A novel Menin-MLL1 inhibitor, DS-1594a, prevents the progression of acute leukemia with rearranged MLL1 or mutated NPM1 von Numata, Masashi, Haginoya, Noriyasu, Shiroishi, Machiko, Hirata, Tsuyoshi, Sato-Otsubo, Aiko, Yoshikawa, Kenji, Takata, Yoshimi, Nagase, Reina, Kashimoto, Yoshinori, Suzuki, Makoto, Schulte, Nina, Polier, Gernot, Kurimoto, Akiko, Tomoe, Yumiko, Toyota, Akiko, Yoneyama, Tomoko, Imai, Emi, Watanabe, Kenji, Hamada, Tomoaki, Kanada, Ryutaro, Watanabe, Jun, Kagoshima, Yoshiko, Tokumaru, Eri, Murata, Kenji, Baba, Takayuki, Shinozaki, Taeko, Ohtsuka, Masami, Goto, Koichi, Karibe, Tsuyoshi, Deguchi, Takao, Gocho, Yoshihiro, Yoshida, Masanori, Tomizawa, Daisuke, Kato, Motohiro, Tsutsumi, Shinji, Kitagawa, Mayumi, Abe, Yuki

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Discovery of Novel Thieno[2,3-d]pyrimidin-4-yl Hydrazone-Based Cyclin-Dependent Kinase 4 Inhibitors: Synthesis, Biological Evaluation and Structure–Activity Relationships von Horiuchi, Takao, Takeda, Yasuyuki, Haginoya, Noriyasu, Miyazaki, Masaki, Nagata, Motoko, Kitagawa, Mayumi, Akahane, Kouichi, Uoto, Kouichi

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Discovery of novel tricyclic compounds as squalene synthase inhibitors von Ichikawa, Masanori, Ohtsuka, Masami, Ohki, Hitoshi, Haginoya, Noriyasu, Itoh, Masao, Sugita, Kazuyuki, Usui, Hiroyuki, Suzuki, Makoto, Terayama, Koji, Kanda, Akira

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Discovery of atrop fixed alkoxy-aminobenzhydrol derivatives: Novel, highly potent and orally efficacious squalene synthase inhibitors von Ichikawa, Masanori, Yokomizo, Aki, Itoh, Masao, Haginoya, Noriyasu, Sugita, Kazuyuki, Usui, Hiroyuki, Terayama, Koji, Kanda, Akira

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Design, synthesis, and SAR of cis-1,2-diaminocyclohexane derivatives as potent factor Xa inhibitors. Part I: Exploration of 5–6 fused rings as alternative S1 moieties von Yoshikawa, Kenji, Yokomizo, Aki, Naito, Hiroyuki, Haginoya, Noriyasu, Kobayashi, Shozo, Yoshino, Toshiharu, Nagata, Tsutomu, Mochizuki, Akiyoshi, Osanai, Ken, Watanabe, Kengo, Kanno, Hideyuki, Ohta, Toshiharu

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Design, synthesis, and SAR of cis-1,2-diaminocyclohexane derivatives as potent factor Xa inhibitors. Part II: Exploration of 6–6 fused rings as alternative S1 moieties von Yoshikawa, Kenji, Kobayashi, Shozo, Nakamoto, Yumi, Haginoya, Noriyasu, Komoriya, Satoshi, Yoshino, Toshiharu, Nagata, Tsutomu, Mochizuki, Akiyoshi, Watanabe, Kengo, Suzuki, Makoto, Kanno, Hideyuki, Ohta, Toshiharu

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Discovery of N-[(1 R,2 S,5 S)-2-{[(5-chloroindol-2-yl)carbonyl]amino}-5-(dimethylcarbamoyl)cyclohexyl]-5-methyl-4,5,6,7-tetrahydrothiazolo[5,4- c]pyridine-2-carboxamide hydrochlori... von Nagata, Tsutomu, Yoshino, Toshiharu, Haginoya, Noriyasu, Yoshikawa, Kenji, Nagamochi, Masatoshi, Kobayashi, Syozo, Komoriya, Satoshi, Yokomizo, Aki, Muto, Ryo, Yamaguchi, Mitsuhiro, Osanai, Ken, Suzuki, Makoto, Kanno, Hideyuki

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Discovery of Novel 11-Membered Templates as Squalene Synthase Inhibitors von Haginoya, Noriyasu, Suzuki, Masanori, Suzuki, Makoto, Ishigai, Yutaka, Terayama, Koji, Kanda, Akira, Sugita, Kazuyuki

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Abstract 1132: Development and characterization of a novel orally bioavailable menin-MLL inhibitor for treatment of acute leukemia patients with MLL -rearrangement or NPM1 mutation von Numata, Masashi, Shiroishi, Machiko, Yoshikawa, Kenji, Haginoya, Noriyasu, Hirata, Tsuyoshi, Takata, Yoshimi, Nagase, Reina, Takashima, Kohei, Kurimoto, Akiko, Tanzawa, Fumie, Tomoe, Yumiko, Hamada, Tomoaki, Kanada, Ryutaro, Watanabe, Jun, Kagoshima, Yoshiko, Tokumaru, Eri, Murata, Kenji, Baba, Takayuki, Shinozaki, Taeko, Hashimoto, Kazuyuki, Kato, Motohiro, Tsutsumi, Shinji, Kitagawa, Mayumi, Fujiwara, Kosaku, Abe, Yuki

