Potent, orally absorbed glucagon receptor antagonists von de Laszlo, Stephen E., Hacker, Candice, Li, Bing, Kim, Dooseop, MacCoss, Malcolm, Mantlo, Nathan, Pivnichny, James V., Colwell, Larry, Koch, Gregory E., Cascieri, Margaret A., Hagmann, William K.

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Stromelysin‐1: Three‐dimensional structure of the inhibited catalytic domain and of the C‐truncated proenzyme von Becker, Joseph W., Marcy, Alice I., Rokosz, Laura L., Axel, Melinda G., Burbaum, Jonathan J., Fitzgerald, Paula M.D., Cameron, Patricia M., Esser, Craig K., Hagmann, William K., Hermes, Jeffrey D., Springer, James P.

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Substituted Imidazoles as Glucagon Receptor Antagonists von Chang, Linda L., Sidler, Kelly L., Cascieri, Margaret A., de Laszlo, Stephen, Koch, Greg, Li, Bing, MacCoss, Malcolm, Mantlo, Nathan, O'Keefe, Stephen, Pang, Margaret, Rolando, Anna, Hagmann, William K.

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Orally active .beta.-lactam inhibitors of human leukocyte elastase-1. Activity of 3,3-diethyl-2-azetidinones von Shah, Shrenik K, Dorn, Conrad P, Finke, Paul E, Hale, Jeffrey J, Hagmann, William K, Brause, Karen A, Chandler, Gilbert O, Kissinger, Amy L, Ashe, Bonnie M

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Human fibroblast stromelysin catalytic domain: expression, purification, and characterization of a C-terminally truncated form von Marcy, Alice I, Eiberger, Laura L, Harrison, Richard, Chan, H. Karen, Hutchinson, Nancy I, Hagmann, William K, Cameron, Patricia M, Boulton, David A, Hermes, Jeffrey D

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Characterization of zinc-binding sites in human stromelysin-1: stoichiometry of the catalytic domain and identification of a cysteine ligand in the proenzyme von Salowe, Scott P, Marcy, Alice I, Cuca, Gregory C, Smith, Catherine K, Kopka, Ihor E, Hagmann, William K, Hermes, Jeffrey D

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Importance of mechanistic drug metabolism studies in support of drug discovery: A case study with an N -sulfonylated dipeptide VLA-4 antagonist in rats von Tang, W., Stearns, R. A., Chen, Q., Bleasby, K., Teffera, Y., Colletti, A., Hafey, M., Evers, R., Dean, D. C., Magriotis, P. A., Lanza, T. J., Lin, L. S., Hagmann, W. K., Baillie, T. A.

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Substituted 2-aminopyridines as inhibitors of nitric oxide synthases von Hagmann, William K, Caldwell, Charles G, Chen, Ping, Durette, Philippe L, Esser, Craig K, Lanza, Thomas J, Kopka, Ihor E, Guthikonda, Ravi, Shah, Shrenik K, MacCoss, Malcolm, Chabin, Renee M, Fletcher, Daniel, Grant, Stephan K, Green, Barbara G, Humes, John L, Kelly, Theresa M, Luell, Sylvie, Meurer, Roger, Moore, Vernon, Pacholok, Stephen G, Pavia, Tony, Williams, Hollis R, Wong, Kenny K

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Characterization of a Novel, Non-peptidyl Antagonist of the Human Glucagon Receptor von Cascieri, M A, Koch, G E, Ber, E, Sadowski, S J, Louizides, D, de Laszlo, S E, Hacker, C, Hagmann, W K, MacCoss, M, Chicchi, G G, Vicario, P P

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Mechanism of inhibition of human leukocyte elastase by two cephalosporin derivatives von Knight, W. B., Maycock, A. L., Green, B. G., Ashe, B. M., Gale, P., Weston, H., Finke, P. E., Hagmann, W. K., Shah, S. K., Doherty, J. B.

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Secondary structure and zinc ligation of human recombinant short-form stromelysin by multidimensional heteronuclear NMR von Gooley, Paul R., Johnson, Bruce A., Marcy, Alice I., Cuca, Gregory C., Salowe, Scott P., Hagmann, William K., Esser, Craig K., Springer, James P.

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Substituted 4,6-diaminoquinolines as inhibitors of C5a receptor binding von Lanza, Thomas J, Durette, Philippe L, Rollins, Thomas, Siciliano, Salvatore, Cianciarulo, Dana N, Kobayashi, Sumire V, Caldwell, Charles G, Springer, Martin S, Hagmann, William K

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Mechanism of inhibition of human leucocyte elastase by monocyclic β-lactams von CHABIN, R, GREEN, B. G, SHAH, S. K, UNDERWOOD, D, DOHERTY, J. B, KNIGHT, W. B, GALE, P, MAYCOCK, A. L, WESTON, H, DORN, C. P, FINKE, P. E, HAGMANN, W. K, HALE, J. J, MACCOSS, M

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The NMR structure of the inhibited catalytic domain of human stromelysin-1 von Gooley, Paul R, O'Connell, John F, Marcy, Alice I, Cuca, Gregory C, Salowe, Scott P, Bush, Bruce L, Hermes, Jeffrey D, Esser, Craig K, Hagmann, William K, Springer, James P, Johnson, Bruce A

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Studies on the Kinetic and Chemical Mechanism of Inhibition of Stromelysin by an N-(Carboxyalkyl)dipeptide von Izquierdo-Martin, Maria, Chapman, K. T, Hagmann, W. K, Stein, Ross L

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Deprotection of N- tert-butoxycarbonyl (Boc) groups in the presence of tert-butyl esters von Lin, Linus S, Lanza, Thomas, de Laszlo, Stephen E, Truong, Quang, Kamenecka, Theodore, Hagmann, William K

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Mechanism of inhibition of human leukocyte elastase by monocyclic .beta.-lactams von Chabin, R, Green, B. G, Gale, P, Maycock, A. L, Weston, H, Dorn, C. P, Finke, P. E, Hagmann, W. K, Hale, J. J

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4-AZASTEROIDS AS 5α-REDUCTASE INHIBITORS: IDENTIFICATION OF 4,7β-DIMETHYL-4-AZA-5α-CHOLESTAN-3-ONE (MK-386) AS A SCALP ISOZYME SELECTIVE INHIBITOR von Tolman, Richard L., Aster, Susan, Bakshi, Raman K., Bergman, Jeffrey P., Bull, Herb G., Chang, Benedict, Cimis, George, Dolenga, Michael P., Durette, Phillippe, Ellsworth, Kenneth, Esser, Craig, Graham, Donald W., Hagmann, William K., Harris, Georgianna, Kopka, Ihor, Lanza, Thomas, Patel, Gool, Polo, Scott, Rasmusson, Gary H., Sahoo, Soumya, Toney, Jeffrey H., Von Langen, Derek, Witzel, Bruce

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Effects of Matrix Metalloproteinases on Cartilage Biophysical Properties in Vitro and in Vivo von BONASSAR, L. J., PAGUIO, C. G., FRANK, E. H., JEFFRIES, K. A., MOORE, V. L., LARK, M. W., CALDWELL, C. G., HAGMANN, W. K., GRODZINSKY, A. J.

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Inhibition of matrix metalloproteinases by N-carboxyalkyl peptides von Chapman, Kevin T, Kopka, Ihor E, Durette, Philippe L, Esser, Craig K, Lanza, Thomas J, Izquierdo-Martin, Maria, Niedzwiecki, Lisa, Chang, Benedict, Harrison, Richard K

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