexander J F, Peto, Myron, Cho, Raymond J, Stoeck, Alexander, Haines, Brian B, Sathayanrayanan, Sriram, Rodig, Scott, Aster, Jon C

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Exploring the pharmacokinetic properties of phosphorus-containing selective HDAC 1 and 2 inhibitors (SHI-1:2) von HEIDEBRECHT, Richard W, CHENARD, Melissa, KRAL, Astrid M, MIDDLETON, Richard E, MUSHTI, Chandrasekhar, OZEROVA, Nicole, SZEWCZAK, Alexander A, HONGMEI WANG, WILSON, Kevin, WITTER, David J, SECRIST, J. Paul, MILLER, Thomas A, CLOSE, Joshua, DAHLBERG, William K, FLEMING, Judith, GRIMM, Jonathan B, HAMILL, Julie E, HARSCH, Andreas, HAINES, Brian B, HUGHES, Bethany

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Gene silencing using micro-RNA designed hairpins von McMANUS, MICHAEL T., PETERSEN, CHRISTIAN P., HAINES, BRIAN B., CHEN, JIANZHU, SHARP, PHILLIP A.

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Ridaforolimus (MK-8669) synergizes with Dalotuzumab (MK-0646) in hormone-sensitive breast cancer von Becker, Marc A, Hou, Xiaonan, Tienchaianada, Piyawan, Haines, Brian B, Harrington, Sean C, Weroha, S John, Sathyanarayanan, Sriram, Haluska, Paul

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Small Interfering RNA-Mediated Gene Silencing in T Lymphocytes von McManus, Michael T, Haines, Brian B, Dillon, Christopher P, Whitehurst, Charles E, van Parijs, Luk, Chen, Jianzhu, Sharp, Phillip A

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The T-Cell Receptor β Variable Gene Promoter Is Required for Efficient Vβ Rearrangement but Not Allelic Exclusion von Ryu, Chun Jeih, Haines, Brian B., Lee, Hye Ran, Kang, Yun Hee, Draganov, Dobrin D., Lee, Minhui, Whitehurst, Charles E., Hong, Hyo Jeong, Chen, Jianzhu

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Recombination Activating Genes (RAG) in Lymphoma Development von Haines, Brian B., Ryu, Chun Jeih, Chen, Jianzhu

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Divergent Kinetics Differentiate the Mechanism of Action of Two HDAC Inhibitors von Kral, Astrid M, Ozerova, Nicole, Close, Joshua, Jung, Joon, Chenard, Melissa, Fleming, Judith, Haines, Brian B, Harrington, Paul, Maclean, John, Miller, Thomas A, Secrist, Paul, Wang, Hongmei, Heidebrecht, Richard W

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Delayed and Prolonged Histone Hyperacetylation with a Selective HDAC1/HDAC2 Inhibitor von Methot, Joey L, Hoffman, Dawn Mampreian, Witter, David J, Stanton, Matthew G, Harrington, Paul, Hamblett, Christopher, Siliphaivanh, Phieng, Wilson, Kevin, Hubbs, Jed, Heidebrecht, Richard, Kral, Astrid M, Ozerova, Nicole, Fleming, Judith C, Wang, Hongmei, Szewczak, Alexander A, Middleton, Richard E, Hughes, Bethany, Cruz, Jonathan C, Haines, Brian B, Chenard, Melissa, Kenific, Candia M, Harsch, Andreas, Secrist, J. Paul, Miller, Thomas A

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Evidence of mTOR Activation by an AKT-Independent Mechanism Provides Support for the Combined Treatment of PTEN-Deficient Prostate Tumors with mTOR and AKT Inhibitors von Zhang, Weisheng, Haines, Brian B, Efferson, Clay, Zhu, Joe, Ware, Chris, Kunii, Kaiko, Tammam, Jennifer, Angagaw, Minilik, Hinton, Marlene C, Keilhack, Heike, Paweletz, Cloud P, Zhang, Theresa, Winter, Chris, Sathyanarayanan, Sriram, Cheng, Jonathan, Zawel, Leigh, Fawell, Stephen, Gilliland, Gary, Majumder, Pradip K

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