The impact of SF3B1 mutations in CLL on the DNA-damage response von te Raa, G D, Derks, I A M, Navrkalova, V, Skowronska, A, Moerland, P D, van Laar, J, Oldreive, C, Monsuur, H, Trbusek, M, Malcikova, J, Lodén, M, Geisler, C H, Hüllein, J, Jethwa, A, Zenz, T, Pospisilova, S, Stankovic, T, van Oers, M H J, Kater, A P, Eldering, E

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p53-dependent non-coding RNA networks in chronic lymphocytic leukemia von Blume, C J, Hotz-Wagenblatt, A, Hüllein, J, Sellner, L, Jethwa, A, Stolz, T, Slabicki, M, Lee, K, Sharathchandra, A, Benner, A, Dietrich, S, Oakes, C C, Dreger, P, te Raa, D, Kater, A P, Jauch, A, Merkel, O, Oren, M, Hielscher, T, Zenz, T

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Drug-based perturbation screen uncovers synergistic drug combinations in Burkitt lymphoma von Tomska, K., Kurilov, R., Lee, K. S., Hüllein, J., Lukas, M., Sellner, L., Walther, T., Wagner, L., Oleś, M., Brors, B., Huber, W., Zenz, T.

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Dissection of CD20 regulation in lymphoma using RNAi von Słabicki, M, Lee, K S, Jethwa, A, Sellner, L, Sacco, F, Walther, T, Hüllein, J, Dietrich, S, Wu, B, Lipka, D B, Oakes, C C, Mamidi, S, Pyrzyńska, B, Winiarska, M, Oleś, M, Seifert, M, Plass, C, Kirschfink, M, Boettcher, M, Gołąb, J, Huber, W, Fröhling, S, Zenz, T

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535: Small RNA sequencing identifies microRNAs involved in B-cell receptor signaling in chronic lymphocytic leukemia von Blume, C.J, Hielscher, T, Hotz-Wagenblatt, A, Sellner, L, Hüllein, J, Stolz, T, Oakes, C.C, Merkel, O, Zenz, T

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Rationale and design of the CRAFT (Continuous ReAssessment with Flexible ExTension in Rare Malignancies) multicenter phase II trial von Heilig, C.E., Horak, P., Kreutzfeldt, S., Teleanu, V., Mock, A., Renner, M., Bhatti, I.A., Hutter, B., Hüllein, J., Fröhlich, M., Uhrig, S., Süße, H., Heiligenthal, L., Ochsenreither, S., Illert, A.L., Vogel, A., Desuki, A., Heinemann, V., Heidegger, S., Bitzer, M., Scheytt, M., Brors, B., Hübschmann, D., Baretton, G., Stenzinger, A., Steindorf, K., Benner, A., Jäger, D., Heining, C., Glimm, H., Fröhling, S., Schlenk, R.F.

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Subgroup-specific gene expression profiles and mixed epistasis in chronic lymphocytic leukemia von Lütge, Almut, Lu, Junyan, Hüllein, Jennifer, Walther, Tatjana, Sellner, Leopold, Wu, Bian, Rosenquist, Richard, Oakes, Christopher C, Dietrich, Sascha, Huber, Wolfgang, Zenz, Thorsten

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56P Multi-omic profiling in cholangiocarcinoma to enable scientific advancement within the DKFZ/NCT/DKTK MASTER study von Nichetti, F., Korell, F., Schwab, M., Hoffmeister, P.K.M., Hüllein, J., Uhrig, S., Teleanu, M-V., Kreutzfeldt, S., Horak, P., Glimm, H., Heining, C., Rieke, D.T., Kindler, T., Hübschmann, D., Springfeld, C., Jenzer, M., Heilig, C.E., Fröhling, S., Köhler, B.C.

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2318P Value of broad molecular profiling for cancer diagnosis von Werstein, L.V.A., Heilig, C.E., Teleanu, M-V., Hüllein, J., Singh, M., Bauer, S., Kindler, T., Klauschen, F., Brandts, C.H., Rieke, D.T., Illert, L., Börries, M., Kreutzfeldt, S., Horak, P., Hübschmann, D., Lipka, D.B., Glimm, H., Hartmann, W., Fröhling, S.

