Lipoxygenase and Leukotriene Pathways: Biochemistry, Biology, and Roles in Disease von Haeggström, Jesper Z, Funk, Colin D

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Unbiased classification of sensory neuron types by large-scale single-cell RNA sequencing von Usoskin, Dmitry, Furlan, Alessandro, Islam, Saiful, Abdo, Hind, Lönnerberg, Peter, Lou, Daohua, Hjerling-Leffler, Jens, Haeggström, Jesper, Kharchenko, Olga, Kharchenko, Peter V, Linnarsson, Sten, Ernfors, Patrik

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Structures of Leukotriene Biosynthetic Enzymes and Development of New Therapeutics von Haeggström, Jesper Z, Newcomer, Marcia E

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Investigation of Clozapine and Olanzapine Reactive Metabolite Formation and Protein Binding by Liquid Chromatography-Tandem Mass Spectrometry von Geib, Timon, Thulasingam, Madhuranayaki, Haeggström, Jesper Z, Sleno, Lekha

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Crystal structures of human MGST2 reveal synchronized conformational changes regulating catalysis von Thulasingam, Madhuranayaki, Orellana, Laura, Nji, Emmanuel, Ahmad, Shabbir, Rinaldo-Matthis, Agnes, Haeggström, Jesper Z.

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Modulation of the 5-Lipoxygenase Pathway by Chalcogen-Containing Inhibitors of Leukotriene A4 Hydrolase von Teder, Tarvi, König, Stefanie, Singh, Rajkumar, Samuelsson, Bengt, Werz, Oliver, Garscha, Ulrike, Haeggström, Jesper Z.

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Leukotriene biosynthetic enzymes as therapeutic targets von Haeggstrom, Jesper Z

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Asthmatics exhibit altered oxylipin profiles compared to healthy individuals after subway air exposure von Lundström, Susanna L, Levänen, Bettina, Nording, Malin, Klepczynska-Nyström, Anna, Sköld, Magnus, Haeggström, Jesper Z, Grunewald, Johan, Svartengren, Magnus, Hammock, Bruce D, Larsson, Britt-Marie, Eklund, Anders, Wheelock, Åsa M, Wheelock, Craig E

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Biosynthesis of resolvin D1, resolvin D2, and RCTR1 from 7,8(S,S)-epoxytetraene in human neutrophils and macrophages von Nshimiyimana, Robert, Simard, Mélissa, Teder, Tarvi, Rodriguez, Ana R, Spur, Bernd W, Haeggström, Jesper Z, Serhan, Charles N

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A role for microsomal glutathione transferase 1 in melanin biosynthesis and melanoma progression von Zhang, Jie, Ye, Zhi-wei, Bräutigam, Lars, Chakraborty, Paramita, Luo, Zhenwu, Culpepper, John, Aslam, Muhammad, Zhang, Leilei, Johansson, Katarina, Haeggström, Jesper Z., Xu, Jianqiang, Olsson, Magnus, Townsend, Danyelle M., Mehrotra, Shikhar, Morgenstern, Ralf, Tew, Kenneth D.

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Activation of succinate receptor 1 boosts human mast cell reactivity and allergic bronchoconstriction von Tang, Xiao, Rönnberg, Elin, Säfholm, Jesper, Thulasingam, Madhuranayaki, Trauelsen, Mette, Schwartz, Thue W., Wheelock, Craig E., Dahlén, Sven‐Erik, Nilsson, Gunnar, Haeggström, Jesper Z.

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The IRE1α Inhibitor KIRA6 Blocks Leukotriene Biosynthesis in Human Phagocytes von Tang, Xiao, Teder, Tarvi, Samuelsson, Bengt, Haeggström, Jesper Z

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Structure and inhibition of mouse leukotriene C4 synthase von Niegowski, Damian, Kleinschmidt, Thea, Ahmad, Shabbir, Qureshi, Abdul Aziz, Mårback, Michaela, Rinaldo-Matthis, Agnes, Haeggström, Jesper Z

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Allergic asthmatics show divergent lipid mediator profiles from healthy controls both at baseline and following birch pollen provocation von Lundström, Susanna L, Yang, Jun, Källberg, Henrik J, Thunberg, Sarah, Gafvelin, Guro, Haeggström, Jesper Z, Grönneberg, Reidar, Grunewald, Johan, van Hage, Marianne, Hammock, Bruce D, Eklund, Anders, Wheelock, Åsa M, Wheelock, Craig E

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Cathelicidin LL-37 Induces Angiogenesis via PGE2–EP3 Signaling in Endothelial Cells, In Vivo Inhibition by Aspirin von Salvado, M Dolores, Di Gennaro, Antonio, Lindbom, Lennart, Agerberth, Birgitta, Haeggström, Jesper Z

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Binding of Pro-Gly-Pro at the active site of leukotriene A4 hydrolase/aminopeptidase and development of an epoxide hydrolase selective inhibitor von Stsiapanava, Alena, Olsson, Ulrika, Wan, Min, Kleinschmidt, Thea, Rutishauser, Dorothea, Zubarev, Roman A., Samuelsson, Bengt, Rinaldo-Matthis, Agnes, Haeggström, Jesper Z.

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Catalytic Characterization of Human Microsomal Glutathione S‑Transferase 2: Identification of Rate-Limiting Steps von Ahmad, Shabbir, Niegowski, Damian, Wetterholm, Anders, Haeggström, Jesper Z, Morgenstern, Ralf, Rinaldo-Matthis, Agnes

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A dynamic Asp–Arg interaction is essential for catalysis in microsomal prostaglandin E₂ synthase von Brock, Joseph S., Hamberg, Mats, Balagunaseelan, Navisraj, Goodman, Michael, Morgenstern, Ralf, Strandback, Emilia, Samuelsson, Bengt, Rinaldo-Matthis, Agnes, Haeggström, Jesper Z.

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Structural basis for synthesis of inflammatory mediators by human leukotriene C4 synthase von MARTINEZ MOLINA, Daniel, WETTERHOLM, Anders, KOHL, Andreas, MCCARTHY, Andrew A, NIEGOWSKI, Damian, OHLSON, Eva, HAMMARBERG, Tove, ESHAGHI, Said, HAEGGSTRÖM, Jesper Z, NORDLUND, Pär

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Leukotriene B₄-induced changes in vascular permeability are mediated by neutrophil release of heparin-binding protein (HBP/CAP37/azurocidin) von Di Gennaro, Antonio, Kenne, Ellinor, Wan, Min, Soehnlein, Oliver, Lindbom, Lennart, Haeggström, Jesper Z

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