Extended pharmacodynamic responses observed upon PROTAC-mediated degradation of RIPK2 von Mares, Alina, Miah, Afjal H., Smith, Ian E. D., Rackham, Mark, Thawani, Aditya R., Cryan, Jenni, Haile, Pamela A., Votta, Bartholomew J., Beal, Allison M., Capriotti, Carol, Reilly, Michael A., Fisher, Don T., Zinn, Nico, Bantscheff, Marcus, MacDonald, Thomas T., Vossenkamper, Anna, Dace, Phoebe, Churcher, Ian, Benowitz, Andrew B., Watt, Gillian, Denyer, Jane, Scott-Stevens, Paul, Harling, John D.

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Identification of benzimidazole diamides as selective inhibitors of the nucleotide-binding oligomerization domain 2 (NOD2) signaling pathway von Rickard, David J, Sehon, Clark A, Kasparcova, Viera, Kallal, Lorena A, Zeng, Xin, Montoute, Monica N, Chordia, Tushar, Poore, Derek D, Li, Hu, Wu, Zining, Eidam, Patrick M, Haile, Pamela A, Yu, Jong, Emery, John G, Marquis, Robert W, Gough, Peter J, Bertin, John

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Enantioselective Total Synthesis of Brevetoxin A: Unified Strategy for the B, E, G, and J Subunits von Crimmins, Michael T., Ellis, J. Michael, Emmitte, Kyle A., Haile, Pamela A., McDougall, Patrick J., Parrish, Jonathan D., Zuccarello, J. Lucas

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Identification of selective small molecule inhibitors of the nucleotide-binding oligomerization domain 1 (NOD1) signaling pathway von Rickard, David J, Sehon, Clark A, Kasparcova, Viera, Kallal, Lorena A, Haile, Pamela A, Zeng, Xin, Montoute, Monica N, Poore, Derek D, Li, Hu, Wu, Zining, Eidam, Patrick M, Emery, John G, Marquis, Robert W, Gough, Peter J, Bertin, John

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Optimization of a Series of RIPK2 PROTACs von Miah, Afjal H, Smith, Ian E. D, Rackham, Mark, Mares, Alina, Thawani, Aditya R, Nagilla, Rakesh, Haile, Pamela A, Votta, Bartholomew J, Gordon, Laurie J, Watt, Gillian, Denyer, Jane, Fisher, Don T, Dace, Phoebe, Giffen, Paul, Goncalves, Andrea, Churcher, Ian, Scott-Stevens, Paul, Harling, John D

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The Identification and Pharmacological Characterization of 6‑(tert-Butylsulfonyl)‑N‑(5-fluoro‑1H‑indazol-3-yl)quinolin-4-amine (GSK583), a Highly Potent and Selective Inhibitor of... von Haile, Pamela A, Votta, Bartholomew J, Marquis, Robert W, Bury, Michael J, Mehlmann, John F, Singhaus, Robert, Charnley, Adam K, Lakdawala, Ami S, Convery, Máire A, Lipshutz, David B, Desai, Biva M, Swift, Barbara, Capriotti, Carol A, Berger, Scott B, Mahajan, Mukesh K, Reilly, Michael A, Rivera, Elizabeth J, Sun, Helen H, Nagilla, Rakesh, Beal, Allison M, Finger, Joshua N, Cook, Michael N, King, Bryan W, Ouellette, Michael T, Totoritis, Rachel D, Pierdomenico, Maria, Negroni, Anna, Stronati, Laura, Cucchiara, Salvatore, Ziółkowski, Bartłomiej, Vossenkämper, Anna, MacDonald, Thomas T, Gough, Peter J, Bertin, John, Casillas, Linda N

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Understanding Pharmacokinetic Disconnect in Preclinical Species for 4-Aminoquinolines: Consequences of Low Permeability and High P-glycoprotein Efflux Ratio on Rat and Dog Oral Pha... von Mahajan, Mukesh K., Rivera, Elizabeth J., Sun, Helen H., Nagilla, Rakesh, DeMartino, Michael P., Haile, Pamela A., Casillas, Linda N., Marquis, Robert W., Votta, Bartholomew J., Bertin, John, Reilly, Michael A.