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Comprehensive cancer predisposition testing within the prospective MASTER trial identifies hereditary cancer patients and supports treatment decisions for rare cancers von Jahn, A., Rump, A., Widmann, T.J., Heining, C., Horak, P., Hutter, B., Paramasivam, N., Uhrig, S., Gieldon, L., Drukewitz, S., Kübler, A., Bermudez, M., Hackmann, K., Porrmann, J., Wagner, J., Arlt, M., Franke, M., Fischer, J., Kowalzyk, Z., William, D., Weth, V., Oster, S., Fröhlich, M., Hüllein, J., Valle González, C., Kreutzfeldt, S., Mock, A., Heilig, C.E., Lipka, D.B., Möhrmann, L., Hanf, D., Oleś, M., Teleanu, V., Allgäuer, M., Ruhnke, L., Kutz, O., Knurr, A., Laßmann, A., Endris, V., Neumann, O., Penzel, R., Beck, K., Richter, D., Winter, U., Wolf, S., Pfütze, K., Geörg, C., Meißburger, B., Buchhalter, I., Augustin, M., Aulitzky, W.E., Hohenberger, P., Kroiss, M., Schirmacher, P., Schlenk, R.F., Keilholz, U., Klauschen, F., Folprecht, G., Bauer, S., Siveke, J.T., Brandts, C.H., Kindler, T., Boerries, M., Illert, A.L., von Bubnoff, N., Jost, P.J., Metzeler, K.H., Bitzer, M., Schulze-Osthoff, K., von Kalle, C., Brors, B., Stenzinger, A., Weichert, W., Hübschmann, D., Fröhling, S., Glimm, H., Schröck, E., Klink, B.

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99P Fibroblast activation protein alpha (FAP) as theranostic target in solitary fibrous tumor von Hamacher, R.W., Pabst, K.M., Cheung, P.F., Heilig, C.E., Hüllein, J., Liffers, S-T., Schaarschmidt, B.M., Costa, P., Kessler, L., Falkenhorst, J., Glimm, H., Umutlu, L., Schuler, M.H.H., Hübschmann, D., Bauer, S., Fröhling, S., Herrmann, K., Siveke, J., Schildhaus, H-U., Fendler, W.

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Drug-perturbation-based stratification of blood cancer von Dietrich, Sascha, Oleś, Małgorzata, Lu, Junyan, Sellner, Leopold, Anders, Simon, Velten, Britta, Wu, Bian, Hüllein, Jennifer, da Silva Liberio, Michelle, Walther, Tatjana, Wagner, Lena, Rabe, Sophie, Ghidelli-Disse, Sonja, Bantscheff, Marcus, Oleś, Andrzej K, Słabicki, Mikołaj, Mock, Andreas, Oakes, Christopher C, Wang, Shihui, Oppermann, Sina, Lukas, Marina, Kim, Vladislav, Sill, Martin, Benner, Axel, Jauch, Anna, Sutton, Lesley Ann, Young, Emma, Rosenquist, Richard, Liu, Xiyang, Jethwa, Alexander, Lee, Kwang Seok, Lewis, Joe, Putzker, Kerstin, Lutz, Christoph, Rossi, Davide, Mokhir, Andriy, Oellerich, Thomas, Zirlik, Katja, Herling, Marco, Nguyen-Khac, Florence, Plass, Christoph, Andersson, Emma, Mustjoki, Satu, von Kalle, Christof, Ho, Anthony D, Hensel, Manfred, Dürig, Jan, Ringshausen, Ingo, Zapatka, Marc, Huber, Wolfgang, Zenz, Thorsten

