SUBSTITUTED PYRIMIDO[1,2-B]INDAZOLES AND THEIR USE AS MODULATORS OF THE PI3K/AKT PATHWAY [12-B] PI3K/AKT von BOEMER, ULF U, POLITZ, OLIVER O, NEUHAUS, ROLAND R, HAEGEBARTH, ANDREA A, REHWINKEL, HARTMUT H

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AMINO-SUBSTITUTED IMIDAZOPYRIDAZINES von SCHULZE, VOLKER V, BOEMER, ULF U, LIENAU, PHILIP P, ZORN, LUDWIG L, PETERSEN, KIRSTIN K, SUELZLE, DETLEV D, EIS, KNUT K, HAEGEBARTH, ANDREA A, PUEHLER, FLORIAN F

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SUBSTITUTED IMIDAZO[1,2-B]PYRIDAZINES [12-B] von HAEGEBARTH, Andrea A, POLITZ, Oliver O, REHWINKEL, Hartmut H, NEUHAUS, Roland R, BOEMER, Ulf U

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AMINOALCOHOL SUBSTITUTED 2,3-DIHYDROIMIDAZO[1,2-C]QUINAZOLINE DERIVATIVES USEFUL FOR TREATING HYPER-PROLIFERATIVE DISORDERS AND DISEASES ASSOCIATED WITH ANGIOGENESIS 23- [12-C] von HAEGEBARTH, Andrea A, MOENNING, Ursula U, BOEMER, Ulf U, MOEWES, Manfred M, SCOTT, William W, LIU, Ningshu

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Wnt Signaling, Lgr5, and Stem Cells in the Intestine and Skin von Haegebarth, Andrea, Clevers, Hans

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Transcription Factor Achaete Scute-Like 2 Controls Intestinal Stem Cell Fate von van der Flier, Laurens G., van Gijn, Marielle E., Hatzis, Pantelis, Kujala, Pekka, Haegebarth, Andrea, Stange, Daniel E., Begthel, Harry, van den Born, Maaike, Guryev, Victor, Oving, Irma, van Es, Johan H., Barker, Nick, Peters, Peter J., van de Wetering, Marc, Clevers, Hans

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Are Metformin Doses Used in Murine Cancer Models Clinically Relevant? von Chandel, Navdeep S., Avizonis, Dania, Reczek, Colleen R., Weinberg, Samuel E., Menz, Stephan, Neuhaus, Roland, Christian, Sven, Haegebarth, Andrea, Algire, Carolyn, Pollak, Michael

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Lgr6 Marks Stem Cells in the Hair Follicle That Generate All Cell Lineages of the Skin von Snippert, Hugo J, Haegebarth, Andrea, Kasper, Maria, Jaks, Viljar, van Es, Johan H, Barker, Nick, van de Wetering, Marc, van den Born, Maaike, Begthel, Harry, Vries, Robert G, Stange, Daniel E, Toftgård, Rune, Clevers, Hans

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A Critical Role for the Wnt Effector Tcf4 in Adult Intestinal Homeostatic Self-Renewal von van Es, Johan H., Haegebarth, Andrea, Kujala, Pekka, Itzkovitz, Shalev, Koo, Bon-Kyoung, Boj, Sylvia F., Korving, Jeroen, van den Born, Maaike, van Oudenaarden, Alexander, Robine, Sylvie, Clevers, Hans

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Dynamics of Lgr6+ Progenitor Cells in the Hair Follicle, Sebaceous Gland, and Interfollicular Epidermis von Füllgrabe, Anja, Joost, Simon, Are, Alexandra, Jacob, Tina, Sivan, Unnikrishnan, Haegebarth, Andrea, Linnarsson, Sten, Simons, Benjamin D., Clevers, Hans, Toftgård, Rune, Kasper, Maria

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Diabetes Risk Gene and Wnt Effector Tcf7l2/TCF4 Controls Hepatic Response to Perinatal and Adult Metabolic Demand von Boj, Sylvia F., van Es, Johan H., Huch, Meritxell, Li, Vivian S.W., José, Anabel, Hatzis, Pantelis, Mokry, Michal, Haegebarth, Andrea, van den Born, Maaike, Chambon, Pierre, Voshol, Peter, Dor, Yuval, Cuppen, Edwin, Fillat, Cristina, Clevers, Hans

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Synergistic activity of IDH1 inhibitor BAY1436032 with azacitidine in IDH1 mutant acute myeloid leukemia von Chaturvedi, Anuhar, Gupta, Charu, Gabdoulline, Razif, Borchert, Nora M, Goparaju, Ramya, Kaulfuss, Stefan, Görlich, Kerstin, Schottmann, Renate, Othman, Basem, Welzenbach, Julia, Panknin, Olaf, Wagner, Markus, Geffers, Robert, Ganser, Arnold, Thol, Felicitas, Jeffers, Michael, Haegebarth, Andrea, Heuser, Michael

