Toll-like receptor 4 is a therapeutic target for prevention and treatment of liver failure von Engelmann, Cornelius, Sheikh, Mohammed, Sharma, Shreya, Kondo, Takayuki, Loeffler-Wirth, Henry, Zheng, Yu Bao, Novelli, Simone, Hall, Andrew, Kerbert, Annarein J.C., Macnaughtan, Jane, Mookerjee, Rajeshwar, Habtesion, Abeba, Davies, Nathan, Ali, Tauhid, Gupta, Saurabh, Andreola, Fausto, Jalan, Rajiv

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Recombinant Alkaline Phosphatase Prevents Acute on Chronic Liver Failure von Engelmann, Cornelius, Adebayo, Danielle, Oria, Marc, De Chiara, Francesco, Novelli, Simone, Habtesion, Abeba, Davies, Nathan, Andreola, Fausto, Jalan, Rajiv

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The role of RIPK1 mediated cell death in acute on chronic liver failure von Kondo, Takayuki, Macdonald, Stewart, Engelmann, Cornelius, Habtesion, Abeba, Macnaughtan, Jane, Mehta, Gautam, Mookerjee, Rajeshwar P., Davies, Nathan, Pavesi, Marco, Moreau, Richard, Angeli, Paolo, Arroyo, Vicente, Andreola, Fausto, Jalan, Rajiv

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Impaired brain glymphatic flow in experimental hepatic encephalopathy von Hadjihambi, Anna, Harrison, Ian F., Costas-Rodríguez, Marta, Vanhaecke, Frank, Arias, Natalia, Gallego-Durán, Rocío, Mastitskaya, Svetlana, Hosford, Patrick S., Olde Damink, Steven W.M., Davies, Nathan, Habtesion, Abeba, Lythgoe, Mark F., Gourine, Alexander V., Jalan, Rajiv

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Correction: The role of RIPK1 mediated cell death in acute on chronic liver failure von Kondo, Takayuki, Macdonald, Stewart, Engelmann, Cornelius, Habtesion, Abeba, Macnaughtan, Jane, Mehta, Gautam, Mookerjee, Rajeshwar P., Davies, Nathan, Pavesi, Marco, Moreau, Richard, Angeli, Paolo, Arroyo, Vicente, Andreola, Fausto, Jalan, Rajiv

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Hyperammonaemia induces mitochondrial dysfunction and neuronal cell death von Angelova, Plamena R., Kerbert, Annarein J.C., Habtesion, Abeba, Hall, Andrew, Abramov, Andrey Y., Jalan, Rajiv

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Abnormal brain oxygen homeostasis in an animal model of liver disease von Hadjihambi, Anna, Cudalbu, Cristina, Pierzchala, Katarzyna, Simicic, Dunja, Donnelly, Chris, Konstantinou, Christos, Davies, Nathan, Habtesion, Abeba, Gourine, Alexander V, Jalan, Rajiv, Hosford, Patrick S

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The Lipopolysaccharide-Sensing Caspase(s)-4/11 Are Activated in Cirrhosis and Are Causally Associated With Progression to Multi-Organ Injury von Soffientini, Ugo, Beaton, Nigel, Baweja, Sukriti, Weiss, Emmanuel, Bihari, Chhagan, Habtesion, Abeba, Patel, Vishal, Paradis, Valerie, Sharma, Archana, Luong, Tu Vinh, Hall, Andrew, Nadar, Aida, Sarin, Shiv, Chokshi, Shilpa, Williams, Roger, Py, Benedicte, Moreau, Richard, Jalan, Rajiv, Mehta, Gautam

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WED-069 Bone morphogenic protein 9 (BMP9): a novel therapeutic agent for the prevention of extrahepatic organ failure in acute-onchronic liver failure (ACLF) von Phillips, Alexandra, Habtesion, Abeba, Andreola, Fausto, Davies, Nathan, Upton, Paul, Morrell, Nick, Jalan, Rajiv

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WED-080 Hepatic inflammation-senescence-regeneration gene expression during recovery from ACLF and the effect of granulocyte-colony stimulating factor (GCSF), toll-like receptor-4... von Saeidinejad, MohammadMahdi, Shaw, Daniel, Engelmann, Cornelius, Habtesion, Abeba, Andreola, Fausto, Jalan, Rajiv