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Evolution of DNA methylation is linked to genetic aberrations in chronic lymphocytic leukemia von Oakes, Christopher C, Claus, Rainer, Gu, Lei, Assenov, Yassen, Hüllein, Jennifer, Zucknick, Manuela, Bieg, Matthias, Brocks, David, Bogatyrova, Olga, Schmidt, Christopher R, Rassenti, Laura, Kipps, Thomas J, Mertens, Daniel, Lichter, Peter, Döhner, Hartmut, Stilgenbauer, Stephan, Byrd, John C, Zenz, Thorsten, Plass, Christoph

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Clonal diversity predicts adverse outcome in chronic lymphocytic leukemia von Leeksma, Alexander C., Taylor, Justin, Wu, Bian, Gardner, Jeffrey R., He, Jie, Nahas, Michelle, Gonen, Mithat, Alemayehu, Wendimagegn G., te Raa, Doreen, Walther, Tatjana, Hüllein, Jennifer, Dietrich, Sascha, Claus, Rainer, de Boer, Fransien, de Heer, Koen, Dubois, Julie, Dampmann, Maria, Dürig, Jan, van Oers, Marinus H. J., Geisler, Christian H., Eldering, Eric, Levine, Ross L., Miller, Vincent, Mughal, Tariq, Lamanna, Nicole, Frattini, Mark G., Heaney, Mark L., Zelenetz, Andrew, Zenz, Thorsten, Abdel-Wahab, Omar, Kater, Arnon P.

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Comprehensive Genomic and Transcriptomic Analysis for Guiding Therapeutic Decisions in Patients with Rare Cancers von Horak, Peter, Heining, Christoph, Kreutzfeldt, Simon, Hutter, Barbara, Mock, Andreas, Huellein, Jennifer, Froehlich, Martina, Uhrig, Sebastian, Jahn, Arne, Rump, Andreas, Gieldon, Laura, Moehrmann, Lino, Hanf, Dorothea, Teleanu, Veronica, Heilig, Christoph E., Lipka, Daniel B., Allgaeuer, Michael, Ruhnke, Leo, Lassmann, Andreas, Endris, Volker, Neumann, Olaf, Penzel, Roland, Beck, Katja, Richter, Daniela, Winter, Ulrike, Wolf, Stephan, Pfuetze, Katrin, Geoerg, Christina, Meissburger, Bettina, Buchhalter, Ivo, Augustin, Marinela, Aulitzky, Walter E., Hohenberger, Peter, Kroiss, Matthias, Schirmacher, Peter, Schlenk, Richard F., Keilholz, Ulrich, Klauschen, Frederick, Folprecht, Gunnar, Bauer, Sebastian, Siveke, Jens Thomas, Brandts, Christian H., Kindler, Thomas, Boerries, Melanie, Illert, Anna L., von Bubnoff, Nikolas, Jost, Philipp J., Spiekermann, Karsten, Bitzer, Michael, Schulze-Osthoff, Klaus, von Kalle, Christof, Klink, Barbara, Brors, Benedikt, Stenzinger, Albrecht, Schroeck, Evelin, Huebschmann, Daniel, Weichert, Wilko, Glimm, Hanno, Froehling, Stefan

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BRAF inhibition in hairy cell leukemia with low-dose vemurafenib von Dietrich, Sascha, Pircher, Andreas, Endris, Volker, Peyrade, Frédéric, Wendtner, Clemens-Martin, Follows, George A., Hüllein, Jennifer, Jethwa, Alexander, Ellert, Elena, Walther, Tatjana, Liu, Xiyang, Dyer, Martin J.S., Elter, Thomas, Brummer, Tilman, Zeiser, Robert, Hermann, Michael, Herold, Michael, Weichert, Wilko, Dearden, Claire, Haferlach, Torsten, Seiffert, Martina, Hallek, Michael, von Kalle, Christof, Ho, Anthony D., Gaehler, Anita, Andrulis, Mindaugas, Steurer, Michael, Zenz, Thorsten