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Discovery of Pyrazolocarboxamides as Potent and Selective Receptor Interacting Protein 2 (RIP2) Kinase Inhibitors von Haffner, Curt D, Charnley, Adam K, Aquino, Christopher J, Casillas, Linda, Convery, Máire A, Cox, Julie A, Elban, Mark A, Goodwin, Nicole C, Gough, Peter J, Haile, Pamela A, Hughes, Terry V, Knapp-Reed, Beth, Kreatsoulas, Constantine, Lakdawala, Ami S, Li, Huijie, Lian, Yiqian, Lipshutz, David, Mehlmann, John F, Ouellette, Michael, Romano, Joseph, Shewchuk, Lisa, Shu, Arthur, Votta, Bartholomew J, Zhou, Huiqiang, Bertin, John, Marquis, Robert W

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Total Synthesis of Brevetoxin A von Crimmins, Michael T, Zuccarello, J. Lucas, Ellis, J. Michael, McDougall, Patrick J, Haile, Pamela A, Parrish, Jonathan D, Emmitte, Kyle A

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Silylene-Mediated Ring Contraction of Homoallylic Ethers To Form Allylic Silanes von Bourque, Laura E, Haile, Pamela A, Woerpel, K. A

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Silylene oxonium ylides: di- tert-butylsilylene insertion into C–O bonds von Bourque, Laura E., Haile, Pamela A., Loy, Janice M.N., Woerpel, K.A.

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CCR2 receptor antagonists: Optimization of biaryl sulfonamides to increase activity in whole blood von Wang, Gren Z., Haile, Pamela A., Daniel, Tom, Belot, Benjamin, Viet, Andrew Q., Goodman, Krista B., Sha, Deyou, Dowdell, Sarah E., Varga, Norbert, Hong, Xuan, Chakravorty, Subhas, Webb, Christine, Cornejo, Carla, Olzinski, Alan, Bernard, Roberta, Evans, Christopher, Emmons, Amanda, Briand, Jacques, Chung, Chun-Wa, Quek, Ruben, Lee, Dennis, Gough, Peter J., Sehon, Clark A.

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RIP3 Induces Apoptosis Independent of Pronecrotic Kinase Activity von Mandal, Pratyusha, Berger, Scott B., Pillay, Sirika, Moriwaki, Kenta, Huang, Chunzi, Guo, Hongyan, Lich, John D., Finger, Joshua, Kasparcova, Viera, Votta, Bart, Ouellette, Michael, King, Bryan W., Wisnoski, David, Lakdawala, Ami S., DeMartino, Michael P., Casillas, Linda N., Haile, Pamela A., Sehon, Clark A., Marquis, Robert W., Upton, Jason, Daley-Bauer, Lisa P., Roback, Linda, Ramia, Nancy, Dovey, Cole M., Carette, Jan E., Chan, Francis Ka-Ming, Bertin, John, Gough, Peter J., Mocarski, Edward S., Kaiser, William J.

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Ion−Molecule Chemistry within Boron Tribromide Clusters:  Experiment and Theory von Hales, David A, Kautzman, Kathryn E, Williams, Nathan G, Haile, Pamela A, Barker, Michael P

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Discovery of a First-in-Class Receptor Interacting Protein 2 (RIP2) Kinase Specific Clinical Candidate, 2‑((4-(Benzo[d]­thiazol-5-ylamino)-6‑(tert-butylsulfonyl)­quinazolin-7-yl)ox... von Haile, Pamela A, Casillas, Linda N, Votta, Bartholomew J, Wang, Gren Z, Charnley, Adam K, Dong, Xiaoyang, Bury, Michael J, Romano, Joseph J, Mehlmann, John F, King, Bryan W, Erhard, Karl F, Hanning, Charles R, Lipshutz, David B, Desai, Biva M, Capriotti, Carol A, Schaeffer, Michelle C, Berger, Scott B, Mahajan, Mukesh K, Reilly, Michael A, Nagilla, Rakesh, Rivera, Elizabeth J, Sun, Helen H, Kenna, John K, Beal, Allison M, Ouellette, Michael T, Kelly, Mike, Stemp, Gillian, Convery, Máire A, Vossenkämper, Anna, MacDonald, Thomas T, Gough, Peter J, Bertin, John, Marquis, Robert W