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WED-099-YI Hyperammonemia-induced mitochondrial dysfunction is abrogated by targeting toll-like receptor 4 von Sriphoosanaphan, Supachaya, Kerbert, Annarein, Habtesion, Abeba, Andreola, Fausto, Mehta, Gautam, Taanman, Jan-Willem, Jalan, Rajiv

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Combination of G-CSF and a TLR4 inhibitor reduce inflammation and promote regeneration in a mouse model of ACLF von Engelmann, Cornelius, Habtesion, Abeba, Hassan, Mohsin, Kerbert, Annarein JC, Hammerich, Linda, Novelli, Simone, Fidaleo, Marco, Philips, Alexandra, Davies, Nathan, Ferreira-Gonzalez, Sofia, Forbes, Stuart J., Berg, Thomas, Andreola, Fausto, Jalan, Rajiv

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OS-014-YI Long-term albumin infusion reduces the mortality of cirrhosis and ACLF animal models by modulating the gut-liver axis and hepatic TLR4 signalling von Phillips, Alexandra, Zhao, Qianwen, Habtesion, Abeba, Andreola, Fausto, Davies, Nathan, Edwards, Lindsey, Macnaughtan, Jane, Klein, Sabine, Trebicka, Jonel, Jalan, Rajiv

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P31 Long-term albumin administration improves survival, reduces TLR4 mediated hepatic inflammation and reduces gut translocation in models of cirrhosis von Phillips, Alexandra, Zhao, Qianwen, Habtesion, Abeba, Andreola, Fausto, Davies, Nathan, Edwards, Lindsey, Macnaughtan, Jane, Jalan, Rajiv

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P55 Exploration of mechanisms underlying the beneficial effect of long-term albumin in models of cirrhosis and ACLF von Phillips, Alexandra, Zhao, Qianwen, Habtesion, Abeba, Andreola, Fausto, Davies, Nathan, Edwards, Lindsey, MacNaughtan, Jane, Klein, Sabine, Trebicka, Jonel, Jalan, Rajiv

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P094 Potential mechanisms underlying the protective effect of long-term albumin infusion in cirrhosis von Zhao, Qianwen, Phillips, Alexandra, Habtesion, Abeba, Andreola, Fausto, Davies, Nathan, MacNaughtan, Jane, Jalan, Rajiv

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Ammonia Scavenging Prevents Progression of Fibrosis in Experimental Nonalcoholic Fatty Liver Disease von De Chiara, Francesco, Thomsen, Karen Louise, Habtesion, Abeba, Jones, Helen, Davies, Nathan, Gracia‐Sancho, Jordi, Manicardi, Nicolò, Hall, Andrew, Andreola, Fausto, Paish, Hannah L., Reed, Lee H., Watson, Abigail A., Leslie, Jack, Oakley, Fiona, Rombouts, Krista, Mookerjee, Rajeshwar Prosad, Mann, Jelena, Jalan, Rajiv

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THU-207-YI Brain dysfunction is prevented by alpha 2A adrenergic receptor antagonism in a rodent model of diet-induced metabolic dysfunction-associated steatotic liver disease von Mikkelsen, Anne Catrine Daugaard, Kjærgaard, Kristoffer, Bay-Richter, Cecilie, Habtesion, Abeba, Phillips, Alexandra, Greenham, Olivia, Hamilton-Dutoit, Stephen, Hadjihambi, Anna, Thomsen, Karen Louise, Mookerjee, Rajeshwar Prosad

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Long-term albumin administration improves survival, reduces TLR4 mediated hepatic inflammation and reduces gut translocation in models of cirrhosis von Phillips, Alexandra, Zhao, Qianwen, Habtesion, Abeba, Andreola, Fausto, Davies, Nathan, Edwards, Lindsey A, Macnaughtan, Jane, Jalan, Rajiv

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Recombinant glutamine synthetase (AM-535): a novel therapeutic approach for the treatment of hyperammonaemia and its deleterious effects on multiple systems von Siakalli, Antria, Kerbert, Annarein, Habtesion, Abeba, Hall, Andrew, Nicolson, Tamara, Jalan, Rajiv, Macnaughtan, Jane

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