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Recurrent CDKN1B (p27) mutations in hairy cell leukemia von Dietrich, Sascha, Hüllein, Jennifer, Lee, Stanley Chun-Wei, Hutter, Barbara, Gonzalez, David, Jayne, Sandrine, Dyer, Martin J.S., Oleś, Małgorzata, Else, Monica, Liu, Xiyang, Słabicki, Mikołaj, Wu, Bian, Troussard, Xavier, Dürig, Jan, Andrulis, Mindaugas, Dearden, Claire, von Kalle, Christof, Granzow, Martin, Jauch, Anna, Fröhling, Stefan, Huber, Wolfgang, Meggendorfer, Manja, Haferlach, Torsten, Ho, Anthony D., Richter, Daniela, Brors, Benedikt, Glimm, Hanno, Matutes, Estella, Abdel Wahab, Omar, Zenz, Thorsten

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Abstract 821: Comprehensive genomic analysis of rare cancers: Results of the MASTER precision oncology trial of the German Cancer Consortium von Horak, Peter, Heining, Christoph, Mock, Andreas, Kreutzfeldt, Simon, Lassmann, Andreas, Möhrmann, Lino, Hüllein, Jennifer, Hanf, Dorothea, Jahn, Arne, Ruhnke, Leo, Gieldon, Laura, Heilig, Christoph E., Teleanu, Veronica, Fröhlich, Martina, Uhrig, Sebastian, Beck, Katja, Richter, Daniela, Wolf, Stephan, Pfütze, Katrin, Geörg, Christina, Meissburger, Bettina, Klauschen, Frederick, Keilholz, Ulrich, Ochsenreither, Sebastian, Folprecht, Gunnar, Siveke, Jens, Bauer, Sebastian, Kindler, Thomas, Brandts, Christian, Boerries, Melanie, Illert, Anna L., von Bubnoff, Nikolas, Spiekermann, Karsten, Jost, Philipp J., Schulze-Osthoff, Klaus, Bitzer, Michael, Schirmacher, Peter, von Kalle, Christof, Schlenk, Richard F., Klink, Barbara, Hutter, Barbara, Hübschmann, Daniel, Stenzinger, Albrecht, Weichert, Wilko, Schröck, Evelin, Brors, Benedikt, Glimm, Hanno, Fröhling, Stefan

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Etiology-independent activation of the LTβ-LTβR-RELB axis drives aggressiveness and predicts poor prognosis in HCC von Scherr, Anna-Lena, Nader, Luisa, Xu, Kaiyu, Elssner, Christin, Ridder, Dirk A, Nichetti, Federico, Mastel, Manuel, Fritzsche, Sarah, Kelmendi, Eblina, Schmitt, Nathalie, Hoffmeister-Wittmann, Paula, Weiler, Sofia M E, Korell, Felix, Albrecht, Thomas, Schwab, Maximilian, Isele, Hanna, Kessler, Annika, Hüllein, Jennifer, Seretny, Agnieszka, Ye, Liangtao, Urbanik, Toni, Welte, Stefan, Leblond, Anne-Laure, Heilig, Christoph E, Rahbari, Mohammad, Ali, Adnan, Gallage, Suchira, Lenoir, Bénédicte, Wilhelm, Nina, Gärtner, Ulrike, Ogrodnik, Simon J, Springfeld, Christoph, Tschaharganeh, Darjus, Fröhling, Stefan, Longerich, Thomas, Schulze-Bergkamen, Henning, Jäger, Dirk, Brandl, Lydia, Schirmacher, Peter, Straub, Beate K, Weber, Achim, De Toni, Enrico N, Goeppert, Benjamin, Heikenwalder, Mathias, Jackstadt, Rene, Roessler, Stephanie, Breuhahn, Kai, Köhler, Bruno C

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Heterogeneity and Evolution Of DNA Methylation In Chronic Lymphocytic Leukemia von Oakes, Christopher C, Claus, Rainer, Gu, Lei, Assenov, Yassen, Hüllein, Jennifer, Zucknick, Manuela, Brocks, David, Bogatyrova, Olga, Schmidt, Christopher R., Rassenti, Laura, Kipps, Thomas J., Mertens, Daniel, Lichter, Peter, Döhner, Hartmut, Stilgenbauer, Stephan, Byrd, John C., Zenz, Thorsten, Plass, Christoph

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