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Evidence for an alternative fatty acid desaturation pathway increasing cancer plasticity von Vriens, Kim, Christen, Stefan, Parik, Sweta, Broekaert, Dorien, Yoshinaga, Kazuaki, Talebi, Ali, Dehairs, Jonas, Escalona-Noguero, Carmen, Schmieder, Roberta, Cornfield, Thomas, Charlton, Catriona, Romero-Pérez, Laura, Rossi, Matteo, Rinaldi, Gianmarco, Orth, Martin F., Boon, Ruben, Kerstens, Axelle, Kwan, Suet Ying, Faubert, Brandon, Méndez-Lucas, Andrés, Kopitz, Charlotte C., Chen, Ting, Fernandez-Garcia, Juan, Duarte, João A. G., Schmitz, Arndt A., Steigemann, Patrick, Najimi, Mustapha, Hägebarth, Andrea, Van Ginderachter, Jo A., Sokal, Etienne, Gotoh, Naohiro, Wong, Kwok-Kin, Verfaillie, Catherine, Derua, Rita, Munck, Sebastian, Yuneva, Mariia, Beretta, Laura, DeBerardinis, Ralph J., Swinnen, Johannes V., Hodson, Leanne, Cassiman, David, Verslype, Chris, Christian, Sven, Grünewald, Sylvia, Grünewald, Thomas G. P., Fendt, Sarah-Maria

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Metabolic pathway analyses identify proline biosynthesis pathway as a promoter of liver tumorigenesis von Ding, Zhaobing, Ericksen, Russell E., Escande-Beillard, Nathalie, Lee, Qian Yi, Loh, Abigail, Denil, Simon, Steckel, Michael, Haegebarth, Andrea, Wai Ho, Timothy Shen, Chow, Pierce, Toh, Han Chong, Reversade, Bruno, Gruenewald, Sylvia, Han, Weiping

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Identification of stem cells in small intestine and colon by marker gene Lgr5 von Barker, Nick, van Es, Johan H., Kuipers, Jeroen, Kujala, Pekka, van den Born, Maaike, Cozijnsen, Miranda, Haegebarth, Andrea, Korving, Jeroen, Begthel, Harry, Peters, Peter J., Clevers, Hans

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Functional diversity of inhibitors tackling the differentiation blockage of MLL-rearranged leukemia von Brzezinka, Krzysztof, Nevedomskaya, Ekaterina, Lesche, Ralf, Steckel, Michael, Eheim, Ashley L, Haegebarth, Andrea, Stresemann, Carlo

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Novel Class of Potent and Cellularly Active Inhibitors Devalidates MTH1 as Broad-Spectrum Cancer Target von Ellermann, Manuel, Eheim, Ashley, Rahm, Fredrik, Viklund, Jenny, Guenther, Judith, Andersson, Martin, Ericsson, Ulrika, Forsblom, Rickard, Ginman, Tobias, Lindström, Johan, Silvander, Camilla, Trésaugues, Lionel, Giese, Anja, Bunse, Stefanie, Neuhaus, Roland, Weiske, Jörg, Quanz, Maria, Glasauer, Andrea, Nowak-Reppel, Katrin, Bader, Benjamin, Irlbacher, Horst, Meyer, Hanna, Queisser, Nina, Bauser, Marcus, Haegebarth, Andrea, Gorjánácz, Mátyás

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Preclinical Efficacy of the Novel Monocarboxylate Transporter 1 Inhibitor BAY-8002 and Associated Markers of Resistance von Quanz, Maria, Bender, Eckhard, Kopitz, Charlotte, Grünewald, Sylvia, Schlicker, Andreas, Schwede, Wolfgang, Eheim, Ashley, Toschi, Luisella, Neuhaus, Roland, Richter, Carmen, Toedling, Joern, Merz, Claudia, Lesche, Ralf, Kamburov, Atanas, Siebeneicher, Holger, Bauser, Marcus, Hägebarth, Andrea

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The novel dihydroorotate dehydrogenase (DHODH) inhibitor BAY 2402234 triggers differentiation and is effective in the treatment of myeloid malignancies von Christian, Sven, Merz, Claudia, Evans, Laura, Gradl, Stefan, Seidel, Henrik, Friberg, Anders, Eheim, Ashley, Lejeune, Pascale, Brzezinka, Krzysztof, Zimmermann, Katja, Ferrara, Steven, Meyer, Hanna, Lesche, Ralf, Stoeckigt, Detlef, Bauser, Marcus, Haegebarth, Andrea, Sykes, David B, Scadden, David T, Losman, Julie-Aurore, Janzer, Andreas

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Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling von de Lau, Wim, Barker, Nick, Low, Teck Y., Koo, Bon-Kyoung, Li, Vivian S. W., Teunissen, Hans, Kujala, Pekka, Haegebarth, Andrea, Peters, Peter J., van de Wetering, Marc, Stange, D. E., van Es, J., Guardavaccaro, Daniele, Schasfoort, Richard B. M., Mohri, Yasuaki, Nishimori, Katsuhiko, Mohammed, Shabaz, Heck, Albert J. R., Clevers, Hans

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