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DS-1205b, a novel selective inhibitor of AXL kinase, blocks resistance to EGFR-tyrosine kinase inhibitors in a non-small cell lung cancer xenograft model von Jimbo, Takeshi, Hatanaka, Mana, Komatsu, Takahiro, Taira, Tomoe, Kumazawa, Kentaro, Maeda, Naoyuki, Suzuki, Takashi, Ota, Masahiro, Haginoya, Noriyasu, Isoyama, Takeshi, Fujiwara, Kosaku

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Discovery of DF-461, a Potent Squalene Synthase Inhibitor von Ichikawa, Masanori, Ohtsuka, Masami, Ohki, Hitoshi, Ota, Masahiro, Haginoya, Noriyasu, Itoh, Masao, Shibata, Yoshihiro, Sugita, Kazuyuki, Ishigai, Yutaka, Terayama, Koji, Kanda, Akira, Usui, Hiroyuki

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Cycloalkanediamine derivatives as novel blood coagulation factor Xa inhibitors von Nagata, Tsutomu, Yoshino, Toshiharu, Haginoya, Noriyasu, Yoshikawa, Kenji, Isobe, Yumiko, Furugohri, Taketoshi, Kanno, Hideyuki

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Synthesis and Conformational Analysis of a Non-Amidine Factor Xa Inhibitor That Incorporates 5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine as S4 Binding Element von Haginoya, Noriyasu, Kobayashi, Syozo, Komoriya, Satoshi, Yoshino, Toshiharu, Suzuki, Makoto, Shimada, Takashi, Watanabe, Kengo, Hirokawa, Yumiko, Furugori, Taketoshi, Nagahara, Takayasu

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Discovery of Novel Thieno[2,3-d]pyrimidin-4-yl Hydrazone-Based Cyclin-Dependent Kinase 4 Inhibitors von Horiuchi, Takao, Takeda, Yasuyuki, Haginoya, Noriyasu, Miyazaki, Masaki, Nagata, Motoko, Kitagawa, Mayumi, Akahane, Kouichi, Uoto, Kouichi

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Correction to “Discovery of DF-461, a Potent Squalene Synthase Inhibitor” von Ichikawa, Masanori, Ohtsuka, Masami, Ohki, Hitoshi, Ota, Masahiro, Haginoya, Noriyasu, Itoh, Masao, Shibata, Yoshihiro, Ishigai, Yutaka, Terayama, Koji, Kanda, Akira, Sugita, Kazuyuki

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Design, synthesis, and biological activity of novel factor Xa inhibitors: Improving metabolic stability by S1 and S4 ligand modification von Komoriya, Satoshi, Kobayashi, Shozo, Osanai, Ken, Yoshino, Toshiharu, Nagata, Tsutomu, Haginoya, Noriyasu, Nakamoto, Yumi, Mochizuki, Akiyoshi, Nagahara, Takayasu, Suzuki, Makoto, Shimada, Takashi, Watanabe, Kengo, Isobe, Yumiko, Furugoori, Taketoshi

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Design, synthesis, and biological activity of non-amidine factor Xa inhibitors containing pyridine N-oxide and 2-carbamoylthiazole units von Haginoya, Noriyasu, Kobayashi, Syozo, Komoriya, Satoshi, Yoshino, Toshiharu, Nagata, Tsutomu, Hirokawa, Yumiko, Nagahara, Takayasu

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Design, synthesis, and biological activity of non-basic compounds as factor Xa inhibitors: SAR study of S1 and aryl binding sites von Komoriya, Satoshi, Haginoya, Noriyasu, Kobayashi, Shozo, Nagata, Tsutomu, Mochizuki, Akiyoshi, Suzuki, Masanori, Yoshino, Toshiharu, Horino, Haruhiko, Nagahara, Takayasu, Suzuki, Makoto, Isobe, Yumiko, Furugoori, Taketoshi

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Discovery of Novel Thieno[2,3-d]pyrimidin-4-yl Hydrazone-Based Cyclin-Dependent Kinase 4 Inhibitors: Synthesis, Biological Evaluation and Structure-Activity Relationships von Takao HORIUCHIa, Yasuyuki TAKEDAa, Noriyasu HAGINOYAa, Masaki MIYAZAKIa, Motoko NAGATAb, Mayumi KITAGAWAb, Kouichi AKAHANEb, Kouichi UOTOa

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Discovery of N-[(1R,2S,5S)-2-{[(5-chloroindol-2-yl)carbonyl]amino}-5-(dimethylc arbamoyl) cyclohexyl]-5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-c arboxamid e hydrochlori... von Nagata, Tsutomu, Yoshino, Toshiharu, Haginoya, Noriyasu, Yoshikawa, Kenji, Nagamochi, Masatoshi, Kobayashi, Syozo, Komoriya, Satoshi, Yokomizo, Aki, Muto, Ryo, Yamaguchi, Mitsuhiro, Osanai, Ken, Suzuki, Makoto, Kanno, Hideyuki

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