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Identification of Quinoline-Based RIP2 Kinase Inhibitors with an Improved Therapeutic Index to the hERG Ion Channel von Haile, Pamela A, Casillas, Linda N, Bury, Michael J, Mehlmann, John F, Singhaus, Robert, Charnley, Adam K, Hughes, Terry V, DeMartino, Michael P, Wang, Gren Z, Romano, Joseph J, Dong, Xiaoyang, Plotnikov, Nikolay V, Lakdawala, Ami S, Convery, Maire A, Votta, Bartholomew J, Lipshutz, David B, Desai, Biva M, Swift, Barbara, Capriotti, Carol A, Berger, Scott B, Mahajan, Mukesh K, Reilly, Michael A, Rivera, Elizabeth J, Sun, Helen H, Nagilla, Rakesh, LePage, Carol, Ouellette, Michael T, Totoritis, Rachel D, Donovan, Brian T, Brown, Barry S, Chaudhary, Khuram W, Gough, Peter J, Bertin, John, Marquis, Robert W

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Discovery of Pyrazolocarboxamides as Potent and Selective Receptor Interacting Protein 2 (RIP2) Kinase Inhibitors von Ha, #64256, ner, Curt D., Charnley, Adam K., Aquino, Christopher J., Casillas, Linda, Convery, Ma, #769, ire, A., Cox, Julie A., Elban, Mark A., Goodwin, Nicole C., Gough, Peter J., Haile, Pamela A., Hughes, Terry V., Knapp-Reed, Beth, Kreatsoulas, Constantine, Lakdawala, Ami S., Li, Huijie, Lian, Yiqian, Lipshutz, David, Mehlmann, John F., Ouellette, Michael, Romano, Joseph, Shewchuk, Lisa, Shu, Arthur, Votta, Bartholomew J., Zhou, Huiqiang, Bertin, John, Marquis, Robert W.

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Identification of Selective Small Molecule Inhibitors of the Nucleotide-Binding Oligomerization Domain 1 von Rickard, David J, Sehon, Clark A, Kasparcova, Viera, Kallal, Lorena A, Haile, Pamela A, Zeng, Xin, Montoute, Monica N, Poore, Derek D, Li, Hu, Wu, Zining, Eidam, Patrick M, Emery, John G, Marquis, Robert W, Gough, Peter J, Bertin, John

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Correction to Identification of Quinoline-Based RIP2 Kinase Inhibitors with an Improved Therapeutic Index to the hERG Ion Channel von Haile, Pamela A., Casillas, Linda N., Bury, Michael J., Mehlmann, John F., Singhaus, Robert, Charnley, Adam K., Hughes, Terry V., DeMartino, Michael P., Wang, Gren Z., Romano, Joseph J., Dong, Xiaoyang, Plotnikov, Nikolay V., Lakdawala, Ami S., Duraiswami, Chaya, Convery, Maire A., Votta, Bartholomew J., Lipshutz, David B., Desai, Biva M., Swift, Barbara, Capriotti, Carol A., Berger, Scott B., Mahajan, Mukesh K., Reilly, Michael A., Rivera, Elizabeth J., Sun, Helen H., Nagilla, Rakesh, LePage, Carol, Ouellette, Michael T., Totoritis, Rachel D., Donovan, Brian T., Brown, Barry S., Chaudhary, Khuram W., Gough, Peter J., Bertin, John, Marquis, Robert W.

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RIP3 induces apoptosis independent of pro-necrotic kinase activity von Mandal, Pratyusha, Berger, Scott B., Pillay, Sirika, Moriwaki, Kenta, Huang, Chunzi, Guo, Hongyan, Lich, John D., Finger, Joshua, Kasparcova, Viera, Votta, Bart, Ouellette, Michael, King, Bryan W., Wisnoski, David, Lakdawala, Ami S., DeMartino, Michael P., Casillas, Linda N., Haile, Pamela A., Sehon, Clark A., Marquis, Robert W., Upton, Jason, Daley-Bauer, Lisa P., Roback, Linda, Ramia, Nancy, Dovey, Cole M., Carette, Jan E., Chan, Francis, Bertin, John, Gough, Peter J., Mocarski, Edward S., Kaiser, William J.

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